L’infinitif en anglais : to et la personne

On a l’habitude, en anglais comme en français, de distinguer entre des formes personnelles (modes indicatif et subjonctif) et non personnelles (infinitif et participes) du verbe. Or, une telle distinction, fondée sur la présence ou absence d’une désinence ou d’un substantif (pronom) indiquant le sujet, implique que la catégorie grammaticale de la personne est totalement absente de l’infinitif et des deux participes. Le présent article met en question le bien-fondé de cette présomption, essaie de démontrer que l’infinitif fait partie du paradigme grammatical de la personne et examine à la lumière de cette hypothèse l’emploi de la particule to devant l’infinitif en anglais.It is customary in both English and French to draw a distinction between the personal (indicative and subjunctive) and non-personal (infinitive and participles) forms of the verb. While such a distinction is based on the presence or absence of a grammatical ending or a noun (pronoun) denoting the verb's subject, it nonetheless implies that the grammatical category of person is totally absent in the infinitive and the two participles. The author of the present article questions the soundness of this assumption and attempts to show not only that the infinitive does participate in the paradigm of grammatical person but that postulating person in the infinitive throws new light on the use of to with the infinitive in English

Person in the English Verb: the Problem of -s

When one thinks of the -5 ending in English, the first use that comes to mind is probably that in which it expresses the notion of plurality. However the -5 morph is also pressed into service for other very different purposes: as a sign of the possessive with the noun, and as a third person singular marker with the verb. It is this latter use which will occupy us more specifically here

America\u27s Out-of-Style Pastime

An ethically driven essay regarding the recruiting tactics and methods that have been used by MLB for years to find young, Latin talent. Bringing a light to something that baseball has gone great lengths to keep in the shadows and away from the common fan. This doesn\u27t just create questions surrounding baseball, but overall the silencing of human rights

Pressure-measuring syringe utilizing elastomeric bellows

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p. 28).Endotracheal tube insertion requires the measurement of very low pressure. Currently, there exists no reliable method or device that is integral with the inflation syringe for measuring this pressure. Thus, a device for quickly and easily reading the pressure was created within the syringe currently used to pressurize the tube. This device takes the form of elastomeric bellows. These bellows were analyzed to determine the optimum geometry for the pressures involved in the procedure. Although no closed-form model exists for this analysis, FEA was used to obtain accurate results. Using the optimized bellows, a complete for-manufacturing design was created. This design concept has received much acclaim from the medical community and has great promise in transforming many medical procedures which require such measurement..by Samuel C. Duffley.S.B

Individuals with Age-Related Vision Loss: Experiences of Learning to Use Assistive Technology

Vision and hearing loss are senescent changes that occur during the aging process. Assistive technology is available that can assist individuals with adapting to this new life world. Technology can be expensive and research has indicated a 24% abandonment rate. Studies have indicated successful implementation of devices have occurred when individuals have a choice in device selection and training. The purpose of this existential phenomenological study was to explore the experiences of adults with age-related vision loss who learned to use assistive technology. A purposive sample was recruited from a Blinded Veterans Association located in Kentucky. The sample was comprised of seven male veterans with age-related vision loss, who were between the ages of 58-89. Each of these individuals participated in a phenomenological interview, which allowed me to understand the essence of the lived experience of these men. Four figural themes emerged that characterized the learning experience against a contextual ground of others, body, and time. The themes: “They take you by the hand and take you through it”; “learning to do it in a different way”; “I found I can be self-sufficient”; and “encourage other veterans” described the process of learning to use assistive technology that began with the instructor at the center and concluded with the veteran returning to his home and sharing his acquired knowledge. Findings from the study indicate the instructors were the guides into the new life-world of a person with a visual impairment. Learning to use assistive technology resulted in maintaining self-sufficiency and independence. Recommendations for practice for rehabilitation teachers, adult educators, and assistive technology practitioners indicates providing a learning environment consistent with Knowles (1980) assumptions of andragogy may result in successful use of assistive technology, which may in turn reduce abandonment rate. Recommendations for research include phenomenological studies with individuals who elected not to use assistive technology to determine if choice and training were reasons they elected not to use. Finally, instructors who provide rehabilitation training need to be interviewed about the phenomenon of teaching to establish best practices for recipients of assistive technology

What's on your mind is not on your brain- hopefully

The mind-body question is frequently framed in terms of “how the brain creates the mind” (Damasio 1999). The goal of this paper will be to contribute to the debate by a linguistic study of the words mind and brain, using data drawn from the British National Corpus, the Oxford English Dictionary, the Corpus of Contemporary American and Webster’s Dictionary. Evidence shows that the folk-concepts of ‘mind’ and ‘brain’ imply the causal priority of the mental over the physical. This converges with the conclusions of Penfield (1966), who proposed that “one might well say that the brain of man is molded by his mind,” a position also defended by Eccles 1994

Anyone for non-scalarity?

This paper examines the status of scalarity in the analysis of the meaning of the English determiner any. The latter’s position as a prime exemplar of the category of polarity-sensitive items has led it to be generally assumed to have scalar meaning. Scalar effects are absent however from a number of common uses of this word. This suggests that any does not involve scales as part of its core meaning, but produces them as a derived interpretative property. The role of three factors in the derivation of the expressive effect of scalarity is explored: grammatical number, stress and the presence of gradable concepts in the NP. The general conclusions point to the importance of developing a causal semantic analysis in which the contributions of each of the various meaningful components of an utterance to the overall message expressed are carefully distinguished

L'équipe d’aide et de sensibilisation aux opioïdes : un exemple novateur d'éducation médicale et de partenariat communautaire

Implication Statement  The Opioid Awareness and Support Team (OAST) at the Memorial University Faculty of Medicine is a novel student-led initiative designed to supplement medical student learning related to opioid use disorder and the opioids crisis. OAST has focused on grounding educational initiatives related to opioid use disorder in the local community context, working with community partners, and bringing in individuals with lived experience. We present initial findings from an Opioid Education Day that suggest student-led supplemental education for medical students can improve student knowledge surrounding opioid use.Énoncé des implications de la recherche L’équipe d’aide et de sensibilisation aux opioïdes (OAST) est une initiative des étudiants de la faculté de médecine de l’Université Memorial qui apporte un complément à la formation que reçoivent les étudiants sur le trouble lié à l’usage d’opioïdes. L'OAST s'est efforcée d’inscrire les initiatives éducatives liées à la crise des opïodes dans un contexte local en collaboration avec des partenaires communautaires et de faire participer des personnes ayant une expérience de terrain. Nous présentons les résultats préliminaires d'une journée de sensibilisation aux opioïdes qui suggèrent que cette activité éducative menée par les étudiants en médecine peut améliorer les connaissances des apprenants sur la consommation d’opioïdes

Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome

BACKGROUND: Deep brain stimulation (DBS) targeting the globus pallidus internus (GPi) can improve tics and comorbid obsessive-compulsive behavior (OCB) in patients with treatment-refractory Tourette syndrome (TS). However, some patients’ symptoms remain unresponsive, the stimulation applied across patients is variable, and the mechanisms underlying improvement are unclear. Identifying the fiber pathways surrounding the GPi that are associated with improvement could provide mechanistic insight and refine targeting strategies to improve outcomes. METHODS: Retrospective data were collected for 35 patients who underwent bilateral GPi DBS for TS. Computational models of fiber tract activation were constructed using patient-specific lead locations and stimulation settings to evaluate the effects of DBS on basal ganglia pathways and the internal capsule. We first evaluated the relationship between activation of individual pathways and symptom improvement. Next, linear mixed-effects models with combinations of pathways and clinical variables were compared in order to identify the best-fit predictive models of tic and OCB improvement. RESULTS: The best-fit model of tic improvement included baseline severity and the associative pallido-subthalamic pathway. The best-fit model of OCB improvement included baseline severity and the sensorimotor pallidosubthalamic pathway, with substantial evidence also supporting the involvement of the prefrontal, motor, and premotor internal capsule pathways. The best-fit models of tic and OCB improvement predicted outcomes across the cohort and in cross-validation. CONCLUSIONS: Differences in fiber pathway activation likely contribute to variable outcomes of DBS for TS. Computational models of pathway activation could be used to develop novel approaches for preoperative targeting and selecting stimulation parameters to improve patient outcomes

Does in utero HIV exposure and the early nutritional environment influence infant development and immune outcomes? Findings from a pilot study in Pretoria, South Africa

BACKGROUND : As mother-to-child transmission of HIV decreases, and the population of infants who are born HIV-exposed, but uninfected (HEU) continues to rise, there is a growing need to understand the development and health outcomes of infants who are HEU to ensure that they have the healthiest start to life. METHODS : In a prospective cohort pilot study at Kalafong Hospital, Pretoria, South Africa, we aimed to determine if we could recruit new mothers living with HIV on antiretrovirals (ART; n = 20) and not on ART (n = 20) and new mothers without HIV (n = 20) through our clinics to study the effects of HEU on growth and immune- and neurodevelopment in infants in early life, and test the hypothesis that infants who were HEU would have poorer health outcomes compared to infants who were HIV-unexposed, uninfected (HUU). We also undertook exploratory analyses to investigate relationships between the early nutritional environment, food insecurity and infant development. Infant growth, neurodevelopment (Guide for Monitoring Child Development [GMCD]) and levels of monocyte subsets (CD14, CD16 and CCR2 expression [flow cytometry]) were measured in infants at birth and 12 weeks (range 8–16 weeks). RESULTS : We recruited 33 women living with HIV on ART and 22 women living without HIV within 4 days of delivery from June to December 2016. Twenty-one women living with HIV and 10 without HIV returned for a follow-up appointment at 12 weeks postpartum. The high mobility of this population presented major challenges to participant retention. Preliminary analyses revealed lower head circumference and elevated CCR2+ (% and median fluorescence intensity) on monocytes at birth among infants who were HEU compared to HUU. Maternal reports of food insecurity were associated with lower maternal nutrient intakes at 12 weeks postpartum and increased risk of stunting at birth for infants who were HEU, but not infants who were HUU. CONCLUSIONS : Our small feasibility pilot study suggests that HEU may adversely affect infant development, and further, infants who are HEU may be even more vulnerable to the programming effects of suboptimal nutrition in utero and postnatally. This pilot and preliminary analyses have been used to inform our research questions and protocol in our ongoing, full-scale study.Additional file 1: Supplementary Figure S1. Sequential gating approach for the measurement of CCR2 expression by CD14+ monocytes. The sequential gating approached used was as follows: First, the viable (7-AAD negative; region ‘Viable”) cells were identified using a 7-AAD vs SS Log density plot. A “Viable” region was created around the 7-AAD negative cells. Gated on the “Viable”cells, a SSLog vs FS plot was used to capture intact cells in the “E” region. CD14+ monocytes were identified (“CD14+” region) using a CD14 vs SS Log density plot that were gated on viable, intact cells (“E” region). CD14+ monocytes that express CCR2 were quantified using a CD192 (CCR2) vs SS Log plot. The proportion of CD14+/CCR2+ cells were captured in the “CD14+ CCR2+” region. The gating strategy followed to quantify CCR2 expression by CD16+ neutrophils was similar to what was described for CD14+ monocytes, but instead of identifying CD14+ monocytes, CD16+ neutrophils were identified (“CD16+” region) using a CD16 vs SS Log density plot that were gated on viable, intact cells (“E” region). CD16+ neutrophils that express CCR2 were quantified using a CD192 (CCR2) vs SS Log plot. The proportion of CD14+/CCR2+ cells was captured in the “CD16+ CCR2+” region.Additional file 2: Supplementary Figure S2. Sequential gating approach for the measurement of CCR2 expression by monocyte subpopulations. Doublets and debris were removed (Region ‘K’) using a FS Area vs FS Height density plot. A 7-AAD vs SS Log density plot, gated on ‘K’ was used to exclude all non-viable cells. Viable cells were captured in region ‘Viable’. Viable CD14+ monocytes were identified (Region ‘CD14+ Monocytes’) using a CD14 APC vs SS Log density plot. Monocyte sub-populations were identified using a CD16 FITC vs CD14 PE density plot gated on viable, CD14+ monocytes. Four monocyte sub-populations were identified: CD14+/CD16-; CD14++/CD16-; CD14+/CD16+; and CD14++/CD16+. The percentage CCR2+ monocytes present in each of the respective monocyte sub-populations were identified using CD195 (CCR2) PE vs SS Log two-parameter plots gated on the respective subpopulations. The overlay plots within the black bordered square indicates the strategy used to determine CCR2 expression of the different monocyte subsets. The negative/positive staining boundaries were determined based on the negative expression of CCR2 by CD16++/CD14- neutrophils (indicated in red in the overlay plots). The CCR2+ populations are indicated in blue.Additional file 3: Supplementary Figure S3. Maternal intake of estimated average requirements for macronutrients, vitamins and minerals for mothers who report on household food security circumstances. Maternal reports of food insecurity did not associate with intake levels of macronutrients or minerals. Maternal reports of experiencing food runout or inability to afford balanced meals associated with lower intake of vitamin B12 (p=0.01; p=0.04). Many women, irrespective of food security reports, are at risk of inadequate macronutrient, vitamin and mineral intakes. Percent intake of EARs for 36 nutrients were calculated for lactating women 14-18, 19-30 or 31-50 years of age [37]. Calculations for EAR for total protein considered maternal weight at time of dietary recall. Data are % intake of EAR reported in maternal dietary recall for macronutrients, *p<0.05 [ANOVA for normal distribution/ equal variance; Kruskal-Wallis/Wilcoxon test for nonparametric data; or Welch’s test for normal data/unequal variance]). CHO = carbohydrates.Additional file 4: Supplementary Figure S4. Cooccurrence of maternal HIV and food insecurity may increase risk of stunting at birth. Amongst infants whose mothers report worrying about food runout, risk of stunting at birth is greater for HEU compared to HUU infants (e; RR=4.90 [0.76, 31.5], ARD=0.56 [0.17, 0.94], p=0.0498). The red line represents the proportion of infants who had stunting at birth or 12 weeks PP. Mosaic plots are proportion (%) of HUU or HEU infants who have stunting (<-2 SD length-for-age standardised according to WHO child growth standards [28]) at birth and 12 weeks old. HUU = HIV-unexposed, uninfected infant; HEU = HIV-exposed, uninfected infant. RR = Relative risk. ARD = Absolute risk difference.Additional file 5: Supplementary Figure S5. Food insecurity may associate with low attainment of GMCD milestones for HUU and HEU infants. Infants whose mothers reported household food insecurity did not attain 1-3 month GMCD milestones (A, C, E) for receptive language, large movement, relating and response behaviour or play activities, or 3-5 month GMCD milestones (B, D, F) for fine movement or relating and response behaviour in the same proportion as the international standardization sample. Maternal reports of food insecurity did not associate with risk of not attaining all 1-3 month or 3-5 month GMCD milestones (A-F, [p>0.05], Fisher’s exact 2-Tail). Data are proportion (%) of infants who attained all age-appropriate GMCD milestones. The horizontal dotted line represents the GMCD standardised international sample proportion (85%) of infants who attained all milestones in that age category, when they were in that age range. The numbers underneath the bars represent the number of infants attaining all milestones for each milestone. GMCD = Guide for monitoring child development; HUU = HIVunexposed, uninfected infant; HEU = HIVexposed, uninfected infant.Additional file 6: Supplementary Table S1. Flow cytometry reagent list (including lasers and detectors used). Supplementary Table S2. Flow cytometry compensation matrix. Supplementary Table S3. Maternal nutrient intakes from one 24-hour dietary recall for mothers with and without HIV who attended follow up. Supplementary Table S4. Maternal nutrient intake from one 24-hour dietary recall for mothers who report experiencing food insecurity compared to those who do not experience food insecurity.The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER); the Faculty of Science, Carleton University; the Canadian Institutes of Health Research (CIHR); a Canadian Graduate Scholarship-Master’s and a Michael Smith Foreign Study Supplement from CIHR.https://pilotfeasibilitystudies.biomedcentral.comam2021ImmunologyObstetrics and GynaecologyPaediatrics and Child Healt