Children cannot ignore what they hear: Incongruent emotional information leads to an auditory dominance in children

Effective emotion recognition is imperative to successfully navigating social situations. Research suggests differing developmental trajectories for the recognition of bodily and vocal emotion, but emotions are usually studied in isolation and rarely considered as multimodal stimuli in the literature. When presented with basic multimodal sensory stimuli, the Colavita effect suggests that adults have a visual dominance (they state how many stimuli they have seen rather than heard), whereas more recent research finds that an auditory sensory dominance may be present in children under 8 years of age. However, it is not currently known whether this phenomenon holds for more complex multimodal social stimuli. Here we presented children and adults with multimodal social stimuli consisting of emotional bodies and voices, asking them to recognise the emotion in one modality while ignoring the other. We found that adults can perform this task with no detrimental effects to performance, regardless of whether the ignored emotion was congruent or not. However, children find it extremely challenging to recognise bodily emotion while trying to ignore incongruent vocal emotional information. In several instances they perform below chance level, indicating that the auditory modality actively informs their choice of bodily emotion. This is therefore the first evidence, to our knowledge, of an auditory dominance in children when presented with socially meaningful stimuli

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients