Going out, getting about: atmospheres of mobility in Melbourne’s night-time economy

Drawing from recent affective geographies of drinking and drunkenness, this article explores the affective atmospheres of spaces of mobility in Melbourne’s night-time economy and how these atmospheres shape the experience of alcohol-related problems. Our discussion is grounded in the analysis of interview data collected in 2012 among 60 young adults living in Melbourne. Participants included youth residing in the inner-city who reported taking a tram, walking or cycling to nearby venues along with youth from periurban communities who used trains, buses or taxis to travel to and from venues in the inner-city. Each group reported spending varying amounts of time on the move during a night-out drinking, although the atmospherics of mobility differed for each group. Inner-city participants described ‘comfortable’ or ‘fun’ journeys on the tram, walking or cycling, whereas participants from periurban communities spoke of ‘boring’ or ‘unpleasant’ journeys via train, night-bus or taxi. Moving beyond reports of the ‘priming’ effects of affective atmospheres, we conclude that these atmospheres are(co-)constituted in encounters between bodies, human and non-human, as they move. We close with a brief discussion of the implications of our analysis for the study of alcohol-related problems in the city at night

Healing Architecture in Healthcare:A Scoping Review

OBJECTIVES: The purpose of this scoping review is to identify evidence on how characteristics of healing architecture in clinical contexts impact clinical practice and patient experiences. Based on these insights, we advance a more practice-based approach to the study of how healing architectures work. BACKGROUND: The notion of "healing architecture" has recently emerged in discussions of the spatial organization of healthcare settings, particularly in the Nordic countries. This scoping review summarizes findings from seven articles which specifically describe how patients and staff experience characteristics of healing architecture. METHODS: This scoping review was conducted using the framework developed by Arksey and O'Malley. We referred to the decision tool developed by Pollock et al. to confirm that this approach was the most appropriate evidence synthesis type to identify characteristics related to healing architecture and practice. To ensure the rigor of this review, we referred to the methodological guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews. RESULTS: There are two main findings of the review. First, there is no common or operative definition of healing architecture used in the selected articles. Secondly, there is limited knowledge of how healing architecture shapes clinical and patient outcomes. CONCLUSIONS: We conclude that further research is needed into how healing architectures make a difference in everyday clinical practices, both to better inform the development of evidence-based designs in the future and to further elaborate criteria to guide postoccupancy evaluations of purpose-built sites

Leaving rehab: enhancing transitions into stable housing

The project will examine the coordination between residential treatment and housing and social support services using international comparisons and linked administrative data followed by testing in the field. It aims to enhance transition planning and reduce the risk of housing instability for individuals leaving treatment for mental health and/or substance use problems

Speed and space: rates of motion in health and wellbeing

The posthumanist turn in health and wellbeing research has paid attention to the qualities of space, particularly through the work of geographers. Although a range of these qualities have been explicitly articulated and well explored, a clear omission in the literature has been ‘speed’ - an important quality in its own right, and evident in all other qualities. This review paper takes a good look at speed. First it considers what speed is, and the myriad ways in which it arises and is registered according to science and other intellectual paradigms. Second it considers speed as a distinctive feature of twenty-first century life and the health and wellbeing involvements and implications of this life. Third it considers some partial precedent for a focus on speed and space in health and wellbeing research, by drawing speed out of current studies where it is implicit or a minor consideration. To conclude, the paper thinks about the issues, challenges and possibilities for researching speed more fully, and the opportunities this might open up

The Brain Imaging Data Structure, a Format for Organizing and Describing Outputs of Neuroimaging Experiments

The development of magnetic resonance imaging (MRI) techniques has defined modern neuroimaging. Since its inception, tens of thousands of studies using techniques such as functional MRI and diffusion weighted imaging have allowed for the non-invasive study of the brain. Despite the fact that MRI is routinely used to obtain data for neuroscience research, there has been no widely adopted standard for organizing and describing the data collected in an imaging experiment. This renders sharing and reusing data (within or between labs) difficult if not impossible and unnecessarily complicates the application of automatic pipelines and quality assurance protocols. To solve this problem, we have developed the Brain Imaging Data Structure (BIDS), a standard for organizing and describing MRI datasets. The BIDS standard uses file formats compatible with existing software, unifies the majority of practices already common in the field, and captures the metadata necessary for most common data processing operations

The symmetry algebras of Euclidean M-theory

We study the Euclidean supersymmetric D=11 M-algebras. We consider two such D=11 superalgebras: the first one is N=(1,1) self-conjugate complex-Hermitean, with 32 complex supercharges and 1024 real bosonic charges, the second is N=(1,0) complex-holomorphic, with 32 complex supercharges and 528 bosonic charges, which can be obtained by analytic continuation of known Minkowski M-algebra. Due to the Bott's periodicity, we study at first the generic D=3 Euclidean supersymmetry case. The role of complex and quaternionic structures for D=3 and D=11 Euclidean supersymmetry is elucidated. We show that the additional 1024-528=496 Euclidean tensorial central charges are related with the quaternionic structure of Euclidean D=11 supercharges, which in complex notation satisfy SU(2) pseudo-Majorana condition. We consider also the corresponding Osterwalder-Schrader conjugations as implying for N=(1,0) case the reality of Euclidean bosonic charges. Finally, we outline some consequences of our results, in particular for D=11 Euclidean supergravity.Comment: LaTex, 12 pages. Minor corrections and acknowledgment added. The text as appeared in PL

The social life of HIV care: On the making of ‘care beyond the virus’

Treating care as an effect of material implementations, we use qualitative interviews with people living with HIV in London, most of whom are migrants, to explore care practices linked to clinical treatment delivered as part of the ‘cascade of HIV care’. We consider how HIV care is done, and what HIV care does, drawing on assemblage theory. We ask how is care affected by the situations in which it is enacted? and what contingent forms of care does the HIV care cascade potentiate? A prime actor in the care assemblages revealed in our study is immigration, from which multiple uncertainties flow, including access to vital resources such as housing and income. Yet we also found that clinical HIV care is worked-with in practice to afford multiple forms of care. Here, viral care is translated into matters of vital concern to produce care which extends ‘beyond the virus’. Practices of care beyond the virus afford social protection, including through making-up social relations and networks, and novel modes of sociality. Friendship connections, community organisations and HIV clinics are among the key actors involved. Being attuned to how HIV care is made to matter helps generate new ways of knowing and doing care

Britain and Europe: A new settlement? EPC Challenge Europe 23, May 2016

Britain's European problem, Stephen Wall; Britain's contribution to the EU: an insider's view, David Hannay; 'Foreign judges' and the law of the European Union, David Edward; The United Kingdom and the Charter of Fundamental Rights of the EU, Peter Goldsmith; European foreign policy: five and a half stories, Robert Cooper; External relations and the transformative power of enlargement, Heather Grabbe; Recalibrating British European policy in foreign affairs, Fraser Cameron; The European Union and the wider Europe, Graham Avery; From Common Market to Single Market: an unremarked success, Malcolm Harbour; Lost in translation: Britain, Germany and the euro, Quentin Peel; After Cameron's EU deal, Kirsty Hughes; Re-imagining the European Union, Caroline Lucas; Britain and European federalism, Brendan Donnelly; Europe's British problem, Andrew Duff

Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immune response to invading pathogens, it is responsible for the collateral host tissue damage observed in chronic conditions such as chronic obstructive pulmonary disease (COPD), and in more acute disorders such as the lung injuries associated with COVID-19 infection. Previously, a combinatorially selected activity-based probe revealed an unexpected substrate preference for oxidised methionine, which suggests a link to oxida-tive pathogen clearance by neutrophils. Here we use oxidised model substrates and inhibitors to confirm this observation and to show that neutrophil elastase is specifically selective for the di-oxygenated methionine sulfone rather than the mono-oxygenated methionine sulfoxide. We also posit a critical role for ordered solvent in the mechanism of HNE discrimination between the two oxidised forms methionine residue. Preference for the sulfone form of oxidised methionine is especially significant. While both host and pathogens have the ability to reduce methionine sulfoxide back to methionine, a biological pathway to reduce methionine sulfone is not known. Taken to-gether, these data suggest that the oxidative activity of neutrophils may create rapidly cleaved elas-tase “super substrates” that directly damage tissue, while initiating a cycle of neutrophil oxidation that increases elastase tissue damage and further neutrophil recruitment