634 research outputs found
Techniques for the Synthesis of Reversible Toffoli Networks
This paper presents novel techniques for the synthesis of reversible networks
of Toffoli gates, as well as improvements to previous methods. Gate count and
technology oriented cost metrics are used. Our synthesis techniques are
independent of the cost metrics. Two new iterative synthesis procedure
employing Reed-Muller spectra are introduced and shown to complement earlier
synthesis approaches. The template simplification suggested in earlier work is
enhanced through introduction of a faster and more efficient template
application algorithm, updated (shorter) classification of the templates, and
presentation of the new templates of sizes 7 and 9. A novel ``resynthesis''
approach is introduced wherein a sequence of gates is chosen from a network,
and the reversible specification it realizes is resynthesized as an independent
problem in hopes of reducing the network cost. Empirical results are presented
to show that the methods are effective both in terms of the realization of all
3x3 reversible functions and larger reversible benchmark specifications.Comment: 20 pages, 5 figure
Diversified Late Acceptance Search
The well-known Late Acceptance Hill Climbing (LAHC) search aims to overcome
the main downside of traditional Hill Climbing (HC) search, which is often
quickly trapped in a local optimum due to strictly accepting only non-worsening
moves within each iteration. In contrast, LAHC also accepts worsening moves, by
keeping a circular array of fitness values of previously visited solutions and
comparing the fitness values of candidate solutions against the least recent
element in the array. While this straightforward strategy has proven effective,
there are nevertheless situations where LAHC can unfortunately behave in a
similar manner to HC. For example, when a new local optimum is found, often the
same fitness value is stored many times in the array. To address this
shortcoming, we propose new acceptance and replacement strategies to take into
account worsening, improving, and sideways movement scenarios with the aim to
improve the diversity of values in the array. Compared to LAHC, the proposed
Diversified Late Acceptance Search approach is shown to lead to better quality
solutions that are obtained with a lower number of iterations on benchmark
Travelling Salesman Problems and Quadratic Assignment Problems
Integrating morphological and physiological responses of tomato plants to light quality to the crop level by 3D modeling
Next to its intensity, the spectral composition of light is one of the most important factors affecting plant growth and morphology. The introduction of light emitting diodes (LEDs) offers perspectives to design optimal light spectra for plant production systems. However, knowledge on the effects of light quality on physiological plant processes is still limited. The aim of this study is to determine the effects of six light qualities on growth and plant architecture of young tomato plants, and to upscale these effects to the crop level using a multispectral, functional-structural plant model. Young tomato plants were grown under 210 ÎĽmol m-2 s-1 blue, green, amber, red, white or red/blue (92%/8%) LED light with a low intensity of sunlight as background. Plants grown under blue light were shorter and developed smaller leaves which were obliquely oriented upward. Leaves grown under blue light contained the highest levels of light harvesting pigments, but when exposed to blue light only, they had the lowest rate of leaf photosynthesis. However, when exposed to white light these leaves had the highest rate of photosynthesis. Under green light, tomato plants were taller and leaves were nearly horizontally oriented, with a high specific leaf area. The open plant structure combined with a high light transmission and reflection at the leaf level allowed green light to penetrate deeper into the canopy. Plants grown under red, amber and white light were comparable with respect to height, leaf area and biomass production. The 3D model simulations indicated that the observed changes in plant architecture had a significant impact on light absorbance at the leaf and crop level. The combination of plant architecture and spectrum dependent photosynthesis was found to result in the highest rate of crop photosynthesis under red light in plants initially grown under green light. These results suggest that dynamic light spectra may offer perspectives to increase growth and production in high value production systems such as greenhouse horticulture and vertical farming.</p
Strong Secrecy for Multiple Access Channels
We show strongly secret achievable rate regions for two different wiretap
multiple-access channel coding problems. In the first problem, each encoder has
a private message and both together have a common message to transmit. The
encoders have entropy-limited access to common randomness. If no common
randomness is available, then the achievable region derived here does not allow
for the secret transmission of a common message. The second coding problem
assumes that the encoders do not have a common message nor access to common
randomness. However, they may have a conferencing link over which they may
iteratively exchange rate-limited information. This can be used to form a
common message and common randomness to reduce the second coding problem to the
first one. We give the example of a channel where the achievable region equals
zero without conferencing or common randomness and where conferencing
establishes the possibility of secret message transmission. Both coding
problems describe practically relevant networks which need to be secured
against eavesdropping attacks.Comment: 55 page
Improving Benefit-harm Assessment of Therapies from the Patient Perspective: OMERACT Premeeting Toward Consensus on Core Sets for Randomized Controlled Trials
Objective: Outcome Measures in Rheumatology (OMERACT) convened a premeeting in 2018 to bring together patients, regulators, researchers, clinicians, and consumers to build upon previous OMERACT drug safety work, with patients fully engaged throughout all phases.
Methods: Day 1 included a brief introduction to the history of OMERACT and methodology, and an overview of current efforts within and outside OMERACT to identify patient-reported medication safety concerns. On Day 2, two working groups presented results; after each, breakout groups were assembled to discuss findings.
Results: Five themes pertaining to drug safety measurement emerged.
Conclusion: Current approaches have failed to include data from the patient’s perspective. A better understanding of how individuals with rheumatic diseases view potential benefits and harms of therapies is essential
Impact of Zumba on Cognition and Quality of Life is Independent of APOE4 Carrier Status in Cognitively Unimpaired Older Women: A 6-Month Randomized Controlled Pilot Study
Objective: To investigate the association of a 6-month Zumba intervention with cognition and quality of life among older cognitively unimpaired apolipoprotein SMALL ELEMENT OF4 (APOE4) carrier and noncarrier women.
Methods: Fifty-three women were randomly assigned to either twice-weekly Zumba group classes or maintenance of habitual exercise (control group) for 6 months. At baseline, 3, and 6 months, all participants underwent neuropsychological, physical activity, and quality-of-life assessments.
Results: Overall, neuropsychological test scores and level of physical activity did not differ between intervention and control groups at any time. However, compared to the control group, quality of life was higher at 3 months, and visuospatial working memory and response inhibition improved more in the intervention group by 6 months. Apolipoprotein SMALL ELEMENT OF4 status did not affect the results.
Discussion: Zumba may strengthen performance on visuospatial working memory among cognitively unimpaired older women but this needs to be tested in a larger clinical trial
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