Deep excursion beyond the proton dripline. I. Argon and chlorine isotope chains

The proton-unbound argon and chlorine isotopes have been studied by measuring trajectories of their decay-in-flight products by using a tracking technique with micro-strip detectors. The proton (1p) and two-proton (2p) emission processes have been detected in the measured angular correlations “heavy-fragment”+p and “heavy-fragment”+p+p, respectively. The ground states of the previously unknown isotopes 30Cl and 28Cl have been observed for the first time, providing the 1p separation energies Sp of −0.48(2) and −1.60(8) MeV, respectively. The relevant systematics of 1p and 2p separation energies have been studied theoretically in the core+p and core+p+p cluster models. The first-time observed excited states of 31Ar allow to infer the 2p-separation energy S2p of 6(34) keV for its ground state. The first-time observed state in 29Ar with S2p = −5.50(18) MeV can be identified either as a ground or an excited state according to different systematics.This work was supported in part by the Helmholtz International Center for FAIR (HIC for FAIR); the Helmholtz Association (Grant No. IK-RU-002); the Russian Science Foundation (Grant No. 17-12-01367); the Polish National Science Center (Contract No. UMO-2015/17/B/ST2/00581); the Polish Ministry of Science and Higher Education (Grant No. 0079/DIA/2014/43, Grant Diamentowy); the Helmholtz-CAS Joint Research Group (Grant No. HCJRG-108); the Ministry of Education & Science, Spain (Contract No. FPA2016-77689-C2-1-R); the Hessian Ministry for Science and Art (HMWK) through the LOEWE funding scheme Helmholtz International Center for FAIR (HIC for FAIR); the Justus-Liebig-Universitat Giessen (JLU) and the GSI under the JLU-GSI strategic Helmholtz partnership agreement. This work was carried out in the framework of the Super-FRS Experiment collaboration. This article is a part of the Ph.D. thesis of D. Kostyleva

Deep excursion beyond the proton dripline. II. Towards the limits of nuclear structure existence

Prospects of experimental studies of argon and chlorine isotopes located far beyond the proton dripline are studied by using systematics and cluster models. The deviations from the widespread systematics observed in 28 , 29 Cl and 29 , 30 Ar have been theoretically substantiated, and analogous deviations have been predicted for the lighter chlorine and argon isotopes. The limits of nuclear structure existence are predicted for Ar and Cl isotopic chains, with 26 Ar and 25 Cl found to be the lightest sufficiently long-living nuclear systems. By simultaneous measurements of protons and γ rays following decays of such systems as well as their β -delayed emission, an interesting synergy effect may be achieved, which is demonstrated by the example of 30 Cl and 31 Ar ground-state studies. Such a synergy effect may be provided by the new EXPERT setup (EXotic Particle Emission and Radioactivity by Tracking) being operated inside the fragment separator and spectrometer facility at GSI, Darmstadt.This work was supported in part by the Hessian Ministry for Science and Art (HMWK) through the LOEWE funding scheme Helmholtz International Center for FAIR (HIC for FAIR); the Helmholtz Association (Grant No. IK-RU-002); the Russian Science Foundation (Grant No. 17-12-01367); the Polish National Science Center (Contract No. UMO-2015/17/B/ST2/00581); the Polish Ministry of Science and Higher Education (Grant No. 0079/DIA/2014/43, Grant Diamentowy); the Helmholtz-CAS Joint Research Group (Grant No. HCJRG-108); the Ministry of Education & Science, Spain (Contract No. FPA2016-77689-C2-1-R); the Ministry of Education, Youth and Sports, Czech Republic (Projects No. LTT17003 and No. LM2015049); and the Justus-Liebig-Universitat Giessen (JLU) and the GSI under the JLU-GSI strategic Helmholtz partnership agreement. This work was carried out in the framework of the Super-FRS Experiment collaboration. This article is a part of the Ph.D. thesis of D. Kostyleva

Effects of ripening stages and of plant vegetative vigor on the phenolic composition of grapes (Vitis vinifera L.) cv. Cabernet Sauvignon in the Maipo Valley (Chile)

Quantitative changes in the composition of phenolic compounds in skins and seeds were determined during ripening of grape of Cabernet Sauvignon vines growing with low, medium or high vigor. Compounds in the skins were gallic and syringic acid, (+)-catechin, (-)-epicatechin, quercetin-3-galactoside, quercetin-3-rutinoside, quercetin-3-arabinglucoside, quercetin-3-glucoside, and quercetin-3-rhamnoside, kaempferol-3-rutinoside and kaempferol-3-glucoside. The following compounds were identified in seeds: gallic acid, (+)-catechin, (-)-epicatechin, and procyanidins B1, B2, B3 and B4. The composition of compounds depended on the stage of ripening and vigor. No clear relationship was found between groups of compounds.

The administration of chitosan-tripolyphosphate-DNA nanoparticles to express exogenous SREBP1a enhances conversion of dietary carbohydrates into lipids in the liver of Sparus aurata

In addition to being essential for the transcription of genes involved in cellular lipogenesis, increasing evidence associates sterol regulatory element binding proteins (SREBPs) with the transcriptional control of carbohydrate metabolism. The aim of this study was to assess the effect of overexpression SREBP1a, a potent activator of all SREBP-responsive genes, on the intermediary metabolism of Sparus aurata, a glucose-intolerant carnivorous fish. Administration of chitosan-tripolyphosphate nanoparticles complexed with a plasmid driving expression of the N-terminal transactivation domain of SREBP1a significantly increased SREBP1a mRNA and protein in the liver of S. aurata. Overexpression of SREBP1a enhanced the hepatic expression of key genes in glycolysis-gluconeogenesis (glucokinase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase), fatty acid synthesis (acetyl-CoA carboxylase 1 and acetyl-CoA carboxylase 2), elongation (elongation of very long chain fatty acids protein 5) and desaturation (fatty acid desaturase 2) as well as reduced nicotinamide adenine dinucleotide phosphate production (glucose-6-phosphate 1-dehydrogenase) and cholesterol synthesis (3-hydroxy-3-methylglutaryl-coenzyme A reductase), leading to increased blood triglycerides and cholesterol levels. Beyond reporting the first study addressing in vivo effects of exogenous SREBP1a in a glucose-intolerant model, our findings support that SREBP1a overexpression caused multigenic effects that favoured hepatic glycolysis and lipogenesis and thus enabled protein sparing by improving dietary carbohydrate conversion into fatty acids and cholesterolPeer ReviewedPostprint (published version

Deposition of SiNx : H thin films by the electron cyclotron resonance and its application to Al/SiNx : H/Si structures

We have analyzed the electrical properties and bonding characteristics of SiNx:H thin films deposited at 200 degrees C by the electron cyclotron resonance plasma method. The films show the presence of hydrogen bonded to silicon (at the films with the ratio N/Si<1.33) or to nitrogen (for films where the ratio N/Si is higher than 1.33). In the films with the N/Si ratio of 1.38, the hydrogen content is 6 at. %. For compositions which are comprised of between N/Si=1.1 and 1.4, hydrogen concentration remains below 10 at. %. The films with N/Si=1.38 exhibited the better values of the electrical properties (resistivity, 6x10(13) Omega cm; and electric breakdown field, 3 MV/cm). We have used these films to make metal-insulator-semiconductor (MIS) devices on n-type silicon wafers. C-V measurements accomplished on the structures indicate that the interface trap density is kept in the range (3 - 5) x 10(11) cm(-2) eV(-1) for films with the N/Si ratio below 1.38. For films where the N/Si ratio is higher than 1.3, the trap density suddenly increases, following the same trend of the concentration of N-H bonds in the SiNx:H films. The results are explained on the basis of the model recently reported by Lucovsky [J. Vac. Sci. Technol. B 14, 2832 (1996)] for the electrical behavior of (oxide-nitride-oxide)/Si structures. The model is additionally supported by deep level transient spectroscopy measurements, that show the presence of silicon dangling bonds at the insulator/semiconductor interface (the so-called P-bN0 center), The concentration of these centers follows the same trend with the film composition of the interface trap density and, as a consequence, with the concentration of N-H bonds. This result further supports the N-H bonds located at the insulator/semiconductor interface which act as a precursor site to the defect generation of the type . Si=Si-3, i.e., the P-bN0 centers. A close relation between interface trap density, P-bN0 centers and N-H bond density is established

Antiparkinsonian efficacy of guanosine in rodent models of movement disorder

Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing motor impairments in several rodent movement disorder models, including catalepsy, tremor, and hemiparkinsonism. Our results showed that orally administered GUO antagonized reserpine-mediated catalepsy, reduced reserpine-induced tremulous jaw movements, and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine in unilaterally 6-hydroxidopamine-lesioned rats. In addition, at 5 and 7.5 mg/kg, GUO inhibited L-DOPA-induced dyskinesia in rats chronically treated with a pro-dopaminergic agent. Overall, we describe the therapeutic potential of GUO, which may be effective not only for reversing parkinsonian motor impairments but also for reducing dyskinesia induced by treatment for PD

What does it take to make integrated care work? A ‘cookbook’ for large-scale deployment of coordinated care and telehealth

The Advancing Care Coordination & Telehealth Deployment (ACT) Programme is the first to explore the organisational and structural processes needed to successfully implement care coordination and telehealth (CC&TH) services on a large scale. A number of insights and conclusions were identified by the ACT programme. These will prove useful and valuable in supporting the large-scale deployment of CC&TH. Targeted at populations of chronic patients and elderly people, these insights and conclusions are a useful benchmark for implementing and exchanging best practices across the EU. Examples are: Perceptions between managers, frontline staff and patients do not always match; Organisational structure does influence the views and experiences of patients: a dedicated contact person is considered both important and helpful; Successful patient adherence happens when staff are engaged; There is a willingness by patients to participate in healthcare programmes; Patients overestimate their level of knowledge and adherence behaviour; The responsibility for adherence must be shared between patients and health care providers; Awareness of the adherence concept is an important factor for adherence promotion; The ability to track the use of resources is a useful feature of a stratification strategy, however, current regional case finding tools are difficult to benchmark and evaluate; Data availability and homogeneity are the biggest challenges when evaluating the performance of the programmes

Validation of age determination using otoliths of the European anchovy (Engraulis encrasicolus L.) in the Bay of Biscay

Validation of the age determination procedure using otoliths of European anchovy in the Bay of Biscay was achieved by monitoring very strong year-classes in successive spring catches and surveys, as well as the seasonal occurrence of edge types. Historical corroboration of the ageing method was obtained by cross-correlation between successive age groups by year-classes in catches and surveys (1987–2013). Summary annual growth in length is also presented. Yearly annuli consist of a hyaline zone (either single or composite) and a wide opaque zone, disrupted occasionally by some typical checks (mainly at age-0 and age-1 at peak spawning time). Age determination, given a date of capture, requires knowledge of the typical annual growth pattern of otoliths, their seasonal edge formation by ages and the most typical checks. Most opaque growth occurs in summer and is minimal (translucent) in winter. Opaque zone formation begins earlier in younger fish (in spring), and this helps distinguish age-1 from age-2þ.Versión del edito