Ordinanza sirchia sui cani potenzialmente pericolosi: valutazione degli effetti nella città di Firenze

RIASSUNTO L’aggressività canina risulta essere un tema largamente dibattuto, soprattutto quando vede coinvolto l’uomo come parte lesionata. Il problema delle morsicature canine rivolte all’uomo deve essere affrontato ed analizzato in modo scientifico, al fine di permettere l’individuazione dei fattori di rischio. Lo scopo di questo lavoro è stato quello di valutare l’influenza dell’Ordinanza Sirchia del 9 settembre 2003 intitolata “Tutela dell’incolumità pubblica dal rischio di aggressioni da parte di cani potenzialmente pericolosi” sull’andamento delle morsicature canine rivolte all’uomo nella città di Firenze. Per questo studio sono stati raccolti 556 casi di morsicature verificatesi nel periodo compreso tra settembre 2002 ed agosto 2005, desunti dalle certificazioni dei referti medici dei vari D.E.A. di Firenze, dalle denunce effettuate all’ufficio dell’anagrafe canina e dalle schede di osservazione per la profilassi della rabbia. I dati sono stati inseriti in un database ed esaminati statisticamente grazie al test del 2. La presente ricerca ha dimostrato che la suddetta Ordinanza non ha provocato, nel campione preso in esame, significativi cambiamenti sull’andamento delle morsicature canine né a breve né a lungo termine. Infatti, anche se è stata evidenziata una diminuzione numerica di queste nel periodo successivo all’ordinanza (210 vs 172 morsicature), una tendenza alla diminuzione era già in atto dal 1986. Inoltre le caratteristiche dei proprietari, dei lesionati e degli animali coinvolti nelle morsicature sono rimaste invariate. I risultati del presente studio sembrerebbero dunque indicare che provvedimenti legislativi a carattere restrittivo in materia di cani potenzialmente pericolosi non si rivelano efficaci nel contenimento di tale fenomeno. Sirchia. SUMMARY Canine aggressiveness is a very discussed topic, especially when a person is the damaged part. The problem of canine bites towards human beings must be tackled and analyzed scientifically, in order to allow the identifying of risk factors. The aim of this research was to assess the effects of the Sirchia’s Ordinance of the 9th September 2003 called “Protection of the public safety against the risk of aggressions by potentially dangerous dogs” on the trend of canine bites towards people in the city of Florence. For this research 556 cases of bites, occurred from September 2002 to August 2005, have been gathered. They drew from the certifications of medical reports in different D.E.A. of Florence, from the denunciation done at registry office for dogs and from the observational reports for the prophylaxis of the rabies. Data have been inserted in a database and statistically examined with the 2 test. This research demonstrated that the above-mentioned ordinance has caused no significant changes on the trend of canine bites in the taken sample nor in the short-term neither in the long-term. In fact, even if a numerical decrease has been observed in the period following the ordinance (210 vs 172 bites), a trend of reduction was already in progress since 1986. Moreover characteristics of owners, injureds and animals involved in the events of bites remained unvaried. Therefore, results seem to show that restrictive legislative measures in point of potentially dangerous dogs are not effective for the control of such phenomenon

Biogenic Amines Content of Four Types of "Pecorino" Cheese Manufactured in Tuscany

Biogenic amines content of four types of Tuscan ewes' milk "pecorino" cheese was evaluated using HPLC-UV analysis. All cheeses were manufactured in the same dairy factory with different combinations of milk (raw or pasteurized) and type of ripening. Total biogenic amines and tyramine levels of a raw milk "pecorino" ripened five months, partly in a traditional cave, were significantly higher than those of a pasteurized milk "pecorino" with a similar ripening; and of a two months raw milk "pecorino" ripened in the dairy plant. No statistical significant difference was found when comparing total biogenic amines and tyramine contents of the same five month ripened raw milk "pecorino" with a pasteurized milk "pecorino" ripened six months, partly in a traditional "fossa." In raw milk cave-ripened and "fossa"-ripened cheeses, total biogenic amines exceeded 1000 mg/kg. In cheeses manufactured with raw milk and/or in particular ripening environments, specific hygienic cares are needed to limit biogenic amines form..

Brief note about plasma catecholamines kinetics and submaximal exercise in untrained standardbreds

Four untrained standardbred horses performed a standardized exercise test on the treadmill and an automated blood collection system programmed to obtain blood samples every 15 s was used for blood collection in order to evaluate the kinetics of adrenaline and noradrenaline. The highest average values obtained for adrenaline and noradrenaline were 15.0 +/- 3.0 and 15.8 +/- 2.8 nmol/l respectively, with exponential accumulation of adrenaline (r = 0.977) and noradrenaline (r = 0.976) during the test. Analysis of the correlation between noradrenaline and adrenaline for each phase of the test shows that correlation coefficient decreases as the intensity of exercise increases (from r = 0.909 to r = 0.788). This suggests that during submaximal exercise, the process for release, distribution and clearance of adrenaline into blood circulation differs from that of noradrenaline

Metodi di controllo delle popolazioni di colombo (Columba livia) in ambiente urbano

RIASSUNTO L’ambiente cittadino è divenuto un habitat ottimale per un considerevole numero di specie animali, variamente distribuite lungo la scala zoologica. Tra le specie sinantrope il colombo (Columba livia) è una di quelle che ha conosciuto in questi ultimi anni un vero e proprio boom demografico, raggiungendo in alcune aree del nostro paese, la densità media di 3000 individui/km2, con un numero di colombi che supera le 100.000 unità nelle grandi città. Scopo del presente articolo è stato quello di analizzare in modo critico i differenti metodi di contenimento numerico delle popolazioni di colombo urbano, ponendo particolare attenzione alla tutela del benessere degli animali. Allo stato attuale non esiste ancora un trattamento ottimale che sia efficace nel ridurre la fertilità del colombo per un tempo sufficientemente lungo (4-6 mesi) in modo da permetterne una somministrazione saltuaria, che sia innocuo o scarsamente tossico e privo di effetti collaterali sia nel colombo che in altre specie (uomo compreso) che potrebbero accidentalmente venirne a contatto, che rispetti il benessere dell’animale, non solo non arrecando sofferenze fisiche all’animale, ma non alterandone il repertorio comportamentale, soprattutto nell’ambito riproduttivo e sociale ed infine che abbia un costo contenuto e di facile somministrazione. La nicarbazina (4,4 dinitrocarbanilide, 2 idrossi-4,6 dimetilpirimidina) è un coccidiostatico impiegato nei polli in cui interferisce profondamente con l’attività riproduttiva. Alla dose di 400-800 ppm non provoca effetti indesiderati né risulta tossica, esercitando un’attività negativa sulla maturazione dell’uovo, conseguente all’aumento di temperatura interna corporea, causato dall’incremento del metabolismo dell’organismo. Un recente studio condotto nelle provincie di Parma, Modena e Forlì ha evidenziato un calo medio del 48,26% del numero degli animali dopo otto mesi di trattamento quotidiano con nicarbazina. La riduzione della popolazione di colombi si è realizzata soprattutto a carico dei “novelli”, attestando un forte impatto sulla capacità riproduttiva degli animali. Per quanto riguarda la mortalità, essa si è mantenuta su valori normali e non ha manifestato cambiamenti nelle rispettive condizioni ambientali. In base a questi dati si può affermare che allo stato attuale la nicarbazina costituisce l’unico trattamento farmacologicamente valido ed applicabile per il controllo delle popolazioni di colombo in ambiente urbano, anche se la necessità di ricorrere a somministrazioni giornaliere richiede un impegno economico notevole da parte delle amministrazioni pubbliche. SUMMARY Urban environment has become an excellent habitat for a wide range of animal species. In Italy the pigeon (Columbia livia) in the last years showed a demographic explosion reaching, in some places, a density of 3000 animals/Km2. Aim of this review is to verify the different methods of demographic control of pigeon populations, with a particular attention on the animal welfare. At the present, chemical agents reducing pigeons fertility for a long period (4-6 months) are not yet found. In fact these drugs should be innocuous, very low toxic avoiding any side effects in other animal species including humans. Moreover these substances should not alter the pigeon behaviour profile, especially in reproductive and social patterns. Finally these drugs must not be expensive with an easy administrating protocol. The 4.4 dinitrocarbanilide, 2 idrossi-4.6 dimetilpirimidina (nicarbazine) is a cocciodiostatic used in chicken breeding. This substance, at the dose of 400-800 ppm, does not cause side effects interfering with the reproductive activity by inhibiting the maturation of eggs triggered by the increase of body temperature raised by an enanching of the animal metabolism. A recent research made in the districts of Modena, Parma and Forlì has showed a reduction of pigeons population of approximately of 48% after 8 months of a daily administration. The population reduction interested mainly young animal, confirming a strong impact on the reproductive capacity of this drug. Togheter these data are confirming that nicarbazina is the only available pharmacological treatment capable to control to pigeons populations in urban environment altough daily administration is necessary

Identification of cork characters for phenotypic selection

Global change effects can determine major changes in species distribution and productivity. In the Mediterranean region of the severity of hot and dry periods is growing and an increased frequency of extreme events and a major vulnerability of natural ecosystems is evident. Cork oak (Quercus suber L.) is widely spread in the West Mediterranean region and its economic and social is important

Marginality indices for biodiversity conservation in forest trees

Marginal and peripheral populations are important for biodiversity conservation. Their original situation in a species’ geographic and ecological space often confers them genetic diversity and traits of high adaptive value. Yet theoretical hypotheses related to marginality are difficult to test because of confounding factors that influence marginality, namely environment, geography, and history. There is an urgent need to develop metrics to disentangle these confounding factors. We designed nine quantitative indices of marginality and peripherality that define where margins lie within species distributions, from a geographical, an environmental and a historical perspective. Using the distribution maps of eight European forest tree species, we assessed whether these indices were idiosyncratic or whether they conveyed redundant information. Using a database on marginal and peripheral populations based on expert knowledge, we assessed the capacity of the indices to predict the marginality status of a population. There was no consistent pattern of correlation between indices across species, confirming that the indices conveyed different information related to the specific geometry of the species distributions. Contrasting with this heterogeneity of correlation patterns across species, the relative importance of the indices to predict the marginality status of populations was consistent across species. However, there was still a significant country effect in the marginality status, showing a variation in expert opinion of marginality vis-á-vis the species distribution. The marginality indices that we developed are entirely based on distribution maps and can be used for any species. They pave the way for testing hypotheses related to marginality and peripherality, with important implications in quantitative ecology, genetics, and biodiversity conservation

Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia

<p>Abstract</p> <p>Background</p> <p>One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to patients who do not have an optimal response to clozapine has been cited as the most common reason for simultaneously prescribing a second antipsychotic drug in combination treatment strategies. In a clinical area where the pressing need of providing therapeutic answers has progressively increased the occurrence of antipsychotic polypharmacy, despite the lack of robust evidence of its efficacy, we sought to implement a pre-planned protocol where two alternative therapeutic answers are systematically provided and evaluated within the context of a pragmatic, multicentre, independent randomised study.</p> <p>Methods/Design</p> <p>The principal clinical question to be answered by the present project is the relative efficacy and tolerability of combination treatment with clozapine plus aripiprazole compared with combination treatment with clozapine plus haloperidol in patients with an incomplete response to treatment with clozapine over an appropriate period of time. This project is a prospective, multicentre, randomized, parallel-group, superiority trial that follow patients over a period of 12 months. Withdrawal from allocated treatment within 3 months is the primary outcome.</p> <p>Discussion</p> <p>The implementation of the protocol presented here shows that it is possible to create a network of community psychiatric services that accept the idea of using their everyday clinical practice to produce randomised knowledge. The employed pragmatic attitude allowed to randomly allocate more than 100 individuals, which means that this study is the largest antipsychotic combination trial conducted so far in Western countries. We expect that the current project, by generating evidence on whether it is clinically useful to combine clozapine with aripiprazole rather than with haloperidol, provides physicians with a solid evidence base to be directly applied in the routine care of patients with schizophrenia.</p> <p>Trial Registration</p> <p><b>Clincaltrials.gov Identifier</b>: NCT00395915</p

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies