Proposal of Steam Combustion Turbine for Steam Boiler Room

Import 26/06/2013Bakalářská práce je zaměřená na návrh velikosti mikroturbíny, ve které probíhá výroba tepla a elektrické energie. V rešerši jsou popsány typy a využití spalovacích turbín. V dalším kroku je uvedena energetická bilance tepelného hospodářství konkrétního případu, dále pak stanovení množství vyrobeného tepla a elektrické energie. Závěrem práce je vyhodnocení ekonomické návratnosti mikroturbíny a celkové zhodnocení instalace zařízení.This bachelor thesis is aimed at concept of micro turbine, which is produces combine heat and power. In the recherché are described types and uses for combustion turbines. Further is shown energy balance of heat economy that is shown on concrete situation. Furthermore is determined amount of created heat and power. At the end of this thesis is evaluated return of investment into the micro turbine and overall evaluation of installation of this device.361 - Katedra energetikyvýborn

Temperature effect in the Casimir attraction of a thin metal film

The Casimir effect for conductors at arbitrary temperatures is theoretically studied. By using the analytical properties of the Green functions and applying the Abel-Plan formula to Lifshitz's equation, the Casimir force is presented as sum of a temperature dependent and vacuum contributions of the fluctuating electromagnetic field. The general results are applied to the system consisting of a bulk conductor and a thin metal film. It is shown that a characteristic frequency of the thermal fluctuations in this system is proportional to the square root of a thickness of the metal film. For the case of the sufficiently high temperatures when the thermal fluctuations play the main role in the Casimir interaction, this leads to the growth of the effective dielectric permittivity of the film and to a disappearance of the dependence of Casimir's force on the sample thickness.Comment: LaTeX 2.09, 8 pages, no figure

Pregabalin long-term treatment and assessment of discontinuation in patients with generalized anxiety disorder

This study was funded by Pfizer Inc. Editorial support to prepare this manuscript for submission was provided by Lorna Forse, PhD, of Engage Scientific Solutions and funded by Pfizer In

Application of Nanocomposite Coatings with Different Structural Physical and Chemical Characteristics in Tissue Engineering

The research covers the results of experimental studies of the effect character of nanocomposite coatings with different physical and chemical parameters (type, roughness, hydrophilic-hydrophobic characteristics) on structural and functional properties (adhesive potential, phenotype, gene expression) of mesenchymal stem cells (MSCs). On the tested nanocoatings (Al2O3, ZrO2, Ta2O5) the capability of oxide coating Al2O3 to enrich the in vitro cultured bone marrow (BM) with the cells of MSCs phenotype markers as well as to increase the expression rate of ido gene in them, which may extend the spectrum of their therapeutic application in clinics, has been found. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3496

Project of Intesification Heat Production for Industry Plant with Utilization of Waste Heat

Import 23/07/2015Diplomová práce je zaměřena na optimalizaci výroby tepla v průmyslovém podniku. V rešerši jsou popsány možnosti využití odpadního tepla a dále pak srovnání decentralizované a centralizované výroby tepla. V praktické části byla stanovena stávající energetická bilance, ztráty v rozvodech, byly navrženy varianty řešení decentralizace podniku, kde byly stanoveny investiční a provozní náklady. Závěrem práce je ekonomické vyhodnocení opatření.The thesis is focused on the optimization of heat production in industrial company. In the literature review are described possibilities of utilization of waste heat and then is compared centralized and decentralized heat production. In the practical part was determined the current energy balance, distribution losses, were designed variants of solving the decentralization of the company where were established investment and operating costs. In conclusion work is the economic evaluation of the measures.361 - Katedra energetikyvelmi dobř

Fragon: rapid high-resolution structure determination from ideal protein fragments

Correctly positioning ideal protein fragments by molecular replacement presents an attractive method for obtaining preliminary phases when no template structure for molecular replacement is available. This has been exploited in several existing pipelines. This paper presents a new pipeline, named Fragon, in which fragments (ideal α-helices or β-strands) are placed using Phaser and the phases calculated from these coordinates are then improved by the density-modification methods provided by ACORN. The reliable scoring algorithm provided by ACORN identifies success. In these cases, the resulting phases are usually of sufficient quality to enable automated model building of the entire structure. Fragon was evaluated against two test sets comprising mixed α/β folds and all-β folds at resolutions between 1.0 and 1.7 Å. Success rates of 61% for the mixed α/β test set and 30% for the all-β test set were achieved. In almost 70% of successful runs, fragment placement and density modification took less than 30 min on relatively modest four-core desktop computers. In all successful runs the best set of phases enabled automated model building with ARP/wARP to complete the structure

Serial measurements of cardiac biomarkers in patients after allogeneic hematopoietic stem cell transplantation

<p>Abstract</p> <p>Background</p> <p>Previous therapy with anthracyclines (ANT) and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT) represents a high risk for development of cardiotoxicity. The aim of this study was to assess subclinical myocardial damage after HSCT using echocardiography and cardiac biomarkers - high sensitive cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and to identify patients at risk of developing clinical cardiotoxicity.</p> <p>Patients and methods</p> <p>Thirty-seven patients who were treated with allogeneic HSCT for hematologic diseases at median age of 28 years at time of HSCT were studied. Conditioning regimen included either chemotherapy without total body irradiation (TBI) or combination of chemotherapy with TBI. Twenty-nine (78,3%) patients were pretreated with ANT therapy. Cardiac biomarkers were serially measured before conditioning regimen and at days 1, 14 and 30 after HSCT. Cardiac systolic and diastolic functions were assessed before conditioning regimen and 1 month after HSCT by echocardiography.</p> <p>Results</p> <p>The changes in plasma NT-proBNP and hs-cTnT levels during the 30 days following the HSCT were statistically significant (<it>P </it>< 0,01 v.s. <it>P </it>< 0,01). Persistent elevations of NT-proBNP and hs-cTnT simultaneously for a period exceeding 14 days after HSCT were found in 29,7% patients. Serum concentrations of cardiomarkers were significantly elevated in ANT group compared to non-ANT group. These observations were underscored by the echocardiographic studies which did reveal significant changes in systolic and diastolic parameters. Five of 37 (13,5%) patients developed clinical manifestation of cardiotoxicity.</p> <p>Conclusions</p> <p>Elevations in both cardiac biomarkers were found before clinical signs of cardiotoxicity developed. Persistent elevations in NT-pro-BNP and hs-cTnT concentrations simultaneously for a period exceeding 14 days might be used for identification of patients at risk of developing cardiotoxicity and requiring further cardiological follow up.</p

FireProt(DB): database of manually curated protein stability data

The majority of naturally occurring proteins have evolved to function under mild conditions inside the living organisms. One of the critical obstacles for the use of proteins in biotechnological applications is their insufficient stability at elevated temperatures or in the presence of salts. Since experimental screening for stabilizing mutations is typically laborious and expensive, in silico predictors are often used for narrowing down the mutational landscape. The recent advances in machine learning and artificial intelligence further facilitate the development of such computational tools. However, the accuracy of these predictors strongly depends on the quality and amount of data used for training and testing, which have often been reported as the current bottleneck of the approach. To address this problem, we present a novel database of experimental thermostability data for single-point mutants FireProt(DB). The database combines the published datasets, data extracted manually from the recent literature, and the data collected in our laboratory. Its user interface is designed to facilitate both types of the expected use: (i) the interactive explorations of individual entries on the level of a protein or mutation and (ii) the construction of highly customized and machine learning-friendly datasets using advanced searching and filtering. The database is freely available at https://loschmidt.chemi.muni.cz/fireprotdb

Application of Nanocomposite Coatings with Different Structural Physical and Chemical Characteristics in Tissue Engineering

The research covers the results of experimental studies of the effect character of nanocomposite coatings with different physical and chemical parameters (type, roughness, hydrophilic-hydrophobic characteristics) on structural and functional properties (adhesive potential, phenotype, gene expression) of mesenchymal stem cells (MSCs). On the tested nanocoatings (Al2O3, ZrO2, Ta2O5) the capability of oxide coating Al2O3 to enrich the in vitro cultured bone marrow (BM) with the cells of MSCs phenotype markers as well as to increase the expression rate of ido gene in them, which may extend the spectrum of their therapeutic application in clinics, has been found. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3496

Biome stability and fragmentation under critical environmental temperature change

Critical phenomena in the climate system can cause drastic changes in the state of planetary ecosystems as well the entire biosphere. There also are mechanisms through which the biosphere can make an effect on climate. In this manuscript, we study the nonlinear dynamics of the interaction of the climate system with the biosphere by linking an energy balance climate model to different species competition models. We develop an asymptotic approach to these models and investigate how migration strengthens biome stability and biodiversity. Moreover, we derive relations describing biome boundary shifts under global warming (or cooling) and check those relations against paleo data on plant biome location. Finally, the models demonstrate that critical rates of changes in the environmental temperature dynamics may shift biome stability