Non universality of entanglement convertibility

Recently, it has been suggested that operational properties connected to quantum computation can be alternative indicators of quantum phase transitions. In this work we systematically study these operational properties in 1D systems that present phase transitions of different orders. For this purpose, we evaluate the local convertibility between bipartite ground states. Our results suggest that the operational properties, related to non-analyticities of the entanglement spectrum, are good detectors of explicit symmetries of the model, but not necessarily of phase transitions. We also show that thermodynamically equivalent phases, such as Luttinger liquids, may display different convertibility properties depending on the underlying microscopic model.Comment: 5 pages + references, 4 figures - improved versio

Optimal design of THEDES based on Perillyl Alcohol and Ibuprofen

Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratios. Our comprehensive strategy includes the characterization of their thermal and structural behavior to identify the molar ratios that successfully form deep eutectic systems. The in vitro solubility of the different systems prepared has demonstrated that, unlike other reported examples, the presence of the terpene did not affect the solubility of the anti-inflammatory agent in a physiological simulated media. The biological performance of the systems was studied in terms of their antimicrobial activity against a wide panel of microorganisms. The examined THEDES showed relevant antimicrobial activity against all tested microbial strains, with the exception of P. aeruginosa. A synergistic effect from the combination of POH and IBU as a eutectic system was verified. Furthermore, the cytotoxic profile of these eutectic systems towards colorectal cancer (CRC) in vitro cell models was also evaluated. The results provide the indication that the cell viability varies in a dose-dependent manner, with a selective THEDES action towards CRC cells. With tunable bioactivities in a ratio-dependent manner, THEDES enhanced the antimicrobial and anticancer properties, representing a possible alternative to conventional therapies. Therefore, this study provides foreseeable indications about the utility of THEDES based on POH and IBU as strong candidates for novel active pharmaceutical systems.Foundation for Science and Technology (FCT), through project PTDC/BBB-490 EBB/1676/2014–Des.Zyme, Light2Skin-PTDC/CTM-CTM/29813/2017 and ERC-2016-CoG 725034 (ERC Consolidator Grant Des.solve). E.S. would also like to acknowledge the financial support by the FCT through the doctoral grant with reference number SFHR/BD/143902/2019. J.M.S. would also like to acknowledge the financial support by the FCT through the post-doctoral grant with reference number SFRH/BPD/116779/201

Exploring Kepler Giant Planets in the Habitable Zone

The Kepler mission found hundreds of planet candidates within the habitable zones (HZ) of their host star, including over 70 candidates with radii larger than 3 Earth radii ($R_\oplus$) within the optimistic habitable zone (OHZ) (Kane et al. 2016). These giant planets are potential hosts to large terrestrial satellites (or exomoons) which would also exist in the HZ. We calculate the occurrence rates of giant planets ($R_p =$~3.0--25~$R_\oplus$) in the OHZ and find a frequency of $(6.5 \pm 1.9)\%$ for G stars, $(11.5 \pm 3.1)\%$ for K stars, and $(6 \pm 6)\%$ for M stars. We compare this with previously estimated occurrence rates of terrestrial planets in the HZ of G, K and M stars and find that if each giant planet has one large terrestrial moon then these moons are less likely to exist in the HZ than terrestrial planets. However, if each giant planet holds more than one moon, then the occurrence rates of moons in the HZ would be comparable to that of terrestrial planets, and could potentially exceed them. We estimate the mass of each planet candidate using the mass-radius relationship developed by Chen & Kipping (2016). We calculate the Hill radius of each planet to determine the area of influence of the planet in which any attached moon may reside, then calculate the estimated angular separation of the moon and planet for future imaging missions. Finally, we estimate the radial velocity semi-amplitudes of each planet for use in follow up observations.Comment: 19 Pages, 16 Figures, 5 Table

Variabilidade genética em cervídeos do gênero Mazama baseada no polimorfismo da transferrina, albumina sérica e hemoglobina

The genus Mazama is currently represented in Brazil by five species: M. nana, M. americana, M. gouazoubira, M. bororo, and M. nemorivaga. The objective of the present study was to determine the electrophoretic characteristics of transferrin, serum albumin, and hemoglobin in the genus Mazama in order to evaluate the polymorphism among different species in Brazil. Blood samples from 138 animals, kept in captivity and with a known origin in nature and coming from all regions of the country, were studied by polyacrylamide gel electrophoresis. Variability for the transferrin locus ranged from monomorphism in M. nana and M. bororo to six different electromorphs in M. gouazoubira. Monomorphism was found at the serum albumin locus but two alleles were observed in M. gouazoubira. Hemoglobin presented three phenotypes but no significant differences in gene frequencies were observed.O gênero Mazama é atualmente representado no Brasil por cinco espécies: M. nana, M. americana, M. gouazoubira, M. bororo e M. nemorivaga. O objetivo do presente trabalho foi avaliar as características eletroforéticas das transferrinas, albuminas séricas e hemoglobinas em cervídeos do gênero Mazama no que diz respeito ao polimorfismo entre as diferentes espécies brasileiras. Foram analisadas em eletroforese em gel de poliacrilamida amostras de plasma sangüíneo e hemoglobina de 138 animais, mantidos em cativeiro, com origem conhecida na natureza e provenientes de todas as regiões do país. O sistema das transferrinas apresentou variabilidade crescente nas espécies M. nana, M. americana e M. gouazoubira, variando do monomorfismo na primeira espécie à ocorrência de seis diferentes fenótipos na última. As albuminas séricas apresentaram-se monomórficas, porém o perfil eletroforético observado em M. gouazoubira foi diferente das outras espécies. As hemoglobinas apresentaram três fenótipos, aparentemente compostos por dois alelos A e B, não sendo observadas diferenças significativas em relação às freqüências fenotípicas

Tuberculosis among HIV-1-infected subjects in a tertiary out-patient service in São Paulo city, Brazil

Atualmente, a tuberculose (TB) é considerada a doença infecciosa mais importante entre os pacientes infectados pelo HIV-1 nos países em desenvolvimento, como o Brasil. Análise retrospectiva dos casos de tuberculose ocorridos a partir de janeiro 1995 até dezembro de 2010 foi realizada em nossa coorte de 599 pacientes HIV positivos. O desfecho primário foi a ocorrência de TB ativa, e 41 casos da doença foram diagnosticados durante este período de 16 anos. As contagens médias do nadir de células T CD4 e ao momento do diagnóstico de TB foram de 146 e 217 células/mm³, respectivamente. A carga viral média de HIV foi de 5,19 log10 cópias/mL, e 59% dos pacientes estavam em tratamento com ART. A incidência de TB foi de 1,47 casos por 100 pessoas-ano, para um tempo total de seguimento da coorte de 2775 pessoas-ano. A probabilidade de sobreviver até 10 anos após o diagnóstico foi de 75% para pacientes com TB, em oposição a 96% para pacientes com outras doenças oportunistas não-TB (p = 0,03). A tuberculose pode ser considerada problema de saúde pública entre as pessoas que vivem com HIV no Brasil, apesar da ampla utilização de anti-retrovirais para o tratamento da infecção pelo HIV / AIDS.TB is currently considered to be the most important infectious disease among HIV-1-infected subjects in developing countries, such as Brazil. A retrospective analysis of TB cases was performed, occurring from January 1995 to December 2010 in our cohort of 599 HIV positive patients. The primary outcome was the occurrence of active TB. Forty-one TB cases were diagnosed over this period of 16 years, among 599 HIV positive patients in an open cohort setting in the city of Sao Paulo, Brazil. All-time lowest mean CD4 T cell count at the time of TB diagnosis was 146 and 186 cells/mm³, respectively. The mean HIV viral load was 5.19 log10 copies/mL, and 59% of the patients were on HAART. TB incidence was 1.47 per 100 person-years, for a total follow-up time of 2775 person-years. The probability of surviving up to 10 years after diagnosis was 75% for TB patients as opposed to 96% for patients with other, non-TB opportunistic diseases (p = 0.03). TB can be considered a public health problem among people living with HIV in Brazil despite of the widespread use of antiretrovirals for the treatment of HIV infection/AIDS

Coordination of power reactive management considering variations in wind speed from wind farms and power transmission limits

Proceedings of: XLI Ibero-Latin-American Congress on Computational Methods in Engineering, ABMEC. Foz do Iguaçu/PR, Brazil, November 16-19, 2020This paper presents a methodology that allows performing the optimized and coordinated management of reactive power injection in power systems with wind farms and other sources of reactive injection, such as capacitor banks or static voltage compensators, minimizing the losses in the transmission power system. The variation in wind speed is characterized by the Weibull distribution. The values of this distribution are used as input data for the optimal power flow model whose output provides a sample of values for defining the confidence intervals of the injected reactive power, as well as the voltage values in each bus of the electrical system. The proposed methodology was tested using a real 140 buses system to determine the dispatch of reactive sources available in the power system. The results found by the proposal can help to make a better management of the available reactive sources in the real-time operation

A estrutura a termo de taxas de juros no Brasil: modelos, estimação e testes

In this paper, we propose a methodology for the construction of the risk-free interest rate term structure in Brazil, using the Svensson model for interpolation and extrapolation of the interest rate curves, and genetic algorithms, in complement to traditional algorithms of nonlinear optimization, for estimation of model parameters. The objective is to contribute to the Brazilian insurance market, so that insurance ces can appropriately measure their long-term obligations discounting cash flows in a manner that is consistent and coherent, considering the adoption of international standards of solvency supervision and financial reporting by the Superintendência de Seguros Privados (SUSEP). We present the results found in modeling the term structure of a number of interest rate curves in Brazil.Neste artigo, propomos uma metodologia para a construção da estrutura a termo da taxa de juros livre de risco no Brasil, usando o modelo de Svensson para interpolação e extrapolação das curvas de juros e algoritmos genéticos, em complemento aos algoritmos tradicionais de otimização não linear, para a estimação dos parâmetros do modelo. O objetivo é contribuir para que o mercado segurador brasileiro mensure suas obrigações descontando seus fluxos de caixa de maneira consistente e coerente, considerando a adoção, pela Superintendência de Seguros Privados (SU-SEP), de padrões internacionais de supervisão de solvência e de reporte financeiro. Ao longo do artigo, apresentamos os resultados encontrados na modelagem das estruturas a termo de diferentes curvas de juros no Brasil

Mineral content in French type bread with sodium replacement using fluorescence spectrometry X-rays by energy dispersive

The present study aimed to determine the mineral composition of the French type bread with partial replacement of sodium chloride by potassium chloride using the technique of X-ray fluorescence energy dispersive. The excitation energy used was 50 keV and detector operation at -176°C. The detected variations were from 10.16 to 613.69 mg 100 g-1 for sodium and from 211.58 to 958.96 mg 100 g-1 for potassium. The concentrations of iron, magnesium, phosphorus and calcium ranged from 10.62 to 21.45, 16.59 to 30.78, 92.53 to 125.77 and from 16.54 to 100.88 mg 100 g-1, respectively. The use of this simple technique proved to be reliable on detecting the variations imposed on the French type bread formulation. The results of this study indicate that, at the levels studied, the addition of potassium chloride assisted in getting French type bread with lower levels of sodium and proved the technological feasibility of producing French type bread with 43% salt reduction (1.0% in the commercial formulation) with 0.5% potassium chloride, which provide bread with the amount of sodium proposed to meet the set limits (174.09 mg.50 g-1), related to the salt standard formulation of 1.88% (306.5 mg.50 g-1).Key words: French bread, replacement, sodium chloride, potassium chloride, food analysis, minerals, energy dispersive