338 research outputs found
Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens. The influence of these components on pulmonary inflammation has been largely studied in the context of individual agonists, despite knowledge that they can have synergistic effects when used in combination. Here we have explored the effects of LPS and Ī²-glucan, two commonly-encountered microbial agonists, on the pathogenesis of allergic and non-allergic respiratory responses to house dust mite allergen. Notably, sensitization with these micro-bial components in combination acted synergistically to promote robust neutrophilic inflammation, which involved both Dectin-1 and TLR-4. This pulmonary neutrophilic inflammation was corticosteroid-refractory, resembling that found in patients with severe asthma. Thus our results provide key new insights into how microbial components influence the development of respiratory pathology
Microbial ligand costimulation drives neutrophilic steroid-refractory asthma
Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
1997 Wild Blueberry Progress Reports
The 1997 edition of the Wild Blueberry Progress Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Investigation of processing damage of IQF blueberries
2. Use of sorter rejects and wild blueberry puree to prevent warmed over flavor in processed beef patties
3. Factors affecting the quality of IQF wild blueberries
4. Determination of pesticide residue levels in fresh and processed wild blueberries
5. Pollination ecology of wild blueberries in Maine
6. Control tactics for wild blueberry pest insects
7. IPM Strategies
8. Pest Biology
9. Effect of antidessication treatments on wild blueberry cold temperature tolerance
10. Phosphorus/nitrogen fertilizer ratio
11. Effect of boron application methods on boron uptake in wild blueberries
12. Effect of foliar zinc application on growth and yield of wild blueberries
13. Effect of soil pH on nutrient uptake
14. Crop year fertilization of wild blueberry
15. Effect of PhotomagĀ® on growth and yield of wild blueberries
16. Evaluation of Pronone MGĀ® spot treatments for control of St. Johnswort, dogbane, bracken fern, witch grass/fall panicum and bunchberry
17. Effect of hexazinone formulation on movement through the soil profile
18. Effect of time of fall pruning on wild blueberry fruit set and yield
19. Effect of pre and postemergence herbicide applications on control of grasses
20. Hexazinone groundwater survey
21. Effect of plant source and density on spread of wild blueberry
22. Effect of surfactant and ammonium sulfate on glyphosate activity
23. Effect of crop year application of hexazinone on weed control, yield and hexazinone residue.
24. Long term effects of tribenuron methyl on wild blueberries and weed species composition
25. Effect of VelparĀ® DF/MAP on wild blueberry fruit set and yield.
26. Effect of reduced volume lmidanĀ® 2.5 EC UL V applications on wild blueberry residue and efficacy
27. Wild blueberry extension education progra
1998 CSREES Wild Blueberry Project Results
The 1998 edition of the CSREES Wild Blueberry Project Results was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Separation of Maggot Infested Blueberries in the IQF Processing Line
2. Assessment of Preharvest Treatments on Wild blueberry Fruit Quality
3. Blueberries as a Natural Colorant for Breakfast Cereals
4. Factors Affecting Quality of IQF Wild Blueberries
5. Control Tactics for Wild blueberry Pest Insects
6. Biology and Ecology of Wild blueberry Pest Insects
7. Sustainable Pollination of Wild blueberry
8. Evaluation of Foliar Fungicides for Control of Mummy Berry
9. Phosphorus/Nitrogen Fertilizer Ratio
10. Effect of Boron Application Methods on Boron Uptake in Wild Blueberries
11. Effect of Zinc Application on Growth and Yield of Wild Blueberries
12. Effect of Soil pH of Nutrient Uptake
13. Crop Year Fertilization of Wild blueberry
14. Effect of Fertilizer Timing on Wild blueberry Growth and Productivity
15. Alternative Methods of Grass Control
16. Cultural Weed Management Using pH
17. Investigation of Hexazinone Alternatives for Weed Control
18. Evaluation of Hexazinone Applications in the Cropping Year
19. Effect of Surfactant and Ammonium Sulfate on Glyphosate Activity
20. Evaluation of Pronone MGĀ® Spot Treatments for Control of St Jobnswort, Dogbane, Bracken Fem, Witch Grass/Fall Panicum and Bunchberry
21. Hexazinone Groundwater Surve
Report of the 14th Genomic Standards Consortium Meeting, Oxford, UK, September 17-21, 2012
Ā© The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Standards in Genomic Sciences 9 (2014): 1236-1250, doi:10.4056/sigs.4319681.This report summarizes the proceedings of the 14th workshop of the Genomic Standards Consortium (GSC) held at the University of Oxford in September 2012. The workshopās primary goal was to work towards the launch of the Genomic Observatories (GOs) Network under the GSC. For the first time, it brought together potential GOs sites, GSC members, and a range of interested partner organizations. It thus represented the first meeting of the GOs Network (GOs1). Key outcomes include the formation of a core group of āchampionsā ready to take the GOs Network forward, as well as the formation of working groups. The workshop also served as the first meeting of a wide range of participants in the Ocean Sampling Day (OSD) initiative, a first GOs action. Three projects with complementary interests ā COST Action ES1103, MG4U and Micro B3 ā organized joint sessions at the workshop. A two-day GSC Hackathon followed the main three days of meetings.This work was supported in part by the US Na-tional Science Foundation through the research coordination network award RCN4GSC, DBI-0840989 and in part by a grant from the Gordon and Betty Moore Foundation, and travel grants of COST Action ES1103. The stakeholder session was supported by the European Unionās Seventh Framework Programme (FP7 /2007-2013) under grant agreement no 266055, and the Marine Ge-nomics for Users EU FP7 project (Coordination and support action, call FP7-KBBE-2010-4) grant no. 266055. We thank Eppendorf and Biomatters Ltd. for their sponsorship of the meeting
Wild Blueberries 1999 CSREES Progress Reports
The 1999 edition of the Wild Blueberries CSREES Progress Reports was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Effects of QF Processing on Microbiological Quality of Maine Wild Blueberries
2. Separation of Maggot-Infested Blueberries in the IQF Processing Line
3. Determination of Pesticide Residue Levels in Fresh and Processed Wild Blueberries
4. Control Tactics for Blueberry Pest Insects
5. IPM Strategies
6. Biology and Ecology of Blueberry Pest Insects
7. Survey of Stem Blight and Leaf Spot Diseases in Lowbush Blueberry Fields
8. Phosphorus/Nitrogen Fertilizer Ratio
9. Effect of Fertilizer Timing on Lowbush Blueberry Growth and Productivity
10. Effect of Soil pH on Nutrient Uptake
11. Effect of Boron Application Methods on Boron Uptake in Lowbush Blueberries
12. Effect of Nutri-Phite P+K on growth and yield of lowbush blueberry
13. Effect of Crop-Set on growth and yield of lowbush blueberry
14. Crop year fertilization of lowbush blueberry
15. Alternative Methods of Grass Control
16. Cultural Weed Management Using pH
17. Investigation of Hexazinone Alternatives for Weed Control
18. Comparison of Sulfosate and Glyphosate for Weed Control
19. Evaluation of VC1447 for Weed Control in Wild blueberries
20. Blueberry/ Cranberry Extension Education Program in 1999
21. Effect of Rate, Formulation and Application Method on Efficacy and Phytotoxicity of Granular Hexazinone in Wild Blueberry Fields
22. 1999 Fungicide Evaluation Field Trial
23. 1999 Hexazinone Groundwater Survey Pollination
24. Sustainable Pollination of Wild Blueberr
1996 Wild Blueberry CSREES Progress Reports/1996 Wild Blueberry Tax Reports
The 1996 edition of the Wild Blueberry CSREES Progress Reports/Wild Blueberry Tax Reports was prepared for the Maine Wild Blueberry Commission and the University of Maine Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
Wild Blueberry CSREES Progress Reports:
1. Factors affecting the quality of Individually Quick Frozen (IQF) wild blueberries
2. Factors affecting the physical and chemical properties of IQF wild blueberries
3. Preventing the bleeding of blueberry fruit in bakery products
4. Amylase test development
5. Determination of pesticide residue levels in freshly harvested and processed wild blueberries
6. Sustainable pollination of wild blueberry
7. Potential for biological control of insect pests of wild blueberry
8. Effect of desiccation on wild blueberry winter survival and cold temperature tolerance
9. Population variation in low-temperature tolerance of wild blueberry
10. Influence of flower delaying sprays on seasonal variation of low temperature tolerance in wild blueberry
11. Effect of various levels of disbudding on yield of wild blueberry
12. Effect of boron and the polyamine putrescine on wild blueberry fruit set and yield
13. Effect of soil pH on nutrient uptake
14. Phosphorus uptake
15. Correcting boron deficiency
16. Hexazinone groundwater survey
17. Effect of time of fall pruning on growth and productivity of wild blueberries
18. Evaluation of PrononeĀ® spot treatments for control of St. Johnswort, dogbane, bracken fern, witch grass/fall panicum and bunchberry
19. Effect of hexazinone formulation on movement through the soil profile
20. Effect of plant source and density on spread of wild blueberry
Wild Blueberry Tax Reports:
21. Control of wild blueberry diseases
22. Control of wild blueberry pest insects
23. Biology and action thresholds of secondary blueberry pest insects
24. Phosphorus/nitrogen fertilizer ratio
25. Effect of surfactant and ammonium sulfate on glyphosate activity
26. Blueberry Extension Education Program Bas
2002 Wild Blueberry Project Reports
The 2002 edition of the Wild Blueberry Project Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Factors Affecting Microbial and Pesticide Residue Levels on Wild Blueberries
2. Effect of Blueberry Products on Oxidation in Meat Based Food
3. Determination of Pesticide Residue Levels in Freshly Harvested and Processed Wild Blueberries
4. Detection of Infested Wild Blueberries using Near-Infrared Spectroscopy
5. Investigation Of The Mechanism By Which Blueberry Fractions Maintain Arterial Integrity
6. Antioxidant Assessment in the Elderly
7. Water Use of Wild Blueberries and the Impact of Plant Water Stress on Yield
8. Control Tactics for Wild blueberry Pest Insects
9. IPM Strategies
10. Pest Biology
11. Wild Blueberry Pollination Research
12. Survey and Determination of Effective Control of Stem Blight and Leaf Spot Diseases in Wild Blueberry Fields
13. Effect of Foliar-applied Iron Chelate Concentration on Leaf Iron Concentration, Wild Blueberry Growth and Yield
14. Effect of Boron Application Methods on Boron Uptake in Wild Blueberries
15. Effect of Foliar N spray on Leaf N Concentration, Growth and Yield of Wild Blueberries
16. Effect of Foliar Spray (4-13-15) on Leaf Nutrient Concentration, Growth and Yield of Wild Blueberries
17. Effect of Foliar Copper Application on Growth and Yield of Wild Blueberries
18. Effect of Foliar Copper and/or Iron Application on Growth and Yield of Wild Blueberries
19. Effect of Soil pH on Nutrient Uptake
20. Assessment of Hexazinone Alternatives for Weed Control in Wild Blueberries and Weed Control
21. Evaluation of Fall Applications of Sulfonylurea Herbicides for Bunchberry Control in Wild Blueberries
22. Evaluation and Demonstration of Techniques for Filling in Bare Spots in Wild Blueberry Fields
23. Blueberry Extension Education Program Base
24. 2002 Pesticide Groundwater Survey
25. Cultural Weed Management using sulfur to lower the p
2005 Wild Blueberry Project Reports
The 2005 edition of the Wild Blueberry Project Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Evaluation of Emerging Disinfections Technologies for Wild Blueberry Processing
1A. Incorporation of wild blueberry puree into a soy-based burger and its effect on sensory and chemical properties of the broiled burgers.
2. Incorporation of wild blueberry puree into a soy-based burger and its effect on sensory and chemical properties of the broiled burgers
3. Wild blueberries and Arterial Functional Properties
4. Practical Microbial Control Approach and Antimicrobial Properties Study for Wild Blueberries
5. Wild Blueberries Reduce Risks for Cardiovascular Disease āNo Report at this time, data is still under analysis.
6. Irrigation Water Use in Wild Blueberry Production
7. Control Tactics for Blueberry Pest Insects, 2005
8. Integrated Pest Management (IPM) strategies, 2005
9. Control Tactics for Blueberry Pest Insects, 2005
10. The Effect of Fungicides and Cultural Treatments on Monilinia Blight, Yield and Post-Harvest Disease in Wild Blueberries
11. Effect of Soil pH on Nutrient Uptake
12. Effect of Manganese on Growth and Yield of Wild Blueberry
13. Raising Foliar Nitrogen by Application of CoRoN
14. Effects of Summer Foliar Fertilization to Increase Branch Length and Flower Bud Formation in the Prune Year
15. Assessment of Hexazinone Alternatives for Weed Control in Wild Blueberries and Field Cover Program Base
16. Evaluation of Fall Applications of Tribenuron Methyl for Bunchberry Control in Wild Blueberries
17. Evaluation of spot treatments of Tribenuron Methyl for weed control in Wild Blueberries
18. Evaluation and Demonstration of Techniques for Filling in Bare Spots in Wild Blueberry Fields
19. Assessment of Evitol and Kerb for Sedge Control in Wild Blueberrie
1995 CSREES Reports
The 1995 edition of the CSREES Reports was prepared for the Maine Wild Blueberry Commission and the University of Maine Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Factors Affecting the Quality of IQF Blueberries
2. Preventing the Bleeding of Blueberry Fruit in Bakery Products
3. Removing Water from Blueberries Before Freezing
4. Determination of Pesticide Residue Levels in Freshly Harvested and Processed Lowbush Blueberries
5. Industrial Ingredients from Cull Blueberries
6. Application of Heat as a Method of Controlling Secondary Pest Insects on Lowbush Blueberries
7. The Phenology and Biology of Bumble Bees, Bombus, spp., that Pollinate Lowbush blueberry, Vaccinium spp., in Maine
8. Pollination Ecology of Lowbush Blueberry in Maine
9. Effects of Irrigation on Lowbush Blueberry Yield
10. Effect of Brief Warming Treatments on Late Winter Low-Temperature Tolerance of Native Lowbush Blueberry
11. Correlation of Late-winter/Early-spring Cold Hardiness with Date of Flowering
12. Evaluation of Cold Tolerance of Opening Flowers of Lowbush Blueberry
13. Influence of Flower Delaying Sprays on Seasonal Variation of Low Temperature Tolerance in Lowbush Blueberry
14. Effect of Various Levels of Disbudding on Yield of Lowbush Blueberry
15. Effect of Boron and the Polyamine Putrescine on Lowbush Blueberry Fruit Set and Yield
16. Effect of Boron and the Polyamine Putrescine on Extending the Receptivity of Lowbush Blueberry Blossoms
17. Effect of Soil pH on Nutrient Uptake
18. Correcting Boron Deficiency - missing
19. Phosphorus Uptake
20. Evaluation of Hexazinone Formulation on Soil Movement and Weed Control
21. Effect of Time of Fall Pruning on Growth and Productivity of Blueberries
22. Hexazinone Ground Water Survey
23. Effect of hexazinone formulation on movement through the soil profile
24. Evaluation of Tribenuron Methyl for Bunchberry Control
25. Evaluation of Tribenuron Methyl Commercial Applications for Bunchberry Control
26. Effectiveness of Resin-Exchange Columns to Determine Efficacy in Removing Hexazinone from Well Water
27. Effect of Clopyralid for Vetch Control
28. Evaluation of Tribenuron Methyl/VelparĀ® Tank Mix for Bunchberry Control
29. Blueberry Extension Education Progra
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