High variety of known and new RNA and DNA viruses of diverse origins in untreated sewage

Deep sequencing of untreated sewage provides an opportunity to monitor enteric infections in large populations and for high-throughput viral discovery. A metagenomics analysis of purified viral particles in untreated sewage from the United States (San Francisco, CA), Nigeria (Maiduguri), Thailand (Bangkok), and Nepal (Kathmandu) revealed sequences related to 29 eukaryotic viral families infecting vertebrates, invertebrates, and plants (BLASTx E score, <10(−4)), including known pathogens (>90% protein identities) in numerous viral families infecting humans (Adenoviridae, Astroviridae, Caliciviridae, Hepeviridae, Parvoviridae, Picornaviridae, Picobirnaviridae, and Reoviridae), plants (Alphaflexiviridae, Betaflexiviridae, Partitiviridae, Sobemovirus, Secoviridae, Tombusviridae, Tymoviridae, Virgaviridae), and insects (Dicistroviridae, Nodaviridae, and Parvoviridae). The full and partial genomes of a novel kobuvirus, salivirus, and sapovirus are described. A novel astrovirus (casa astrovirus) basal to those infecting mammals and birds, potentially representing a third astrovirus genus, was partially characterized. Potential new genera and families of viruses distantly related to members of the single-stranded RNA picorna-like virus superfamily were genetically characterized and named Picalivirus, Secalivirus, Hepelivirus, Nedicistrovirus, Cadicistrovirus, and Niflavirus. Phylogenetic analysis placed these highly divergent genomes near the root of the picorna-like virus superfamily, with possible vertebrate, plant, or arthropod hosts inferred from nucleotide composition analysis. Circular DNA genomes distantly related to the plant-infecting Geminiviridae family were named Baminivirus, Nimivirus, and Niminivirus. These results highlight the utility of analyzing sewage to monitor shedding of viral pathogens and the high viral diversity found in this common pollutant and provide genetic information to facilitate future studies of these newly characterized viruses

Pattern recognition receptors in immune disorders affecting the skin.

Contains fulltext : 109004.pdf (publisher's version ) (Open Access)Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs

Ezra Stoller : Photographs of Architecture 1939-1980

"Ezra Stoller's photographs are now part of the history of modern architecture in the United States. If he made some buildings look a little better than they were, the improvement provided an image for aspiring architects. For better or for worse, his photographs have been more real to architectural students, and more intensely experienced, than most of the buildings they memorialize. Their instrumental value in spreading the good word may now yield to their more durable value as art." -- p. [3]

Masters of World Architecture: Ludwig Mies Van Der Rohe

From the Back Cover: LUDWIG MIES VAN DER ROHE was born in Aachen, Germany in 1886. His father was a mason and owned a small stone-cutting shop where as a young boy Mies learned the elements of masonry construction. He received no formal architectural training, but was apprenticed as a draftsman and designer of classical stucco ornament in local architectural offices. Later he went to Berlin and from 1908 to 1911 he worked for Peter Behrens, opening his own architectural office in 1912. After the First World War, Mies, supporting avant-garde art movements and publications, emerged as a strongly original architect. Some of his most daring projects, the glass skyscrapers among them, date from this period in the early 1920\u27s. Later as an official of the Deutscher Werkbund he directed the important Stuttgart Exposition of 1927, in which the most notable European architects participated. His German Pavilion for the Barcelona Exposition of 1929 would have assured him lasting fame if he had never built anything else. He became director of the Bauhaus in 1930 by closed it three years later because of the unfavorable cultural climate in Germany, the reason also why he departed in 1938 to become a permanent resident of the United States. Here he became head of the architectural department of the Illinois Institute of Technology and planned his first extensive project: a new campus for the Institute. Many of the buildings have now been completed. Also in Chicago he has built a spectacular series of glass-wall steel-frame apartment skyscrapers fronting Lake Michigan. The Farnsworth House of 1950, his first private-house commission in the United States, demonstrating his structural ideas on a domestic scale, has occasioned extensive discussion in architectural circles. His Seagram Building is one of the finest examples of a skyscraper in New York or anywhere else. Since his retirement from the Illinois Institute of Technology he has devoted full time to his private architectural practice.https://nsuworks.nova.edu/nsudigital_flwbooks/1136/thumbnail.jp

The Drawings of Frank Lloyd Wright

The drawings included in this book were first selected for an exhibition of original Frank Lloyd Wright drawings held at The Museum of Modern Art, New York, from March 14 to May 6, 1962. The preliminary selection of drawings was made at Taliesin, Wisconsin, by Arthur Drexler, Director, and Wilder Green, Assistant Director, of the Museum\u27s Department of Architecture and Design. Wilder Green made the final selection for the exhibition and designed the installation; the final selection of material for the book was made by the author.https://nsuworks.nova.edu/nsudigital_flwbooks/1169/thumbnail.jp

The Architecture of Richard Neutra : From international style to California modern

New York114 p.; ilus.; 25 cm

Ludwig Mies van der Rohe.

"Bibliography of articles written by Mies van der Rohe": p. 117. "Selected bibliography on Mies van der Rohe": p. 119-121.Mode of access: Internet

Kompetenzentwicklung in KMUs

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Berufliche Kompetenzentwicklung von Supervisor/innen in Ausbildung

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