К актуальности разработки информационных систем для поддержки социальных исследований

This article is devoted to the problem of social researches information support and designed for the purpose of weaknesses identification in the current methods of organizing large-scale sociological studies (within the region) and also for assessment of related costs

Las primeras obras públicas en el Nuevo Mundo y su financiación: Santo Domingo 1494-1572

55 pagesPeer reviewe

Synthesis of tailored oxymethylene ether (OME) fuels via transacetalization reactions

In the field of alternative diesel fuels, so-called oxymethylene ethers (OMEs) are currently intensely investigated. Particularly OMEs of the type CH$_{3}$O(CH$_{2}$O)$_{n}$CH$_{3}$ with n = 3–5 exhibit promising fuel properties and combustion characteristics with strongly reduced particle and NO$_{x}$ emissions. According to their molecular structure, OMEs can be produced from methanol thus enabling sustainable production strategies from CO$_{2}$ and renewable resources. Compared to the methyl derivatives, analogous compounds with higher alkyl groups (oxymethylene dialkyl ethers, OMDAEs) have been investigated to a much lesser extent. Thus, commercially available OMDAEs, i.e. compounds of the type ROCH$_{2}$OR bearing ethyl, propyl, butyl and 2-ethylhexyl groups, have been studied. Furthermore, asymmetric compounds of the type R$^{1}$OCH$_{2}$OR$^{2}$ have been synthesized from the symmetric compounds employing transacetalization reactions catalyzed by zeolite BEA-25. The OMDAEs have been characterized by spectroscopic and spectrometric methods and several physico-chemical, thermodynamic and fuel-related data have been determined and compared. Despite their structural peculiarities, such as the oxygen-containing acetal moiety in the molecular backbone, all OMDAEs exhibit properties similar to conventional diesel fuels. Based on experimental and analytical data, the development of tools for the prediction of properties by a simple regression method is described. Furthermore, the suitability of group contribution modelling is investigated for OMDAE compounds

A Map of the Nanoworld: Sizing up the Science, Politics, and Business of the Infinitesimal

Mapping out the eight main nodes of nanotechnology discourse that have emerged in the past decade, we explore how various scientific, social, and ethical islands of discussion have developed, been recognized, and are being continually renegotiated. We do so by (1) identifying the ways in which scientists, policy makers, entrepreneurs, educators, and environmental groups have drawn boundaries on issues relating to nanotechnology; (2) describing concisely the perspectives from which these boundaries are drawn; and (3) exploring how boundaries on nanotechnology are marked and negotiated by various nodes of nanotechnology discourse.Comment: 25 page

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.

The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation. To investigate the influence of damage density and complexity on recruitment kinetics, which cannot be done by UV laser irradiation used in former studies, we utilized 43 MeV carbon ions with high linear energy transfer per ion (LET = 370 keV/µm) to create a large fraction of clustered DSBs, thus forming complex DNA damage, and 20 MeV protons with low LET (LET = 2.6 keV/µm) to create mainly isolated DSBs. Kinetics for all three proteins was characterized by a time lag period T(0) after irradiation, during which no foci are formed. Subsequently, the proteins accumulate into foci with characteristic mean recruitment times τ(1). Mdc1 accumulates faster (T(0) = 17 ± 2 s, τ(1) = 98 ± 11 s) than 53BP1 (T(0) = 77 ± 7 s, τ(1) = 310 ± 60 s) after high LET irradiation. However, recruitment of Mdc1 slows down (T(0) = 73 ± 16 s, τ(1) = 1050 ± 270 s) after low LET irradiation. The recruitment kinetics of Rad52 is slower than that of Mdc1, but exhibits the same dependence on LET. In contrast, the mean recruitment time τ(1) of 53BP1 remains almost constant when varying LET. Comparison to literature data on Mdc1 recruitment after UV laser irradiation shows that this rather resembles recruitment after high than low LET ionizing radiation. So this work shows that damage quality has a large influence on repair processes and has to be considered when comparing different studies

Галльский пласт в современном немецком литературном языке: структурно-системный и функционально-динамический аспекты

Диссертационное исследование Меремкуловой Татьяны Игоревны выполнено в русле контактной лингвистики, стремительно развивающейся ветви исторического языкознания, и посвящено определению структурно-системных и функционально-динамических характеристик заимствованных лексических единиц галльского пласта в системе современного немецкого литературного языка и в синхронной немецкой литературной речи.The dissertation research of Meremkulova Tatyana Igorevna is carried out in the mainstream of the contact linguistics, the rapidly developing branch of historical linguistics, and is devoted to the determination of structural-systemic and functional-dynamic characteristics of the borrowed lexical units of the Gallic layer in the system of modern German literary language and in synchronous German literary speech