144 research outputs found

    A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

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    Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically significant biomarkers that can indicate impending spinal cord ischaemia. This work therefore presents a novel measurement method for proteins, namely albumin, as a precursor to further work in this area. The work uses an interdigitated electrode (IDE) sensor and shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz (R2 = 0.991) and 4 GHz (R2 = 0.975)

    Principles of environmentally-sustainable anaesthesia: a global consensus statement from the World Federation of Societies of Anaesthesiologists

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    The Earth’s mean surface temperature is already approximately 1.1°C higher than pre-industrial levels. Exceeding a mean 1.5°C rise by 2050 will make global adaptation to the consequences of climate change less possible. To protect public health, anaesthesia providers need to reduce the contribution their practice makes to global warming. We convened a Working Group of 45 anaesthesia providers with a recognised interest in sustainability, and used a three-stage modified Delphi consensus process to agree on principles of environmentally sustainable anaesthesia that are achievable worldwide. The Working Group agreed on the following three important underlying statements: patient safety should not be compromised by sustainable anaesthetic practices; high-, middle- and low-income countries should support each other appropriately in delivering sustainable healthcare (including anaesthesia); and healthcare systems should be mandated to reduce their contribution to global warming. We set out seven fundamental principles to guide anaesthesia providers in the move to environmentally sustainable practice, including: choice of medications and equipment; minimising waste and overuse of resources; and addressing environmental sustainability in anaesthetists’ education, research, quality improvement and local healthcare leadership activities. These changes are achievable with minimal material resource and financial investment, and should undergo re-evaluation and updates as better evidence is published. This paper discusses each principle individually, and directs readers towards further important references

    Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

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    Modern blank holding systems in the process of stamping

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    W ostatnich latach prace w zakresie doskonalenia procesów głębokiego tłoczenia obejmują nowe sposoby dociskania materiału w czasie procesu wytłaczania. W artykule opisano najnowsze sposoby dociskania stosowane przez różnych wytwórców pras i narzędzi do tłoczenia jak i najnowsze wyniki badań w tej dziedzinieIn recent years, works on improvement of deep drawing processes include new ways of material holding during the process of drawing. The paper describes the newest ways of holding applied by various manufacturers of presses and drawing tools, as well as the latest investigation results in the field

    Comparative analysis of the results of computer simulation of thin-walled product forming processes

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    W artykule przedstawiono wyniki analizy działania algorytmów obliczeniowych programów symulacyjnych. Przedstawiono wyniki symulacji procesów kształtowania obrotowego oraz tłoczenia wytłoczki prostokątnej wykonanej za pomocą programów Pam-Stamp 2G i Autoform i porównano z modelowaniem fizycznym wykonanych wytłoczek. Z wyników badań wynika celowość modelowania komputerowego z wykorzystaniem siatki MES na grubości wytłoczek. Wyniki symulacji pokazują, że program Pam-Stamp pozwala lepiej, niż program Autoform odwzorować proces technologiczny kształtowania wytłoczek prostokątnych. Wykazano dużą przydatność tego programu dla oceny przebiegu tłoczenia.The paper presents the results of the functioning of computational algorithms of simulation programs. The resultsof flow forming and deep drawing of a rectangular drawpiece made by means of Pam-Stamp 2G and Autoform programs have been described and compared to physical modeling of the manufactured drawpieces. The investigation results prove purposefulness of computer modeling with the utilization of FEM grid on the drawpiece thickness. The simulation results show that the Pam-Stamp program allows for better imaging of the technological process of forming rectangular drawpieces than the Autoform program. The program has been proved highly suitable for the assessment of the drawing process

    Ocular responses after intravenous lidocaine

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