872 research outputs found
Endocrine tumors of the gastrointestinal tract and pancreas:grading, tumor size and proliferation index do not predict malignant behavior
<p>Abstract</p> <p>Context</p> <p>Gastrointestinal and pancreatic (GIP) endocrine tumors (ETs) have been regarded as slow growing neoplasms with distinct morphologic characteristics that behave less aggressively than carcinomas. The malignant potential of these tumors is difficult to predict.</p> <p>Objective</p> <p>To evaluate prognostic parameters, namely tumor size, tumor grade, and Ki-67 index in relationship to metastatic behavior of GIP ETs.</p> <p>Design</p> <p>Biopsies and surgical specimens from 38 patients with GIP ETs were selected. The study group comprised 16 males and 22 females (mean age 62.6 years; range 24–91). Formalin-fixed, paraffin-embedded tissue sections were stained with H&E, synaptophysin, chromogranin A, and Ki-67. Ki-67 index was evaluated using ChromaVision Automated Assisted Image Analysis software. Proliferative index was compared to tumor grade, and the degree of associations between tumor size, tumor grade, Ki-67 index and metastatic behavior of GIP ETs were evaluated.</p> <p>Results</p> <p>Fifteen of the twenty-two (68.18%) surgically staged neoplasms presented with peritoneal dissemination, lymphogeneous, and/or hematogeneous metastases. Nine of the metastatic tumors were G1 (9/13, or 69.23%), 5 were G2 (5/7, or 71.42%), and 1 – G3 (1/2, or 50%). Overall, 10/15 (66.66%) metastatic tumors showed < 2% Ki-67 immunoreactivity. Four ileal ETs had a synchronous malignancy. No significant correlation was found to exist between tumor grade and Ki-67 index as well as between tumor size, tumor grade, Ki-67 index and metastatic behavior.</p> <p>Conclusion</p> <p>The findings suggest that tumor size, tumor grade and Ki-67 index do not accurately predict malignant behavior of GIP ETs.</p
Graft dysfunction in simultaneous pancreas kidney transplantation (SPK): Results of concurrent kidney and pancreas allograft biopsies
Simultaneous pancreas and kidney transplants offer significant therapeutic advantages but present a diagnostic approach dilemma in the diagnosis of rejection. Because both organs are from the same donor, the kidney has been treated traditionally as the “sentinel” organ to biopsy, presumably representing the status of both allografts. Truly concurrent biopsy studies, however, are needed to confirm this hypothesis. We examined 101 concurrent biopsies from 70 patients with dysfunction in either or both organs. Results showed concurrent rejection in 23 of 57 (40%) of cases with rejection; 19 of 57 (33.5%) and 15 of 57 (26.5%) showed kidney or pancreas only rejection, respectively. The degree and type of rejection differed in the majority (13 of 23, 56.5%) of cases with concurrent rejection, with the pancreas more often showing higher rejection grade. Taking into account pancreas dysfunction, a positive kidney biopsy should correctly predict pancreas rejection in 86% of the instances. However, the lack of complete concordance between the 2 organs, the discrepancies in grade and type of rejection, and the tendency for higher rejection grades in concurrent or pancreas only rejections, all support the rationale for pancreas biopsies. The latter provide additional data on the overall status of the organ, as well as information on nonrejection-related pathologies.Fil: Uva, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Instituto de Nefrología de Buenos Aires; ArgentinaFil: Papadimitriou, J. C.. University of Maryland; Estados UnidosFil: Drachenberg, Cinthia B.. University of Maryland; Estados UnidosFil: Toniolo, María F.. Instituto de Nefrología de Buenos Aires; ArgentinaFil: Quevedo, Alejandra. Instituto de Nefrología de Buenos Aires; ArgentinaFil: Dotta, A. C.. Instituto de Nefrología de Buenos Aires; ArgentinaFil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Casadei, D. H.. Instituto de Nefrología de Buenos Aires; Argentin
Observation of charge asymmetry dependence of pion elliptic flow and the possible chiral magnetic wave in heavy-ion collisions
We present measurements of and elliptic flow, , at
midrapidity in Au+Au collisions at 200, 62.4, 39, 27,
19.6, 11.5 and 7.7 GeV, as a function of event-by-event charge asymmetry,
, based on data from the STAR experiment at RHIC. We find that
() elliptic flow linearly increases (decreases) with charge asymmetry
for most centrality bins at and higher.
At , the slope of the difference of
between and as a function of exhibits a
centrality dependence, which is qualitatively similar to calculations that
incorporate a chiral magnetic wave effect. Similar centrality dependence is
also observed at lower energies.Comment: 6 pages, 4 figure
Azimuthal anisotropy in U+U and Au+Au collisions at RHIC
Collisions between prolate uranium nuclei are used to study how particle
production and azimuthal anisotropies depend on initial geometry in heavy-ion
collisions. We report the two- and four-particle cumulants, and
, for charged hadrons from U+U collisions at =
193 GeV and Au+Au collisions at = 200 GeV. Nearly fully
overlapping collisions are selected based on the amount of energy deposited by
spectators in the STAR Zero Degree Calorimeters (ZDCs). Within this sample, the
observed dependence of on multiplicity demonstrates that ZDC
information combined with multiplicity can preferentially select different
overlap configurations in U+U collisions. An initial-state model with gluon
saturation describes the slope of as a function of multiplicity in
central collisions better than one based on Glauber with a two-component
multiplicity model.Comment: Final paper version accepted for publication in Phys. Rev. Lett. New
version includes comparisons to a constituent quark glauber mode
Centrality and transverse momentum dependence of elliptic flow of multi-strange hadrons and meson in Au+Au collisions at = 200 GeV
We present high precision measurements of elliptic flow near midrapidity
() for multi-strange hadrons and meson as a function of
centrality and transverse momentum in Au+Au collisions at center of mass energy
200 GeV. We observe that the transverse momentum dependence of
and is similar to that of and , respectively,
which may indicate that the heavier strange quark flows as strongly as the
lighter up and down quarks. This observation constitutes a clear piece of
evidence for the development of partonic collectivity in heavy-ion collisions
at the top RHIC energy. Number of constituent quark scaling is found to hold
within statistical uncertainty for both 0-30 and 30-80 collision
centrality. There is an indication of the breakdown of previously observed mass
ordering between and proton at low transverse momentum in the
0-30 centrality range, possibly indicating late hadronic interactions
affecting the proton .Comment: 7 pages and 4 figures, Accepted for publication in Physical Review
Letter
An Experimental Exploration of the QCD Phase Diagram: The Search for the Critical Point and the Onset of De-confinement
The QCD phase diagram lies at the heart of what the RHIC Physics Program is
all about. While RHIC has been operating very successfully at or close to its
maximum energy for almost a decade, it has become clear that this collider can
also be operated at lower energies down to 5 GeV without extensive upgrades. An
exploration of the full region of beam energies available at the RHIC facility
is imperative. The STAR detector, due to its large uniform acceptance and
excellent particle identification capabilities, is uniquely positioned to carry
out this program in depth and detail. The first exploratory beam energy scan
(BES) run at RHIC took place in 2010 (Run 10), since several STAR upgrades,
most importantly a full barrel Time of Flight detector, are now completed which
add new capabilities important for the interesting physics at BES energies. In
this document we discuss current proposed measurements, with estimations of the
accuracy of the measurements given an assumed event count at each beam energy.Comment: 59 pages, 78 figure
Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in at GeV
We report the observation of transverse polarization-dependent azimuthal
correlations in charged pion pair production with the STAR experiment in
collisions at RHIC. These correlations directly probe quark
transversity distributions. We measure signals in excess of five standard
deviations at high transverse momenta, at high pseudorapidities eta>0.5, and
for pair masses around the mass of the rho-meson. This is the first direct
transversity measurement in p+p collisions. Comparing the results to data from
lepton-nucleon scattering will test the universality of these spin-dependent
quantities.Comment: 11 pages, 5 figures, 15 tables. Submitted to PR
Isolation of Flow and Nonflow Correlations by Two- and Four-Particle Cumulant Measurements of Azimuthal Harmonics in 200 GeV Au+Au Collisions
A data-driven method was applied to measurements of Au+Au collisions at
200 GeV made with the STAR detector at RHIC to isolate
pseudorapidity distance -dependent and -independent
correlations by using two- and four-particle azimuthal cumulant measurements.
We identified a component of the correlation that is -independent,
which is likely dominated by anisotropic flow and flow fluctuations. It was
also found to be independent of within the measured range of
pseudorapidity . The relative flow fluctuation was found to be for particles of transverse momentum
less than GeV/. The -dependent part may be attributed to
nonflow correlations, and is found to be relative to the
flow of the measured second harmonic cumulant at
System size and energy dependence of near-side di-hadron correlations
Two-particle azimuthal () and pseudorapidity ()
correlations using a trigger particle with large transverse momentum () in
+Au, Cu+Cu and Au+Au collisions at =\xspace 62.4 GeV and
200~GeV from the STAR experiment at RHIC are presented. The \ns correlation is
separated into a jet-like component, narrow in both and
, and the ridge, narrow in but broad in .
Both components are studied as a function of collision centrality, and the
jet-like correlation is studied as a function of the trigger and associated
. The behavior of the jet-like component is remarkably consistent for
different collision systems, suggesting it is produced by fragmentation. The
width of the jet-like correlation is found to increase with the system size.
The ridge, previously observed in Au+Au collisions at = 200
GeV, is also found in Cu+Cu collisions and in collisions at
=\xspace 62.4 GeV, but is found to be substantially smaller at
=\xspace 62.4 GeV than at = 200 GeV for the
same average number of participants ().
Measurements of the ridge are compared to models.Comment: 17 pages, 14 figures, submitted to Phys. Rev.
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