In-vitro propagation, organic farming and comparative phytochemical evaluation of Curculigo Orchioides Gaertn. (Musali)

Medicinal plants belong to the oldest known health care products that have been used by mankind all over the world in the form of folklore medicine, traditional medicines or ethnic medicines. But due to the over dependence of herbal drug industry on the plant population, wild source became depleted. Several drugs became endangered while some others had been in the verge of extinction. Musali (Curculigo orchioides) is such a plant which is facing a threat of extinction. These plants can be produced by different methods. The main 2 methods for the propagation of plants will come under the following headings viz; Conventional way of propagation and Non-conventional way of propagation (In Vitro propagation). If a small change in climate and temperature is affecting the chemical composition of plants, then obviously there may be chances for change in the same while propagating it through different techniques. In this study the preliminary analytical profile of the three samples were done in order to know whether the organic and In Vitro variety can be replaced with the wild. As Musali (Curculigo orchioides Gaertn.) is a drug used in several formulations and Musali Khadiradi Kashayam is one among the important one used for the reproductive problems. So the formulation also needs to be analysed in order to know whether the variation in cultivation techniques will affect the physicochemical and chromatographic parameters

Cluster Based Analysis and Consumption of Food Products in Targeted Public Distribution System

The Public Distribution System in India is 50 years old. At present it is being carried on as an anti-inflationary and antipoverty system. Tamil Nadu, the southernmost State in the country, is adopting the Universal Public Distribution System covering its entire population and supplying regularly rice, wheat, sugar, kerosene and other products like pulses, edible oil etc. The PDS is a centrally sponsored scheme that entitles beneficiaries to subsidized food grains every month. Several challenges have been identified in the implementation of PDS like (i) Targeting errors (ii) Large leakages or diversion (iii) The elimination of bogus cards and (iv) The problems in Fair Price Shops. This paper analyses and evaluates the problems and finds the possible solutions using the data mining techniques based on preprocessing and clustering. The K-means and K-harmonic means algorithms are combined to cluster the data based on the type of food commodities for rice and wheat

Asana (Pterocarpus marsupium Roxb.) - A Drug Review

Asana (Pterocarpus marsupium Roxb.) commonly known as Honne Mara in Kannada, Bijasal in Hindi, Indian kino or Malabar kino in English, belongs to the family Fabaceae and it is widely distributed among several regions of India. It is one of the important medicinal plant of Indian traditional system of medicines and it has been used in India for several medicinal purposes. The Indian Kino is a medium to large; deciduous tree having chemical constituents like pterostilbene, (-)-epicatechin, pterosupin, marsupsin, etc. Asana have the pharmacological activity like antioxidant, antiinflammatory, antibacterial, etc

Bioinformatics Based: in Silico Docking Analysis of Polyherbal Formulation for The Management of Parkinson’s Disease (Nadukku Vatham)

Background: The discipline of Siddha medicine, particularly herbal formulations, can benefit greatly from the use of molecular docking because it enables the molecular interactions of the formulation’s lead molecules with receptors to be understood, as well as the inference of the formulation's basic biochemical targets.  Aim: The goal of this study is to carry out an In-silico computational analysis of the phytochemicals found in Kuruver Kudineer (KK), a traditional Siddha remedy that is used for managing behavioral deficit in Parkinsons disease.  Methodology: The ligand structures were developed and optimized using Auto Dock Tools (Morris, Goodsell et al., 1998). Using Auto dock Vina, the compounds were all docked. The function of the target protein Monoamine Oxidase -A (PDB 2Z5X), which is involved in the breakdown of the neurotransmitters by MAO-A, will be inhibited by the creation of a hydrogen bond between phytocomponents and the target's core amino acids (Tyr 69, Ile 335, Tyr 407, and Tyr 444). In order to control the dopamine level, phytocomponents that inhibit the target enzyme MAO-A may be used as potential targets. Results: The compounds present in Kuruver Kudineer (KK) like Gingerenone-A, Betulinic acid, Zingiberene, Rutin, Geniposide and β-sitosterol showed maximum interactions with MAO –A when compared to that of Clorgyline. According to the outcomes of the computational investigation, the bio-active substances present in the Siddha formulation Kuruver Kudineer (KK) have significant affinity to the target MAO-A (PDB 2Z5X). Conclusions: From the results of the present study, it was concluded that the MAO – A reveal significant effect to managing the behavioral deficit and thereby considered an excellent drug choice for the clinical management of Parkinson’s disease (Nadukku vatham

A Review on Enhancing Organization Security using Attribute-Based Encryption for Data Sharing

With the recent growth of networking, peoples can share their data with others through online, by using social networks or cloud computing but at the same time there has been increasing demand for data security. People would like to make their private data only accessible to the authorized people. In data sharing systems, access policies and the support of policies updates are most challenging issues. Attribute-based encryption (ABE) and Cipher text policy attribute based encryption (CP-ABE) are becoming promising cryptographic solutions to this issue and achives a fine-grained data access control. It enables data owners to define their own access policies over user attributes and enforce the policies on the data to be distributed. The major drawback of these systems is the key escrow problem. The proposed scheme solves the key escrow problem which depends on attribute based encryption technique for the shared data. Paillier Cryptosystem is utilized for encryption of keys for assignment and revocation process while Twofish algorithm is used to encrypt and decrypt stored data of users. Whenever data owner upload personal documents on cloud server, first the keywords will get fetched from the documents and index will be created. Lucene indexing algorithm is used for indexing of keywords. A Blind Storage scheme allows a client to store a set of files on a remote server

Impact Factor: 2.265 Global

ABSTRACT The third-party administrative control is done in cloud computing which gives rise to security concerns the attacks may happens by data of other users and nodes within the cloud hence, high security measures are required to protect data within the cloud. In this paper we propose (DROPS) Division and Replication of Data in the Cloud for Optimal Performance and Security that will collectivel1y approaches the security and performance issues. Here we divide a file into fragments and replicate the fragmented data over the cloud nodes. The nodes stores only a single fragment of a particular data file that ensures that even in case of a successful attack and so no meaningful information is revealed to the attacker. Furthermore, the traditional cryptographic techniques for the data security is not used by DROP which reduces cost. Then we also compare the performance of the DROPS methodology with ten other schemes for providing higher level of security

REVIEW ON THERMAL SEEDS IN MAGNETIC HYPERTHERMIA THERAPY

We present the short review on Magnetic nanoparticle specifically for biomedical application. This study shows the overview on magnetic material properties and its biocompatibility. Moreover focusing on engineering aspect of hyperthermia

Plakophilin3 Loss Leads to an Increase in PRL3 Levels Promoting K8 Dephosphorylation, Which Is Required for Transformation and Metastasis

The desmosome anchors keratin filaments in epithelial cells leading to the formation of a tissue wide IF network. Loss of the desmosomal plaque protein plakophilin3 (PKP3) in HCT116 cells, leads to an increase in neoplastic progression and metastasis, which was accompanied by an increase in K8 levels. The increase in levels was due to an increase in the protein levels of the Phosphatase of Regenerating Liver 3 (PRL3), which results in a decrease in phosphorylation on K8. The increase in PRL3 and K8 protein levels could be reversed by introduction of an shRNA resistant PKP3 cDNA. Inhibition of K8 expression in the PKP3 knockdown clone S10, led to a decrease in cell migration and lamellipodia formation. Further, the K8 PKP3 double knockdown clones showed a decrease in colony formation in soft agar and decreased tumorigenesis and metastasis in nude mice. These results suggest that a stabilisation of K8 filaments leading to an increase in migration and transformation may be one mechanism by which PKP3 loss leads to tumor progression and metastasis