A mantle melting profile across the Basin and Range, SW USA

This is the published version. Copyright 2002 American Geophysical Union. All Rights Reserved.The major and trace element composition of late Cenozoic basalts (0–10 Ma) across the Basin and Range province (B&R) preserve a clear signal of mantle melting depth variations. FeO, Fe8.0, and Tb/Yb increase, whereas Si8.0 and Al8.0 decrease, from west to east across the B&R along a profile at 36°–37°N. These variations are qualitatively consistent with shallower melting beneath the Western Great Basin (WGB) than in the central B&R. In order to quantify the depth range and percent of decompression melting, we invert primary Na2O and FeO contents of basalts using a melting model based on the partitioning of FeO and MgO in olivine and Na2O in clinopyroxene. An independent inversion, using the rare earth elements (REE), corroborates the melting depths obtained from the major element model and places most of the melting beneath the central B&R in the garnet-peridotite stability field. We find that the shape of the melting region across the B&R closely mimics the shape of the mantle lithosphere, as inferred from geological and geophysical observations. Melting across the study area occurs largely within the asthenosphere and generally stops at the base of the mantle lithosphere. In the WGB, melting paths are shallow, from 75 to 50 km, and in some cases extend almost to the base of the crust. These melting paths are consistent with adiabatic melting in normal-temperature asthenosphere, beneath an extensively thinned (or absent) mantle lithosphere. Shallow melting is consistent with geobarometry and isotopic compositions of local mantle xenoliths. Lithospheric thinning was caused by thermal erosion during Mesozoic subduction and/or simple shear or foundering during Cenozoic extension. In contrast, melting beneath the central B&R occurs beneath thick mantle lithosphere and requires mantle potential temperatures 200°C hotter than normal (melting paths from 140 to 100 km). The excess temperature beneath the central B&R is consistent with active upwelling of hot mantle in this region

Geochemistry of Mafic Magmas in the Hurricane Volcanic Field, Utah: Implications for Small‐ and Large‐Scale Chemical Variability of the Lithospheric Mantle

This is the publisher's version, also available electronically from http://www.jstor.org/stable/info/10.1086/314355.Low‐silica basanite, basanite, and alkali basalt lava flows and cinder cones make up the late Quaternary Hurricane volcanic field (HVF) in the Colorado Plateau/Basin and Range transition zone of southwestern Utah. Strombolian‐ and Hawaiian‐style eruptions produced thin (10 m) a'a lava flows and 10 cinder and scoria cones that group geographically into five clusters. The five clusters can be further divided into four isotopic magma types that vary in 87Sr/86Sr from 0.7035 to 0.7049, εNd from 1.6 to −7.5, and 206Pb/204Pb from 17.4 to 18.7. Except for the Radio Towers and Volcano Mountain cone clusters, each volcano had a different parent magma and evolved by fractional crystallization of different amounts and proportions of olivine and clinopyroxene. Parent magmas of each isotope group formed by 0.5%–7% partial melting of lithospheric mantle composed of fertile lherzolite varying in garnet content from 1 to 4 wt %. New 40Ar/39Ar dates indicate that the HVF formed over a period of at least 100 ka during the late Quaternary. Along a transect from the Basin and Range to the Colorado Plateau, the source for Pliocene–late Quaternary alkali basalt magmas changes from asthenosphere in the Basin and Range to lithospheric mantle on the Colorado Plateau. The melting of a heterogeneous lithospheric mantle is the most viable mechanism for producing the observed chemical variability in the transition zone–Colorado Plateau part of the transect. Furthermore, chemical differences across the transect may reflect a major lithospheric boundary originally defined on the basis of Nd and Pb isotopes that is older and perhaps more fundamental than the present structural and physiographic boundary between the Basin and Range and Colorado Plateau

Evolution of a mafic volcanic field in the central Great Basin, south central Nevada

This is the published version. Copyright 2012 American Geophysical Union. All Rights Reserved.Evolution of a mafic volcanic field is investigated through a study of Pliocene age rocks in the Reveille Range in south central Nevada. Pliocene activity began with the eruption of relatively abundant hawaiite (episode 1, 5–6 Ma), which was followed by trachytic volcanism (4.3 Ma) and by a second episode of lower-volume hawaiite and basanite (episode 2, 3.0–4.7 Ma). Incompatible elements indicate an asthenospheric source. Isotopically, episode 2 basalts cluster around 87Sr/86Sr = 0.7035 and εNd = +4.2, but episode 1 samples vary to high 87Si/86Sr (up to 0.7060) over a narrow range of εNd (+0.8 to +4.5). Trachytic rocks (MgO ∼ 0.5%) are isotopically akin to the episode 1 basalts. Geochemical variation requires the addition of a crustal component (high 87Sr/86Sr, Sr/Nd, Pb/La, low εNd) to the episode 1 hawaiites and trachytic samples, probably by assimilation of carbonate-rich sedimentary wall rock. The volcanic field developed in at least two eruptive cycles of approximately equal duration. Basanites (deeper and lower percentage melts) appear only in the younger episode. Eruptive episodes were apparently linked to separate melting events in the mantle. Through time, basalts were produced in diminishing volumes by lower percentage melting, magma generation and storage was at greater depths, and magma ascent was at higher velocities. Spatially, the melting anomalies were large in the Pliocene but progressively diminished in size so that by Pleistocene time, volcanism was restricted to a small area near the northern end of the initial outbreak

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

Introduction Advances in liquid chromatography-mass spectrometry (LC-MS) have enabled high-resolution metabolomics (HRM) to emerge as a sensitive tool for measuring environmental exposures and corresponding biological response. Using measurements collected as part of a large, panel-based study of car commuters, the current analysis examines in-vehicle air pollution concentrations, targeted inflammatory biomarker levels, and metabolomic profiles to trace potential metabolic perturbations associated with on-road traffic exposures. Methods A 60-person panel of adults participated in a crossover study, where each participant conducted a highway commute and randomized to either a side-street commute or clinic exposure session. In addition to in-vehicle exposure characterizations, participants contributed pre- and post-exposure dried blood spots for 2-hr changes in targeted proinflammatory and vascular injury biomarkers and 10-hr changes in the plasma metabolome. Samples were analyzed on a Thermo QExactive MS system in positive and negative electrospray ionization (ESI) mode. Data were processed and analyzed in R using apLCMS, xMSanalyzer, and limma. Features associated with environmental exposures or biological endpoints were identified with a linear mixed effects model and annotated through human metabolic pathway analysis in mummichog. Results HRM detected 10-hr perturbations in 110 features associated with in-vehicle, particulate metal exposures (Al, Pb, and Fe) which reflect changes in arachidonic acid, leukotriene, and tryptophan metabolism. Two-hour changes in proinflammatory biomarkers hs-CRP, IL-6, IL-8, and IL-1β were also associated with 10-hr changes in the plasma metabolome, suggesting diverse amino acid, leukotriene, and antioxidant metabolism effects. A putatively identified metabolite, 20-OH-LTB4, decreased after in-vehicle exposure to particulate metals, suggesting a subclinical immune response. Conclusions Acute exposures to traffic-related air pollutants are associated with broad inflammatory response, including several traditional markers of inflammation

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer\u27s disease and aged brains: increased levels correlate with neuropathology.

Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and regulator of lysosomal function. A single mutation in the human GRN gene resulting in reduced PGRN expression causes types of frontotemporal lobar degeneration resulting in frontotemporal dementia. Prosaposin (PSAP) is also a multifunctional neuroprotective secreted protein and regulator of lysosomal function. Interactions of PGRN and PSAP affect their functional properties. Their roles in Alzheimer\u27s disease (AD), the leading cause of dementia, have not been defined. In this report, we examined in detail the cellular expression of PGRN in middle temporal gyrus samples of a series of human brain cases (n = 45) staged for increasing plaque pathology. Immunohistochemistry showed PGRN expression in cortical neurons, microglia, cerebral vessels and amyloid beta (Aβ) plaques, while PSAP expression was mainly detected in neurons and Aβ plaques, and to a limited extent in astrocytes. We showed that there were increased levels of PGRN protein in AD cases and corresponding increased levels of PSAP. Levels of PGRN and PSAP protein positively correlated with amyloid beta (Aβ), with PGRN levels correlating with phosphorylated tau (serine 205) levels in these samples. Although PGRN colocalized with lysosomal-associated membrane protein-1 in neurons, most PGRN associated with Aβ plaques did not. Aβ plaques with PGRN and PSAP deposits were identified in the low plaque non-demented cases suggesting this was an early event in plaque formation. We did not observe PGRN-positive neurofibrillary tangles. Co-immunoprecipitation studies of PGRN from brain samples identified only PSAP associated with PGRN, not sortilin or other known PGRN-binding proteins, under conditions used. Most PGRN associated with Aβ plaques were immunoreactive for PSAP showing a high degree of colocalization of these proteins that did not change between disease groups. As PGRN supplementation has been considered as a therapeutic approach for AD, the possible involvement of PGRN and PSAP interactions in AD pathology needs to be further considered

NGC 5548 in a Low-Luminosity State: Implications for the Broad-Line Region

We describe results from a new ground-based monitoring campaign on NGC 5548, the best studied reverberation-mapped AGN. We find that it was in the lowest luminosity state yet recorded during a monitoring program, namely L(5100) = 4.7 x 10^42 ergs s^-1. We determine a rest-frame time lag between flux variations in the continuum and the Hbeta line of 6.3 (+2.6/-2.3) days. Combining our measurements with those of previous campaigns, we determine a weighted black hole mass of M_BH = 6.54 (+0.26/-0.25) x 10^7 M_sun based on all broad emission lines with suitable variability data. We confirm the previously-discovered virial relationship between the time lag of emission lines relative to the continuum and the width of the emission lines in NGC 5548, which is the expected signature of a gravity-dominated broad-line region. Using this lowest luminosity state, we extend the range of the relationship between the luminosity and the time lag in NGC 5548 and measure a slope that is consistent with alpha = 0.5, the naive expectation for the broad line region for an assumed form of r ~ L^alpha. This value is also consistent with the slope recently determined by Bentz et al. for the population of reverberation-mapped AGNs as a whole.Comment: 24 pages, 3 tables, 7 figures, accepted for publication in Ap

The Mass of the Black Hole in the Seyfert 1 Galaxy NGC 4593 from Reverberation Mapping

We present new observations leading to an improved black hole mass estimate for the Seyfert 1 galaxy NGC 4593 as part of a reverberation-mapping campaign conducted at the MDM Observatory. Cross-correlation analysis of the H_beta emission-line light curve with the optical continuum light curve reveals an emission-line time delay of 3.73 (+-0.75) days. By combining this time delay with the H_beta line width, we derive a central black hole mass of M_BH = 9.8(+-2.1)x10^6 M_sun, an improvement in precision of a factor of several over past results.Comment: 22 pages, 3 tables, 5 figures, accepted for publication in Ap

Moral enhancement: do means matter morally?

One of the reasons why moral enhancement may be controversial, is because the advantages of moral enhancement may fall upon society rather than on those who are enhanced. If directed at individuals with certain counter-moral traits it may have direct societal benefits by lowering immoral behavior and increasing public safety, but it is not directly clear if this also benefits the individual in question. In this paper, we will discuss what we consider to be moral enhancement, how different means may be used to achieve it and whether the means we employ to reach moral enhancement matter morally. Are certain means to achieve moral enhancement wrong in themselves? Are certain means to achieve moral enhancement better than others, and if so, why? More specifically, we will investigate whether the difference between direct and indirect moral enhancement matters morally. Is it the case that indirect means are morally preferable to direct means of moral enhancement and can we indeed pinpoint relevant intrinsic, moral differences between both? We argue that the distinction between direct and indirect means is indeed morally relevant, but only insofar as it tracks an underlying distinction between active and passive interventions. Although passive interventions can be ethical provided specific safeguards are put in place, these interventions exhibit a greater potential to compromise autonomy and disrupt identity