A radio-map of the colliding winds in the very massive binary system HD 93129A

Radio observations are an effective tool to discover particle acceleration regions in colliding-wind binaries, through detection of synchrotron radiation; these regions are natural laboratories for the study of relativistic particles. Wind-collision region (WCR) models can reproduce the radio continuum spectra of massive binaries that contain both thermal and non-thermal radio emission; however, key constraints for models come from high-resolution imaging. Only five WCRs have been resolved to date at radio frequencies at milliarcsec (mas) angular scales. The source HD 93129A, prototype of the very few known O2 I stars, is a promising target for study: recently, a second massive, early-type star about 50 mas away was discovered, and a non-thermal radio source detected in the region. Preliminary long-baseline array data suggest that a significant fraction of the radio emission from the system comes from a putative WCR. We sought evidence that HD 93129A is a massive binary system with colliding stellar winds that produce non-thermal radiation, through spatially resolved images of the radio emitting regions. We completed observations with the Australian Long Baseline Array (LBA) to resolve the system at mas angular resolutions and reduced archival Australia Telescope Compact Array (ATCA) data to derive the total radio emission. We also compiled optical astrometric data of the system in a homogeneous way. We reduced historical Hubble Space Telescope data and obtained absolute and relative astrometry with milliarcsec accuracy. The astrometric analysis leads us to conclude that the two stars in HD 93129A form a gravitationally bound system. The LBA data reveal an extended arc-shaped non-thermal source between the two stars, indicative of a WCR. The wind momentum-rate ratio of the two stellar winds is estimated. The ATCA data show a point source with a change in flux level ...Comment: Accepted in Astronomy and Astrophysic

Independent Study 490A: Do Play Groups for Shelter Dogs Reduce In-Kennel Arousal and Excitability Levels?

The objective of this study was to determine if 5-dog and 3-dog play groups had observable effects on-kennel arousal behavioral levels. This study was performed at the Animal Rescue League (ARL) of Iowa, located in Des Moines. A total of 36 dogs of mixed sex, breed, and age were observed. Two treatments were compared (1) 3-dog groups (n = 24) and (2) 5-dog groups (n = 12). All dogs included in this study had never been exposed to a play group before at the ARL-IA. Each dog was observed before play group (baseline) at 9 am and after play group (after) at 11 am respectively. Play sessions were held between 9 and10 am. Two dogs, one from each treatment, was removed for aggression issues and euthanized. Their data will not be presented. The observer watched one dog at a time, and stood in front of the kennel for 10 s, observing each dog and recording its behavior. Dogs allocated to both treatments during baseline all scored a recording level one, indicating a dog that was not displaying overt signs of behavioral anxiety in the kennel. When looking within categories, there were improvements within this category for in kennel behaviors between baseline and after. In the 5-dog play group, dogs displayed less barking (\u3c30%) and jumping (\u3c25%). The dogs in the 3-dog treatment showed improvements across all measures except for position in kennel, where no change was observed. In conclusion, both treatments showed improvement within recording level one for in-kennel behaviors and a decrease in in-kennel arousal levels post-play group. However, dogs displaying more severe in-kennel behavior(s) should be included in a future study to see if play groups improve in-kennel behavioral arousal levels resulting in improved adoptability and overall dog well-being

HD 93129A at different radio scales

Recent observations toward the O2 If* star HD 93129A have revealed important non-thermal radio emission, and that it has an early O companion 140 AU away if at 2.5 kpc (FGS-HST data). These facts strongly support the possibility of a massive stars wind-collision region as the acceleration site of the synchrotron-emitting relativistic electrons. We have carried out LBA VLBI observations at 2.37 GHz to resolve the non-thermal source, and search for a bow-shock shape, typical of a wind-collision region. Preliminary results are presented here.Fil: Benaglia, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto Argentino de Radioastronomia (i); ArgentinaFil: Dougherty, S. M.. National Research Council of Canada, Herzberg Institute for Astrophysics, Dominion Radio Astrophysical Observatory; CanadáFil: Phillips, C.. Australia Telescope National Facility, CSIRO; AustraliaFil: Koribalski, B.. Australia Telescope National Facility, CSIRO; AustraliaFil: Tzioumis, T.. Australia Telescope National Facility, CSIRO; Australi

Discovering the colliding wind binary HD 93129A

HD 93129A is a binary system including an O2 If+ and probably an O3.5 V-star orbiting at a distance of about 140 AU (55 mas given the distance of 2.5 kpc), which potentially makes the system the most massive one in the Galaxy, ahead of eta-Carina. Its non-thermal radio emission was proposed to be originated by the collision between the winds of both stars. HST/FGS data have been reanalyzed to derive an accurate absolute position of the stars to compare them with the radio emission. The analysis of ATCA radio observations along several years reveals a power-lawspectrum with an increase on the radio flux density along time. We conducted an observation with the Australian Long Baseline Array (LBA) at 2.3 GHz in 2008 to resolve the radio source and its location within the stellar system. These radio data revealed a bow-shape extended emissionlocated between both stars, as expected in a wind collision region. The observed structure allows us to roughly estimate the mass-loss rate ratio for the two stars in the system, concluding that dM_b/dt = 0.7 dM_a/dt. The multiwavelength analysis points out that the detected radio emission is likely to be originated by one of the most massive collision wind binary in the Galaxy.Fil: Marcote, B.. Universidad de Barcelona; EspañaFil: Benaglia, Paula. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Moldon, J.. Netherlands Institute for Radio Astronomy; Países BajosFil: Nelan, E.. Space Telescope Science Institute; Estados UnidosFil: De Becker, M.. Université de Liège; BélgicaFil: Dougherty, S, M.. NRC Herzberg Astronomy And Astrophysics; CanadáFil: Koribalski, Bärbel. Australia Telescope National Facility; Australia12th European VLBI Network Symposium and Users MeetingCagliariItaliaIstituto di Radioastronomi

Joint Annual Wellness Visit Scheduling

Problem/Impact Statement: The pharmacists in Scarborough & Westbrook Primary Care conduct Medicare Annual Wellness Visits (AWVs) with a physician. The pharmacist and physician see the patient individually. The practices achieved and sustained FY18 Joint AWV volume goals through a new process to reschedule physician-only AWVs to Joints AWVs with a pharmacist. This leads to reschedule rework and reduced time practice staff have for patient care

High-resolution radio emission from RCW 49/Westerlund 2

Aims. The HII region RCW49 and its ionizing cluster form an extensive, complex region that has been widely studied at infrared (IR) and optical wavelengths. The Molonglo 843 MHz and Australia Telescope Compact Array data at 1.4 and 2.4 GHz showed two shells. Recent high-resolution IR imaging revealed a complex dust structure and ongoing star formation. New high-bandwidth and high-resolution data of the RCW 49 field have been obtained to survey the radio emission at arcsec scale and investigate the smallscale features and nature of the HII region. Methods. Radio observations were collected with the new 2-GHz bandwidth receivers and the CABB correlator of the Australia Telescope Compact Array [ATCA], at 5.5 and 9.0 GHz. In addition, archival observations at 1.4 and 2.4 GHz have been re-reduced and re-analyzed in conjunction with observations in the optical, IR, X-ray, and gamma-ray regimes. Results. The new 2-GHz bandwidth data result in the most detailed radio continuum images of RCW 49 to date. The radio emission closely mimics the near-IR emission observed by Spitzer, showing pillars and filaments. The brightest continuum emission comes from the region known as the bridge. The overall flattish spectral index is typically consistent with a free-free emission mechanism. However, hints of nonthermal components are also present in the bridge. An interesting jet-like structure surrounded by a bubble feature whose nature is still unclear has been discovered close to the Westerlund 2 core. Two apparent bow shocks and a number of discrete sources have been detected as well in the surroundings of RCW 49. In addition, we also report on and discuss the possible detection of a hydrogen recombination line. Conclusions. The radio results support an association between the cm continuum and molecular emission. The detection of the radio recombination line kinematically favors a RCW49 distance of 6-7 kpc. If the negative spectral indices measured at the bridge should be confirmed to be caused by synchrotron emission, we propose a scenario where high-energy emission could be produced. Finally, the newly discovered jet-like structure appears to be an intriguing source that deserves a detailed study by itself.Facultad de Ciencias Astronómicas y GeofísicasInstituto Argentino de Radioastronomí

Switching to Glycerol Phenylbutyrate in 48 Patients with Urea Cycle Disorders: Clinical Experience in Spain

Clinical practice; Glycerol phenylbutyrate; Urea cycle disordersPráctica clinica; Fenilbutirato de glicerol; Trastornos del ciclo de la ureaPràctica clínica; Fenilbutirat de glicerol; Trastorns del cicle de la ureaBackground and objectives: Glycerol phenylbutyrate (GPB) has demonstrated safety and efficacy in patients with urea cycle disorders (UCDs) by means of its clinical trial program, but there are limited data in clinical practice. In order to analyze the efficacy and safety of GPB in clinical practice, here we present a national Spanish experience after direct switching from another nitrogen scavenger to GPB. Methods: This observational, retrospective, multicenter study was performed in 48 UCD patients (age 11.7 ± 8.2 years) switching to GPB in 13 centers from nine Spanish regions. Clinical, biochemical, and nutritional data were collected at three different times: prior to GPB introduction, at first follow-up assessment, and after one year of GPB treatment. Number of related adverse effects and hyperammonemic crisis 12 months before and after GPB introduction were recorded. Results: GPB was administered at a 247.8 ± 102.1 mg/kg/day dose, compared to 262.6 ± 126.1 mg/kg/day of previous scavenger (46/48 Na-phenylbutyrate). At first follow-up (79 ± 59 days), a statistically significant reduction in ammonia (from 40.2 ± 17.3 to 32.6 ± 13.9 μmol/L, p < 0.001) and glutamine levels (from 791.4 ± 289.8 to 648.6 ± 247.41 μmol/L, p < 0.001) was observed. After one year of GPB treatment (411 ± 92 days), we observed an improved metabolic control (maintenance of ammonia and glutamine reduction, with improved branched chain amino acids profile), and a reduction in hyperammonemic crisis rate (from 0.3 ± 0.7 to less than 0.1 ± 0.3 crisis/patients/year, p = 0.02) and related adverse effects (RAE, from 0.5 to less than 0.1 RAEs/patients/year p < 0.001). Conclusions: This study demonstrates the safety of direct switching from other nitrogen scavengers to GPB in clinical practice, which improves efficacy, metabolic control, and RAE compared to previous treatments.This study was funded by AECOM (Spanish Association for the Study of Inborn Errors of Metabolism). Immedica Pharma Spain funded medical writing support and article processing charges

High-resolution radio emission from RCW 49/Westerlund 2

Aims. The HII region RCW49 and its ionizing cluster form an extensive, complex region that has been widely studied at infrared (IR) and optical wavelengths. The Molonglo 843 MHz and Australia Telescope Compact Array data at 1.4 and 2.4 GHz showed two shells. Recent high-resolution IR imaging revealed a complex dust structure and ongoing star formation. New high-bandwidth and high-resolution data of the RCW 49 field have been obtained to survey the radio emission at arcsec scale and investigate the smallscale features and nature of the HII region. Methods. Radio observations were collected with the new 2-GHz bandwidth receivers and the CABB correlator of the Australia Telescope Compact Array [ATCA], at 5.5 and 9.0 GHz. In addition, archival observations at 1.4 and 2.4 GHz have been re-reduced and re-analyzed in conjunction with observations in the optical, IR, X-ray, and gamma-ray regimes. Results. The new 2-GHz bandwidth data result in the most detailed radio continuum images of RCW 49 to date. The radio emission closely mimics the near-IR emission observed by Spitzer, showing pillars and filaments. The brightest continuum emission comes from the region known as the bridge. The overall flattish spectral index is typically consistent with a free-free emission mechanism. However, hints of nonthermal components are also present in the bridge. An interesting jet-like structure surrounded by a bubble feature whose nature is still unclear has been discovered close to the Westerlund 2 core. Two apparent bow shocks and a number of discrete sources have been detected as well in the surroundings of RCW 49. In addition, we also report on and discuss the possible detection of a hydrogen recombination line. Conclusions. The radio results support an association between the cm continuum and molecular emission. The detection of the radio recombination line kinematically favors a RCW49 distance of 6-7 kpc. If the negative spectral indices measured at the bridge should be confirmed to be caused by synchrotron emission, we propose a scenario where high-energy emission could be produced. Finally, the newly discovered jet-like structure appears to be an intriguing source that deserves a detailed study by itself.Facultad de Ciencias Astronómicas y GeofísicasInstituto Argentino de Radioastronomí

Switching to Glycerol Phenylbutyrate in 48 Patients with Urea Cycle Disorders: Clinical Experience in Spain

Background and objectives: Glycerol phenylbutyrate (GPB) has demonstrated safety and efficacy in patients with urea cycle disorders (UCDs) by means of its clinical trial program, but there are limited data in clinical practice. In order to analyze the efficacy and safety of GPB in clinical practice, here we present a national Spanish experience after direct switching from another nitrogen scavenger to GPB. Methods: This observational, retrospective, multicenter study was performed in 48 UCD patients (age 11.7 ± 8.2 years) switching to GPB in 13 centers from nine Spanish regions. Clinical, biochemical, and nutritional data were collected at three different times: prior to GPB introduction, at first follow-up assessment, and after one year of GPB treatment. Number of related adverse effects and hyperammonemic crisis 12 months before and after GPB introduction were recorded. Results: GPB was administered at a 247.8 ± 102.1 mg/kg/day dose, compared to 262.6 ± 126.1 mg/kg/day of previous scavenger (46/48 Na-phenylbutyrate). At first follow-up (79 ± 59 days), a statistically significant reduction in ammonia (from 40.2 ± 17.3 to 32.6 ± 13.9 μmol/L, p < 0.001) and glutamine levels (from 791.4 ± 289.8 to 648.6 ± 247.41 μmol/L, p < 0.001) was observed. After one year of GPB treatment (411 ± 92 days), we observed an improved metabolic control (maintenance of ammonia and glutamine reduction, with improved branched chain amino acids profile), and a reduction in hyperammonemic crisis rate (from 0.3 ± 0.7 to less than 0.1 ± 0.3 crisis/patients/year, p = 0.02) and related adverse effects (RAE, from 0.5 to less than 0.1 RAEs/patients/year p < 0.001). Conclusions: This study demonstrates the safety of direct switching from other nitrogen scavengers to GPB in clinical practice, which improves efficacy, metabolic control, and RAE compared to previous treatments.This study was funded by AECOM (Spanish Association for the Study of Inborn Errors of Metabolism). Immedica Pharma Spain funded medical writing support and article processing charges

Regulation of Glucose Homeostasis by KSR1 and MARK2

Protein scaffolds control the intensity and duration of signaling and dictate the specificity of signaling through MAP kinase pathways. KSR1 is a molecular scaffold of the Raf/MEK/ERK MAP kinase cascade that regulates the intensity and duration of ERK activation. Relative to wild-type mice, ksr1-/- mice are modestly glucose intolerant, but show a normal response to exogenous insulin. However, ksr1-/- mice also demonstrate a three-fold increase in serum insulin levels in response to a glucose challenge, suggesting a role for KSR1 in insulin secretion. The kinase MARK2 is closely related to C-TAK1, a known regulator of KSR1. Mice lacking MARK2 have an increased rate of glucose disposal in response to exogenous insulin, increased glucose tolerance, and are resistant to diet-induced obesity. mark2-/-ksr1-/- (DKO) mice were compared to wild type, mark2-/-, and ksr1-/- mice for their ability to regulate glucose homeostasis. Here we show that disruption of KSR1 in mark2-/- mice reverses the increased sensitivity to exogenous insulin resulting from MARK2 deletion. DKO mice respond to exogenous insulin similarly to wild type and ksr1-/- mice. These data suggest a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1. Consistent with this model, we found that MARK2 binds and phosphorylates KSR1 on Ser392. Phosphorylation of Ser392 is a critical regulator of KSR1 stability, subcellular location, and ERK activation. These data reveal an unexpected role for the molecular scaffold KSR1 in insulin-regulated glucose metabolism