BIOMECHANICS OF RUNNING - Electromyographic Analysis of the Hip during Jogging, Running and Sprinting

The patterns of muscle action during human locomotion have been investigated for several decades. Lower extremity electromyographic activity in walking was investigated by Bartholomew and the Prosthetic Research Group at Berkeley in 1953. (1) Others investigated the actions of specific muscles during various leg movements. Basmajian and LeBan et al. (6) examined the electromyographic action of the iliopsoas muscle. These studies have led to the investigation of running. Saito et aI., (10) presented temporal data on the gait cycle of running. James and Brubaker (5) presented a descriptive analysis of running. Other researchers have directed their work toward sprinting: Fenn (4) investigated frictional and kinetic factors in 1930, and Dillman (3) and Ralph Mann (7) used kinetic analysis. Mann and Hagy (9) and Mann et aI. (8) investigated temporal and electromyographic patterns of walking, running and sprinting. This study investigates and describes the electromyographic activity ofthe lower extrJmities and trunk musculature duringjogging, running, and sprinting

Sampling Time Effects for Persistence and Survival in Step Structural Fluctuations

The effects of sampling rate and total measurement time have been determined for single-point measurements of step fluctuations within the context of first-passage properties. Time dependent STM has been used to evaluate step fluctuations on Ag(111) films grown on mica as a function of temperature (300-410 K), on screw dislocations on the facets of Pb crystallites at 320K, and on Al-terminated Si(111) over the temperature range 770K - 970K. Although the fundamental time constant for step fluctuations on Ag and Al/Si varies by orders of magnitude over the temperature ranges of measurement, no dependence of the persistence amplitude on temperature is observed. Instead, the persistence probability is found to scale directly with t/Dt where Dt is the time interval used for sampling. Survival probabilities show a more complex scaling dependence which includes both the sampling interval and the total measurement time tm. Scaling with t/Dt occurs only when Dt/tm is a constant. We show that this observation is equivalent to theoretical predictions that the survival probability will scale as Dt/L^z, where L is the effective length of a step. This implies that the survival probability for large systems, when measured with fixed values of tm or Dt should also show little or no temperature dependence.Comment: 27 pages, 10 figure

Correlations Between Body Weight and Size-Specific Dose Estimate on Thoracic Computed Tomography Examination

The dose received by a patient on CT examination is expressed in size-specific dose estimates (SSDE) which is a function of the patient diameter, x-ray attenuation, and scanner output (volume computed tomography dose index, CTDIvol). Patient diameter and x-ray attenuation are represented as water equivalent diameter (Dw). We conducted the research to analyze the relationships between body weight and Dw, CTDIvol, and size-specific dose estimates (SSDE) in contrast-enhanced thorax examinations. We used images from 100 patients (50 women and 50 men patients) whose weight range from 2.8 kg to 80 kg. The values of Dw, CTDIvol, and SSDE were automatically calculated from axial CT images using the IndoseCT software. Statistical analysis showed that the patient's body weight correlates linearly with the Dw. The linearity coefficient (R2) values for body weight and Dw is 0.43 (women) and 0.55 (men). However, weight was independent of the patient dose in terms of CTDIvol and SSDE. This was because the CT system used tube current modulation (TCM), which automatically adapted the tube current to patient size, resulting in a relatively constant dose regardless of the patient size (Dw)

Survival in equilibrium step fluctuations

We report the results of analytic and numerical investigations of the time scale of survival or non-zero-crossing probability $S(t)$ in equilibrium step fluctuations described by Langevin equations appropriate for attachment/detachment and edge-diffusion limited kinetics. An exact relation between long-time behaviors of the survival probability and the autocorrelation function is established and numerically verified. $S(t)$ is shown to exhibit simple scaling behavior as a function of system size and sampling time. Our theoretical results are in agreement with those obtained from an analysis of experimental dynamical STM data on step fluctuations on Al/Si(111) and Ag(111) surfaces.Comment: RevTeX, 4 pages, 3 figure

Currents associated with Saturn's intra-D ring azimuthal field perturbations

During the final 22 full revolutions of the Cassini mission in 2017, the spacecraft passed at periapsis near the noon meridian through the gap between the inner edge of Saturn’s D ring and the denser layers of the planet’s atmosphere, revealing the presence of an unanticipated low-latitude current system via the associated azimuthal perturbation field peaking typically at ~10-30 nT. Assuming approximate axisymmetry, here we use the field data to calculate the associated horizontal meridional currents flowing in the ionosphere at the feet of the field lines traversed, together with the exterior field-aligned currents required by current continuity. We show that the ionospheric currents are typically~0.5–1.5 MA per radian of azimuth, similar to auroral region currents, while the field-aligned current densities above the ionosphere are typically ~5-10 nA m-2 , more than an order less than auroral values. The principal factor involved in this difference is the ionospheric areas into which the currents map. While around a third of passes exhibit unidirectional currents flowing northward in the ionosphere closing southward along exterior field lines, many passes also display layers of reversed northward field-aligned current of comparable or larger magnitude in the region interior to the D ring, which may reverse sign again on the innermost field lines traversed. Overall, however, the currents generally show a high degree of north-south conjugacy indicative of an interhemispheric system, certainly on the larger overall spatial scales involved, if less so for the smaller-scale structures, possibly due to rapid temporal or local time variations

Comparisons of Water-Equivalent Diameter Measured on Images of Abdominal Routine Computed Tomography with and without A Contrast Agent

The size-specific dose estimate (SSDE) is a metric for an estimation of patient dose in computed tomography (CT). The SSDE strongly depends on the       water-equivalent diameter (DW). In abdominal CT examinations, a contrast agent is sometimes used to more clearly visualize tissue lesions. The Hounsfield unit (HU) of CT images with and without the use of a contrast agent at specific areas is slightly different and it may affect the DW value. This study aimed to compare the DW values calculated from axial CT images in patients who had undergone routine abdominal scans both with and without the use of a contrast agent. Axial images of 144 patients with a weight range of 3.5 kg to 90 kg who had undergone routine abdominal scans both with and without the use of a contrast agent using a Siemens Sensation 64 CT scanner were retrospectively collected. The DW values were automatically calculated using the Matlab-based IndoseCT (version 15a) software. The results show the percentage difference between DW,contrast and DW,non-contrast is below 2 %.As a result, the mean SSDEcontrast is 1.5 % smaller than SSDEnon-contrast. Due to the effect of a contrast agent on the DW and SSDE values is below 2 %, the axial images of CT abdomen without the use of a contrast agent can be used as the accurate estimation of DW and SSDE for images with the use of a contrast agent

An Automated Measurement of Image Slice Thickness of Computed Tomography

Measurement of the slice thickness in computed tomography (CT) is usually made using a special phantom, such as the AAPM CT performance phantom. Images of the phantom are analyzed manually and subjectively. The purpose of this study is to develop an automated system for measuring the slice thickness of the CT image of the phantom using MATLAB software.The CT AAPM performance phantom was scanned by a 128 multi-slice computed tomography scanner (Revolution Evo, GE Healthcare, Waukesha, WI) at a slice thickness of 5 mm with four different phantom orientations and also scanned by a 6 multi-slice CT scanner (Somatom Emotion 6, Siemens AG, Forchheim, Germany) for two slice thicknesses of 5 and 10 mm. Our automatedmethod produced an accurateslice thickness value less than 0.5 mm different from the nominal slice thicknesses and manual measurements. Similar results were obtained when the phantom was rotated. This system is more objective and effective compared to manual systems

Cassini observations of ion and electron beams at Saturn and their relationship to infrared auroral arcs

We present Cassini Visual and Infrared Mapping Spectrometer observations of infrared auroral emissions from the noon sector of Saturn's ionosphere revealing multiple intense auroral arcs separated by dark regions poleward of the main oval. The arcs are interpreted as the ionospheric signatures of bursts of reconnection occurring at the dayside magnetopause. The auroral arcs were associated with upward field-aligned currents, the magnetic signatures of which were detected by Cassini at high planetary latitudes. Magnetic field and particle observations in the adjacent downward current regions showed upward bursts of 100–360 keV light ions in addition to energetic (hundreds of keV) electrons, which may have been scattered from upward accelerated beams carrying the downward currents. Broadband, upward propagating whistler waves were detected simultaneously with the ion beams. The acceleration of the light ions from low altitudes is attributed to wave-particle interactions in the downward current regions. Energetic (600 keV) oxygen ions were also detected, suggesting the presence of ambient oxygen at altitudes within the acceleration region. These simultaneous in situ and remote observations reveal the highly energetic magnetospheric dynamics driving some of Saturn's unusual auroral features. This is the first in situ identification of transient reconnection events at regions magnetically conjugate to Saturn's magnetopause

Associations between purine metabolites and clinical symptoms in schizophrenia

Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology of schizophrenia. Methodology/Principal Findings: Breakdown products in purine pathway were measured using high-pressure liquid chromatography coupled with a coulometric multi-electrode array system for 25 first-episode neuroleptic-naïve patients with schizophrenia at baseline and at 4-weeks following initiation of treatment with antipsychotic medication. Associations between these metabolites and clinical and neurological symptoms were examined at both time points. The ratio of uric acid and guanine measured at baseline predicted clinical improvement following four weeks of treatment with antipsychotic medication. Baseline levels of purine metabolites also predicted clinical and neurological symtpoms recorded at baseline; level of guanosine was associated with degree of clinical thought disturbance, and the ratio of xanthosine to guanosine at baseline predicted degree of impairment in the repetition and sequencing of actions. Conclusions/Significance: Findings suggest an association between optimal levels of purine byproducts and dynamics in clinical symptoms and adjustment, as well as in the integrity of sensory and motor processing. Taken together, alterations in purine catabolism may have clinical relevance in schizophrenia pathology

Polarized Epithelial Cysts in vitro: A Review of Cell and Explant Culture Systems that Exhibit Epithelial Cyst Formation

The purpose of this paper is to review in vitro cell and explant culture systems that exhibit epithelial cyst formation and that are used as models of polarized epithelial function. We examine a number of culture systems derived from a variety of cell and organ types, briefly describe the methodology and conditions used to establish these cultures and discuss aspects of the experimental application of each system. We conclude that the characteristics of epithelial cyst-forming cultures are dependent upon the origin and identity of the cell population, as well as the multiple factors that define the culture environment. Culture systems in which epithelial cyst development occurs provide tools to study fundamental problems in epithelial biology, such as the establishment and maintenance of cell polarity, cell recognition and cell sorting, also cell-specific functions involving solute and water transport and the production and modification of secreted products. In addition, epithelial cyst culture systems offer useful models to better understand cellular behavior in various pathologic conditions of cyst formation in man