Enseñanza de la Informática en el marco de la Educación Musical

En este artículo se presenta un nuevo enfoque para la enseñanza de las nuevas tecnologías aplicadas a la música. Nuestro objetivo es promover el aprendizaje activo de conceptos y el manejo de herramientas que favorezcan, en lo posible, la adquisición de experiencia. Se propone para ello unos sencillos pero efectivos ejercicios que están siendo utilizados en la asignatura Informática Básica de la Titulación de Maestro Especialista en Educación Musical impartida en la Universidad de La Laguna

Utilización de Software en la docencia de Técnicas Algorítmicas

La optimización combinatoria tiene una gran repercusión en los campos de planificación, producción y gestión de recursos. En este trabajo se presenta un ejemplo del tipo de problemas que se plantea a los alumnos de diversas asignaturas de Centros de las Universidades Canarias. En primer lugar se describe el entorno donde ha tenido lugar la experiencia docente y se presentan las herramientas que se han utilizado en la realización de las prácticas: LINGO y MALLBA. A continuación, se describe con detalle una propuesta de ejercicio práctico utilizando el Problema de la Mochila Entera. Finalmente, se describen los resultados derivados de la utilización de estas herramientas en la docencia.Este trabajo ha sido parcialmente subvencionado por el proyecto CICYT-TIC1999-0754-C03

Complejidad Algorítmica: de la Teoría a la Práctica

En este trabajo se presentan las herramientas CALL y LLAC que facilitan el análisis de complejidad de aplicaciones tanto secuenciales como paralelas. La descripción del modo de uso se realiza mediante el estudio de un caso práctico. El ejemplo elegido ha sido el Problema de la Mochila 0/1. La resolución del mismo se aborda mediante la técnica de Ramificación y Acotación, presentando dos opciones de implementación: recursiva y paralela. La principal aportación del uso de estas herramientas en la docencia es establecer un puente entre el análisis teórico de la complejidad de los algoritmos y el análisis práctico de los parámetros de rendimiento de los programas, simplificando la labor de ejecución, recolección y estudio de resultados computacionales.Este trabajo ha sido financiado parcialmente por los proyectos del ministerio de Ciencia y Tecnología: TIC2002-04498-C05-05 (TRACER) y TIC2002-04400-C03-03 (PELICAN)

Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study

Objective To investigate the influence of COVID-19 vaccination on disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients under targeted therapies.Patients and methods 1765 vaccinated patients COVID-19, 1178 (66.7%) with RA and 587 (33.3%) with PsA from the COVID-19 registry in patients with rheumatic diseases (COVIDSER) project, were included. Demographics, disease characteristics, Disease Activity Score in 28 joints (DAS28) and targeted treatments were collected. DAS28-based flare rates and categorised disease activity distribution prevaccination and post vaccination were analysed by log-linear regression and contingency analyses, respectively. The influence of vaccination on DAS28 variation as a continuous measure was evaluated using a random coefficient model.Results The distribution of categorised disease activity and flare rates was not significantly modified by vaccination. Log-linear regression showed no significant changes in the rate of flares in the 6-month period after vaccination compared with the same period prior to vaccination in neither patients with RA nor patients with PsA. When DAS28 variations were analysed using random coefficient models, no significant variations in disease activity were detected after vaccination for both groups of patients. However, patients with RA treated with Janus kinase inhibitors (JAK-i) (1) and interleukin-6 inhibitor (IL-6-i) experienced a worsening of disease activity (1.436±0.531, p=0.007, and 1.201±0.550, p=0.029, respectively) in comparison with those treated with tumour necrosis factor inhibitor (TNF-i). Similarly, patients with PsA treated with interleukin-12/23 inhibitor (IL-12/23-i) showed a worsening of disease activity (4.476±1.906, p=0.019) compared with those treated with TNF-i.Conclusion COVID-19 vaccination was not associated with increased rate of flares in patients with RA and PsA. However, a potential increase in disease activity in patients with RA treated with JAK-i and IL-6-i and in patients with PsA treated with IL-12/23-i warrants further investigation

The ALHAMBRA survey: evolution of galaxy clustering since z∼1

PA-M was supported by an ERC StG Grant (DEGAS-259586). PN acknowledges the support of the Royal Society through the award of a University Research Fellowship and the European Research Council, through receipt of a Starting Grant (DEGAS-259586). This work was supported by the Science and Technology Facilities Council (grant number ST/F001166/1), by the Generalitat Valenciana (project of excellence Prometeo 2009/064), by the Junta de Andalucía (Excellence Project P08-TIC-3531) and by the SpanishMinistry for Science and Innovation (grantsAYA2010-22111-C03-01 and CSD2007-00060).Peer Reviewe

Quorum sensing network in clinical strains of A. baumannii : AidA is a new quorum quenching enzyme

Acinetobacter baumannii is an important pathogen that causes nosocomial infections generally associated with high mortality and morbidity in Intensive Care Units (ICUs). Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen. We analyzed these mechanisms in seven clinical isolates of A. baumannii. Microarray analysis of one of these clinical isolates, Ab1 (A. baumannii ST-2-clon-2010), previously cultured in the presence of 3-oxo-C12-HSL (a QS signalling molecule) revealed a putative QQ enzyme (α/β hydrolase gene, AidA). This QQ enzyme was present in all nonmotile clinical isolates (67% of which were isolated from the respiratory tract) cultured in nutrient depleted LB medium. Interestingly, this gene was not located in the genome of the only motile clinical strain growing in this medium (A. baumannii strain Ab421-GEIH-2010 [Ab7], isolated from a blood sample). The AidA protein expressed in E. coli showed QQ activity. Finally, we observed downregulation of the AidA protein (QQ system attenuation) in the presence of HO (ROS stress). In conclusion, most of the A. baumannii clinical strains were not surface motile (84%) and were of respiratory origin (67%). Only the pilT gene was involved in surface motility and related to the QS system. Finally, a new QQ enzyme (α/β hydrolase gene, AidA protein) was detected in these strains

The ALHAMBRA survey: B-band luminosity function of quiescent and star-forming galaxies at 0.2 ≤ z < 1 by PDF analysis

[Aims]: Our goal is to study the evolution of the B-band luminosity function (LF) since z ∼ 1 using ALHAMBRA data. [Methods]: We used the photometric redshift and the I-band selection magnitude probability distribution functions (PDFs) of those ALHAMBRA galaxies with I ≤ 24 mag to compute the posterior LF. We statistically studied quiescent and star-forming galaxies using the template information encoded in the PDFs. The LF covariance matrix in redshift - magnitude - galaxy type space was computed, including the cosmic variance. That was estimated from the intrinsic dispersion of the LF measurements in the 48 ALHAMBRA sub-fields. The uncertainty due to the photometric redshift prior is also included in our analysis. [Results]: We modelled the LF with a redshift-dependent Schechter function affected by the same selection effects than the data. The measured ALHAMBRA LF at 0.2 ≤ z < 1 and the evolving Schechter parameters both for quiescent and star-forming galaxies agree with previous results in the literature. The estimated redshift evolution of M ∝ Q is Q = -1.03±0.08 and Q = -0.80±0.08, and of logφ ∝ P is P = -0.01±0.03 and P = -0.41 ± 0.05. The measured faint-end slopes are α = -1.29 ± 0.02 and α = -0.53 ± 0.04. We find a significant population of faint quiescent galaxies with M ≳ -18, modelled by a second Schechter function with slope β = -1.31 ± 0.11. [Conclusions]: We present a robust methodology to compute LFs using multi-filter photometric data. The application to ALHAMBRA shows a factor 2.55 ± 0.14 decrease in the luminosity density j of star-forming galaxies, and a factor 1.25 ± 0.16 increase in the j of quiescent ones since z = 1, confirming the continuous build-up of the quiescent population with cosmic time. The contribution of the faint quiescent population to j increases from 3% at z = 1 to 6% at z = 0. The developed methodology will be applied to future multi-filter surveys such as J-PAS.This work has been mainly funded by the FITE (Fondos de Inversiones de Teruel) and the projects AYA2015-66211-C2-1, AYA2012-30789, AYA2006-14056, and CSD2007-00060. We also acknowledge support from the Spanish Ministry for Economy and Competitiveness and FEDER funds through grants AYA2010-15081, AYA2010-15169, AYA2010-22111-C03-01, AYA2010-22111-C03-02, AYA2011-29517-C03-01, AYA2012-39620, AYA2013-40611-P, AYA2013-42227-P, AYA2013-43188-P, AYA2013-48623-C2-1, AYA2013- 48623-C2-2, ESP2013-48274, AYA2014-58861-C3-1, Aragón Government Research Group E103, Generalitat Valenciana projects Prometeo 2009/064 and PROMETEOII/2014/060, Junta de Andalucía grants TIC114, JA2828, P10-FQM-6444, and Generalitat de Catalunya project SGR-1398. E.T. acknowledges the support by the ETAg grants IUT26-2, IUT40-2, and by the European Regional Development Fund (TK133). A.M. acknowledges the financial support of the Brazilian funding agency FAPESP (Post-doc fellowship – process number 2014/11806-9). B.A. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 656354.Peer Reviewe