Rancang Bangun Collaborative System Pemasaran Hotel Secara On-line Dengan Pendekatan Mediator Based

One important aspect of the development of information and communication technology in the economic field is marketing through the Internet. The development of marketing through the Internet network since the last decade very rapidly. Transactions that occur very tempting. That\u27s why up a snowball effect, thus attracting businesses to leverage the Internet as a new marketing channels. This research was conducted to develop a marketing medium collaborative hotels. The approach used mediatore based. The methodology used in this collaborative media development is waterfall with steps Analysis, design, coding and testing. The results of this research is a collaborative media hotel marketing on-line has been implemented according to specifications that have been formulated in the SRS

Data-driven nonlinear model reduction by moment-matching for the ISWEC system

Given the relevance of control-oriented models in optimal control design for wave energy converters (WECs), this paper presents a data-driven approach to nonlinear model reduction by moment-matching for the ISWEC device, a device originally developed at the Politecnico di Torino. The presented model reduction technique is capable of providing simple WEC models, which inherently preserve steady-state response characteristics from the target nonlinear system, by merely using information on the system outputs, defined for a specific class of operating conditions. We demonstrate that the proposed model reduction by moment-matching procedure is well-posed for the ISWEC, and illustrate the efficacy of this reduction technique under a variety of sea conditions

Nonlinear model reduction for wave energy systems: a moment-matching-based approach

Abstract Wave energy converters (WECs) inherently require appropriate control system technology to ensure maximum energy absorption from ocean waves, consequently reducing the associated levelised cost of energy and facilitating their successful commercialisation. Regardless of the control strategy, the definition of the control problem itself depends upon the specification of a suitable WEC model. Not only is the structure of the model relevant for the definition of the control problem, but also its associated complexity: given that the control law must be computed in real-time, there is a limit to the computational complexity of the WEC model employed in the control design procedure, while there is also a limit to the (analytical) complexity of mathematical models for which a control solution can be efficiently found. This paper presents a systematic nonlinear model reduction by moment matching framework for WEC systems, capable of providing control-oriented WEC models tailored for the control application, which inherently preserves steady state response characteristics. Existence and uniqueness of the associated nonlinear moment for WECs are proved in this paper, for a general class of systems. Given that the definition of nonlinear moments depends upon the solution of a nonlinear partial differential equation, an approximation framework for the computation of the nonlinear moment is proposed, tailored for the WEC application. Finally, the use and capabilities of the framework are illustrated by means of case studies, using different WEC systems, under a variety of wave conditions

The beneficial effects of TAVI in mitral insufficiency.

Background Although everolimus potentially improves long-term heart transplantation (HTx) outcomes, its early postoperative safety profile had raised concerns and needs optimization. Methods This 6-month, open-label, multicenter randomized trial was designed to compare the cumulative incidence of a primary composite safety endpoint comprising wound healing delays, pericardial effusion, pleural effusion needing drainage, and renal insufficiency events (estimated glomerular filtration rate ≤30/mL/min per 1.73 m2) in de novo HTx recipients receiving immediate everolimus (EVR-I) (≤144 hours post-HTx) or delayed everolimus (EVR-D) (4-6 weeks post-HTx with mycophenolate mofetil as a bridge) with reduced-dose cyclosporine A. Cumulative incidence of biopsy-proven rejection ≥ 2R, rejection with hemodynamic compromise, graft loss, or death was the secondary composite efficacy endpoint. Results Overall, 181 patients were randomized to the EVR-I (n = 89) or EVR-D (n = 92) arms. Incidence of primary safety endpoint was higher for EVR-I than EVR-D arm (44.9% vs 32.6%; P = 0.191), mainly driven by a higher rate of pericardial effusion (33.7% vs 19.6%; P = 0.04); wound healing delays, acute renal insufficiency events, and pleural effusion occurred at similar frequencies in the study arms. Efficacy failure was not significantly different in EVR-I arm versus EVR-D arm (37.1% vs 28.3%; P = 0.191). Three patients in the EVR-I arm and 1 in the EVR-D arm died. Incidence of clinically significant adverse events leading to discontinuation was higher in EVR-I arm versus EVR-D arm (P = 0.02). Conclusions Compared with immediate initiation, delayed everolimus initiation appeared to provide a clinically relevant early safety benefit in de novo HTx recipients, without compromising efficacy. © 2017 The Author(s). Published by Wolters Kluwer Health, Inc

The implementation of radiation technology program in Portugal

The development of ionizing radiation pplications for Industrial purposes in Portugal began near of 1982 with the support of IAEA. The main steps to put forward prior to the implementation were the sitting and the design study in order to build up the facility. Subsequently, the main parameters to be achieved were the construction, the commissioning, the operation, the maintenance and the foreseen decommission. Once a quality system for the gamma facility was established, the following stage is to develop, validate and control the terilization/disinfection process. The research activities carried out in the UTR have been closely related with the main applications of this technology namely, the sterilization of medical devices and pharmaceuticals and other products’ decontamination. Recently, a research Cobalt-60 equipment was upgraded and a LINAC was implemented in order to sustain the R&D. Fundamental and development research is ngoing in order to understand the irradiation mechanisms of action and to apply the technology with safety and quality patterns.The first author would like to thank Gulbenkian Foundation in Portugal and NIC2010 the financial support for the opportunity to participate at NAARRI International Conference

Exercise addiction, body dysmorphic disorder, and use of enhancement drugs during the COVID-19 pandemic confinement period: a transcultural study

info:eu-repo/semantics/publishedVersio

Uncommon acquired Gerbode defect following extensive bicuspid aortic valve endocarditis

Gerbode defect is a rare type of left ventricle to right atrium shunt. It is usually congenital in origin, but acquired cases are also described, mainly following infective endocarditis, valve replacement, trauma or acute myocardial infarction. We report a case of a 50-year-old man who suffered an extensive and complex infective endocarditis involving a bicuspid aortic valve, the mitral-aortic intervalvular fibrosa and the anterior leaflet of the mitral valve. After dual valve replacement and annular reconstruction, a shunt between the left ventricle and the right atrium - Gerbode defect, and a severe leak of the mitral prosthesis were detected. Reintervention was performed with successful shunt closure with an autologous pericardial patch and paravalvular leak correction. No major complications occurred denying the immediate post-surgery period and the follow-up at the first year was uneventful

Avaliação da contaminação por agrotóxicos numa microbacia do Córrego Tenente Amaral, Jaciara, MT.

O agronegócio é hoje um dos setores de maior participação na economia nacional, representando 23,3% do produto interno bruto do país. A produção de grãos é um dos principais setores, crescendo de forma surpreendente nas últimas décadas. No entanto, para que tais níveis de produtividade se mantenham, a utilização de insumos, como fertilizantes e agrotóxicos se faz cada vez mais necessária. Consequentemente, nos últimos anos o Brasil assumiu o preocupante título de maior consumidor de agrotóxicos do mundo. A expressiva utilização desses produtos aliada ao desconhecimento dos riscos associados e ao desrespeito às normas básicas de segurança, acabam gerando intoxicação humana e ambiental. Com o objetivo de avaliar a contaminação das águas por pesticidas no córrego Tenente Amaral e seu entorno, no Município de Jaciara - MT, onde predominam monoculturas de soja, milho, girassol algodão e cana, além da pecuária, foi implantado um experimento para monitorar a quantidade de água e solo perdidos por escoamento superficial, pelo período de um ano hidrológico (outubro 2013 a setembro 2014), em seis sistemas coletores com área de 10 m2 cada, sendo três em área de pastagem e três em área de plantio consorciado de soja e milho. Foram monitorados ainda três piezômetros para a avalição da água subterrânea, dois lisímetros para análise da água infiltrada, três pontos no Córrego Tenente Amaral, bem como em afloramentos do lençol freático superficial de duas voçorocas presentes na região. Os pesticidas estudados foram: trifluralina, atrazina, metolacloro, metribuzin, clorpirifós, ? endossulfam e permetrina, sendo a identificação e quantificação por CG/MS. Os resultados indicaram a presença de clorpirifós e atrazina (respectivamente, Altamente Perigoso - Classe I e Perigoso ? Classe III ao meio ambiente) nas águas de escoamento superficial; clorpirifós e metolacloro (Muito Perigoso ao meio ambiente ? Classe II) em águas subterrâneas e metolacloro e metribuzin (Muito Perigoso ? Classe II) em águas superficiais. Na maioria dos pontos os resultados obtidos estavam dentro dos limites permitidos; somente em uma parcela da lavoura encontrou-se o princípio ativo atrazina com concentração de 5,19 ?g.L-1. Embora em baixas concentrações, este estudo demostra a vulnerabilidade ambiental à contaminação constante por agrotóxicos numa microbacia afluente do Rio Tenente Amaral, que por sua vez é tributário do Rio São Lourenço, um dos principais rios formadores do Pantanal Mato-Grossense

Experimental thermochemical study of two 2-alkylbenzimidazole isomers (alkyl = propyl and isopropyl)

This paper reports the values of the standard (p∘=0.1 MPa) molar enthalpy of formation in the condensed, at T=298.15 K, for 2-R-benzimidazoles (R=propyl, isopropyl), derived from, the respective enthalpies of combustion in oxygen, measured by static bomb combustion calorimetry and the standard molar enthalpies of sublimation, at T=298.15 K, obtained using Calvet microcalorimetry in the case of 2-isopropylbenzimidazole and, by the variation of vapour pressures, determined by the Knudsen effusion technique, with temperatures between (344 and 365) K for 2-propylbenzimidazole. Heat capacities, in the temperature ranges from T=268 K to near their respective melting temperatures, T=421 K for 2-propylbenzimidazole and T=464 K for 2-isopropylbenzimidazole, were measured with a differential scanning calorimeter. These values were used to derive the standard molar enthalpies of formation, of the two 2-benzimidazole derivatives, in gaseous phase.Thanks are due to Instituto de Cooperação Cientı́fica e Tecnológica Industrial (ICCTI), Lisbon, Portugal, and Consejo Superior de Investigaciones Cientı́ficas (CSIC), Madrid, Spain for a joint research project CSIC/ICCTI; M.L.P.F.A. thanks Fundação para a Ciência e Tecnologia (FCT), Lisbon, Portugal, for the award of a postdoctoral fellowship (SRFH/BPD/5595/2001). The Spanish DGI/MCyT is acknowledged under projects BQU2000-0252, 0906 and 1497; M.T. thanks MECD/SEEU, AP2002-0603, Spain for financial support

Substituent and ring effects on enthalpies of formation: 2-methyl- and 2-ethylbenzimidazoles versus benzene-and imidazole-derivatives

The enthalpies of combustion, heat capacities, enthalpies of sublimation and enthalpies of formation of 2-methylbenzimidazole (2MeBIM) and 2-ethylbenzimidazole (2EtBIM) are reported and the results compared with those of benzimidazole itself (BIM). Theoretical estimates of the enthalpies of formation were obtained through the use of atom equivalent schemes. The necessary energies were obtained in single-point calculations at the B3LYP/6-311+G(d,p) on B3LYP/6-31G* optimized geometries. The comparison of experimental and calculated values of benzenes, imidazoles and benzimidazoles bearing H (unsubstituted), methyl and ethyl groups shows remarkable homogeneity. The energetic group contribution transferability is not followed, but either using it or adding an empirical interaction term, it is possible to generate an enormous collection of reasonably accurate data for different substituted heterocycles (pyrazole-derivatives, pyridine-derivatives, etc.) from the large amount of values available for substituted benzenes and those of the parent (pyrazole, pyridine) heterocycles.We acknowledge the financial support of the DGI/MCyT (project nos. BQU-2003-00976, 01251 and 05827). This work has been partially supported by the DGI project no. BQU-2003-00894. A generous allocation of computational time at the CCC of the Universidad Auto´noma de Madrid is also gratefully acknowledged. Thanks are also due to Instituto de Cooperac¸a˜o Cientı´fica e Tecnolo´gica Internacional (ICCTI), Lisbon, Portugal, and Consejo Superior de Investigaciones Cientı´ficas (CSIC), Madrid, Spain, for a joint research project ICCTI/CSIC. MLPFA thanks Fundac¸a˜o para a Cieˆncia e Tecnologia (FCT), Lisbon, Portugal, for the award of a postdoctoral fellowship (PRAXIS XXI/BPD/16319/98) and MT thanks MECD/SEEU (AP 2002-0603), Spain, for financial support