A predatory Rusophycus burrow from the Cambrian of southern New Brunswick, eastern Canada

A specimen of the trilobite-produced trace fossil Rusophycus is intimately associated with the annelid-produced meandering burrow Helminthopsis hieroglyphica on the upper surface of an amalgamated quartz arenite of the King Square Formation (late Middle - early Late Cambrian), Saint John Group, southern New Brunswick. Observations suggest that the rusophycid reflects, and is a rather unusual example of, predatory behaviour. Similar, but rare, examples have only occasionally been reported in the geologic record. The occurrence documented herein is the first from strata of this age and also the first from Canada. RÉSUMÉ Un spécimen d'une trace fossilises de trilobite de l'èspece Rusophycus est directement reliée au tube méandrique produit par des annelidés Helminthopsis hieroglyphica sur la surface superieure de ('assemblage de quartz arenite de la formation de King Square (fin du Cambrien intermédiaire au début du Cambrien supérieur), groupe de Saint-Jean, dans le sud du Nouveau-Brunswick. Les observations portent à croire que I'activité rusophycide reflète et traduit même un exemple assez inusité de prestation. D'autres exemples semblables, mais rares, ont à l'occasion éxé observés dans I'histoire géologique. L'exemple cité ici est le premier obtenu dans un étage de cet âge et également le premier du genre au Canada. Traduit par la rédactio

A camerate crinoid from the Upper Silurian (Ludlow) Moydart Formation of Nova Scotia, Canada

Well-preserved fossil echinodcrms are uncommon in the Arisaig Group (early Silurian to early Devonian) of Nova Scotia. Although not preserving sufficient detail to enable specific identification, a crinoid, monobathrid camerate gen. et sp. indet. from the Moydart Formation (late Silurian, late Ludlow), shows the following features: a long, heteromorphic (N212) column of circular section and with convex nodals; a broad, conical dorsal cup with broad, high radials; fixed, uniserial arms which branch twice; 20 long, free arms that are uniserial most proximally, but are otherwise biserial; and numerous, elongate, blade-like pinnules. The column of this species differentiates it from a second taxon commonly preserved perpendicular to bedding in the Moydart Formation. Thus, while one species in this formation is preserved autochthonously in life position, another forms a crinoid lagersiatte and coquinas of more complete specimens, but is, at best, parautochthonous. RÉSUMÉ Les échinodermes fossiles bien conservés sont rares dans le Groupe d'Arisaig (Silurien inférieur au Dévonien inférieur) de la Nouvelle-Écosse. Bien qu'il n'ait pas conservé suffisamment de details pour permettre une identification précise, un erinolde à chambres monobathride de genre et espèce inditérminés provenant de la Formation Moydart (Silurien supérieur, Ludlow supérieur) présente ces caractéristiques : longue colonne hétéromorphe (N212) d'une section circulaire avec nodales convexes; vaste calice dorsal conique avec rayons endosquelertiques élevés et étendus, et bras unisériés à deux niveaux de ramifications; 20 longs bras libres qui sont unisériés proximalcment, mais qui sont bisériés plus loin; ainsi que maintes pinnules oblongues en fer de lance. La colonne de cette espèce la différencie d'un deuxième taxon ordinairement conservé perpendiculairement au litage dans la Formation Moydart. Ainsi, même si une espèce de cette formation est conservée de fa÷on autochtone dans une position vitale, une autre peut être formée de lagersiatte crinoides et de coquillages cunéiformes de specimens plus complets, mais, au mieux, subautochtones. [Traduit par la rédaction

Ichnology of the Palaeogene Richmond Formation of eastern Jamaica - the final chapter?

Previously unrecorded ichnotaxa from the Palaeogene Richmond Formation of eastern Jamaica, namely Cos-morhaphe cf. gracilis, Helminthoida crassa, Paleodictyon? isp. and Taenidium cameronensis, are described. The ichnotaxa are assigned to a previously defined deep-water Scolicia ichnocoenosis characteristic of turbidilic strata. The general exclusion of graphoglyptids in these strata is believed to reflect a combination of the relatively shallow-water depths in which the turbidilic strata accumulated, the abundant organic matter available for biological consumption, and the existence of fluctuating dysaerobic/anoxic and oxygenated conditions at, or immediately below, the sediment-water interface. RÉSUMÉ Les ichnofossiles auparavant non enregistrés provenant de la Formation paleogène de Richmond de Test de la Jamaique, soil Cosmorhaphe cf. gracilis, Helminthoida crassa, Paleodictyon? isp. et Taenidium cameronensis, sont décrits. Ces ichnofossiles sont assigned à l’assemblage d'eau profonde Scolicia anterieurement défini, caractérislique des strates de turbidites. L'absence générate de graphoglyplides dans ces couches est considérée comme refletant une combinaison de la faible profondeur relative à laquelle les strates de turbidites se sont accumulées, l'abondance de matière organique disponible pour la consommation biologique et l’existence de conditions anoxiques et oxygénées fluctuantes è l'interface eau-sédiment ou immédiatement en-dessous. [Traduit par la rédaction

2006 NASA Range Safety Annual Report

Throughout 2006, Range Safety was involved in a number of exciting and challenging activities and events, from developing, implementing, and supporting Range Safety policies and procedures-such as the Space Shuttle Launch and Landing Plans, the Range Safety Variance Process, and the Expendable Launch Vehicle Safety Program procedures-to evaluating new technologies. Range Safety training development is almost complete with the last course scheduled to go on line in mid-2007. Range Safety representatives took part in a number of panels and councils, including the newly formed Launch Constellation Range Safety Panel, the Range Commanders Council and its subgroups, the Space Shuttle Range Safety Panel, and the unmanned aircraft systems working group. Space based range safety demonstration and certification (formerly STARS) and the autonomous flight safety system were successfully tested. The enhanced flight termination system will be tested in early 2007 and the joint advanced range safety system mission analysis software tool is nearing operational status. New technologies being evaluated included a processor for real-time compensation in long range imaging, automated range surveillance using radio interferometry, and a space based range command and telemetry processor. Next year holds great promise as we continue ensuring safety while pursuing our quest beyond the Moon to Mars

4. The School Develops

Between 1947 and 1953, when M.P. Catherwood left the deanship to become New York’s industrial commissioner, the ILR School developed into a full fledged enterprise. These pages attempt to capture some of the excitement of this period of the school’s history, which was characterized by vigor, growth, and innovation. Includes: Alumni Recall Their Lives as Students; The Faculty Were Giants; Alice Cook: Lifelong Scholar, Consummate Teacher; Frances Perkins; Visits and Visitors; Tenth Anniversary: Reflection and Change; The Emergence of Departments at ILR; Development of International Programs and Outreach

Cardiac Masses on Cardiac CT: A Review

Cardiac masses are rare entities that can be broadly categorized as either neoplastic or non-neoplastic. Neoplastic masses include benign and malignant tumors. In the heart, metastatic tumors are more common than primary malignant tumors. Whether incidentally found or diagnosed as a result of patients’ symptoms, cardiac masses can be identified and further characterized by a range of cardiovascular imaging options. While echocardiography remains the first-line imaging modality, cardiac computed tomography (cardiac CT) has become an increasingly utilized modality for the assessment of cardiac masses, especially when other imaging modalities are non-diagnostic or contraindicated. With high isotropic spatial and temporal resolution, fast acquisition times, and multiplanar image reconstruction capabilities, cardiac CT offers an alternative to cardiovascular magnetic resonance imaging in many patients. Additionally, cardiac masses may be incidentally discovered during cardiac CT for other reasons, requiring imagers to understand the unique features of a diverse range of cardiac masses. Herein, we define the characteristic imaging features of commonly encountered and selected cardiac masses and define the role of cardiac CT among noninvasive imaging options

A mouse model for HIV-1 entry

Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody’s ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions

EON-ROSE and the Canadian Cordillera Array – Building Bridges to Span Earth System Science in Canada

EON-ROSE (Earth-System Observing Network - Réseau d’Observation du Système terrestrE) is a new initiative for a pan-Canadian research collaboration to holistically examine Earth systems from the ionosphere into the core. The Canadian Cordillera Array (CC Array) is the pilot phase, and will extend across the Cordillera from the Beaufort Sea to the U.S. border. The vision for EON-ROSE is to install a network of telemetered observatories to monitor solid Earth, environmental and atmospheric processes. EON-ROSE is an inclusive, combined effort of Canadian universities, federal, provincial and territorial government agencies, industry, and international collaborators. Brainstorming sessions and several workshops have been held since May 2016. The first station will be installed at Kluane Lake Research Station in southwestern Yukon during the summer of 2018. The purpose of this report is to provide a framework for continued discussion and development.RÉSUMÉEON-ROSE (Earth-System Observing Network - Réseau d’Observation du Système terrestrE) est une nouvelle initiative de collaboration de recherche pancanadienne visant à étudier de manière holistique les systèmes terrestres, depuis l’ionosphère jusqu’au noyau. Le Réseau canadien de la cordillère (CC Array) en est la phase pilote, laquelle couvrira toute la Cordillère, de la mer de Beaufort jusqu’à la frontière étasunienne. L’objectif d’EON-ROSE est d’installer un réseau d’observatoires télémétriques pour suivre en continu les processusterrestres, environnementaux et atmosphériques. EON-ROSE est un effort combiné et inclusif des universités canadiennes, des organismes gouvernementaux fédéraux, provinciaux et territoriaux, de l’industrie et de collaborateurs internationaux. Des séances de remue-méninges et plusieurs ateliers ont été tenus depuis mai 2016. La première station sera installée à la station de recherche du lac Kluane, dans le sud-ouest du Yukon, au cours de l’été 2018. Le but du présent rapport est de fournir un cadre de discussion et de développement continu

The effects of involving a nurse practitioner in primary care for adult patients with urinary incontinence: The PromoCon study (Promoting Continence)

Contains fulltext : 70765.pdf ( ) (Open Access)BACKGROUND: Urinary incontinence affects approximately 5% (800.000) of the Dutch population. Guidelines recommend pelvic floor muscle/bladder training for most patients. Unfortunately, general practitioners use this training only incidentally, but prescribe incontinence pads. Over 50% of patients get such pads, costing 160 million euros each year. Due to ageing of the population a further increase of expenses is expected. Several national reports recommend to involve nurse specialists to support general practitioners and improve patient care. The main objective of our study is to investigate the effectiveness and cost-effectiveness of involving nurse specialists in primary care for urinary incontinence. This paper describes the study protocol. METHODS/DESIGN: In a pragmatic prospective multi centre two-armed randomized controlled trial in the Netherlands the availability and involvement for the general practitioners of a nurse specialist will be compared with usual care. All consecutive patients consulting their general practitioner within 1 year for urinary incontinence and patients already diagnosed with urinary incontinence are eligible. Included patients will be followed for 12 months.Primary outcome is severity of urinary incontinence (measured with the International Consultation on Incontinence Questionnaire Short Form (ICIQ-UI SF)). Based on ICIQ-UI SF outcome data the number of patients needed to include is 350. For the economic evaluation quality of life and costs will be measured alongside the clinical trial. For the longer term extrapolation of the economic evaluation a Markov modelling approach will be used. DISCUSSION/CONCLUSION: This is, to our knowledge, the first trial on care for patients with urinary incontinence in primary care that includes a full economic evaluation and cost-effectiveness modelling exercise from the societal perspective. If this intervention proves to be effective and cost-effective, implementation of this intervention is considered and anticipated. TRIAL REGISTRATION: Current Controlled Trials ISRCTN62722772

Recommendations for the design of therapeutic trials for neonatal seizures

Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack of data from welldesigned clinical trials. There is increasing interest in conducting trials of novel drugs to treat neonatal seizures, but the unique characteristics of this disorder and patient population require special consideration with regard to trial design. The Critical Path Institute formed a global working group of experts and key stakeholders from academia, the pharmaceutical industry, regulatory agencies, neonatal nurse associations, and patient advocacy groups to develop consensus recommendations for design of clinical trials to treat neonatal seizures. The broad expertise and perspectives of this group were invaluable in developing recommendations addressing: (1) use of neonate-specific adaptive trial designs, (2) inclusion/exclusion criteria, (3) stratification and randomization, (4) statistical analysis, (5) safety monitoring, and (6) definitions of important outcomes. The guidelines are based on available literature and expert consensus, pharmacokinetic analyses, ethical considerations, and parental concerns. These recommendations will ultimately facilitate development of a Master Protocol and design of efficient and successful drug trials to improve the treatment and outcome for this highly vulnerable population