6 research outputs found
Application of quality by design concepts and automation to improve manufacturing process consistency of development and clinical-stage cell therapies
- Publication venue
- ECI Digital Archives
- Publication date
- 15/01/2017
- Field of study
Designing manufacturing processes to reproducibly generate process-sensitive human cells of sufficient quantity and quality for clinical application is challenging and complex. Manufacture of cell therapies in manual flask based processes is controlled primarily through adherence to detailed SOPs which may contain subjective user interventions and relatively poorly defined operating controls. This situation can lead to clinical production processes with limited control of critical quality attributes, significant reliance on endpoint quality testing and consequent product wastage. Applying systematic and data driven approaches to process development, many of which form part of the Quality by Design (QbD) toolset, reduces manufacturing process risk. We have applied these approaches with a series of partners and cell types to demonstrate application of QbD tools to cell therapies. This includes statistical capability analysis to define process confidence limits for expansion processes, to identify sources of process variability, and to quantify process performance in relation to the process specification and necessary scale. This further enables risk assessment and gap analysis to identify and prioritise key manufacture process risks with common recurrent elements including input materials, cryo-strategy, and operational parameters pertaining to culture and medium supply strategy. Key variable screening via statistically designed experiments has enabled improvement in process consistency across multiple operations and an improved understanding of process tolerance to parameter levels. It also highlights where automation could be applied to enhance process reproducibility and increase process scale whilst retaining process format with comparability to prior manufacturing development. CompacT SelecT automated manufacturing processes have demonstrated consistently greater cell yields than manual processes with statistical analysis showing significantly improved confidence intervals between multiple production batches and facilitating identification of remaining sources of variation for further targeted process improvement. Example case studies include a partnership with ReNeuron, a UK-based stem cell therapy business currently undergoing a phase II clinical trial with its CTX cell therapy candidate to enhance motor recovery in disabled stroke patients, to develop scalable robust production processes for the CTX cell line
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
- Dumas Richard
- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
- Fauvel Jean-Pierre
- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
- Fink Raymond
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- Fiorina Paolo
- First Brian
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- Flack John
- Fliesser-G\uf6rzer Evelyn
- Fluck Patrick
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- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
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- Gallouj Karim
- Galphin Claude
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- H Boonstra A
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- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
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- Hamet Pavel
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- Hao Chuanming
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- Hellgren Margareta
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- Hung Cheng-Chieh
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- Ibern\uf3n Meritxell
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- Jamerson Kenneth
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- Jiang Ju-Ying
- Jiang Sheng
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- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
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- Kattah William
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- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
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- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
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- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
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- Anastasiadou Sofia
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- Anwar Sumadi Lukman
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- Arneja Jugpal
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- Balla Andrea
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- Balogun James A.
- Balogun Simon
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- Bonsaana Gilbert Batieka
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- Bracale Umberto
- Brachini Gioia
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- Branagan Graham
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- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
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- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
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- Elnour Moheyaldien Ahmed Elamin
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- Elshahawy Mahmoud Abdelaziz Mohamed
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- Ezanno Anne-Cecile
- Ezeanochie Michael
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- Ezenwa Ekene
- Ezomike Uchechukwu
- Fadalla Tarig
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- Meead Adullah
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- Pramesh C.S.
- Prats Milagros Carrasco
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- Prijović Nebojša
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- Pucher Philip
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- Puri Ajay
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- Pérez Beatriz Gómez
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- Qader Kawthar
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- Quadri Oladeji
- Quaresima Silvia
- Querney Jill
- Quintana-Villamandos Begoña
- Quzli Ahmad
- Rabie Mohamed
- Racine Michaël
- Radhakrishnan Ajay
- Radin Zorana
- Radivojević Renata Curic
- Radulescu Raluca Bievel
- Radwan Asmaa
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- Rahman Atiqur
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- Ronellenfitsch Ulrich
- Ros Emilio Peña
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- Shaban Naseebah
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- Shah Hemina
- Shah Jaffer
- Shah Karishma
- Shah Pritik A
- Shah Vinay
- Shaikh Shafaque
- Shalaby Mostafa
- Shalhoub Joseph
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- Shiwani Haaris
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- Sholadoye Tunde T.
- Shoukrie Shoukrie I. M.
- Shrestha Rashmit
- Siboe Mark
- Sica Giuseppe
- Siddig Esra
- Siddiqui M. Tayyab
- Sidiropoulos Theodoros
- Sievers Denise
- Sigamoney Kohila
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- Singer Georg
- Singh Abhinav
- Singh Baljit
- Singh Kathryn
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- Singh Tanveer
- Sinnerton Robert
- Siragusa Leandro
- Sivaprakasam Rajesh
- Skipworth Richard Je
- Slavchev Mihail
- Sleem Adham
- Smati Ismail
- Smelt Jeremy
- Smith A.
- Smolle-Juettner Freyja-Maria
- Sodhai Vivek
- Sofi Khalid
- Sohrabi Catrin
- Soibiharry Adaiah
- Sokolov Manol
- Solaini Leonardo
- Sole Oriol Martin
- Sole-Sedeno Josep M.
- Soljic Martina
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- Sozzi Giulio
- Sparavigna Marco
- Spartalis Michael
- Spellar Kayleigh
- Spiers Harry V. M.
- Spina Alfio
- Spriano Giuseppe
- Squiers John
- Stabler Robert
- Stamatakis Emmanouil
- Stamatis Konstantinos
- Starr Nichole
- Stather Philip
- Stevens Sean
- Stevenson Andrew
- Stewart Grant D.
- Stijns Jasper
- Stogowski Piotr Tomasz
- Stoleriu Mircea Gabriel
- Stoyanov Vladislav
- Street John
- Strotmann Johanna Josefine
- Stroumpoulis Konstantinos
- Su Yu-Xiong
- Suarez Sara Busto
- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
- Suresh Sreelakshmi
- Surya Ilham Utama
- Swed Sarya
- Syllaios Athanasios
- Symeonidis Dimitrios
- Szabómihályová Katarína
- Szakmany Tamas
- Szatmary Peter
- Sztipits Tamás
- Szyluk Karol
- Sá-Marta Eduarda
- Sánchez Alberto Cabañero
- Sánchez Rosa
- Sánchez-Guillén Luis
- Süleyman Marlen
- Tadic Boris
- Taha Anas
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- Tailor Bhavesh
- Taj Eldeen Samaher Taj Eldeen Hassan
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- Tamburello Sara
- Tamini Nicolò
- Tammo Ömer
- Tamoos Khalil
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- Tan Chih Ying
- Tan Shawn Jia Hwang
- Tanal Mert
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- Tang Alethea
- Tang Yita
- Tani Sobhana Iftekhar
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- Tatsis Dimitris
- Tawalbeh Ra'Fat
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- Tebha Sameer
- Techapongsatorn Suphakarn
- Teixeira Pedro
- Tejero-Pintor Francisco J.
- Tellez Karla Susana Martin
- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
- Thakar Sumit
- Thaw May Htoo
- Theivendran Kanthan
- Thekkinkattil Dinesh
- Theochari Nikoletta
- Theodoropoulos George
- Theophilidou Elena
- Thereska Dariel
- Thiruchandran Gajendiran
- Thomakos Nikolaos
- Thomas Bradley
- Thomas Jerin Jose
- Thuduvage Vasanthika
- Thumbadoo Ruben
- Tian Sarah
- Tidjane Anisse
- Tirloni Luca
- Toia Francesca
- Tokidis Evripidis
- Tokocin Merve
- Tolani Musliu Adetola
- Toma Elena Adelina
- Tomasicchio Giovanni
- Tomlinson James
- Tonini Valeria
- Torre Beatrice
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- Tottman R.
- Tousidonis Manuel
- Trabulsi Nora
- Tranca Sebastian
- Trebol Jacobo
- Trejo-Avila Mario
- Triantafyllou Alexandra
- Triantafyllou Tania
- Trifunovski Aleksandar
- Tripathi Manjul
- Tripathi Prashant
- Tripathy Sujit
- Trivik-Barrientos Felipe
- Trostchansky Ivan
- Trulson Alexander
- Trungu Sokol
- Truss Adam
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsiantoula Paraskevi
- Tsironis Dimitrios
- Tsolakidis Alexandros
- Tsoulfas Georgios
- Tucker Olga
- Tuech Jean Jacques
- Turan Alparslan
- Turi Stefano
- Turna Akif
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Tuyishime Eugene
- Tzelves Lazaros
- Tzima Ioanna
- Tzimas George
- Ubiali Paolo
- Ubom Akaninyene Eseme
- Ugwu Aloy Okechukwu
- Ugwu Ebere
- Ugwu Ifeanyichukwu
- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
- Ulgur Hanife Seyda
- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
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- Usman Muhammad
- Usman Mustapha Ibrahim
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- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
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- Velten Markus
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- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
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- Vincent Elizabeth
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- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
In Their Own Words: Adolescent Views on ADHD and Their Evolving Role Managing Medication
- Author
- April R. Zmitrovich
- Barkley
- Barkley
- Baxley
- Biederman
- Bowen
- Brinkman
- Bussing
- Cox
- Cunningham
- Doran
- Dosreis
- Edward F. Donovan
- Evans
- Giacomini
- Glaser
- Henker
- Kendall
- Kieran J. Phelan
- Knipp
- Krueger
- La Greca
- Lori E. Crosby
- Marty O. Visscher
- Meaux
- Owens
- Patton
- Patton
- Pliszka
- Saylor
- Sleator
- Sofaer
- Stein
- Strange
- Susan N. Sherman
- Swanson
- Visser
- Weiss
- William B. Brinkman
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Determinants of care outcomes for patients who die in hospital in Ireland: a retrospective study
- Author
- A Bjornberg
- A Donabedian
- B Gomes
- B Gomes
- C Quinlan
- C Sepulveda
- C Sprung
- CR Levy
- D Clark
- E Commission
- E Ferrand
- E McGlone
- Feline Engling
- Helen Donovan
- J Addington-Hall
- J Addington–Hall
- J Martin-Moreno
- J Weafer
- JM Teno
- Jonathan Pratschke
- JR Curtis
- K McKeown
- K McKeown
- K McKeown
- Kieran McKeown
- Marie Curie Palliative Care Institute Liverpool
- Marie Curie Palliative Care Institute Liverpool
- National Advisory Committee on Palliative Care
- O Keegan
- P Sawyer
- RL Rhodes
- S McCarthy
- Shelagh Twomey
- SR Connor
- T Szasz
- Trutz Haase
- World Health Organization
- WP Achterberg
- WR Proctor
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Abstracts
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- A. A. Brandes
- A. A. Buylla
- A. Achrol
- A. Adekunle
- A. Adesina
- A. Alvarez-Buylla
- A. Ashworth
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- A. Broniscer
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- A. Buckley
- A. Burford
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- A. C. Resnick
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- A. Cappellano
- A. Chu
- A. Crowther
- A. Desjardins
- A. Dey
- A. Dobrodumov
- A. Donson
- A. Donson
- A. Donson
- A. Donson
- A. Donson
- A. Dubuc
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- A. Dubuc
- A. Dupuy
- A. Dupuy
- A. E. Kulozik
- A. E. Robinson
- A. Erdreich-Epstein
- A. Eychene
- A. Fernandez-Lopez
- A. Fotovati
- A. Fotovati
- A. Friedman
- A. G. Hanno
- A. Gajjar
- A. Gajjar
- A. Gajjar
- A. Gajjar
- A. Gajjar
- A. Gajjar
- A. Garancher
- A. Gevorgian
- A. Griesinger
- A. Griesinger
- A. Griesinger
- A. Griesinger
- A. Griesinger
- A. Griveau
- A. Griveau
- A. Guha
- A. H. Chung
- A. Hanaford
- A. Hanaford
- A. Huang
- A. Huang
- A. Huang
- A. Huang
- A. Huang
- A. Huang
- A. Huang
- A. Huang
- A. Ischenko
- A. J. DiPatri
- A. J. Mungall
- A. J. Sievert
- A. Janss
- A. Jury
- A. K. Olow
- A. Kaul
- A. Kenney
- A. Kenney
- A. Khan
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Korshunov
- A. Kumar
- A. Ligon
- A. Liu
- A. Lo
- A. Lourdusamy
- A. Lourdusamy
- A. Luck
- A. M. Dubuc
- A. Mackay
- A. Mackay
- A. Mackay
- A. Mackay
- A. Mann
- A. Margo
- A. Mariampillai
- A. Martin
- A. Merkelson
- A. Merkelson
- A. Mikhrina
- A. Mita
- A. Molinaro
- A. Morrison
- A. Morrison
- A. Morrison
- A. Mukasa
- A. Mungall
- A. Narendran
- A. Nguyen
- A. Olch
- A. Olow
- A. Olow
- A. Onar-Thomas
- A. Ostman
- A. Pai
- A. Persson
- A. Persson
- A. Price
- A. Rasheed
- A. Resnick
- A. Resnick
- A. Robinson
- A. S. Morrissy
- A. S. Morrissy
- A. S. Reiner
- A. Saratsis
- A. Shelat
- A. Shlien
- A. Sievert
- A. Sievert
- A. Singh
- A. Singh
- A. Singhal
- A. Singhal
- A. Smith
- A. Stemmer-Rachamimov
- A. Studebaker
- A. Thomas
- A. Tovmasyan
- A. von Bueren
- A. von Deimling
- A. Wade
- A. Wade
- A. Whitton
- A. z. Muehlen
- A.-C. Tien
- A.-M. Marino
- B. Afanasyev
- B. Conklin
- B. Coyle
- B. Cristiano
- B. Freeman
- B. Geoerger
- B. Golbourn
- B. Golbourn
- B. Golbourn
- B. Golbourn
- B. Golbourn
- B. Hutzen
- B. Kleinschmidt-DeMasters
- B. Lach
- B. Lannering
- B. Lannering
- B. Manoranjan
- B. Manoranjan
- B. Manoranjan
- B. Manoranjan
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- R. Segal
- R. Sengupta
- R. Sengupta
- R. Sposto
- R. Stewart
- R. Tatevossian
- R. van Ommeren
- R. Van Ommeren
- R. Vanner
- R. Vibhakar
- R. Vibhakar
- R. Weksberg
- S. Agnihotri
- S. Agnihotri
- S. Agnihotri
- S. Agnihotri
- S. Agnihotri
- S. Ahsan
- S. Asgharzadeh
- S. Bannykh
- S. Bannykh
- S. Bannykh
- S. Barshow
- S. Baruchel
- S. Baylin
- S. Bender
- S. Bender
- S. Birks
- S. Blaney
- S. Blaney
- S. Bluml
- S. Bochare
- S. Buhrlage
- S. C. Mack
- S. Cavalheiro
- S. Chang
- S. Cheshier
- S. Chi
- S. Choufani
- S. Clifford
- S. Croul
- S. Croul
- S. Croul
- S. Dahiya
- S. Dahiya
- S. De Vleeschouwer
- S. De Vleeschouwer
- S. Dietl
- S. Dunn
- S. Dunn
- S. Dunn
- S. Dunn
- S. Dunn
- S. Dunn
- S. Dunn
- S. E. Dunn
- S. Fukushima
- S. Gholamin
- S. Gholamin
- S. Gianino
- S. Goldman
- S. Goldman
- S. Goldman
- S. Goldman
- S. Goldman
- S. Goldman
- S. Goldman
- S. Goldman
- S. Gottschalk
- S. Gururangan
- S. Gururangan
- S. H. Ditzler
- S. Hariono
- S. Ho
- S. Hutter
- S. J. E. Threatt
- S. Jackson
- S. Jelveh
- S. K. Singh
- S. Karkare
- S. Kauppinen
- S. Keir
- S. Keir
- S. Keir
- S. Khatau
- S. Krebs
- S. L. Markant
- S. L. Pomeroy
- S. Lambert
- S. Luczak
- S. M. Dietl
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. M. Pfister
- S. Mack
- S. Mack
- S. Mack
- S. Mack
- S. Mack
- S. Masoud
- S. Masoud
- S. Melnick
- S. Milla
- S. Mitra
- S. Mitra
- S. Morrissy
- S. Morrissy
- S. Morrissy
- S. Mueller
- S. Mueller
- S. Mueller
- S. Mueller
- S. Mueller
- S. Mueller
- S. Nair
- S. Nolte
- S. O'Dowd
- S. Obad
- S. Pajovic
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Pfister
- S. Picelli
- S. Pomeroy
- S. Pomeroy
- S. Popov
- S. Puget
- S. Puget
- S. R. Rassekh
- S. Ramkissoon
- S. Riedel
- S. Roberge
- S. Rush
- S. Rush
- S. Rutkowski
- S. Rutkowski
- S. Rutkowski
- S. Safonova
- S. Santaga
- S. Santagata
- S. Sarikaya-Seiwert
- S. Schreiber
- S. Schubert
- S. Schubert
- S. Sengupta
- S. Shah
- S. Shibui
- S. Singh
- S. Singh
- S. Singh
- S. Smith
- S. Stehbens
- S. Sugiarto
- S. T. Keir
- S. Taherbhoy
- S. Toledo
- S. Van Gool
- S. Van Gool
- S. Venkataraman
- S. Ward
- S. Yadavilli
- S. Yadavilli
- S. Yip
- S. Yip
- S. Yip
- S. Younger
- S. Zhao
- S. Zhu
- S. Zuyderduyn
- S.-K. Kim
- S.-S. Lang
- T. Alden
- T. Aviv
- T. Beez
- T. Blauwblomme
- T. Chan
- T. Chan
- T. Dasgupta
- T. Dasgupta
- T. Driscoll
- T. E. Merchant
- T. E. Van Meter
- T. E. Van Meter
- T. Geller
- T. Gershon
- T. Golub
- T. Gunnarsson
- T. Hankinson
- T. Hankinson
- T. Hummel
- T. Iuchi
- T. Iukhta
- T. J. MacDonald
- T. Jaspan
- T. Kumabe
- T. Ladner
- T. MacDonald
- T. MacDonald
- T. Milde
- T. Moriarty
- T. Nicolaides
- T. Nicolaides
- T. Nicolaides
- T. Nicolaides
- T. Ozawa
- T. Peterson
- T. Pietsch
- T. Pietsch
- T. Pietsch
- T. Ponomaryov
- T. Pugh
- T. S. Chan
- T. Sasaki
- T. Schmidt
- T. Sharp
- T. Shibata
- T. Sun
- T. Suzuki
- T. Tominaga
- T. Tomita
- T. Town
- T. Town
- T. Town
- T. Town
- T. Town
- T. Tynes
- T. Tzaridis
- T. Waldman
- T. Yang
- T. Zichner
- U. Bartels
- U. Bartels
- U. Schueller
- U. Schuller
- U. Schuller
- U. Tabori
- U. Tabori
- U. Tabori
- U. Tabori
- U. Tabori
- V. Amani
- V. Amani
- V. Amani
- V. Amani
- V. Brawley
- V. Chandramohan
- V. Chandramohan
- V. Chandramohan
- V. Datar
- V. Datar
- V. Gopalakrishnan
- V. Gopalakrishnan
- V. Gopalakrishnan
- V. Hovestadt
- V. Hovestadt
- V. Lobstein
- V. P. Collins
- V. P. Collins
- V. Prakash
- V. Rajaram
- V. Rajaram
- V. Ramaswamy
- V. Ramaswamy
- V. Ramaswamy
- V. Yang
- W. A. Weiss
- W. A. Weiss
- W. A. Weiss
- W. C. Broaddus
- W. C. Gustafson
- W. C. Gustafson
- W. Chen
- W. E. Reddick
- W. Grajkowska
- W. Grajkowska
- W. Grajkowska
- W. Gump
- W. Gump
- W. Gump
- W. Khachatryan
- W. Li
- W. Reddick
- W. Wang
- W. Weiss
- W. Weiss
- W. Weiss
- W. Weiss
- W. Weiss
- W. Weiss
- W. Weiss
- W. Wetzel
- W. Xie
- W. Zhang
- X. Bao
- X. Cui
- X. Huang
- X. Huang
- X. Liu
- X. Liu
- X. Qin
- X. Ren
- X. Song
- X. Wang
- X. Wang
- X. Wang
- X. Wu
- X. Wu
- X. Wu
- X. Wu
- X. Wu
- X. Yang
- X. Yang
- X. Yang
- X. Zhao
- X. Zhao
- X. Zhao
- X. Zhao
- X. Zhu
- X.-N. Li
- X.-N. Li
- X.-N. Li
- X.-N. Li
- Y. Ando
- Y. Butterfield
- Y. Chornenkyy
- Y. G. Sun
- Y. Hathout
- Y. He
- Y. He
- Y. He
- Y. Hoshida
- Y. Huang
- Y. Huang
- Y. Huang
- Y. Ihara
- Y. Ihara
- Y. Ju
- Y. Khakoo
- Y. Li
- Y. Li
- Y. N. Jan
- Y. Narita
- Y. Pei
- Y. Punanov
- Y. S. Ra
- Y. Totoki
- Y. Wang
- Y. Wang
- Y. Wang
- Y. Yao
- Y. Yoshida
- Y. Yuan
- Y. Zhou
- Y.-H. Chen
- Y.-J. Cho
- Y.-J. Cho
- Y.-J. Cho
- Y.-J. Cho
- Y.-J. Cho
- Y.-J. Cho
- Y.-J. Lu
- Y.-w. Cho
- Z. Jin
- Z. Khatib
- Z. Liu
- Z. Liu
- Z. Patay
- Z. Reitman
- Z. Shi
- Z. Stephen
- Z. Wang
- Z. Yi
- Z. Zhou
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study