Study on the Rheological Properties and Constitutive Model of Shenzhen Mucky Soft Soil

In order to obtain the basic parameters of numerical analysis about the time-space effect of the deformation occurring in Shenzhen deep soft-soil foundation pit, a series of triaxial consolidated-undrained shear rheology tests on the peripheral mucky soft soil of a deep foundation pit support were performed under different confining pressures. The relations between the axial strain of the soil and time, as well as between the pore-water pressure of the soil and time, were achieved, meanwhile on the basis of analyzing the rheological properties of the soil, the relevant rheological models were built. Analysis results were proved that the rheology of Shenzhen mucky soft soil was generally viscous, elastic, and plastic, and had a low yield stress between 90 and 150 kPa. The increase in pore-water pressure made the rheological time effect of the mucky soft soil more remarkable. Thus, the drainage performance in practical engineering should be improved to its maximum possibility extent to decrease the soft-soil rheological deformation. Lastly, a six-component extended Burgers model was employed to fit the test results and the parameters of the model were determined. Findings showed that the extended Burgers model could satisfactorily simulate the various rheological stages of the mucky soft soil. The constitutive model and the determination of its parameters can be served as a foundation for the time-space effect analysis on the deformation of deep soft-soil foundation pits

2,4-Dibromo-6-{(E)-[(R)-1-phenyl­ethyl]imino­meth­yl}phenol

In the title Schiff base, C15H13Br2NO, the benzene and phenyl rings form a dihedral angle of 75.18 (13)°. The N=C bond length of 1.263 (6) Å is shorter than of the N—C bond [1.476 (5) Å], indicating a double bond. In the crystal, there is some pseudosymmetry. This occurs because most of the two mol­ecules are centrosymmetrically related. The mol­ecular structure is stabilized by intra­molecular O—H⋯N hydrogen bonds

Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

<p>Abstract</p> <p>Background</p> <p>Myeloid-related protein 8/14 (MRP8/14) is a stable heterodimer formed by two different calcium-binding proteins (MRP8 and MRP14). Studies have identified that MRP8/14 regulates vascular inflammation and serves as a novel marker of acute coronary syndrome. In this study, we evaluated the correlation between serum levels of MRP8/14, hsCRP, endogenous secretory receptor for advanced glycation end-products (esRAGE) and the occurrence of coronary artery disease (CAD), or carotid intima-media thickness (IMT) when CAD was not yet developed in diabetic patients.</p> <p>Methods</p> <p>Serum levels of MRP8/14, esRAGE and hsCRP were measured in 375 diabetic patients. Then the results of those who had CAD were compared against who had not. Also, we investigated the associations between above-mentioned indicators and IMT of subjects without CAD in both diabetic group and non-diabetic one.</p> <p>Results</p> <p>Serum MRP8/14 was significantly higher in CAD than in non-CAD group (9.7 ± 3.6 ug/ml vs. 8.2 ± 3.0 ug/ml, <it>P </it>< 0.001). It was associated with severity of CAD (<it>r </it>= 0.16, <it>P </it>= 0.026). In non-CAD group, MRP8/14 was associated with IMT in patients with (<it>r </it>= 0.30, <it>P </it>< 0.001) or without diabetes (<it>r </it>= 0.26, <it>P </it>= 0.015). The areas under the curves of receiver operating characteristic for CAD were 0.63 (95% CI 0.57-0.68) for MRP8/14, 0.76 (95% CI 0.71-0.81) for hsCRP and 0.62 (95% CI 0.56 -0.67) for esRAGE.</p> <p>Conclusion</p> <p>In summary, we report that diabetic patients with CAD had elevated plasma MRP8/14 levels which were also positively correlated with the severity of CAD and carotid IMT in patients without clinically overt CAD.</p

Bis[μ-3-(1H-benzimidazol-2-yl)benzoato]dicopper(I)

The dimeric title complex, [Cu2(C14H9N2O2)2], resides on a center of symmetry. In the crystal, the mol­ecules are packed via π–π stacking inter­actions alternating between imidazole and benzene rings [mean inter­planar distances = 3.754 (3) and 3.624 (3) Å]. An inter­molecular N—H⋯O hydrogen bond links the dimers together. The two-coordinate CuI atom displays an O—Cu—N bond angle of 176.3 (2)°. The Cu⋯Cu distance within the dimer is 5.100 (2) Å

Clinical efficacy and safety of Kanglaite injection, adjuvant cemcitabine and cisplatin chemotherapy for advanced non-small-cell lung cancer: A systematic review and meta-analysis

Purpose: To investigate the effectiveness and safety of the combination of Kanglaite injection (KLTi) and gemcitabine and cisplatin (GP) chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC).Methods: PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wan-Fang, CBM, and CQVIP were comprehensively searched from January 2010 till November 2020. Randomized controlled trials (RCTs) of KLTi plus GP in the treatment of NSCLC were selected and assessed for inclusion. Review Manager 5.3 software was used for meta-analysis.Results: Twenty-five RCTs on advanced NSCLC examined the inclusion criteria. The meta-analysis showed that compared with GP chemotherapy alone, KLTi plus GP chemotherapy significantly improved objective response rate (ORR) (RR = 1.36, 95% CI 1.23-1.51, p &lt; 0.00001), disease control rate (DCR) (RR = 1.17, 95% CI 1.11 - 1.23, p &lt; 0.00001), and reduced adverse drug reactions(ADRs) such as hair loss (RR = 0.60, 95% CI 0.47 - 0.76, p &lt; 0.0001), gastrointestinal reaction (RR = 0.68, 95% CI 0.62 - 0.75, p &lt; 0.00001), impairment of liver and kidney function (RR = 0.65, 95% CI 0.53 - 0.80, p &lt; 0.001), nervous system damage (RR = 0.42, 95% CI 0.26 - 0.69, p = 0.0005), myelosuppression (I-II phase) (RR = 0.79, 95 % CI 0.66 - 0.95, p = 0.01), myelosuppression (III-IV phase) (RR = 0.44, 95 % CI0.27 - 0.72, p = 0.001), anemia (RR = 0.74, 95 % CI 0.60 - 0.91, p = 0.006), leukopenia (RR = 0.78, 95% CI 0.69, 0.87, p &lt; 0.0001), thrombocytopenia (RR = 0.59, 95 % CI 0.49, 0.72, p &lt; 0.00001), hypochromia (RR = 0.74, 95% CI 0.59, 0.92, p = 0.008).Conclusion: KLTi adjuvant GP chemotherapy reduces adverse effects in patients with advanced NSCLC. Thus, KLTi might be an effective and safe intervention for NSCLC&nbsp

Ethyl 5-(ethoxy­carbon­yl)-3-(4-methoxy­phen­yl)-1H-pyrazole-1-acetate

In the title compound, C17H20N2O5, all bond lengths and angles show normal values. The dihedral angle between the pyrazole ring and the benzene ring is 6.98 (11)°. The mol­ecules are linked by inter­molecular C—H⋯π inter­actions

Compensatory sweating after restricting or lowering the level of sympathectomy: a systematic review and meta-analysis

OBJECTIVE: To compare compensatory sweating after lowering or restricting the level of sympathectomy. METHOD: A systematic review and meta-analysis were conducted of all randomized controlled trials published in English that compared compensatory sweating after lowering or restricting the level of sympathectomy. The Cochrane collaboration tool was used to assess the risk of bias, and the Mantel-Haenszel odds ratio method was used for the meta-analysis. RESULTS: A total of 11 randomized controlled trials were included, including a total of 1079 patients. Five of the randomized controlled trials studied restricting the level of sympathectomy, and the remaining six studied lowering the level of sympathectomy. CONCLUSIONS: The compiled randomized controlled trial results published so far in the literature do not support the claims that lowering or restricting the level of sympathetic ablation results in less compensatory sweating

Precious metal free hydrogen evolution catalyst design and application

The quest to identify precious metal free hydrogen evolution reaction catalysts has received unprecedented attention in the past decade. In this Review, we focus our attention to recent developments in precious metal free hydrogen evolution reactions in acidic and alkaline electrolyte owing to their relevance to commercial and near-commercial low-temperature electrolyzers. We provide a detailed review and critical analysis of catalyst activity and stability performance measurements and metrics commonly deployed in the literature, as well as review best practices for experimental measurements (both in half-cell three-electrode configurations and in two-electrode device testing). In particular, we discuss the transition from laboratory-scale hydrogen evolution reaction (HER) catalyst measurements to those in single cells, which is a critical aspect crucial for scaling up from laboratory to industrial settings but often overlooked. Furthermore, we review the numerous catalyst design strategies deployed across the precious metal free HER literature. Subsequently, we showcase some of the most commonly investigated families of precious metal free HER catalysts; molybdenum disulfide-based, transition metal phosphides, and transition metal carbides for acidic electrolyte; nickel molybdenum and transition metal phosphides for alkaline. This includes a comprehensive analysis comparing the HER activity between several families of materials highlighting the recent stagnation with regards to enhancing the intrinsic activity of precious metal free hydrogen evolution reaction catalysts. Finally, we summarize future directions and provide recommendations for the field in this area of electrocatalysis