Ciudad, mercado y municipio en Cuenca durante la Edad Media (siglo XV)

Sin resume

Notas sobre los monederos de Cuenca en el siglo XV.

Sin resume

Ciudad, mercado y municipio en Cuenca durante la Edad Media (siglo XV)

Sin resume

Notas sobre los monederos de Cuenca en el siglo XV.

Sin resume

Assessment of somatic maturation of Venezuelan adolescents

Introduction: beginning of adolescence comprises important physical modifications, which affects growth and changes in body composition, therefore it is important to consider maturation assessment. Objective: to develop a non-invasive method to assess maturity status in Venezuelan adolescents from peak height velocity (PHV) by means of anthropometric variables in a cross-sectional sample. Methods: data comprised 681 Venezuelan adolescents 9 up to 18 years of age. Mirwald equation was applied to derived PHV. Regression analysis was used in order to build a model for Venezuelan sample as well as, ROC curves to assess sensitivity and specificity of anthropometric variables. Results: the predictive equations for both sexes, exhibited a high determination coefficient ( 0.75, specially sitting height. Discussion and conclusion: in Venezuela, there is little work based on longitudinal studies of the maturation status. Giving the difficult faced in the longitudinal studies recent works have been used cross-sectional methodology in the assessment of the somatic maturation, both in non athletic and athletic populations. This study provides predicting equations for the assessment of the somatic maturation adjusted to Venezuelan population developed from Mirwald equation, which may be used to aid in evaluation of nutritional and general health, as well as, a reduction of risks associated with miss-classification for chronological age

Hereditary angioedema due to C1 inhibitor deficiency: real-world experience from the Icatibant Outcome Survey in Spain

Bradykinin; Hereditary angioedema; IcatibantBradicinina; Angioedema hereditario; IcatibantBradicinina; Angioedema hereditari; IcatibantBackground The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks. Our goal was to assess disease characteristics and icatibant treatment outcomes in patients with HAE due to C1 inhibitor deficiency (HAE type 1 or 2 (HAE-1/2)) from Spain relative to other countries participating in IOS. Methods Descriptive retrospective analyses of data are reported from 10 centers in Spain vs 51 centers in 12 other participating countries (July 2009 to January 2019). Results No meaningful differences were identified between patients in Spain (n = 119) and patients across other countries (n = 907) regarding median age at symptom onset (15.0 vs 12.0 years) or diagnosis (22.3 vs 20.5 years). Overall HAE attack rates (total attacks/total years of follow-up) were 2.66 in Spain and 1.46 across other countries. Patients in Spain reported fewer severe/very severe HAE attacks before treatment (41.0% vs 45.9%; P < 0.0001) and, for icatibant-treated attacks, longer median time to treatment (2.9 vs 1.0 h), time to attack resolution (18.0 vs 5.5 h), and total attack duration (24.6 vs 8.0 h). Use of androgens for long-term prophylaxis was higher in Spain (51.2% vs 26.7%). Conclusion Patients with HAE-1/2 in Spain reported fewer severe/very severe attacks, administered icatibant later, and had longer-lasting attacks than did patients across other countries in IOS. These differences may indicate varying disease management practices (e.g., delayed icatibant treatment) and reporting. Efforts to raise awareness on the benefits of early on-demand treatment may be warranted.The Icatibant Outcome Survey is funded and supported by Shire International GmbH, a Takeda company, Zurich, Switzerland. Under direction of the authors, Alpa Parmar, PhD, CMPP, Latoya M. Mitchell, PhD, CMPP, and Sophia Shumyatsky, PharmD, CMPP, employees of Excel Medical Affairs, provided writing assistance for this manuscript. Editorial assistance in formatting, proofreading, and copyediting also was provided by Excel Medical Affairs. Takeda Development Center Americas, Inc. provided funding to Excel Medical Affairs, provided funding to Excel Medical Affairs for support in editing this manuscript. The interpretation of the data was made by the authors independently

Body composition and somatotype in university triathletes

Introducción: el triatlón es un deporte de resistencia e individual que está formado por tres disciplinas diferentes: natación, ciclismo y carrera a pie. El objetivo del estudio es describir las características antropométricas en triatletas varones universitarios, además de analizar y describir la composición corporal y el somatotipo de dichos triatletas. Metodología: estudio observacional y descriptivo de las características antropométricas, la composición corporal y el somatotipo de 39 triatletas varones universitarios entre 24 ± 4,5 años, participantes en el campeonato de España universitario de triatlón, modalidad sprint (Alicante 2010), procedentes de diferentes universidades españolas. Según la técnicas de medición antropométrica adoptadas por la International Society for the Advancement of Kinanthropometry (ISAK) y el Grupo Español de Cineantropometría (GREC) por un evaluador acreditado ISAK de nivel II. Resultados: nos encontramos con deportistas de talla baja, en los que destacan valores inferiores a lo normal en los pliegues cutáneos subescapular, supraespinal, tricipital y bicipital, un porcentaje de masa muscular (45,27 ± 3,29%), de masa grasa (10,22 ± 2,92%) y de masa ósea (16,65 ± 1,34%) y un somatotipo en el que predomina la mesomorfia. Discusión: los triatletas y corredores presentan más baja talla que los ciclistas y nadadores. Los triatletas y ciclistas muestran un peso similar, siendo menor que el de los nadadores de fondo y mayor que el de los corredores de 10 km. Los pliegues cutáneos cresta ilíaca, abdominal y muslo frontal de los ciclistas son inferiores al de los triatletas. El porcentaje de masa grasa de triatletas corredores y nadadores son similares; sin embargo, el de la masa muscular de los triatletas suele ser inferior al de los ciclistas pero similar a las demás modalidades. El somatotipo del triatleta se asemeja al del ciclista (mesomorfo). El del corredor es mesomorfo-ectomorfo y el del nadador puede oscilar de mesomorfo a ectomorfo.Introduction: the triathlon is an endurance sport and individual that consists of three different disciplines: swimming, cycling and running. The aim of the study was to describe and analyze the anthropometric characteristics, body composition and somatotype in male college triathletes. Methodology: observational and descriptive study of anthropometric characteristics, body composition and somatotype of 39 male college athletes from 24 ± 4,5 years, participants in the championship of Spain university triathlon sprint mode (Alicante 2010), from different universities Spanish. According to anthropometric measurement techniques adopted by the International Society for the Advancement of Kinanthropometry (ISAK) and the Spanish Group Cineantropometría (GREC) by an accredited assessor ISAK Level II. Results: we find athletes of stunting, where you destacanvalores below normal in the subscapularis, supraspinatus, triceps and biceps skinfold, percentage of muscle mass (45.27 ± 3.29%) and fat mass (10.22 ± 2.92%) and bone (16.65 ± 1.34%) and where mesomorphy somatotipo predominates. Discussion: the triathletes and runners have lower size that cyclists and swimmers. Triathletes and cyclists show a similar weight, less than swimmers line, and more than 10km runners. Iliac crest skinfold, abdominal and thigh front cyclists are less than triathletes. The percentage of fat mass of runners triathletes and swimmers are similar, however the muscle mass of athletes usually less than cyclists but similar to other forms. Somatotype resembles triathlete cyclist (mesomorph). The corridor is ectomorph and mesomorph-swimmer can range from a ectomorph mesomorph

Generación de recursos audiovisuales para la realización de medidas antropométricas en sujetos diagnosticados con obesidad

Objetivo: La valoración antropométrica es muy utilizada en el diagnóstico y seguimiento de las personas con obesidad, aunque la toma de algunas mediciones antropométricas presenta dificultades por el propio morfotipo de la persona y la inexistencia de normas estandarizadas. El objetivo del presente documento fue generar recursos audiovisuales sobre como realizar mediciones corporales en sujetos con obesidad para complementar el conocimiento de los profesionales de la salud sobre los índices de salud y mediciones corporales más adecuados para aplicar a sujetos con obesidad. Metodología: Estudio descriptivo sobre la generación de material audiovisual basado en mediciones posibles y relevantes para el estudio antropométrico en sujetos con obesidad. Se tomaron fotografías y grabaciones en vídeo de dichas mediciones aplicadas en un voluntario de cada sexo con obesidad. Resultados: El material audiovisual consta de nueve medidas antropométricas entre las que se encuentran cuatro pliegues cutáneos (tríceps, subescapular, submandibular y cresta iliaca), 4 perímetros (brazo relajado, cintura, umbilical y cadera) y un diámetro (antero-posterior del abdomen). Conclusión: Existe controversia acerca del protocolo de medición del perímetro de cintura, abdominal y diámetro sagital del abdomen, en personas con obesidad ya que los puntos anatómicos de referencia varían de unos estudios a otros, creando confusión. Por tanto, el material audiovisual creado es novedoso, útil para la enseñanza y el aprendizaje de las mediciones antropométricas y usable tanto en el ámbito académico como en la práctica clínica diaria.Aim: Anthropometric assessment is widely used in the diagnosis and follow-up of people with obesity, although taking some anthropometric measurements presents difficulties due to the person's own morphotype and the non-existence of standardised norms. The aim is to generate, evaluate and standardise audiovisual resources on body measurements in subjects with obesity to complement the knowledge of health professionals on the most appropriate health indices and body measurements to apply to subjects with obesity.Methods: Observational and cross-sectional study on the generation of audiovisual material based on possible and relevant measurements for the anthropometric and nutritional study in patients with obesity. Photographs and video recordings were taken of these measurements applied to a volunteer of each sex with the weight or percentage of fat mass typical of obesity. Results: The audiovisual material consists of 5 data sheets of the selected anthropometric measurements (relaxed and contracted arm girth, A-P abdominal depth, waist girth, umbilical girth, and hips girth). Conclusion: There is controversy about the protocol for measuring waist circumference, abdominal circumference and sagittal diameter of the abdomen in people with obesity, as the anatomical reference points vary from one study to another, creating confusion. Therefore, the audiovisual material created is innovative, useful for teaching and learning anthropometric measurements and usable both in the academic environment and in daily clinical practice

Ecoestabilidad femenina y malnutrición severa infantil: Evidencia a partir de intervenciones de ayuda humanitaria de Acción Contra el Hambre en países africanos, Asiáticos y Latinoamericanos

Introducción: Evidencias previas han reportado diferencias en la condición nutricional de niños y niñas pertenecientes a la misma comunidad y sometidos a idénticas condiciones de privación alimentaria. El objetivo del presente trabajo es analizar las diferencias sexuales en prevalencia de malnutrición severa en menores de 5 años, sometidos a situación de crisis alimentaria. Métodos: Se analizaron datos recogidos en intervenciones de ayuda humanitaria llevadas a cabo por Acción Contra el Hambre entre 2002 y 2010 en 24 países. Dichas intervenciones se efectuaron en poblaciones de Africa, Latinoamérica y Asia que se encontraban en situación de grave crisis alimentaria. La muestra se compone de un total de 367.258 menores (186,156 niños y 181,102 niñas) con edad (E) entre 6 y 59 meses. Se midió el peso (P) y la talla (T) siguiendo la metodología SMART y se estimó la prevalencia de severo bajo peso (P/E <-3DE), desnutrición aguda severa (P/T <-3DE) y desnutrición crónica severa (T/E <-3DE) de acuerdo a los estándares de la OMS. Resultados: Para el total de la muestra, la proporción de niños con severo bajo peso fue de 9,8% en comparación al 7,3% de niñas (p <0.001). La desnutrición aguda severa afectó al 3,9% de los niños frente al 2,5% de las niñas (p <0.001). Las diferencias también fueron notables en la des-nutrición crónica: el 19, 5% de los niños frente al 15% de las niñas (p<0,001) presentaron crecimiento retardado. Conclusiones: Los resultados avalan la idea de la deno-minada eco-estabilidad femenina, de acuerdo a la cual, las mujeres serian menos sensibles a los factores externos que modulan el desarrollo ontogénico, mientras los varones se ve-rían más negativamente afectados por las agresiones medio-ambientales

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1

12 p.-8 fig.Integrin LFA-1 is a receptor that is able to transmit multiple intracellular signals in leukocytes. Herein we show that LFA-1 induces a potent and transient increase in the activity of the small GTPase Rac-1 in T cells. Maximal Rac-1 activity peaked 10-15 min after LFA-1 stimulation and rapidly declined to basal levels at longer times. We have identified Vav, a guanine nucleotide exchange factor for Rac-1, and PI3K/Akt, as regulators of the activation and inactivation phases of the activity of Rac-1, respectively, in the context of LFA-1 signaling based on the following experimental evidence: (i) LFA-1 induced activation of Vav and PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1, (ii) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant-negative Vav mutant blocks LFA-1-mediated Rac activation, (iii) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity, and (iv) overexpression of a dominant-negative or a constitutively active Akt-1 induced or inhibited, respectively, Rac-1 activity. Finally, we show that T cells with a sustained Rac activity have impaired capacity to elongate onto ICAM-1. These results demonstrate that down-regulation of the activity of this GTPase is a requirement for the regulation of T cell morphology and motility and highlight the importance of temporal regulation of the signaling triggered from this integrin.This work was supported in part by Grants CICYT SAF 2001–2807 from Ministerio de Ciencia y Tecnología and FIS-01/1367 from Ministerio de Sanidad y Consumo (to C. C.), a fellowship from Comunidad de Madrid (to L. S.-M.), a Formación de Profesorado Universitario predoctoral fellowship from Ministerio de Educación, Cultura y Deporte (to N. S.-S.), and a postdoctoral fellowship from Ministerio de Educación, Cultura y Deporte (to M. D. G.-L.).Peer reviewe