PD-1依存的な免疫制御機構の抑制は、免疫関連副作用に類似する接触性皮膚炎の悪化を引き起こす

京都大学新制・課程博士博士(医学)甲第23105号医博第4732号新制||医||1050(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 竹内 理, 教授 上野 英樹, 教授 椛島 健治学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

The reactive and dissociative behavior of size-selected clusters and ion complexes in the gas phase

Molecular complexation properties of several types of size-selected ions are examined in the gas phase by mass spectrometric techniques. Transition metal oxide clusters of (MoO₃)[subscript n]⁻ where n = 2-12 and (WO₃)[subscript n]⁻ extending to n = 8 are generated by field and laser desorption, and electron capture in the negative ionization mode. The structures of these clusters are characterized by low energy collision induced dissociation (CID). The clusters dissociate by the neutral loss of metal trioxide units. Reactions of ligands such as ethylene oxide and cyclohexene sulfide are examined to distinguish the structural variations of the clusters. The systematic evaluation of the size effect in molecular recognition processes is examined by association reactions of crown ether macrocyclic hosts with alkali metal ions and primary amine substrates. Ion complexes of crown ethers with two different alkali metals are formed by liquid secondary ion mass spectrometry. These complexes produce crown ether/alkali metal adduct ions upon gas-phase isolation and high energy dissociation. The abundance ratios of product ions are correlated to the alkali metal ion selectivites of the crown ether. The selectivity of 18-crown-6 follows the order of Na⁺ ≥ K⁺ > Li⁺ > Rb⁺ > Cs⁺, and the concept of 'maximum contact point' (MCP) describes this order. In contrast, the high energy activation of alkali metal ion adducts of crown ethers results in homolytic cleavages of C-C or C-O bonds. The metastable ion dissociation of hydrogen bonded complexes of crown ethers with ammonium or methyl-ammonium shows a stability order of 21-crown-7 > 18-crown-6 > 15-crown-5. High energy CID of the ion complexes proceeds by cavity size dependent intramolecular ring opening reactions of the host. Complexes of crown ethers with methyl- and tosyl-hydrazinium ions dissociate by covalent bond cleavages of the N-N or N-S bonds of the guest substrates. Finally, reactions of perfluorinated cyclic or bicyclic ether anions with O₂ are examined as models of oxygen transport by perfluorinated compounds. These complexes show binding strengths that reflect both the topological and chemical nature of the hosts.Chemistr

A novel technique for load frequency control of multi-area power systems

In this paper, an adaptive type-2 fuzzy controller is proposed to control the load frequency of a two-area power system based on descending gradient training and error back-propagation. The dynamics of the system are completely uncertain. The multilayer perceptron (MLP) artificial neural network structure is used to extract Jacobian and estimate the system model, and then, the estimated model is applied to the controller, online. A proportional–derivative (PD) controller is added to the type-2 fuzzy controller, which increases the stability and robustness of the system against disturbances. The adaptation, being real-time and independency of the system parameters are new features of the proposed controller. Carrying out simulations on New England 39-bus power system, the performance of the proposed controller is compared with the conventional PI, PID and internal model control based on PID (IMC-PID) controllers. Simulation results indicate that our proposed controller method outperforms the conventional controllers in terms of transient response and stability

Pharyngeal Aspiration of Complete Upper Denture in 90-Year-Old Man; a Case Report

Foreign body aspiration is unusual in adults, except those who are debilitated or have neuropsychiatric disorders. It can be a life-threatening situation and it often requires a high index of suspicion, because the diagnosis can be obscure. Prompt diagnosis and intervention through foreign body retrieval are critical to prevent significant morbidity and mortality. We present a case of denture aspiration by a debilitated 90 years old man. He had aspirated his complete upper denture to pharynx causing incomplete obstruction with pleasure whistling respiratory sound, dyspnea, dysphagia and dysphonia. He underwent successful retrieval of the dental plate manually by fingers with complete resolution of symptoms.

Confrontations in the historical part of Shahnameh with the approach of Louis Strauss

 The opposition of the opposites is also reflected in the myth of the nations and one of the main fields of the myth is the struggle of different forces. Myth is the mother of epic, and any nation that does not have a myth is also useless of epic, and the main background of the epic of any nation is its myth. So this fundamental concept has also found its way into the epic; But in the process of materialization of phenomena from myth to epic, mythical concepts are formed differently in the epic, and during this process, the confrontation of human beings or heroes with evil forces, the confrontation of two tribes and clans, The two heroes become one with each other. In general, it can be said that epic is the fruit of man's struggle with anything that is against his dreams and aspirations and in opposition to his will and action. Meanwhile, the contrast between the phenomena of nature such as night and day, darkness and light, drought and wet season, greenery and autumn and the like, had caused the human way of thinking and worldview based on the same contrast. And as a result, human mythology is full of these contradictions. Moreover, even in later periods, such a way of thinking has prevailed in the human mind and historical data have been analyzed and explained based on this approach. Another important factor in the existence of confrontation and contradiction in mythology is the existence of secondary ideas in these works; Because the important principle in the dual thought of the myths of ancient Iran is the conflict between the demonic forces and the Ahura forces, which considers the whole world as the place of these two opposing forces; Influenced by this idea, we always encounter confrontation and war between groups in Shahnameh. One of the important sources and a collection of myths and legends and even valuable historical contents of this region is Ferdowsi's Shahnameh, which is divided into three parts: mythology (from the time of Kiomars to the kingdom of Fereydoun), heroism (from the rise of the blacksmith to The assassination of Rostam and the reign of Bahman, son of Esfandiar) and historical (from the reign of Bahman and the birth of Alexander to the opening of Iran to the Arabs) has been divided

Confrontations in the historical part of Shahnameh with the approach of Louis Strauss

 The opposition of the opposites is also reflected in the myth of the nations and one of the main fields of the myth is the struggle of different forces. Myth is the mother of epic, and any nation that does not have a myth is also useless of epic, and the main background of the epic of any nation is its myth. So this fundamental concept has also found its way into the epic; But in the process of materialization of phenomena from myth to epic, mythical concepts are formed differently in the epic, and during this process, the confrontation of human beings or heroes with evil forces, the confrontation of two tribes and clans, The two heroes become one with each other. In general, it can be said that epic is the fruit of man's struggle with anything that is against his dreams and aspirations and in opposition to his will and action. Meanwhile, the contrast between the phenomena of nature such as night and day, darkness and light, drought and wet season, greenery and autumn and the like, had caused the human way of thinking and worldview based on the same contrast. And as a result, human mythology is full of these contradictions. Moreover, even in later periods, such a way of thinking has prevailed in the human mind and historical data have been analyzed and explained based on this approach. Another important factor in the existence of confrontation and contradiction in mythology is the existence of secondary ideas in these works; Because the important principle in the dual thought of the myths of ancient Iran is the conflict between the demonic forces and the Ahura forces, which considers the whole world as the place of these two opposing forces; Influenced by this idea, we always encounter confrontation and war between groups in Shahnameh. One of the important sources and a collection of myths and legends and even valuable historical contents of this region is Ferdowsi's Shahnameh, which is divided into three parts: mythology (from the time of Kiomars to the kingdom of Fereydoun), heroism (from the rise of the blacksmith to The assassination of Rostam and the reign of Bahman, son of Esfandiar) and historical (from the reign of Bahman and the birth of Alexander to the opening of Iran to the Arabs) has been divided

Confrontations in the historical part of Shahnameh with the approach of Louis Strauss

 The opposition of the opposites is also reflected in the myth of the nations and one of the main fields of the myth is the struggle of different forces. Myth is the mother of epic, and any nation that does not have a myth is also useless of epic, and the main background of the epic of any nation is its myth. So this fundamental concept has also found its way into the epic; But in the process of materialization of phenomena from myth to epic, mythical concepts are formed differently in the epic, and during this process, the confrontation of human beings or heroes with evil forces, the confrontation of two tribes and clans, The two heroes become one with each other. In general, it can be said that epic is the fruit of man's struggle with anything that is against his dreams and aspirations and in opposition to his will and action. Meanwhile, the contrast between the phenomena of nature such as night and day, darkness and light, drought and wet season, greenery and autumn and the like, had caused the human way of thinking and worldview based on the same contrast. And as a result, human mythology is full of these contradictions. Moreover, even in later periods, such a way of thinking has prevailed in the human mind and historical data have been analyzed and explained based on this approach. Another important factor in the existence of confrontation and contradiction in mythology is the existence of secondary ideas in these works; Because the important principle in the dual thought of the myths of ancient Iran is the conflict between the demonic forces and the Ahura forces, which considers the whole world as the place of these two opposing forces; Influenced by this idea, we always encounter confrontation and war between groups in Shahnameh. One of the important sources and a collection of myths and legends and even valuable historical contents of this region is Ferdowsi's Shahnameh, which is divided into three parts: mythology (from the time of Kiomars to the kingdom of Fereydoun), heroism (from the rise of the blacksmith to The assassination of Rostam and the reign of Bahman, son of Esfandiar) and historical (from the reign of Bahman and the birth of Alexander to the opening of Iran to the Arabs) has been divided

Confrontations in the historical part of Shahnameh with the approach of Louis Strauss

 The opposition of the opposites is also reflected in the myth of the nations and one of the main fields of the myth is the struggle of different forces. Myth is the mother of epic, and any nation that does not have a myth is also useless of epic, and the main background of the epic of any nation is its myth. So this fundamental concept has also found its way into the epic; But in the process of materialization of phenomena from myth to epic, mythical concepts are formed differently in the epic, and during this process, the confrontation of human beings or heroes with evil forces, the confrontation of two tribes and clans, The two heroes become one with each other. In general, it can be said that epic is the fruit of man's struggle with anything that is against his dreams and aspirations and in opposition to his will and action. Meanwhile, the contrast between the phenomena of nature such as night and day, darkness and light, drought and wet season, greenery and autumn and the like, had caused the human way of thinking and worldview based on the same contrast. And as a result, human mythology is full of these contradictions. Moreover, even in later periods, such a way of thinking has prevailed in the human mind and historical data have been analyzed and explained based on this approach. Another important factor in the existence of confrontation and contradiction in mythology is the existence of secondary ideas in these works; Because the important principle in the dual thought of the myths of ancient Iran is the conflict between the demonic forces and the Ahura forces, which considers the whole world as the place of these two opposing forces; Influenced by this idea, we always encounter confrontation and war between groups in Shahnameh. One of the important sources and a collection of myths and legends and even valuable historical contents of this region is Ferdowsi's Shahnameh, which is divided into three parts: mythology (from the time of Kiomars to the kingdom of Fereydoun), heroism (from the rise of the blacksmith to The assassination of Rostam and the reign of Bahman, son of Esfandiar) and historical (from the reign of Bahman and the birth of Alexander to the opening of Iran to the Arabs) has been divided

Confrontations in the historical part of Shahnameh with the approach of Louis Strauss

 The opposition of the opposites is also reflected in the myth of the nations and one of the main fields of the myth is the struggle of different forces. Myth is the mother of epic, and any nation that does not have a myth is also useless of epic, and the main background of the epic of any nation is its myth. So this fundamental concept has also found its way into the epic; But in the process of materialization of phenomena from myth to epic, mythical concepts are formed differently in the epic, and during this process, the confrontation of human beings or heroes with evil forces, the confrontation of two tribes and clans, The two heroes become one with each other. In general, it can be said that epic is the fruit of man's struggle with anything that is against his dreams and aspirations and in opposition to his will and action. Meanwhile, the contrast between the phenomena of nature such as night and day, darkness and light, drought and wet season, greenery and autumn and the like, had caused the human way of thinking and worldview based on the same contrast. And as a result, human mythology is full of these contradictions. Moreover, even in later periods, such a way of thinking has prevailed in the human mind and historical data have been analyzed and explained based on this approach. Another important factor in the existence of confrontation and contradiction in mythology is the existence of secondary ideas in these works; Because the important principle in the dual thought of the myths of ancient Iran is the conflict between the demonic forces and the Ahura forces, which considers the whole world as the place of these two opposing forces; Influenced by this idea, we always encounter confrontation and war between groups in Shahnameh. One of the important sources and a collection of myths and legends and even valuable historical contents of this region is Ferdowsi's Shahnameh, which is divided into three parts: mythology (from the time of Kiomars to the kingdom of Fereydoun), heroism (from the rise of the blacksmith to The assassination of Rostam and the reign of Bahman, son of Esfandiar) and historical (from the reign of Bahman and the birth of Alexander to the opening of Iran to the Arabs) has been divided