Doctor of Philosophy

dissertationIn this dissertation, I investigate the missionary activities of the American Board of Commissioners for Foreign Missions (ABCFM) in the Ottoman Empire. I am particularly interested in exploring the impact of the activities of one of the most important missionaries, Elias Riggs, on the minorities in the Ottoman Empire throughout the nineteenth century. By analyzing the significance of his missionary work and the fruits of his intellectual and linguistic ability, we can better understand the efforts of the ABCFM missionaries to seek converts to the Protestant faith in the Ottoman Empire. I focus mainly on the period that began with Riggs' sailing from Boston to Athens in 1832 as a missionary of the ABCFM until his death in Istanbul on January 17, 1901. Elias Riggs was one of the most influential missionaries in the Ottoman Empire throughout the nineteenth century, and his life was associated with a period of significant change in the Ottoman Empire and the modern history of missionaries in the Middle East. He was instrumental in the ABCFM's decision to develop a Protestant publishing enterprise for the peoples in the region. In addition to his editorship of religious periodicals, he published a variety of books for the mission. He was a member of the translation committee for the Turkish Bible and he worked several years on translating the Bible into Armenian and Bulgarian. He had an exceptionally long career and worked in many parts of the region

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

<p>Abstract</p> <p>Background</p> <p>Zofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.</p> <p>Methods</p> <p>Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.</p> <p>Results</p> <p>The Sciatic functional Index (SFI) in group Z on 14^thday is different significantly from group S and group C (p = 0.037). But on 42^ndday there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42^ndday there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.</p> <p>Conclusion</p> <p>Our results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.</p

Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats

Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor −1 alpha (HIF-1-α) and receptor activator of NF-kB ligand (RANKL)-positive cells on histopathological and immunohistochemical changes in a rat periodontitis model. Methodology: Thirty male Wistar rats were divided into three groups: 1) Group C (control group); 2) Group SO (systemic ozone group) and 3) Group TO (topical ozone group). Experimental periodontitis was induced with a 3/0 silk suture placed at the mandibular left first molars of rats, and the suture was removed 14 days later. Ozone gas was injected intraperitoneally (0.7 mg/kg) in SO group. Topical ozone application protocol was performed using an ozone generator at 80% concentration (4th grade) 90- degree probe for the duration of 30 s. Both ozone applications were carried out for two weeks at intervals of two days. Histomorphometric and immunohistochemical analysis were performed. Results:ABL was significantly lower in Group SO compared to Group C (p: 0.0052). HIF-1α- positive cells were significantly lower in Group TO than in Group C (p: 0.0043). RANKL-positive cells were significantly lower in Group SO and in Group TO compared to the control group (p: 0.0033, p: 0.0075, respectively). Conclusion: Both ozone applications decreased RANKL-positive cell counts, TO application decreased HIF-1-α positive cells counts, and SO application was found to be more effective in reducing ABL compared to control group

Vocational School of Health 32260

Abstract Objective: The purpose of this study was to investigate growth patterns in human hands, digits and digit ratio (2D : 4D) during the fetal period. Methods: The study is carried out on 161 human fetuses (83 males, 78 females) free from external pathology or malformation with ages ranging between 9 and 40 weeks of gestation. Following general external measurements, length and width of the hand, digit lengths separate for each hand was measured, hand index and the ratio of the lengths of the 2nd finger to the 4th finger (2D : 4D index) was computed. Results: Means and standard deviations of the parameters with respect to gestational weeks, months and trimesters were calculated. There was a significant correlation between all parameters and gestational age ( p b 0.001). No significant differences were observed between sexes or sides for any of the parameters ( p N 0.05). 2D : 4D ratio was significantly higher in females compared to males ( p b 0.05) and mean 2D : 4D did not change with gestational age. Conclusion: Detailed information of hand and digit parameters related to the fetal period will reveal the extent of biological variations of hand and digit parameters to be used in future studies. We hope that data acquired in this study will facilitate other studies on hand and digit anomalies, pathologies and variations as well as diagnoses and treatments of such conditions conducted in obstetrics, perinatology, forensic medicine and fetal pathology departments

Changes That Should Remain in Higher Education Post COVID-19: A Mixed-Methods Analysis of the Experiences at Three Universities

Objectives: The goal of the present study is to describe how the transition to remote emergency delivery was addressed in three universities during the COVID-19 pandemic, to determine the satisfaction levels of their students and faculty with this new teaching-learning experience, and to gather their opinions about the future of higher education. Method: The study uses a mixed-methods approach, including faculty and student surveys and focus groups Results: The study shows high satisfaction with the emergency remote delivery and clearly reflects the relevance of enhancing the digital components of future learning experiences in higher education and a unanimous preference for hybrid education. Participants provide recommendations to institutions regarding what students and faculty would like to keep for a more effective learning experience when the new normal comes. Conclusions: COVID-19 has had terrible consequences; however, the pandemic has brought along some positive effects and improvement opportunities in higher education, and, if the results of the present study are any indication, the future of face-to-face higher education should be hybrid. Implication for Theory and/or Practice: The study results can provide recommendations and inform decision-making by institutional leaders and policy makers regarding the necessary enhancement of the digital component of the teaching and learning process in higher education

Hybrid deep feature generation for appropriate face mask use detection

Mask usage is one of the most important precautions to limit the spread of COVID-19. Therefore, hygiene rules enforce the correct use of face coverings. Automated mask usage classification might be used to improve compliance monitoring. This study deals with the problem of inappropriate mask use. To address that problem, 2075 face mask usage images were collected. The individual images were labeled as either mask, no masked, or improper mask. Based on these labels, the following three cases were created: Case 1: mask versus no mask versus improper mask, Case 2: mask versus no mask + improper mask, and Case 3: mask versus no mask. This data was used to train and test a hybrid deep feature-based masked face classification model. The presented method comprises of three primary stages: (i) pre-trained ResNet101 and DenseNet201 were used as feature generators; each of these generators extracted 1000 features from an image; (ii) the most discriminative features were selected using an improved RelieF selector; and (iii) the chosen features were used to train and test a support vector machine classifier. That resulting model attained 95.95%, 97.49%, and 100.0% classification accuracy rates on Case 1, Case 2, and Case 3, respectively. Having achieved these high accuracy values indicates that the proposed model is fit for a practical trial to detect appropriate face mask use in real time

The Evaluation of Contralateral Breast Lesions in Breast Cancer Patients Using Reduction Mammoplasty

Purpose: This study evaluated the importance of routine pathological examination of contralateral breast specimens in breast cancer patients using reduction mammoplasty. Methods: The weight of breast tissue resected from the contralateral breast in 71 patients and the number of slices used for pathological evaluation were recorded. Breast lesions found in the contralateral breast and accompanying lesions with tumors were examined. Results: High risk proliferative lesions were reported in the contralateral breast of eight (11.2%) patients, and low-risk lesions were detected in 18 (25%). While the mean age of the patients with high-risk lesions was 45.6, it was 52.8 for the other patients (p = 0.036). Conclusion: Bilateral reduction mammoplasty may be beneficial to delineate some pathologies in contralateral breasts even in those patients with normal clinical and radiological findings. The incidental discovery of these pathologies is much more likely in young breast cancer patients

Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever - a randomized controlled noninferiority trial

Background: In this study, we examined the efficacy and safety of a once-daily dosage schema of colchicine compared with a twice-daily dosage schema in pediatric patients with familial Mediterranean fever (FMF). Methods: In this 24-week, multicenter, randomized controlled noninferiority trial, pediatric patients newly diagnosed with FMF carrying a homozygous or compound heterozygous mutation and not receiving any treatment were included. Patients were randomly assigned using a block randomization method to receive treatment with a once- or twice-daily dosage. Clinical and laboratory characteristics and medication side effects were recorded and compared between groups. The study was carried out in compliance with Good Clinical Practice and the Consolidated Standards for Reporting of Trials (CONSORT) statement. Results: A total of 92 patients were selected, and 79 patients completed the study. There were 42 patients in the once-daily dosage group and 37 in the twice-daily dosage group. The results indicated that the once-daily dosage was not inferior to the twice-daily dosage regarding decrease in attack frequency and duration as well as improvement in clinical findings and Mor severity scores. Alterations in laboratory findings indicating inflammation, such as erythrocyte sedimentation rate, C-reactive protein, and serum amyloid A, were similar in both groups. The rates of drug side effects were similar between the once- and twice-daily dosage groups, implying comparable safety of colchicine, with the exception of diarrhea, which was slightly higher in the once-daily dosage group. Conclusions: Using colchicine with either a once- or twice-daily dosage provides similar clinical and laboratory improvements. Considering both efficacy and safety, colchicine can be prescribed with a once-daily dosage. Trial Registration ID: ClinicalTrials.gov identifier NCT02602028. Registered 5 November 2015