Current trends in internet marketing

In article the task to consider tools which are used by tourist operators to promote the tourist product on a social networking. The social network promptly develops and it is very important to be able to use competently them to reach positive result.В статье ставится задача рассмотреть инструменты, которые используют туристические операторы для продвижения своего туристского продукта в социальной сети. Социальная сеть стремительно развивается и очень важно уметь их грамотно использовать, чтобы достичь положительного результата

Hidden potential in predicting wintertime temperature anomalies in the Northern Hemisphere

Variability of the North Atlantic Oscillation (NAO) drives wintertime temperature anomalies in the Northern Hemisphere. Dynamical seasonal prediction systems can skilfully predict the winter NAO. However, prediction of the NAO-dependent air temperature anomalies remains elusive, partially due to the low variability of predicted NAO. Here, we demonstrate a hidden potential of a multi-model ensemble of operational seasonal prediction systems for predicting wintertime temperature by increasing the variability of predicted NAO. We identify and subsample those ensemble members which are close to NAO index statistically estimated from initial autumn conditions. In our novel multi-model approach, the correlation prediction skill for wintertime Central Europe temperature is improved from 0.25 to 0.66, accompanied by an increased winter NAO prediction skill of 0.9. Thereby, temperature anomalies can be skilfully predicted for the upcoming winter over a large part of the Northern Hemisphere through increased variability and skill of predicted NAO

Conformational transitions of heteropolymers in dilute solutions

In this paper we extend the Gaussian self-consistent method to permit study of the equilibrium and kinetics of conformational transitions for heteropolymers with any given primary sequence. The kinetic equations earlier derived by us are transformed to a form containing only the mean squared distances between pairs of monomers. These equations are further expressed in terms of instantaneous gradients of the variational free energy. The method allowed us to study exhaustively the stability and conformational structure of some periodic and random aperiodic sequences. A typical phase diagram of a fairly long amphiphilic heteropolymer chain is found to contain phases of the extended coil, the homogeneous globule, the micro-phase separated globule, and a large number of frustrated states, which result in conformational phases of the random coil and the frozen globule. We have also found that for a certain class of sequences the frustrated phases are suppressed. The kinetics of folding from the extended coil to the globule proceeds through non-equilibrium states possessing locally compacted, but partially misfolded and frustrated, structure. This results in a rather complicated multistep kinetic process typical of glassy systems.Comment: 15 pages, RevTeX, 20 ps figures, accepted for publication in Phys. Rev.

Phase diagram of aggregation of oppositely charged colloids in salty water

Aggregation of two oppositely charged colloids in salty water is studied. We focus on the role of Coulomb interaction in strongly asymmetric systems in which the charge and size of one colloid is much larger than the other one. In the solution, each large colloid (macroion) attracts certain number of oppositely charged small colloids ($Z$-ion) to form a complex. If the concentration ratio of the two colloids is such that complexes are not strongly charged, they condense in a macroscopic aggregate. As a result, the phase diagram in a plane of concentrations of two colloids consists of an aggregation domain sandwiched between two domains of stable solutions of complexes. The aggregation domain has a central part of total aggregation and two wings corresponding to partial aggregation. A quantitative theory of the phase diagram in the presence of monovalent salt is developed. It is shown that as the Debye-H\"{u}ckel screening radius $r_s$ decreases, the aggregation domain grows, but the relative size of the partial aggregation domains becomes much smaller. As an important application of the theory, we consider solutions of long double-helix DNA with strongly charged positive spheres (artificial chromatin). We also consider implications of our theory for in vitro experiments with the natural chromatin. Finally, the effect of different shapes of macroions on the phase diagram is discussed.Comment: 10 pages, 9 figures. The text is rewritten, but results are not change

Localization transition of random copolymers at interfaces

We consider adsorption of random copolymer chains onto an interface within the model of Garel et al. Europhysics Letters 8, 9 (1989). By using the replica method the adsorption of the copolymer at the interface is mapped onto the problem of finding the ground state of a quantum mechanical Hamiltonian. To study this ground state we introduce a novel variational principle for the Green's function, which generalizes the well-known Rayleigh-Ritz method of Quantum Mechanics to nonstationary states. Minimization with an appropriate trial Green's function enables us to find the phase diagram for the localization-delocalization transition for an ideal random copolymer at the interface.Comment: 5 page

Reversible stretching of homopolymers and random heteropolymers

We have analyzed the equilibrium response of chain molecules to stretching. For a homogeneous sequence of monomers, the induced transition from compact globule to extended coil below the $\theta$-temperature is predicted to be sharp. For random sequences, however, the transition may be smoothed by a prevalence of necklace-like structures, in which globular regions and coil regions coexist in a single chain. As we show in the context of a random copolymer, preferential solvation of one monomer type lends stability to such structures. The range of stretching forces over which necklaces are stable is sensitive to chain length as well as sequence statistics.Comment: 14 pages, 4 figure

First example of organonickel complex bearing three cyclic substituents in the σ-bonded aromatic ring: Bromo[(2,2' -bipyridine)-2,4,6-tricyclohexylphenylnickel]

© 2016 Mendeleev Communications. Published by ELSEVIER B.V.The electrochemical reduction of [NiBr2(bpy)] (bpy is 2,2'-bipyridine) complex in the presence of 2,4,6-tricyclohexylphenylbromide (TchpBr) in undivided electrochemical cell supplied with a sacrificial nickel anode results in the one-pot formation of an organonickel complex [NiBr(Tchp)(bpy)] bearing three cyclic substituents in the s-bonded aromatic ring. The synthesized complex was characterized by various methods including single crystal X-ray analysis

Network development in biological gels: role in lymphatic vessel development

In this paper, we present a model that explains the prepatterning of lymphatic vessel morphology in collagen gels. This model is derived using the theory of two phase rubber material due to Flory and coworkers and it consists of two coupled fourth order partial differential equations describing the evolution of the collagen volume fraction, and the evolution of the proton concentration in a collagen implant; as described in experiments of Boardman and Swartz (Circ. Res. 92, 801–808, 2003). Using linear stability analysis, we find that above a critical level of proton concentration, spatial patterns form due to small perturbations in the initially uniform steady state. Using a long wavelength reduction, we can reduce the two coupled partial differential equations to one fourth order equation that is very similar to the Cahn–Hilliard equation; however, it has more complex nonlinearities and degeneracies. We present the results of numerical simulations and discuss the biological implications of our model