Characterization of a synthetic peroxodiiron(III) protein model complex by nuclear resonance vibrational spectroscopy

The vibrational spectrum of an η[superscript 1],η[superscript 1]-1,2-peroxodiiron(III) complex was measured by nuclear resonance vibrational spectroscopy and fit using an empirical force field analysis. Isotopic 18O2 labelling studies revealed a feature involving motion of the {Fe2(O2)}[superscript 4+] core that was not previously observed by resonance Raman spectroscopy.National Institute of General Medical Sciences (U.S.) (GM-032134

Gauge Invariant Higgs mass bounds from the Physical Effective Potential

We study a simplified version of the Standard Electroweak Model and introduce the concept of the physical gauge invariant effective potential in terms of matrix elements of the Hamiltonian in physical states. This procedure allows an unambiguous identification of the symmetry breaking order parameter and the resulting effective potential as the energy in a constrained state. We explicitly compute the physical effective potential at one loop order and improve it using the RG. This construction allows us to extract a reliable, gauge invariant bound on the Higgs mass by unambiguously obtaining the scale at which new physics should emerge to preclude vacuum instability. Comparison is made with popular gauge fixing procedures and an ``error'' estimate is provided between the Landau gauge fixed and the gauge invariant results.Comment: 23 pages, 2 figures, REVTE

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 × 10(-8), in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanisms

Discovery and Follow-up of ASASSN-19dj: An X-ray and UV Luminous TDE in an Extreme Post-Starburst Galaxy

We present observations of ASASSN-19dj, a nearby tidal disruption event (TDE) discovered in the post-starburst galaxy KUG 0810+227 by the All-Sky Automated Survey for Supernovae (ASAS-SN) at a distance of d $\simeq$ 98 Mpc. We observed ASASSN-19dj from $-$21 to 392 days relative to peak UV/optical emission using high-cadence, multi-wavelength spectroscopy and photometry. From the ASAS-SN $g$-band data, we determine that the TDE began to brighten on 2019 February 6.8 and for the first 25 days the rise was consistent with a flux $\propto$ $t^2$ power-law. ASASSN-19dj peaked in the UV/optical on 2019 March 6.5 (MJD = 58548.5) at a bolometric luminosity of $L = (6.2 \pm 0.2) \times 10^{44} \text{ erg s}^{-1}$. Initially remaining roughly constant in X-rays and slowly fading in the UV/optical, the X-ray flux increased by over an order of magnitude $\sim$225 days after peak, resulting from the expansion of the X-ray emitting surface. The late-time X-ray emission is well-fit by a blackbody with an effective radius of $\sim 1 \times 10^{12} \text{ cm}$ and a temperature of $\sim 6 \times 10^{5} \text{ K}$. Analysis of Catalina Real-Time Transient Survey images reveals a nuclear outburst roughly 14.5 years earlier with a smooth decline and a luminosity of $L_V$ $\geq$ $1.4 \times 10^{43}$ erg s$^{-1}$, although the nature of the flare is unknown. ASASSN-19dj occurred in the most extreme post-starburst galaxy yet to host a TDE, with Lick H$\delta_{A}$ = $7.67 \pm 0.17$ \AA.Comment: 25 pages, 14 figures. Will be submitted to MNRAS. For a short video description please see https://youtu.be/WjTZwO7vcF

Micronutrient Deficits Are Still Public Health Issues among Women and Young Children in Vietnam

Background: The 2000 Vietnamese National Nutrition Survey showed that the population’s dietary intake had improved since 1987. However, inequalities were found in food consumption between socioeconomic groups. As no national data exist on the prevalence of micronutrient deficiencies, a survey was conducted in 2010 to assess the micronutrient status of randomly selected 1526 women of reproductive age and 586 children aged 6–75 mo. Principal Findings: In women, according to international thresholds, prevalence of zinc deficiency (ZnD, 67.262.6%) and vitamin B12 deficiency (11.761.7%) represented public health problems, whereas prevalence of anemia (11.661.0%) and iron deficiency (ID, 13.761.1%) were considered low, and folate (,3%) and vitamin A (VAD,,2%) deficiencies were considered negligible. However, many women had marginal folate (25.1%) and vitamin A status (13.6%). Moreover, overweight (BMI$23 kg/m 2 for Asian population) or underweight occurred in 20 % of women respectively highlighting the double burden of malnutrition. In children, a similar pattern was observed for ZnD (51.963.5%), anemia (9.161.4%) and ID (12.961.5%) whereas prevalence of marginal vitamin A status was also high (47.362.2%). There was a significant effect of age on anemia and ID prevalence, with the youngest age group (6–17 mo) having the highest risk for anemia, ID, ZnD and marginal vitamin A status as compared to other groups. Moreover, the poorest groups of population had a higher risk for zinc, anemia and ID