ВИКОРИСТАННЯ МЕТОДИК СИМУЛЯЦІЙНОГО НАВЧАННЯ У ПІДВИЩЕННІ ПРОФЕСІЙНОЇ КОМПЕТЕНЦІЇ ЛІКАРІВ ТА ПАРАМЕДИКІВ НА КАФЕДРАХ ДЗ “ЗМАПО МОЗ УКРАЇНИ”

The modeling techniques, which implemented in the postgraduate education of doctors, and evaluating of competency by Bloome classification were analyzed in this article. Conclusions about the role of use of simulation methods as the main part of relationship of the educational process and the real clinical practice in post-graduate education of physicians were made.У статті представлено аналіз та роль симуляційних методик, впроваджених на кафедрах ДЗ “ЗМАПО МОЗ України”, та оцінку отриманих лікарями компетенцій за класифікацією Блума. Показано, що використання симуляційних методик дозволяє відтворити тісний зв’язок навчального процесу з практикою і максимальну реалістичність клінічної ситуації у післядипломній освіті лікарів

СУЧАСНІ ФОРМИ ОРГАНІЗАЦІЇ ПІСЛЯДИПЛОМНОГО НАВЧАННЯ ТА БЕЗПЕРЕРВНОГО ПРОФЕСІЙНОГО РОЗВИТКУ МЕДИЧНИХ ПРАЦІВНИКІВ

The aim of the work – to highlight some aspects of introduction of modern educational technologies and new forms of organization of training in postgraduate education and continuous professional development of doctors are described in this article. The main body. It is stated, that pedagogical innovations are aimed at the optimizing of the teaching on the principle of the correspondence of the content of the training to the actual conditions of the doctor’s work. The experience of introducing of intermittent courses of thematic improvement and organization of intensive training of doctors on topical problems of modern medicine is presented.Conclusion. The necessity of using various educational models, which based on the achievements of medical science and practice in accordance with the needs of the medical sector and each target group of subjects of training.Мета роботи – висвітлити деякі аспекти із запровадження сучасних освітніх технологій та новітніх форм організації навчання  у післядипломну підготовку і безперервний професійний розвиток лікарів.Основна частина. Наведено, що педагогічні інновації мають на меті  оптимізацію навчання за принципом відповідності змісту навчання реальним умовам роботи лікаря. Представлено досвід із запровадження переривчатих курсів тематичного удосконалення та організації інтенсивного навчання лікарів з актуальних проблем сучасної медицини.Висновок. Необхідним є застосування різноманітних навчальних моделей на підставі досягнень медичної науки і практики відповідно до потреб медичної галузі та  кожної цільової групи суб’єктів навчання

Peculiarities of students’ studying in faculty of dental unit on the module “Local anesthesia in dentistry”

У статті наведено досвід викладання модуля “Місцеве знеболення в стоматології” на кафедрі хірургічної стоматології Одеського національного медичного університету з використанням тренажера для проведення периферичних і центральних провідникових анестезій.The article presents the experience of teaching module “Local anesthesia in dentistry” at the Department of Operative Dentistry of Odessa National Medical University, using the simulator for the peripheral and central anesthesia

Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration

Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells where they can modulate metabolic inflammation. Here, we find that 3-hydroxydecanoate is enriched in the circulation of obese individuals with type 2 diabetes (T2D) compared with nondiabetic controls. Administration of 3-hydroxydecanoate to mice promotes immune cell recruitment to adipose tissue, which was associated with adipose inflammation and increased fasting insulin levels. Furthermore, we demonstrate that 3-hydroxydecanoate stimulates migration of primary human and mouse neutrophils, but not monocytes, through GPR84 and Gαi signaling in vitro. Our findings indicate that 3-hydroxydecanoate is a T2D-associated metabolite that increases inflammatory responses and may contribute to the chronic inflammation observed in diabetes

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting in continuous Gs-coupling and cAMP production without an exogenous ligand. Thus, transcriptional induction of Gpr3 represents the regulatory parallel to ligand-binding of conventional GPCRs. Consequently, increasing Gpr3 expression in thermogenic adipocytes is alone sufficient to drive energy expenditure and counteract metabolic disease in mice. Gpr3 transcription is cold-stimulated by a lipolytic signal, and dietary fat potentiates GPR3-dependent thermogenesis to amplify the response to caloric excess. Moreover, we find GPR3 to be an essential, adrenergic-independent regulator of human brown adipocytes. Taken together, our findings reveal a noncanonical mechanism of GPCR control and thermogenic activation through the lipolysis-induced expression of constitutively active GPR3

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of beta-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting in continuous Gscoupling and cAMP production without an exogenous ligand. Thus, transcriptional induction of Gpr3 represents the regulatory parallel to ligand-binding of conventional GPCRs. Consequently, increasing Gpr3 expression in thermogenic adipocytes is alone sufficient to drive energy expenditure and counteract metabolic disease in mice. Gpr3 transcription is cold-stimulated by a lipolytic signal, and dietary fat potentiates GPR3-dependent thermogenesis to amplify the response to caloric excess. Moreover, we find GPR3 to be an essential, adrenergic-independent regulator of human brown adipocytes. Taken together, our findings reveal a noncanonical mechanism of GPCR control and thermogenic activation through the lipolysis-induced expression of constitutively active GPR3.Diabetes mellitus: pathophysiological changes and therap

Joining S100 proteins and migration:for better or for worse, in sickness and in health

The vast diversity of S100 proteins has demonstrated a multitude of biological correlations with cell growth, cell differentiation and cell survival in numerous physiological and pathological conditions in all cells of the body. This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and invasion, established in both culture and animal model systems and the possible mechanisms that have been proposed to be responsible. These mechanisms involve intracellular events and components of the cytoskeletal organisation (actin/myosin filaments, intermediate filaments and microtubules) as well as extracellular signalling at different cell surface receptors (RAGE and integrins). Finally, we shall attempt to demonstrate how aberrant expression of the S100 proteins may lead to pathological events and human disorders and furthermore provide a rationale to possibly explain why the expression of some of the S100 proteins (mainly S100A4 and S100P) has led to conflicting results on motility, depending on the cells used. © 2013 Springer Basel