Nitrogen modulation of legume root architecture signaling pathways involves phytohormones and small regulatory molecules

Nitrogen, particularly nitrate is an important yield determinant for crops. However, current agricultural practice with excessive fertilizer usage has detrimental effects on the environment. Therefore, legumes have been suggested as a sustainable alternative for replenishing soil nitrogen. Legumes can uniquely form nitrogen-fixing nodules through symbiotic interaction with specialized soil bacteria. Legumes possess a highly plastic root system which modulates its architecture according to the nitrogen availability in the soil. Understanding how legumes regulate root development in response to nitrogen availability is an important step to improving root architecture. The nitrogen-mediated root development pathway starts with sensing soil nitrogen level followed by subsequent signal transduction pathways involving phytohormones, microRNAs and regulatory peptides that collectively modulate the growth and shape of the root system. This review focuses on the current understanding of nitrogen-mediated legume root architecture including local and systemic regulations by different N-sources and the modulations by phytohormones and small regulatory molecules.Nadiatul A. Mohd-Radzman was supported by ANU International PhD Scholarship. This work was supported by an Australian Research Council grant to Michael A. Djordjevic and Nijat Imin (DP140103714)

Heavy Quark Radiative Energy Loss - Applications to RHIC

Heavy quark energy loss in a hot QCD plasma is computed taking into account the competing effects due to suppression of zeroth order gluon radiation bellow the plasma frequency and the enhancement of gluon radiation due to transition energy loss and medium induced Bremsstrahlung. Heavy quark medium induced radiative energy loss is derived to all orders in opacity, $(L/\lambda_g)^n$. Numerical evaluation of the energy loss suggest small suppression of high $p_\perp$ charm quarks, and therefore provide a possible explanation for the null effects observed by PHENIX in the prompt electron spectrum in $Au+Au$ as $\sqrt{s}=130$ and 200 AGeV.Comment: 4 pages, 4 figures, Contributed to 17th International Conference on Ultra Relativistic Nucleus-Nucleus Collisions (Quark Matter 2004), Oakland, California, 11-17 Jan 200

Constrained Dynamics of Tachyon Field in FRWL Spacetime

In this paper we continue study of tachyon scalar field described by a Dirac-Born-Infeld (DBI) type action with constraints in the cosmological context. The proposed extension of the system introducing an auxiliary field in the minisuperspace framework is discussed. A new equivalent set of constraints is constructed, satisfying the usual regularity conditions.Comment: 10 pages, to be published in the Special Issue of the Facta Universitatis Series: Physics, Chemistry and Technology devoted to the SEENET-MTP Balkan Workshop BSW2019 (3-14 June 2018, Nis, Serbia

Heavy-to-light ratios as a test of medium-induced energy loss at RHIC and the LHC

The ratio of nuclear modification factors of high-$p_T$ heavy-flavored mesons tolight-flavored hadrons (heavy-to-light ratio) is shown to be a sensitive tool to test medium-induced energy loss at RHIC and LHC energies. Heavy-to-light ratios of $D$ mesons at RHIC in the region $7<p_T<12$ GeV, and of $D$ and $B$ mesons at the LHC in the region $10<p_T<20$ GeV, are proposed for such a test. Finally, the different contributions to the nuclear modification factor for electrons at RHIC are analyzed. Preliminary PHENIX and STAR data are compatible with radiative energy loss provided the contribution of electrons from beauty decays is small compared to that from charm.Comment: 5 pages, latex, 4 eps figs included using graphicx; to appear in the proceedings of 18th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions: Quark Matter 2005 (QM 2005), Budapest, Hungary, 4-9 Aug 200

Is there gold at the top of the beanstalk?

A report on the 3rd International Legume Genetics and Genomics Conference, Brisbane, Australia, 9-13 April 2006

MicroRNA-Regulated Signaling Pathways: Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and invasive type of pancreatic cancer (PCa) and is expected to be the second most common cause of cancer-associated deaths. The high mortality rate is due to the asymptomatic progression of the clinical features until the advanced stages of the disease and the limited effectiveness of the current therapeutics. Aberrant expression of several microRNAs (miRs/miRNAs) has been related to PDAC progression and thus they could be potential early diagnostic, prognostic, and/or therapeutic predictors for PDAC. miRs are small (18 to 24 nucleotides long) non-coding RNAs, which regulate the expression of key genes by targeting their 3′-untranslated mRNA region. Increased evidence has also suggested that the chemoresistance of PDAC cells is associated with metabolic alterations. Metabolic stress and the dysfunctionality of systems to compensate for the altered metabolic status of PDAC cells is the foundation for cellular damage. Current data have implicated multiple systems as hallmarks of PDAC development, such as glutamine redox imbalance, oxidative stress, and mitochondrial dysfunction. Hence, both the aberrant expression of miRs and dysregulation in metabolism can have unfavorable effects in several biological processes, such as apoptosis, cell proliferation, growth, survival, stress response, angiogenesis, chemoresistance, invasion, and migration. Therefore, due to these dismal statistics, it is crucial to develop beneficial therapeutic strategies based on an improved understanding of the biology of both miRs and metabolic mediators. This review focuses on miR-mediated pathways and therapeutic resistance mechanisms in PDAC and evaluates the impact of metabolic alterations in the progression of PDAC

Jet suppression of pions and single electrons at Au+Au collisions at RHIC

Jet suppression is considered to be a powerful tool to study the properties of a QCD medium created in ultra-relativistic heavy ion collisions. However, theoretical predictions obtained by using jet energy loss in static QCD medium show disagreement with experimental data, which is known as the heavy flavor puzzle at RHIC. We calculate the suppression patterns of pions and single electrons for Au+Au collisions at RHIC by including the energy loss in a finite size dynamical QCD medium, with finite magnetic mass effects taken into account. In contrast to the static case, we here report a good agreement with the experimental results, where this agreement is robust with respect to magnetic mass values. Therefore, the inclusion of dynamical QCD medium effects provides a reasonable explanation of the heavy flavor puzzle at RHIC.Comment: 4 pages, 2 figure

Architectural phenotypes in the transparent testa mutants of Arabidopsis thaliana

Flavonoids are low molecular weight secondary plant metabolites with a myriad of functions. As flavonoids affect auxin transport (an important growth-controlling hormone) and are biologically active in eukaryotes, flavonoid mutants were expected to have undescribed architectural phenotypes. The Arabidopsis thaliana transparent testa (tt) mutants are compromised in the enzymatic steps or transcriptional regulators affecting flavonoid synthesis. tt mutant seedlings were grown on hard-slanted agar (a stress condition), under varying light conditions, and in soil to examine the resulting growth patterns. These tt mutants revealed a wide variety of architectural phenotypes in root and aerial tissues. Mutants with increased inflorescences, siliques, and lateral root density or reduced stature are traits that could affect plant yield or performance under certain environmental conditions. The regulatory genes affected in architectural traits may provide useful molecular targets for examination in other plants