What is the Value of Home? NOT FOR SALE - West End Interventions

Many Australians today are image consumers. We fail to question the importance of lifestyle imagery created and promoted by Real Estate Agencies whom have no actual part in the physical creation of house, or indeed the intimate making of "home" through our experiences of place. Real Estate Markets dictate how, where, when and what we buy. Re-sale values, profit-making, and value-adding interfere with the crafting of a home over time as a tangible, individual, collaborative, and rich lived experience of dwelling. The "NOT FOR SALE" project is a response and critique of the dominance of real estate forces in West End within the context and unshakable presence of a booming inner-city property market. This proposal originated from an experimental dwelling in Avebury St., West End. This project has been fashioned over a period of several years primarily from recycled local materials, interconnected with the changing needs and spatial requirements of the occupants and project participants. The influence of property markets is of little concern in this home "making". The "NOT FOR SALE" project attempts to question and critique the purely financial value that we as a society place upon our homes. By appropriating and re-coding the Real Estate Signage typologies, we aim to provoke social commentary on the dominance of real estate forces in the West End suburb. There is a strong and rich tradition of anti-consumerist activist graffiti in West End. Activists re-code signs and property with political commentary and critique. The "NOT FOR SALE" project draws upon this tradition through our RRESign (Recodified Real Estate Signs): we aim to redress the dominant commercial forces associated with the single house/property. Collectively, at the scale of the street, these RRESigns will reflect a critique of street scale, amenity, and character. Finally, at the scale of the suburb, the network of RRESigns will reflect a critique of the idea of place making. Collectively, the aim of the "NOT FOR SALE" RRESign interventions is to highlight the idea of making and the material characteristics of dwelling that challenges the cultural value of commodified property, re-defining and prioritising the idea of "home". Conventional Real Estate signs use images and text to sell an idea of home: our proposed interventions sell nothing, and are rather celebrations of the joy of making tactile, handcrafted objects, and by extension, the making and crafting of home. The intimate and experiential understanding of home will be harnessed through the engagement of local residents. Community groups within West End such as Local Push can further disseminate the RRESign interventions. The signs will be constructed West End-specific materials (old signs purchased from inexpensive second-hand material merchant Reverse Garbage in Montague Rd.): turning post-consumer waste into objects of material beauty and social critique. Residents and community groups will be encouraged to place their RRESigns outside their properties and adjacent real estate signs, frustrating and recoding the existing For-Sale signs that currently dominate the West End street scape. The project is dependent on the support of the local residents, extending from a few signs in Avebury St. to a network of RRESigns throughout West End. A commentary on people's responses to the project will be linked to the www.apbv.com.au website. What is the value of home

Error Control of Iterative Linear Solvers for Integrated Groundwater Models

An open problem that arises when using modern iterative linear solvers, such as the preconditioned conjugate gradient method or Generalized Minimum RESidual (GMRES) method, is how to choose the residual tolerance in the linear solver to be consistent with the tolerance on the solution error. This problem is especially acute for integrated groundwater models, which are implicitly coupled to another model, such as surface water models, and resolve both multiple scales of flow and temporal interaction terms, giving rise to linear systems with variable scaling. This article uses the theory of “forward error bound estimation” to explain the correspondence between the residual error in the preconditioned linear system and the solution error. Using examples of linear systems from models developed by the US Geological Survey and the California State Department of Water Resources, we observe that this error bound guides the choice of a practical measure for controlling the error in linear systems. We implemented a preconditioned GMRES algorithm and benchmarked it against the Successive Over-Relaxation (SOR) method, the most widely known iterative solver for nonsymmetric coefficient matrices. With forward error control, GMRES can easily replace the SOR method in legacy groundwater modeling packages, resulting in the overall simulation speedups as large as 7.74×. This research is expected to broadly impact groundwater modelers through the demonstration of a practical and general approach for setting the residual tolerance in line with the solution error tolerance and presentation of GMRES performance benchmarking results

Designing with marginal fills

Some of the most sustainable and economical benefits of using geosynthetics are found in reinforcement applications. These applications allow the use of lower quality on-site material such as fine grained soils often referred to as ‘marginal fills’. This paper identifies the state of practice and understanding of designing with these soils in applications such as embankments, slopes and retaining walls. Designers often rely on published guidance documents and the paper discusses the influence BS 8006 (2010) has on the use of ‘marginal fills’ in construction and how the need for clearer more specific guidance. The study highlights that often well compacted fine grained fills placed close to optimum moisture content generate suctions, and this results in relatively high strength interaction between the fill and geosynthetic reinforcement. In cases where a fine grained fill with high moisture content is used, geosynthetic reinforcement that provides in-plane drainage may be beneficial

Constraints and barriers to the application of geosynthetics

This paper outlines the current state of practice in the UK with regard to the use of geosynthetics in construction projects. It examines the awareness that geotechnical engineers possess about the technical and sustainability (i.e. reduced CO2) advantages that geosynthetics can provide over traditional construction techniques, and the barriers to their increased use. A survey of UK International Geosynthetic Society (IGS) Corporate Sponsors was carried out to understand the perceived constraints and barriers to increased early stage inclusion of geosynthetic based design solutions, and to obtain views on the current awareness of the UK construction industry of the sustainability benefits. The findings from the survey highlight a lack of clarity in the guidance on fill material provided in the literature. The survey results also showed that main barriers to the use of geosynthetics were education and the conservative approach of consultants

The environmental security debate and its significance for climate change

Policymakers, military strategists and academics all increasingly hail climate change as a security issue. This article revisits the (comparatively) long-standing “environmental security debate” and asks what lessons that earlier debate holds for the push towards making climate change a security issue. Two important claims are made. First, the emerging climate security debate is in many ways a re-run of the earlier dispute. It features many of the same proponents and many of the same disagreements. These disagreements concern, amongst other things, the nature of the threat, the referent object of security and the appropriate policy responses. Second, given its many different interpretations, from an environmentalist perspective, securitisation of the climate is not necessarily a positive development

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

BACKGROUND: The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be highly streamlined, with glycolysis providing most of the cellular ATP. However, these parasitic stages express all the enzymes needed for a canonical mitochondrial tricarboxylic acid (TCA) cycle, and it was recently proposed that they may catabolize glutamine via an atypical branched TCA cycle. Whether these stages catabolize glucose in the TCA cycle and what is the functional significance of mitochondrial metabolism remains unresolved. RESULTS: We reassessed the central carbon metabolism of P. falciparum asexual and sexual blood stages, by metabolically labeling each stage with (13)C-glucose and (13)C-glutamine, and analyzing isotopic enrichment in key pathways using mass spectrometry. In contrast to previous findings, we found that carbon skeletons derived from both glucose and glutamine are catabolized in a canonical oxidative TCA cycle in both the asexual and sexual blood stages. Flux of glucose carbon skeletons into the TCA cycle is low in the asexual blood stages, with glutamine providing most of the carbon skeletons, but increases dramatically in the gametocyte stages. Increased glucose catabolism in the gametocyte TCA cycle was associated with increased glucose uptake, suggesting that the energy requirements of this stage are high. Significantly, whereas chemical inhibition of the TCA cycle had little effect on the growth or viability of asexual stages, inhibition of the gametocyte TCA cycle led to arrested development and death. CONCLUSIONS: Our metabolomics approach has allowed us to revise current models of P. falciparum carbon metabolism. In particular, we found that both asexual and sexual blood stages utilize a conventional TCA cycle to catabolize glucose and glutamine. Gametocyte differentiation is associated with a programmed remodeling of central carbon metabolism that may be required for parasite survival either before or after uptake by the mosquito vector. The increased sensitivity of gametocyte stages to TCA-cycle inhibitors provides a potential target for transmission-blocking drugs

The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster

The regulatory protein NsrR, a member of the Rrf2 family of transcription repressors, is specifically dedicated to sensing nitric oxide (NO) in a variety of pathogenic and non-pathogenic bacteria. It has been proposed that NO directly modulates NsrR activity by interacting with a predicted [Fe-S] cluster in the NsrR protein, but no experimental evidence has been published to support this hypothesis. Here we report the purification of NsrR from the obligate aerobe Streptomyces coelicolor. We demonstrate using UV-visible, near UV CD and EPR spectroscopy that the protein contains an NO-sensitive [2Fe-2S] cluster when purified from E. coli. Upon exposure of NsrR to NO, the cluster is nitrosylated, which results in the loss of DNA binding activity as detected by bandshift assays. Removal of the [2Fe-2S] cluster to generate apo-NsrR also resulted in loss of DNA binding activity. This is the first demonstration that NsrR contains an NO-sensitive [2Fe-2S] cluster that is required for DNA binding activity

Environmental changes and violent conflict

This letter reviews the scientific literature on whether and how environmental changes affect the risk of violent conflict. The available evidence from qualitative case studies indicates that environmental stress can contribute to violent conflict in some specific cases. Results from quantitative large-N studies, however, strongly suggest that we should be careful in drawing general conclusions. Those large-N studies that we regard as the most sophisticated ones obtain results that are not robust to alternative model specifications and, thus, have been debated. This suggests that environmental changes may, under specific circumstances, increase the risk of violent conflict, but not necessarily in a systematic way and unconditionally. Hence there is, to date, no scientific consensus on the impact of environmental changes on violent conflict. This letter also highlights the most important challenges for further research on the subject. One of the key issues is that the effects of environmental changes on violent conflict are likely to be contingent on a set of economic and political conditions that determine adaptation capacity. In the authors' view, the most important indirect effects are likely to lead from environmental changes via economic performance and migration to violent conflict. © 2012 IOP Publishing Ltd

Heterodinuclear ruthenium(II)-cobalt(III) complexes as models for a new approach to selective cancer treatment

Heterodinuclear ruthenium(ii)-cobalt(iii) complexes have been prepared as part of investigations into a new approach to selective cancer treatment. A cobalt(iii) centre bearing amine ligands, which serve as models for cytotoxic nitrogen mustard ligands, is connected by a bridging ligand to a ruthenium(ii)-polypyridyl moiety. Upon excitation of the ruthenium centre by visible light, electron transfer to the cobalt(iii) centre results in reduction to cobalt(ii) and consequent release of its ligands. We have synthesised several such structures and demonstrated their ability to release ligands upon excitation of the ruthenium centre by visible light