57 research outputs found

    The individual and combined effects of exercise and collagenase on the rodent Achilles tendon

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    Indiana University-Purdue University Indianapolis (IUPUI)Tendinopathy is a common degenerative pathology that is characterized by activity related pain, focal tendon tenderness, intratendinous imaging changes, and typically results in changes in the histological, mechanical, and molecular properties of the tendon. Tendinopathy is difficult to study in humans, which has contributed to limited knowledge of the pathology, and thus a lack of appropriate treatment options. However, most believe that the pathology is degenerative as a result of a combination of both extrinsic and intrinsic factors. In order to gain understanding of this pathology, animal models are required. Because each tendon is naturally exposed to different conditions, a universal model is not feasible; therefore, an appropriate animal model must be established for each tendon susceptible to degenerative changes. While acceptable models have been developed for several tendons, a reliable model for the Achilles tendon remains elusive. The purpose of this dissertation was to develop an animal model of Achilles tendinopathy by investigating the individual and combined effects of an intrinsic and extrinsic factor on the rodent Achilles tendon. Rats selectively bred for high capacity running and Sprague Dawley rats underwent uphill treadmill running (an extrinsic factor) to mechanically overload the Achilles tendon or served as cage controls. Collagenase (intrinsic factor) was injected into one Achilles tendon in each animal to intrinsically break down the tendon. There were no interactions between uphill running and collagenase injection, indicating that the influence of the two factors was independent. Uphill treadmill running alone failed to produce any pathological changes in the histological or mechanical characteristics of the Achilles tendon, but did modify molecular activity. Intratendinous collagenase injection had negative effects on the histological, mechanical, and molecular properties of the tendon. The results of this dissertation demonstrated that the combined introduction of uphill treadmill running and collagenase injection did not lead to degenerative changes consistent with human Achilles tendinopathy. Intratendiouns collagenase injection negatively influenced the tendon; however, these changes were generally transient and not influenced by mechanical overload. Future studies should consider combinations of other intrinsic and extrinsic factors in an effort to develop an animal model that replicates human Achilles tendinopathy

    Health and climate related ecosystem services provided by street trees in the urban environment

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    Published onlineJournal ArticleUrban tree planting initiatives are being actively promoted as a planning tool to enable urban areas to adapt to and mitigate against climate change, enhance urban sustainability and improve human health and well-being. However, opportunities for creating new areas of green space within cities are often limited and tree planting initiatives may be constrained to kerbside locations. At this scale, the net impact of trees on human health and the local environment is less clear, and generalised approaches for evaluating their impact are not well developed.In this review, we use an urban ecosystems services framework to evaluate the direct, and locally-generated, ecosystems services and disservices provided by street trees. We focus our review on the services of major importance to human health and well-being which include 'climate regulation', 'air quality regulation' and 'aesthetics and cultural services'. These are themes that are commonly used to justify new street tree or street tree retention initiatives. We argue that current scientific understanding of the impact of street trees on human health and the urban environment has been limited by predominantly regional-scale reductionist approaches which consider vegetation generally and/or single out individual services or impacts without considering the wider synergistic impacts of street trees on urban ecosystems. This can lead planners and policymakers towards decision making based on single parameter optimisation strategies which may be problematic when a single intervention offers different outcomes and has multiple effects and potential trade-offs in different places.We suggest that a holistic approach is required to evaluate the services and disservices provided by street trees at different scales. We provide information to guide decision makers and planners in their attempts to evaluate the value of vegetation in their local setting. We show that by ensuring that the specific aim of the intervention, the scale of the desired biophysical effect and an awareness of a range of impacts guide the choice of i) tree species, ii) location and iii) density of tree placement, street trees can be an important tool for urban planners and designers in developing resilient and resourceful cities in an era of climatic change

    Health and climate related ecosystem services provided by street trees in the urban environment

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    Dance, Kansas State University Symphony Orchestra Concert

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    December 4, 2018 7:30 PM McCain Auditorium Aaron Copland - Hoe Down Aaron Copland - Laurie's Song Leonard Bernstein - Three Dance Episodes from On the Town I. The Great Lover Displays Himself II. Lonely Town Pas De Deux III. Times Square 1944 Johannes Brahms - Hungarian Dance No. 5 Jules Massanet - En fermant les yeux Camille Saint-Saens - Dance Bacchanal

    Family Fun Night, Kansas State University Symphony Orchestra Concert

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    October 23, 2018 7:30 PM McCain Auditorium Program: Jerry Jay Cranford - An Introduction to the Orchestra Camille Saint-Saens - Carnival of the Animals Sergei Prokofiev - Peter and the Wolf Leonard Bernstein - Mambo, from West Side Stor

    Jim Johnson, Trumpet, Faculty Artists Recital

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    Tuesday, August 21st, 2018 7:30 p.m. All Faiths Chapel Philip Sparke - Song and Dance Roy Milligan - Dreams of Karen Joy Webb - Share My Yoke Tamir Akta - Hope and Toronto Billy Joel - Lullaby (Goodnight My Angel

    A Night of Romance, Kansas State University Symphony Orchestra Concert

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    February 12, 2019 7:30 PM McCain Auditorium Program: Georg Philipp Telemann - Don Quioxte Suite I. Overture II. His Attack on the Windmills Antonio Vivaldi - Allegro molto, from Concerto in A minor, RV 497 Leonard Bernstein/Richard Rogers (arr. Longfield/Turner) - Somewhere - My Funny Valentine Carlos Gardel (arr. Naughtin) - Tango per una cabeza Howard Hanson - Symphony No. 2 I. Adagio II. Andante con tenerezza III. Allegro con bri
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