A benign, low Z electron capture agent for negative ion TPCs

We have identified nitromethane (CH$_3$NO$_2$) as an effective electron capture agent for negative ion TPCs (NITPCs). We present drift velocity and longitudinal diffusion measurements for negative ion gas mixtures using nitromethane as the capture agent. Not only is nitromethane substantially more benign than the only other identified capture agent, CS$_2$, but its low atomic number will enable the use of the NITPC as a photoelectric X{}-ray polarimeter in the 1{}-10 keV band

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity.

Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to human and is hypothesized to be relevant to the cause of human disease. However, the underlying molecular mechanisms of PHP are just emerging and direct disease associations remain obscure. In a forward genetic screen for mutations that block PHP we identified mctp (Multiple C2 Domain Proteins with Two Transmembrane Regions). Here we show that MCTP localizes to the membranes of the endoplasmic reticulum (ER) that elaborate throughout the soma, dendrites, axon and presynaptic terminal. Then, we demonstrate that MCTP functions downstream of presynaptic calcium influx with separable activities to stabilize baseline transmission, short-term release dynamics and PHP. Notably, PHP specifically requires the calcium coordinating residues in each of the three C2 domains of MCTP. Thus, we propose MCTP as a novel, ER-localized calcium sensor and a source of calcium-dependent feedback for the homeostatic stabilization of neurotransmission

The self-assembly of particles with isotropic interactions: Using DNA coated colloids to create designer nanomaterials

Copyright (2014) AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in AIP Conference Proceedings 1590 and may be found at http://dx.doi.org/10.1063/1.4870223Self-consistent field theory equations are presented that are suitable for use as a coarse-grained model for DNA coated colloids, polymer-grafted nanoparticles and other systems with approximately isotropic interactions. The equations are generalized for arbitrary numbers of chemically distinct colloids. The advantages and limitations of such a coarsegrained approach for DNA coated colloids are discussed, as are similarities with block copolymer self-assembly. In particular, preliminary results for three species self-assembly are presented that parallel results from a two dimensional ABC triblock copolymer phase. The possibility of incorporating crystallization, dynamics, inverse statistical mechanics and multiscale modelling techniques are discussed

Belief in a just world and physical attractiveness stereotyping

Just-world theory provides a possible explanation of physical attractiveness stereotyping, in that believing in a just world should lead to a positive bias toward "winners," such as the physically attractive. Several hypotheses derived from this premise were tested by having adults complete the Just World Scale and rate the personality traits and expected life outcomes of an attractive or unattractive stimulus person. Predictions for the personality trait ratings were borne out for male but not for female stimulus persons: (a) Believers in a just world perceived the personalities of attractive, male stimulus persons as more socially desirable than nonbelievers and also attributed more socially desirable personalities to male stimulus persons who were attractive rather than unattractive; and Co) no effects were found for female stimulus persons. Predictions for the life-outcome ratings and differences in correlations between personality and life-outcome ratings as a function of belief in a just world were clearly supported. Implications for just-world theory, status-characteristics theory, and physical attractiveness stereotyping are discussed. Dion, Berscheid, and Walster (1972) were among the first researchers to postulate and demonstrate a stereotype for physical attractiveness. They presented university students with college yearbook photographs of stimulus persons previously categorized by other judges as attractive, average looking, or unattractive. Each stimulus person was rated on a series of personality traits selected to provide an index of overall social desirability. The subjects also estimated the stimulus person's suitability for various roles (e.g., marital partner, parent, etc.) as well as his or her likelihood of finding success and happiness in different spheres of life. The results revealed a pervasive bias in favor of physically attractive individuals. Attractive stimulus persons were perceived as having more socially desirable personalities in general than those who were unattractive. Furthermore, for every dimension of life success and satisfaction except parental competence, attractive stimulus persons were expected to fare better than their less attractive counterparts. Karen Dion and her colleagues summed up these findings by suggesting that in the eye of the beholde

Perbedaan Penurunan Skala Nyeri Antara Bekam Kering, Kompres Panas Kering Dan Infrared Radiasi Pada Penderita Nyeri Punggung Bawah

PERBEDAAN PENURUNAN SKALA NYERI ANTARA BEKAM KERING, KOMPRES PANAS KERING DAN INFRARED RADIASI PADA PENDERITA NYERI PUNGGUNG BAWAHThe Diffrence of Pain Scales Decrease Between Dry Bekam, Dry Heat and Radiation of Infrared on Lower Back PatientsDina Dewi SLI1, Alfrina Hany2, Dion Kuntho Adi31,2)Program Studi Ilmu Keperawatan Fakultas Kedokteran Universitas Brawijaya3)Alumni Mahasiswa Program Studi Ilmu Keperawatan Fakultas Kedokteran Universitas BrawijayaJl. Veteran Malang 65145*)e-mail: [email protected] pinggang bawah merupakan keluhan yang sering dijumpai di masyarakat, yaitu timbulnya rasa pegal, linu, ngilu, atau tidak enak pada daerah lumbal berikut sakrum. Intervensi nyeri dapat dilakukan secara farmakologis dan non farmakologis. Salah satu intervensi non farmakologis adalah kompres panas dan terapi radiasi infra merah termasuk juga terapi bekam merah. Namun seiring dengan biaya pengobatan yang semakin mahal masyarakat banyak yang mencari alternatif dalam menangani nyeri salah satunya adalah terapi bekam kering yang sampai saat ini belum diketahui perbedaannya dengan kompres panas dan radiasi infra merah. Penelitian ini bertujuan untuk mengetahui perbedaan penurunan skala nyeri antara bekam kering, kompres panas kering, dan radiasi infra merah pada penderita nyeri punggung bawah. Desain yang digunakan dalam penelitian adalah quasy experiment dengan tehnik purposive sampling. Dari hasil uji Anova diperoleh informasi adanya perbedaan yang signifikan ketiga intervensi dengan p = 0,00 dan alpha 0,05. Setelah dilakukan uji Tukey didapatkan informasi bahwa terapi radiasi infra merah memberikan pengaruh paling baik dalam menurunkan nyeri punggung bawah dengan p = 0,00 dan alpha 0,05. Berdasarkan penelitian ini disarankan menggunakan terapi bekam kering sebagai alternatif mengurangi nyeri karena lebih efisien dari segi waktu dan biaya.Kata kunci : nyeri, bekam kering, kompres panas kering dan infrared radiasiABSTRACTWaist pain in bone under is the sigh often met in society, that is incidence of feeling stiff, fierce shooting, rugged, or not comfortable at lumbal area following sacrum. Intervention pain in bone can be done by pharmacologist and non pharmacologist. One of the intervention is non pharmacologist is hot compress and infrared radiation therapy. But with the expense of medication is costly progressively society a lot look for the alternative in handle the pain in bone one of them is dry bekam therapy that until now not yet been known by its difference with hot compress and infrared radiation. This research purpose to know difference of degradation of pain in bone scale between dry bekam, hot dry compress and infrared radiation at pain patient in back bone under. Design used in research is quasi experiment with purposive sampling technique. Result from Anova testing obtained by the information is one of the treatment give the result degradation of different pain in bone scale with p = 0,00 and alpha 0,05. Tukey test after being obtained information that the infrared radiation therapy gives the best effect in reducing low back pain with p = 0,00 and alpha 0,05.So that can be taken by the conclusion is difference of degradation of real pain in bone. Pursuant to this research is suggested use the dry bekam therapy as alternatively lessen the pain in bone

WAX INDUCER1 (HvWIN1) transcription factor regulates free fatty acid biosynthetic genes to reinforce cuticle to resist Fusarium head blight in barley spikelets

Fusarium head blight (FHB), caused by Fusarium graminearum, is one of the most devastating diseases of wheat and barley. Resistance to FHB is highly complex and quantitative in nature, and is most often classified as resistance to spikelet infection and resistance to spread of pathogen through the rachis. In the present study, a resistant (CI9831) and a susceptible (H106-371) two-row barley genotypes, with contrasting levels of spikelet resistance to FHB, pathogen or mock-inoculated, were profiled for metabolites based on liquid chromatography and high resolution mass spectrometry. The key resistance-related (RR) metabolites belonging to fatty acids, phenylpropanoids, flavonoids and terpenoid biosynthetic pathways were identified. The free fatty acids (FFAs) linoleic and palmitic acids were among the highest fold change RR induced (RRI) metabolites. These FFAs are deposited as cutin monomers and oligomers to reinforce the cuticle, which acts as a barrier to pathogen entry. Quantitative real-time PCR studies revealed higher expressions of KAS2, CYP86A2, CYP89A2, LACS2 and WAX INDUCER1 (HvWIN1) transcription factor in the pathogen-inoculated resistant genotype than in the susceptible genotype. Knockdown of HvWIN1 by virus-induced genes silencing (VIGS) in resistant genotype upon pathogen inoculation increased the disease severity and fungal biomass, and decreased the abundance of FFAs like linoleic and palmitic acids. Notably, the expression of CYP86A2, CYP89A2 and LAC2 genes was also suppressed, proving the link of HvWIN1 in regulating these genes in cuticle biosynthesis as a defense response.Arun Kumar; Kalenahalli N. Yogendra. Shailesh Karre, Ajjamada C. Kushalappa, Yves Dion, Thin M. Cho

Who is to blame? The relationship between ingroup identification and relative deprivation is moderated by ingroup attributions

Contradictory evidence can be found in the literature about whether ingroup identification and perceived relative deprivation are positively or negatively related. Indeed, theoretical arguments can be made for both effects. It was proposed that the contradictory findings can be explained by considering a hitherto unstudied moderator: The extent to which deprivation is attributed to the ingroup. It was hypothesised that identification would only have a negative impact on deprivation, and that deprivation would only have a negative impact on identification, if ingroup attributions are high. To test this, attributions to the ingroup were experimentally manipulated among British student participants (N = 189) who were asked about their perceived deprivation vis-à-vis German students, yield ing support for the hypotheses

The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity

SummaryIt is now appreciated that the brain is immunologically active. Highly conserved innate immune signaling responds to pathogen invasion and injury and promotes structural refinement of neural circuitry. However, it remains generally unknown whether innate immune signaling has a function during the day-to-day regulation of neural function in the absence of pathogens and irrespective of cellular damage or developmental change. Here we show that an innate immune receptor, a member of the peptidoglycan pattern recognition receptor family (PGRP-LC), is required for the induction and sustained expression of homeostatic synaptic plasticity. This receptor functions presynaptically, controlling the homeostatic modulation of the readily releasable pool of synaptic vesicles following inhibition of postsynaptic glutamate receptor function. Thus, PGRP-LC is a candidate receptor for retrograde, trans-synaptic signaling, a novel activity for innate immune signaling and the first known function of a PGRP-type receptor in the nervous system of any organism