Advances in surface EMG signal simulation with analytical and numerical descriptions of the volume conductor

Surface electromyographic (EMG) signal modeling is important for signal interpretation, testing of processing algorithms, detection system design, and didactic purposes. Various surface EMG signal models have been proposed in the literature. In this study we focus on 1) the proposal of a method for modeling surface EMG signals by either analytical or numerical descriptions of the volume conductor for space-invariant systems, and 2) the development of advanced models of the volume conductor by numerical approaches, accurately describing not only the volume conductor geometry, as mainly done in the past, but also the conductivity tensor of the muscle tissue. For volume conductors that are space-invariant in the direction of source propagation, the surface potentials generated by any source can be computed by one-dimensional convolutions, once the volume conductor transfer function is derived (analytically or numerically). Conversely, more complex volume conductors require a complete numerical approach. In a numerical approach, the conductivity tensor of the muscle tissue should be matched with the fiber orientation. In some cases (e.g., multi-pinnate muscles) accurate description of the conductivity tensor may be very complex. A method for relating the conductivity tensor of the muscle tissue, to be used in a numerical approach, to the curve describing the muscle fibers is presented and applied to representatively investigate a bi-pinnate muscle with rectilinear and curvilinear fibers. The study thus propose an approach for surface EMG signal simulation in space invariant systems as well as new models of the volume conductor using numerical methods

Coats disease ‒ case report

Coats disease is a rare, in about 90% of cases unilateral idiopathic eye pathology. It is characterized by telangiectatic and aneurysmally altered retinal blood vessels and progressive intra- and subretinal exudation, which can lead to exudative retinal detachment. Most often the symptoms manifest in the advanced stages. Purpose: To report a case with Coats disease. 10 year old boy, admitted to the Eye Clinic of the University Alexandrovska Hospital – Sofia, with leucocoria and strabismus of the right eye. Method: Full ophthalmic and orthoptic examination, OCT. Results: 3B stage of Coats disease of the right eye was established. The chance for improvement after surgery was evaluated as very little, so our patient remained under observation with protective glasses and prevention of complications. Conclusion: It is of great importance to early diagnose the disease, so to have more treatment options

Vitamin D status in children with myopia

Introduction. A dramatic increase of myopia worldwide has been observed in recent years. New risk factors for the development of myopia have been the target of numerous investigations. The basis of our research is the correlation between serum levels of vitamin D [25(OH)D] and myopia itself.Purpose: To find out the relationship between serum levels of 25(OH) D and myopia. Patients and methods: The study included 222 children with different refraction status. Full ophthalmologic examination, cycloplegic refraction, echobiometry were performed. The serum levels of 25(OH)D were measured by liquid chromatographic mass spectrometry (level of insufficiency < 80 nmol/L).Results: The average patients’ age (51% boys and 48,2% girls) was 11,7 y (SD ± 3,03). They were subdivided into two groups – children with myopia (84,7%) and those without myopia (15,3%). The mean serum 25(OH)D level of all tested was 61,48 nmol/L (16-140 nmol/L; SD ± 20,15); of myopia – 59,67 nmol/L (16-140 nmol/L; SD ± 19,30) and of the non-myopia group – 71,91 nmol/L (33-111 nmol/L; SD ± 21,79). There was a statistically significant difference in serum levels between the two groups (Р = 0,001). The risk of myopia was higher with the decrease of 25(OH)D values (OR = 1,028 ; 95% CI 1,008-1,048). Conclusion. In our investigation group we established low serum levels of 25(OH)D which indicated the need for conducting a population study of its status among Bulgarian children. The correlation between the higher risk of myopia and the vitamin D scarcity has to be further studied, also considering the factor of outdoor/sun-exposure time.

Solving Multi-choice Secretary Problem in Parallel: An Optimal Observation-Selection Protocol

The classical secretary problem investigates the question of how to hire the best secretary from $n$ candidates who come in a uniformly random order. In this work we investigate a parallel generalizations of this problem introduced by Feldman and Tennenholtz [14]. We call it shared $Q$-queue $J$-choice $K$-best secretary problem. In this problem, $n$ candidates are evenly distributed into $Q$ queues, and instead of hiring the best one, the employer wants to hire $J$ candidates among the best $K$ persons. The $J$ quotas are shared by all queues. This problem is a generalized version of $J$-choice $K$-best problem which has been extensively studied and it has more practical value as it characterizes the parallel situation. Although a few of works have been done about this generalization, to the best of our knowledge, no optimal deterministic protocol was known with general $Q$ queues. In this paper, we provide an optimal deterministic protocol for this problem. The protocol is in the same style of the $1\over e$-solution for the classical secretary problem, but with multiple phases and adaptive criteria. Our protocol is very simple and efficient, and we show that several generalizations, such as the fractional $J$-choice $K$-best secretary problem and exclusive $Q$-queue $J$-choice $K$-best secretary problem, can be solved optimally by this protocol with slight modification and the latter one solves an open problem of Feldman and Tennenholtz [14]. In addition, we provide theoretical analysis for two typical cases, including the 1-queue 1-choice $K$-best problem and the shared 2-queue 2-choice 2-best problem. For the former, we prove a lower bound $1-O(\frac{\ln^2K}{K^2})$ of the competitive ratio. For the latter, we show the optimal competitive ratio is $\approx0.372$ while previously the best known result is 0.356 [14].Comment: This work is accepted by ISAAC 201

Finite-Size and surface effects in maghemite nanoparticles: Monte Carlo simulations

Finite-size and surface effects in fine particle systems are investigated by Monte Carlo simulation of a model of a $\gamma$-Fe$_2$O$_3$ (maghemite) single particle. Periodic boundary conditions have been used to simulate the bulk properties and the results compared with those for a spherical shaped particle with free boundaries to evidence the role played by the surface on the anomalous magnetic properties displayed by these systems at low temperatures. Several outcomes of the model are in qualitative agreement with the experimental findings. A reduction of the magnetic ordering temperature, spontaneous magnetization, and coercive field is observed as the particle size is decreased. Moreover, the hysteresis loops become elongated with high values of the differential susceptibility, resembling those from frustrated or disordered systems. These facts are consequence of the formation of a surface layer with higher degree of magnetic disorder than the core, which, for small sizes, dominates the magnetization processes of the particle. However, in contradiction with the assumptions of some authors, our model does not predict the freezing of the surface layer into a spin-glass-like state. The results indicate that magnetic disorder at the surface simply facilitates the thermal demagnetization of the particle at zero field, while the magnetization is increased at moderate fields, since surface disorder diminishes ferrimagnetic correlations within the particle. The change in shape of the hysteresis loops with the particle size demonstrates that the reversal mode is strongly influenced by the reduced atomic coordination and disorder at the surface.Comment: Twocolumn RevTex format. 19 pages, 15 Figures included. Submitted to Phys. Rev.

The stellar content of the young open cluster Trumpler 37

With an apparent cluster diameter of 1.5{\deg} and an age of ~4 Myr, Trumpler 37 is an ideal target for photometric monitoring of young stars as well as for the search of planetary transits, eclipsing binaries and other sources of variability. The YETI consortium has monitored Trumpler 37 throughout 2010 and 2011 to obtain a comprehensive view of variable phenomena in this region. In this first paper we present the cluster properties and membership determination as derived from an extensive investigation of the literature. We also compared the coordinate list to some YETI images. For 1872 stars we found literature data. Among them 774 have high probability of being member and 125 a medium probability. Based on infrared data we re-calculate a cluster extinction of 0.9-1.2 mag. We can confirm the age and distance to be 3-5 Myr and ~870 pc. Stellar masses are determined from theoretical models and the mass function is fitted with a power-law index of alpha=1.90 (0.1-0.4 M_sun) and alpha=1.12 (1-10 M_sun).Comment: 9 pages, 10 figures, 2 long tables, accepte

Constraints on a second planet in the WASP-3 system

There have been previous hints that the transiting planet WASP-3 b is accompanied by a second planet in a nearby orbit, based on small deviations from strict periodicity of the observed transits. Here we present 17 precise radial velocity measurements and 32 transit light curves that were acquired between 2009 and 2011. These data were used to refine the parameters of the host star and transiting planet. This has resulted in reduced uncertainties for the radii and masses of the star and planet. The radial-velocity data and the transit times show no evidence for an additional planet in the system. Therefore, we have determined the upper limit on the mass of any hypothetical second planet, as a function of its orbital period.Comment: Accepted for publication in The Astronomical Journa

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.

Neurexins are transmembrane synaptic cell adhesion molecules involved in the development and maturation of neuronal synapses. In the present study, we report that Nrxn3β is processed by the metalloproteases ADAM10, ADAM17, and by the intramembrane-cleaving protease γ-secretase, producing secreted neurexin3β (sNrxn3β) and a single intracellular domain (Nrxn3β-ICD). We further completed the full characterization of the sites at which Nrxn3β is processed by these proteases. Supporting the physiological relevance of the Nrxn3β processing, we demonstrate in vivo a significant effect of the secreted shedding product sNrxn3β on the morphological development of adult newborn neurons in the mouse hippocampus. We show that sNrxn3β produced by the cells of the dentate gyrus increases the spine density of newborn neurons whereas sNrxn3β produced by the newborn neuron itself affects the number of its mossy fiber terminal extensions. These results support a pivotal role of sNrxn3β in plasticity and network remodeling during neuronal development

Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study

<p>Abstract</p> <p>Background</p> <p>Despite the characteristic extensive tubulointerstitial fibrosis, Balkan Endemic Nephropathy (BEN) is usually considered a non-inflammatory disease.</p> <p>Methods</p> <p>We examined a marker of inflammation, C-reactive protein (CRP), in the offspring of patients with BEN, a population at risk for BEN, prior to development of established disease to determine if an inflammatory process could be identified in the early stages of the disease. In 2003/04, 102 adult offspring whose parents had BEN and a control group of 99 adult offspring of non-BEN patients were enrolled in this prospective study. This cohort was re-examined yearly for four consecutive years. Levels of serum CRP were measured in years 3 and 4 and compared between groups. The data were analyzed with mixed models.</p> <p>Results</p> <p>Compared to controls, offspring of BEN parents had statistically higher CRP levels in two consecutive years, suggestive of early inflammatory reactivity. Whenever the mother was affected by BEN (both parents, or mother only), serum CRP was significantly increased, but not if only the father had BEN. CRP was inversely related to kidney cortex width but not to markers or renal function.</p> <p>Conclusion</p> <p>Early stages of BEN may involve inflammatory processes. The observation of a maternal involvement supports the concept of fetal programming, which has been implicated in the pathogenesis of other chronic kidney diseases.</p