New insights into the mineralogy and geochemistry of sb ores from Greece

Antimony is a common metalloid occurring in the form of Sb-sulfides and sulfosalts, in various base and noble metal deposits. It is also present in corresponding metallurgical products (concentrates) and, although antimony has been considered a penalty element in the past, recently it has gained interest due to its classification as a critical raw material (CRM) by the European Union (EU). In the frame of the present paper, representative ore samples from the main Sb-bearing deposits of Greece (Kilkis prefecture, Chalkidiki prefecture (Kassandra Mines), and Chios Isl.) have been investigated. According to optical microscopy and electron probe microanalysis (EPMA) data, the Greek ores contain stibnite (Sb2 S3), boulangerite (Pb5 Sb4 S11), bournonite (PbCuSbS3), bertherite (FeSbS4), and valentinite (Sb2 O3). Bulk analyses by inductively coupled plasma mass spectrometry (ICP-MS) confirmed, for the first time published, the presence of a significant Hg content in the Kilkis Sb-ore. Furthermore, Kassandra Mines ores are found to contain remarkable amounts of Bi, As, Sn, Tl, and Se (excluding Ag, which is a bonus element). The above findings could contribute to potential future exploration and exploitation of Sb ores in Greece

METIS D3.4: Final workshops packages: workshops for different educational levels and education contexts

Several decades of research in technology-enhanced learning (TEL) have clearly demonstrated the potential of digital technology to transform education. Yet the impact of TEL research on daily teaching-learning practices is still far from fulfilling this potential. Arguably, this is a gap in the capacity for learning design: educators need the tools and competencies which would allow them to identify educational challenges, describe the context in which they arise, identify the opportunities afforded by technology, project the insights derived from research, and devise new learning experiences. To address this gap, educators need tools and practices. Tools that would support them through the cycle of learning design – from conception to deployment and evaluation of techno-educational innovations. Professional practices that use such tools to ensure the robustness and effectiveness of their innovations and make learning design a daily habit and part of their professional identity. The METIS project (http://metis-project.org/) aims to contribute to this aim, by providing educators with an Integrated Learning Design Environment (ILDE) (Hernández-Leo, Asensio-Pérez, Derntl, Prieto, & Chacón, 2014; Hernández-Leo et al., 2015) and a workshop package for training educators in using the ILDE to support effective learning design. Work Package 3, led by the OU (UK), is concerned with the design and development of the workshop package. This deliverable is the final version of the METIS workshop package. It includes • a meta-design for METIS workshops that provides a flexible reusable structure so that workshops can be customised to meet different needs , • a description of the rationale and pedagogical methodology on which the meta-design is based • guidance for instantiating the meta-design in different contexts and • example workshop packages based on the meta-design for three different educational sectors. This document provides educators with a basis for delivering workshops about using the ILDE to support effective learning design. To create and run a workshop suitable for your own context, please proceed in the following way. Firstly, consider the meta-design; then choose one of the example workshop packages closest to your context; finally, use the guidelines to adapt it for your needs

Μulti-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms

BACKGROUND AND PURPOSE: Assessment of dosimetric accuracy of radiosurgery on different treatment platforms. MATERIAL AND METHODS: Thirty-three single fraction treatment plans were assessed at thirty centres using an anthropomorphic head phantom with target and brainstem structures. The target being a single irregular shaped target, ∼8cc, 10 mm from the brainstem. The phantom was "immobilised", scanned, planned and treated following the local protocols. EBT-XD films and alanine pellets were used to measure absolute dose, inside both the target and the brainstem, and compared with TPS predicted dose distributions. RESULTS: PTV alanine measurements from gantry-based linacs showed a median percentage difference to the TPS of 0.65%. Cyberknife (CK) had the highest median difference of 2.3% in comparison to the other platforms. GammaKnife (GK) showed the smallest median of 0.3%. Similar trends were observed in the OAR with alanine measurements showing median percentage differences of1.1%, 2.0% and 0.4%, for gantry-based linacs, CK and GK respectively. All platforms showed comparable gamma passing rates between axial and sagittal films. CONCLUSIONS: This comparison has highlighted the dosimetric variation between measured and TPS calculated dose for each delivery platforms.. The results suggest that clinically acceptable agreement with the predicted dose distributions is achievable by all treatment delivery systems. Radiosurgery, Dosimetry, End-to-end, Audit, Anthropomorphic Phantom, Alanine, Radiochromic film

DGP Cosmology with a Non-Minimally Coupled Scalar Field on the Brane

We construct a DGP inspired braneworld scenario where a scalar field non-minimally coupled to the induced Ricci curvature is present on the brane. First we investigate the status of gravitational potential with non-minimal coupling and observational constraints on this non-minimal model. Then we further deepen the idea of embedding of FRW cosmology in this non-minimal setup. Cosmological implications of this scenario are examined with details and the quintessence and late-time expansion of the universe within this framework are examined. Some observational constraints imposed on this non-minimal scenario are studied and relation of this model with dark radiation formalism is determined with details.Comment: 26 pages, 3 eps figure

Decidual-Secreted Factors Alter Invasive Trophoblast Membrane and Secreted Proteins Implying a Role for Decidual Cell Regulation of Placentation

Inadequate or inappropriate implantation and placentation during the establishment of human pregnancy is thought to lead to first trimester miscarriage, placental insufficiency and other obstetric complications. To create the placental blood supply, specialized cells, the ‘extravillous trophoblast’ (EVT) invade through the differentiated uterine endometrium (the decidua) to engraft and remodel uterine spiral arteries. We hypothesized that decidual factors would regulate EVT function by altering the production of EVT membrane and secreted factors. We used a proteomics approach to identify EVT membrane and secreted proteins regulated by decidual cell factors. Human endometrial stromal cells were decidualized in vitro by treatment with estradiol (10−8 M), medroxyprogesterone acetate (10−7 M) and cAMP (0.5 mM) for 14 days. Conditioned media (CM) was collected on day 2 (non-decidualized CM) and 14 (decidualized CM) of treatment. Isolated primary EVT cultured on Matrigel™ were treated with media control, non-decidualized or decidualized CM for 16 h. EVT CM was fractionated for proteins <30 kDa using size-exclusion affinity nanoparticles (SEAN) before trypsin digestion and HPLC-MS/MS. 43 proteins produced by EVT were identified; 14 not previously known to be expressed in the placenta and 12 which had previously been associated with diseases of pregnancy including preeclampsia. Profilin 1, lysosome associated membrane glycoprotein 1 (LAMP1), dipeptidyl peptidase 1 (DPP1/cathepsin C) and annexin A2 expression by interstitial EVT in vivo was validated by immunhistochemistry. Decidual CM regulation in vitro was validated by western blotting: decidualized CM upregulated profilin 1 in EVT CM and non-decidualized CM upregulated annexin A2 in EVT CM and pro-DPP1 in EVT cell lysate. Here, non-decidualized factors induced protease expression by EVT suggesting that non-decidualized factors may induce a pro-inflammatory cascade. Preeclampsia is a pro-inflammatory condition. Overall, we have demonstrated the potential of a proteomics approach to identify novel proteins expressed by EVT and to uncover the mechanisms leading to disease states

Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice

Female-controlled contraception/HIV prevention is critical to address health issues associated with gender inequality. Therefore, a contraceptive which can be administered in tandem with a microbicide to inhibit sexually transmitted infections, is desirable. Uterine leukemia inhibitory factor (LIF) is obligatory for blastocyst implantation in mice and associated with infertility in women. We aimed to determine whether a PEGylated LIF inhibitor (PEGLA) was an effective contraceptive following vaginal delivery and to identify non-uterine targets of PEGLA in mice

Orchestrating learning activities using the CADMOS learning design tool

This paper gives an overview of CADMOS (CoursewAre Development Methodology for Open instructional Systems), a graphical IMS-LD Level A & B compliant learning design (LD) tool, which promotes the concept of &#x201C;separation of concerns&#x201D; during the design process, via the creation of two models: the conceptual model, which describes the learning activities and the corresponding learning resources, and the flow model, which describes the orchestration of these activities. According to the feedback from an evaluation case study with 36 participants, reported in this paper, CADMOS is a user-friendly tool that allows educational practitioners to design flows of learning activities using a layered approach