228 research outputs found
Domain Growth, Wetting and Scaling in Porous Media
The lattice Boltzmann (LB) method is used to study the kinetics of domain
growth of a binary fluid in a number of geometries modeling porous media.
Unlike the traditional methods which solve the Cahn-Hilliard equation, the LB
method correctly simulates fluid properties, phase segregation, interface
dynamics and wetting. Our results, based on lattice sizes of up to , do not show evidence to indicate the breakdown of late stage dynamical
scaling, and suggest that confinement of the fluid is the key to the slow
kinetics observed. Randomness of the pore structure appears unnecessary.Comment: 13 pages, latex, submitted to PR
X-ray Near Field Speckle: Implementation and Critical Analysis
We have implemented the newly-introduced, coherence-based technique of x-ray
near-field speckle (XNFS) at 8-ID-I at the Advanced Photon Source. In the near
field regime of high-brilliance synchrotron x-rays scattered from a sample of
interest, it turns out, that, when the scattered radiation and the main beam
both impinge upon an x-ray area detector, the measured intensity shows
low-contrast speckles, resulting from interference between the incident and
scattered beams. We built a micrometer-resolution XNFS detector with a high
numerical aperture microscope objective and demonstrate its capability for
studying static structures and dynamics at longer length scales than
traditional far field x-ray scattering techniques. Specifically, we
characterized the structure and dynamics of dilute silica and polystyrene
colloidal samples. Our study reveals certain limitations of the XNFS technique,
which we discuss.Comment: 53 pages, 16 figure
Homotopic functional connectivity disruptions in glioma patients are associated with tumor malignancy and overall survival
BACKGROUND: Gliomas exhibit widespread bilateral functional connectivity (FC) alterations that may be associated with tumor grade. Limited studies have examined the connection-level mechanisms responsible for these effects. Given the typically strong FC observed between mirroring/homotopic brain regions in healthy subjects, we hypothesized that homotopic connectivity (HC) is altered in low-grade and high-grade glioma patients and the extent of disruption is associated with tumor grade and predictive of overall survival (OS) in a cohort of
METHODS: We used a mirrored FC-derived cortical parcellation to extract blood-oxygen-level-dependent (BOLD) signals and to quantify FC differences between homotopic pairs in normal-appearing brain in a retrospective cohort of glioma patients and healthy controls.
RESULTS: Fifty-nine glioma patients (WHO grade 2,
CONCLUSIONS: These findings demonstrate an association between tumor grade and HC alterations that may underlie global FC changes and provide prognostic information
Asymmetrically cut crystals as optical elements for highly collimated x‐ray beams
Asymmetrically cut perfect crystals, in both the Laue and Bragg geometries, are examined as single crystal monochromators for x‐ray beams that are collimated to a small fraction of the Darwin width, as is typical in experiments with coherent x rays. Both the Laue and asymmetric Bragg geometries are plagued by an inherent chromatic aberration that increases the beam divergence much beyond that of the symmetric Bragg geometry. Measurements from a recent experiment at the ESRF are presented to compare Si(220) (symmetric Bragg), diamond(111) (asymmetric Laue), and diamond(111) (symmetric Bragg inclined) geometries. © 1995 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70952/2/RSINAK-66-2-1506-1.pd
Evidence for Two Superconducting Gaps in
We have measured the Raman spectra of polycrystalline MgB from 25 {\cm}
to 1200 {\cm}. When the temperature was decreased below the superconducting
transition temperature , we observed a superconductivity-induced
redistribution in the electronic Raman continuum. Two pair-breaking peaks
appear in the spectra, suggesting the presence of two superconducting gaps.
Furthermore, we have analyzed the measured spectra using a quasi
two-dimensional model in which two s-wave superconducting gaps open on two
sheets of Fermi surface. For the gap values we have obtained (2.7 meV) and (6.2 meV). Our results suggest
that a conventional phonon-mediated pairing mechanism occurs in the planar
boron bands and is responsible for the superconductivity of MgB.Comment: 3 figure
Project-Based Learning in Introductory Statistics: Comparing Course Experiences and Predicting Positive Outcomes for Students from Diverse Educational Settings
In order to evaluate the acceptability and potential impact of the Passion-Driven Statistics curriculum, this article describes background characteristics, and course experiences and outcomes of students enrolled in the multidisciplinary, introductory, project-based course in liberal arts colleges, large state universities, regional college/universities, and community colleges. We found that the course could be successfully delivered across these diverse educational settings. After controlling for educational setting and pre-survey responses to individual outcome measures, consistent predictors of positive course outcomes included student’s initial interest in conducting research, their higher likelihood of enrolling in a statistics course if it were not required, finding the project-based course less challenging, and finding the research project more rewarding than other students. Regional college/university, and community college students reported working significantly harder in the course and finding the course more challenging than students taking the course at liberal arts colleges or state universities. Students from liberal arts colleges generally reported more positive course experiences than students from other educational settings. However, when compared to students from both liberal arts colleges and large state universities, those from regional colleges/universities reported being more likely to have learned more in the project-based course than in other college courses they had taken. Taken together, the project-based course was successfully delivered across diverse post-secondary educational settings and provides a promising model for getting students hooked on the power and excitement of applied statistics
Rigid Chiral Membranes
Statistical ensembles of flexible two-dimensional fluid membranes arise
naturally in the description of many physical systems. Typically one encounters
such systems in a regime of low tension but high stiffness against bending,
which is just the opposite of the regime described by the Polyakov string. We
study a class of couplings between membrane shape and in-plane order which
break 3-space parity invariance. Remarkably there is only {\it one} such
allowed coupling (up to boundary terms); this term will be present for any
lipid bilayer composed of tilted chiral molecules. We calculate the
renormalization-group behavior of this relevant coupling in a simplified model
and show how thermal fluctuations effectively reduce it in the infrared.Comment: 11 pages, UPR-518T (This replaced version has fonts not used
removed.
Synthesis and properties of 2′-deoxy-2′,4′-difluoroarabinose-modified nucleic acids
© 2015 American Chemical Society. We report the synthesis, thermal stability, and RNase H substrate activity of 2′-deoxy-2′,4′-difluoroarabino-modified nucleic acids. 2′-Deoxy-2′,4′-difluoroarabinouridine (2,′4′-diF-araU) was prepared in a stereoselective way in six steps from 2′-deoxy-2′-fluoroarabinouridine (2′-F-araU). NMR analysis and quantum mechanical calculations at the nucleoside level reveal that introduction of 4′-fluorine introduces a strong bias toward the North conformation, despite the presence of the 2′-βF, which generally steers the sugar pucker toward the South/East conformation. Incorporation of the novel monomer into DNA results on a neutral to slightly stabilizing thermal effect on DNA-RNA hybrids. Insertion of 2′,4′-diF-araU nucleotides in the DNA strand of a DNA-RNA hybrid decreases the rate of both human and HIV reverse transcriptase-associated RNase H-mediated cleavage of the complement RNA strand compared to that for an all-DNA strand or a DNA strand containing the corresponding 2′-F-araU nucleotide units, consistent with the notion that a 4′-fluorine in 2′-F-araU switches the preferred sugar conformation from DNA-like (South/East) to RNA-like (North).Peer Reviewe
Major Depression Is a Risk Factor for Shorter Time to First Cigarette Irrespective of the Number of Cigarettes Smoked Per Day: Evidence From a National Population Health Survey
Article deposited according to Oxford Open Self-Archiving policy: http://www.oxfordjournals.org/oxfordopen/policies.html, January 12, 2012.YesFunding provided by the Open Access Authors Fund
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