La limitation de responsabilité dans le transport multimodal

"Mémoire présenté à la Faculté des études supérieures en vue de l'obtention du grade de L.L.M. en droit des affaires"L'objet de ce mémoire est d'étudier la façon dont la limitation de responsabilité est appliquée dans le transport multimodal international de marchandises. La première partie du mémoire déterminera le concept du transport multimodal, ainsi que les origines de la limitation de responsabilité dans le transport de marchandises. On étudiera aussi comment la responsabilité est limitée dans les divers modes de transport qui peuvent composer le transport multimodal, avec un spécial intérêt sur l'Amérique du Nord. La deuxième partie du mémoire fera une analyse des diverses conventions et traités internationaux qui peuvent régir le transport multimodal international, en étudiant la façon dont la limitation de responsabilité est régie par ces conventions. De même, une analyse sera faite sur l'utilité et justification actuelle d'une limite à la responsabilité des transporteurs de marchandises. Finalement on étudiera les possibilités d'obtenir un traité international qui régisse le transport multimodal et qui puisse établir une limite de responsabilité uniforme a travers le monde.The purpose of this thesis is to study the manner in which liabilities are limited in the international multimodal transport of goods. The first part of the thesis will establish the concept of multimodal transport, as well as the origins of the limitation of liability in the transportation of goods. We shall also study how the liability is limited in the various modes of transport that conform multimodal transport, making a special emphasis in North America. The second part of the thesis will analyze the different conventions and international treaties that may regulate the multimodal transport of goods, by studying the manner in which limitation of liability is regulated in these conventions. It will also analyze will be made about the present need and justification of a limitation of liability for transporters of goods. Finally, we shall study the possibility of an international treaty being created which will regulate the multimodal international transport of goods and which will establish a uniform limitation of liability through out the world

EFFECT OF LANDING SURFACE AND UPPER EXTREMITY CONSTRAINT ON BIOMECHANICS GRADED BY THE LANDING ERROR SCORING SYSTEM

The purpose of this study was to compare jump-landing biomechanics across 1) landing surface condition; and 2) upper extremity constraint condition as graded by the Landing Error Scoring System (LESS). Recreational athletes (N=40; 21M, 19F) performed three jump-landings with three surface (Grass (GS), Court (CS), and Tile (TS)) and upper extremity constraint conditions (unconstrained (UN), football (AF), and lacrosse stick (LS)). The jump-landings were recorded via 2D videography and graded using the LESS. No differences were observed by surface (GS=5.01±1.40; CS=4.83±1.31; TS=5.09±1.86, p=0.52) or constraint condition (UN=5.09±1.86; FB=4.76±1.65; LS=4.86±1.76; p=0.21). The results indicate that the LESS is a robust instrument biomechanical screening in different landing environments and with sports with different upper extremity equipment

Core-periphery dynamics in a plant-pollinator network

Mutualistic networks are highly dynamic, characterized by high temporal turnover of species and interactions. Yet, we have a limited understanding of how the internal structure of these networks and the roles species play in them vary through time. We used 6 years of observation data and a novel statistical method (dynamic stochastic block models) to assess how network structure and species' structural position within the network change throughout subseasons of the flowering season and across years in a quantitative plant–pollinator network from a dryland ecosystem in Argentina. Our analyses revealed a core–periphery structure persistent through subseasons and years. Yet, species structural position as core or peripheral was highly dynamic: virtually all species that were at the core in some subseasons were also peripheral in other subseasons, while many other species always remained peripheral. Our results illuminate our understanding of the dynamics of mutualistic networks and have important implications for ecosystem management and conservation.Fil: Miele, Vincent. Centre National de la Recherche Scientifique; FranciaFil: Ramos Jiliberto, Rodrigo. Universidad Mayor; ChileFil: Vazquez, Diego P.. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; Argentin

Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience

Background: Frailty is characterized by an accumulation of deficits that lead to vulnerability to adverse health outcomes. The Frailty Index (FI) quantifies frailty by measuring deficits that increase susceptibility to stressors. This study focused on a population of Mexican Americans living in vulnerable communities in the Rio Grande Valley of south Texas. We used a Frailty Index developed based on common health-related data--the Patient Health Questionnaire (PHQ-9) and a Health-related Quality of Life survey (Duke Health Profile). Quality of life, resilience, and frailty are interrelated and influenced by chronic illness, mental illness, poverty, cognitive impairment, and community support. Methods: We used Logistic regression analysis, factor component analysis, receiver operating characteristic curves, and odds ratios to identify potential associations between clinical variables and candidate predictor variables and seven physiological health variables, and two survey instruments. We analyzed data obtained from participants (894) that live in two Colonias located on the Texas-Mexico border. We calculated the FI with seven physiological variables, PHQ-9 score, and the 11 domain-specific Duke Profile scores, for a total of 19 health deficits. We then dichotomized FI (\u3e0.25) and determined ROC curves through model selection to determine best predictors of frailty. Results: Females (n = 622) had a higher starting frailty, and males (n = 272) had a significantly greater change rate with age. Women score higher in anxiety, depression, anxiety/depression, and pain. The frailty index and quality of life markers are strongly inversely related; poorer quality of life leads to greater frailty independent physiological health variables, the PHQ 9, sex, and age. Conclusion: The study highlights the importance of addressing modifiable mental health and social stressors to reduce frailty. Furthermore, it suggests that factors supporting resilience and well-being, such as physical and mental health, social support, and perceived health, play a crucial role in frailty development. The findings have implications for interventions targeting vulnerable populations and emphasize the need for further research on the relationship between health-related quality of life and frailty

Cell wall component and mycotoxin moieties involved in binding of fumonisin B1 and B2 by lactic acid bacteria.

International audienceAims: The ability of lactic acid bacteria (LAB) to bind fumonisins B1 and B2 (FB1, FB2) in fermented foods and feeds and in the gastrointestinal tract could contribute to decrease their bioavailability and toxic effects on farm animals and humans. The aim of this work was to identify the bacterial cell wall component(s) and the functional group(s) of FB involved in the LAB-FB interaction. Methods and Results: The effect of physicochemical, enzymatic and genetic treatments of bacteria and the removal/inactivation of the functional groups of FB on toxin binding were evaluated. Treatments affecting the bacterial wall polysaccharides, lipids and proteins increased binding, while those degrading peptidoglycan (PG) partially decreased it. In addition, purified PG from Gram-positive bacteria bound FB in a manner analogue to that of intact LAB. For FB, tricarballylic acid (TCA) chains play a significant role in binding as hydrolysed FB had less affinity for LAB. Conclusions: Peptidoglycan and TCA are important components of LAB and FB, respectively, involved in the binding interaction. Significance and Impact of the Study: Lactic acid bacteria binding efficiency seems related to the peptide moiety structure of the PG. This information can be used to select probiotics with increased FB binding efficiency

Strategy and model building in the fourth dimension: a null model for genotype × age interaction as a Gaussian stationary stochastic process

BACKGROUND: Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype × age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. RESULTS: We found evidence for genotype × age interaction for fasting glucose and systolic blood pressure. CONCLUSIONS: There is polygenic genotype × age interaction for fasting glucose and systolic blood pressure and quantitative trait locus × age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM

Movie Editing and Cognitive Event Segmentation in Virtual Reality Video

Traditional cinematography has relied for over a century on a well-established set of editing rules, called continuity editing, to create a sense of situational continuity. Despite massive changes in visual content across cuts, viewers in general experience no trouble perceiving the discontinuous flow of information as a coherent set of events. However, Virtual Reality (VR) movies are intrinsically different from traditional movies in that the viewer controls the camera orientation at all times. As a consequence, common editing techniques that rely on camera orientations, zooms, etc., cannot be used. In this paper we investigate key relevant questions to understand how well traditional movie editing carries over to VR. To do so, we rely on recent cognition studies and the event segmentation theory, which states that our brains segment continuous actions into a series of discrete, meaningful events. We first replicate one of these studies to assess whether the predictions of such theory can be applied to VR. We next gather gaze data from viewers watching VR videos containing different edits with varying parameters, and provide the first systematic analysis of viewers' behavior and the perception of continuity in VR. From this analysis we make a series of relevant findings; for instance, our data suggests that predictions from the cognitive event segmentation theory are useful guides for VR editing; that different types of edits are equally well understood in terms of continuity; and that spatial misalignments between regions of interest at the edit boundaries favor a more exploratory behavior even after viewers have fixated on a new region of interest. In addition, we propose a number of metrics to describe viewers' attentional behavior in VR. We believe the insights derived from our work can be useful as guidelines for VR content creation

Lidar Systems for Precision Navigation and Safe Landing on Planetary Bodies

The ability of lidar technology to provide three-dimensional elevation maps of the terrain, high precision distance to the ground, and approach velocity can enable safe landing of robotic and manned vehicles with a high degree of precision. Currently, NASA is developing novel lidar sensors aimed at needs of future planetary landing missions. These lidar sensors are a 3-Dimensional Imaging Flash Lidar, a Doppler Lidar, and a Laser Altimeter. The Flash Lidar is capable of generating elevation maps of the terrain that indicate hazardous features such as rocks, craters, and steep slopes. The elevation maps collected during the approach phase of a landing vehicle, at about 1 km above the ground, can be used to determine the most suitable safe landing site. The Doppler Lidar provides highly accurate ground relative velocity and distance data allowing for precision navigation to the landing site. Our Doppler lidar utilizes three laser beams pointed to different directions to measure line of sight velocities and ranges to the ground from altitudes of over 2 km. Throughout the landing trajectory starting at altitudes of about 20 km, the Laser Altimeter can provide very accurate ground relative altitude measurements that are used to improve the vehicle position knowledge obtained from the vehicle navigation system. At altitudes from approximately 15 km to 10 km, either the Laser Altimeter or the Flash Lidar can be used to generate contour maps of the terrain, identifying known surface features such as craters, to perform Terrain relative Navigation thus further reducing the vehicle s relative position error. This paper describes the operational capabilities of each lidar sensor and provides a status of their development. Keywords: Laser Remote Sensing, Laser Radar, Doppler Lidar, Flash Lidar, 3-D Imaging, Laser Altimeter, Precession Landing, Hazard Detectio

Unraveling the Mechanisms by Which Smoking and Alcohol Alter Pancreatic Cancer Pathogenesis

Pancreatic cancer is the 3rd leading cause of cancer in United States with a 5-to-7-year relative survival rate. This can be attributed to the late onset of symptoms and diagnosis of the disease, which makes it unmanageable at its later stage. Ethnic differences in pancreatic cancer incidence have been reported, especially regarding higher incidence in African Americans. African Americans are more likely than Asian, Hispanic, or whites’ people to develop pancreatic cancer. They have highest incidence rate between 28% and 59% higher than other racial groups. The mortality rate for Blacks is 13.3 per 100,000 people, while for Whites it is 11.0 per 100,000. Incidence of pancreatic cancer and increased smoking and alcohol consumption among African Americans indicates lifestyle risk rather than genetics. The purpose of this study is to identify underlying mechanisms that may contribute to this racial disparity. Herein, we have demonstrated that cigarette smoking and alcohol consumption are associated with pancreatic cancer and poor patient survival. Our results demonstrate that smoking and drinking alters tumor microenvironment and enhances bidirectional tumor-stromal cells interaction between sonic hedgehog (SHH) pathway and an oncogenic CXCR4/CXCL12 signaling axis. Our results particularly signify an aberrant overexpression of a mucin, MUC13 in the nuclear compartment of cells from the patient tissues who smoke or drink. Also, this study analyzes the association of MUC13 with effects due to smoking and alcohol consumption. This study is significant in understanding potential risk factors in pancreatic cancer. Smoking and excess drinking cessation programs can help prevent pancreatic cancer