190 research outputs found
Primary Care Endometrial Sampling for Abnormal Uterine Bleeding: A Pilot Study
Background
Most cases of abnormal uterine bleeding (AUB) could potentially be managed in primary care but
lack of access to endometrial sampling leads to avoidable referrals to hospital to rule out
endometrial hyperplasia and cancer.
Aims
To design and evaluate a pilot service for primary care endometrial sampling (PCES).
Design
Retrospective analysis of data from two service evaluations.
Setting
General practices and the gynaecology department in a large city in the United Kingdom.
Methods
1) To design the new service we identified all the endometrial samples taken in the city’s
gynaecology department in 2012/13 and estimated the proportion of these with AUB that would be
suitable for PCES. 2) To evaluate the new PCES service we analysed data from the first year of
activity.
Results
1) 1894 endometrial samples were taken in hospital in 2012/13. An estimated 424 (22.4%) of these
were from patients with AUB who fitted the criteria for PCES. 2) In the first year of the PCES service
108 samples were taken by GPs. Initial management of these patients was exclusively in primary
care in 97.2% (104/108), most patients were treated with Mirena IUS (79/109; 73.1%) and there
were no cases of hyperplasia or cancer.
Conclusions
Most pre-menopausal patients with AUB could potentially be managed in primary care without
referral to hospital if ES was made available to appropriately trained and supported GPs. However,
this study was limited by it’s retrospective non-interventional design and more research is required
to demonstrate safety and cost-effectiveness.
Key Message Points
Primary care is a crucial part of the care pathway for patients with abnormal uterine bleeding.
In the first instance, the majority of patients with AUB can be managed exclusively in primary care
without referral to hospital.
Primary care management of AUB may be cost effective but an economic model of the care pathway
is required to make accurate comparisons between primary care and secondary care
Prevalence of High-Grade Anal Intraepithelial Neoplasia (AIN) in Anal Lesions in HIV+Men Who Have Sex with Men (MSM) from a Venezuelan Private Medical Center
A sensorimotor control framework for understanding emotional communication and regulation
Action Contro
Syn-sedimentary hydrothermal dolomites in a lacustrine rift basin: petrographic and geochemical evidence from the Lower Cretaceous Erlian Basin, Northern China
Differential cross section and recoil polarization measurements for the gamma p to K+ Lambda reaction using CLAS at Jefferson Lab
We present measurements of the differential cross section and Lambda recoil
polarization for the gamma p to K+ Lambda reaction made using the CLAS detector
at Jefferson Lab. These measurements cover the center-of-mass energy range from
1.62 to 2.84 GeV and a wide range of center-of-mass K+ production angles.
Independent analyses were performed using the K+ p pi- and K+ p (missing pi -)
final-state topologies; results from these analyses were found to exhibit good
agreement. These differential cross section measurements show excellent
agreement with previous CLAS and LEPS results and offer increased precision and
a 300 MeV increase in energy coverage. The recoil polarization data agree well
with previous results and offer a large increase in precision and a 500 MeV
extension in energy range. The increased center-of-mass energy range that these
data represent will allow for independent study of non-resonant K+ Lambda
photoproduction mechanisms at all production angles.Comment: 22 pages, 16 figure
Measurement of the Nucleon Structure Function F2 in the Nuclear Medium and Evaluation of its Moments
We report on the measurement of inclusive electron scattering off a carbon
target performed with CLAS at Jefferson Laboratory. A combination of three
different beam energies 1.161, 2.261 and 4.461 GeV allowed us to reach an
invariant mass of the final-state hadronic system W~2.4 GeV with four-momentum
transfers Q2 ranging from 0.2 to 5 GeV2. These data, together with previous
measurements of the inclusive electron scattering off proton and deuteron,
which cover a similar continuous two-dimensional region of Q2 and Bjorken
variable x, permit the study of nuclear modifications of the nucleon structure.
By using these, as well as other world data, we evaluated the F2 structure
function and its moments. Using an OPE-based twist expansion, we studied the
Q2-evolution of the moments, obtaining a separation of the leading-twist and
the total higher-twist terms. The carbon-to-deuteron ratio of the leading-twist
contributions to the F2 moments exhibits the well known EMC effect, compatible
with that discovered previously in x-space. The total higher-twist term in the
carbon nucleus appears, although with large systematic uncertainites, to be
smaller with respect to the deuteron case for n<7, suggesting partial parton
deconfinement in nuclear matter. We speculate that the spatial extension of the
nucleon is changed when it is immersed in the nuclear medium.Comment: 37 pages, 15 figure
First measurement of direct photoproduction on the proton
We report on the results of the first measurement of exclusive
meson photoproduction on protons for GeV and GeV. Data were collected with the CLAS detector at the Thomas
Jefferson National Accelerator Facility. The resonance was detected via its
decay in the channel by performing a partial wave analysis of the
reaction . Clear evidence of the meson
was found in the interference between and waves at GeV. The -wave differential cross section integrated in the mass range of
the was found to be a factor of 50 smaller than the cross section
for the meson. This is the first time the meson has been
measured in a photoproduction experiment
Pressão e temperatura da água de lavagem na população microbiana da superfície de carcaças bovinas
ATP synthase: from single molecule to human bioenergetics
ATP synthase (FoF1) consists of an ATP-driven motor (F1) and a H+-driven motor (Fo), which rotate in opposite directions. FoF1 reconstituted into a lipid membrane is capable of ATP synthesis driven by H+ flux. As the basic structures of F1 (α3β3γδε) and Fo (ab2c10) are ubiquitous, stable thermophilic FoF1 (TFoF1) has been used to elucidate molecular mechanisms, while human F1Fo (HF1Fo) has been used to study biomedical significance. Among F1s, only thermophilic F1 (TF1) can be analyzed simultaneously by reconstitution, crystallography, mutagenesis and nanotechnology for torque-driven ATP synthesis using elastic coupling mechanisms. In contrast to the single operon of TFoF1, HFoF1 is encoded by both nuclear DNA with introns and mitochondrial DNA. The regulatory mechanism, tissue specificity and physiopathology of HFoF1 were elucidated by proteomics, RNA interference, cytoplasts and transgenic mice. The ATP synthesized daily by HFoF1 is in the order of tens of kilograms, and is primarily controlled by the brain in response to fluctuations in activity
Partial wave analysis of the reaction gamma p -> p omega$ and the search for nucleon resonances
An event-based partial wave analysis (PWA) of the reaction gamma p -> p omega
has been performed on a high-statistics dataset obtained using the CLAS at
Jefferson Lab for center-of-mass energies from threshold up to 2.4 GeV. This
analysis benefits from access to the world's first high precision spin density
matrix element measurements, available to the event-based PWA through the decay
distribution of omega-> pi+ pi - pi0. The data confirm the dominance of the
t-channel pi0 exchange amplitude in the forward direction. The dominant
resonance contributions are consistent with the previously identified states
F[15](1680) and D[13](1700) near threshold, as well as the G[17](2190) at
higher energies. Suggestive evidence for the presence of a J(P)=5/2(+) state
around 2 GeV, a "missing" state, has also been found. Evidence for other states
is inconclusive
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