10 research outputs found

    Being Your True Self at Work: Integrating the Fragmented Research on Authenticity in Organizations

    No full text
    In tandem with a surge of public interest in authenticity, there is a growing number of empirical studies on individual authenticity in work settings. However, these studies have been generated within separate literatures on topics such as authentic leadership, emotional labor, and identity management, among many others, making it difficult for scholars to integrate and build on the authenticity research to date. To facilitate and advance future investigations, this article reviews the extant empirical work across 10 different authenticity constructs. Following our research review, we use a power lens to help synthesize our major findings and insights. We conclude by identifying six directions for future research, including the need for scholars to embrace a multifaceted view of authenticity in organizations. Overall, our review both reinforces and tempers the enthusiasm in contemporary discussions of authenticity in the popular and business press

    Globalization Reconsidered: The Historical Geography of Modern Western Male Attire

    No full text

    Mapping genomic loci implicates genes and synaptic biology in schizophrenia

    No full text
    Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.11Nsciescopu

    Mapping genomic loci implicates genes and synaptic biology in schizophrenia

    Get PDF
    Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

    Being Your True Self at Work: Integrating the Fragmented Research on Authenticity in Organizations

    No full text
    corecore