Interacting holographic dark energy model and generalized second law of thermodynamics in non-flat universe

In the present paper we consider the interacting holographic model of dark energy to investigate the validity of the generalized second laws of thermodynamics in non-flat (closed) universe enclosed by the event horizon measured from the sphere of the horizon named $L$. We show that for $L$ as the system's IR cut-off the generalized second law is respected for the special range of the deceleration parameter.Comment: 11 pages, no figure

The Holographic Model of Dark Energy and Thermodynamics of Non-Flat Accelerated Expanding Universe

Motivated by recent results on non-vanishing spatial curvature \cite{curve} we employ the holographic model of dark energy to investigate the validity of first and second laws of thermodynamics in non-flat (closed) universe enclosed by apparent horizon $R_A$ and the event horizon measured from the sphere of horizon named $L$. We show that for the apparent horizon the first law is roughly respected for different epochs while the second laws of thermodynamics is respected while for $L$ as the system's IR cut-off first law is broken down and second law is respected for special range of deceleration parameter. It is also shown that at late-time universe $L$ is equal to $R_A$ and the thermodynamic laws are hold, when the universe has non-vanishing curvature. Defining the fluid temperature to be proportional to horizon temperature the range for coefficient of proportionality is obtained provided that the generalized second law of thermodynamics is hold.Comment: 12 pages, no figure, abstract and text extended, references added, accepted for publication in JCA

Cosmic Acceleration in Brans-Dicke Cosmology

We consider Brans-Dicke theory with a self-interacting potential in Einstein conformal frame. We show that an accelerating expansion is possible in a spatially flat universe for large values of the Brans-Dicke parameter consistent with local gravity experiments.Comment: 10 Pages, 3 figures, To appear in General Relativity and Gravitatio

Neutrinoless double beta decay in seesaw models

We study the general phenomenology of neutrinoless double beta decay in seesaw models. In particular, we focus on the dependence of the neutrinoless double beta decay rate on the mass of the extra states introduced to account for the Majorana masses of light neutrinos. For this purpose, we compute the nuclear matrix elements as functions of the mass of the mediating fermions and estimate the associated uncertainties. We then discuss what can be inferred on the seesaw model parameters in the different mass regimes and clarify how the contribution of the light neutrinos should always be taken into account when deriving bounds on the extra parameters. Conversely, the extra states can also have a significant impact, cancelling the Standard Model neutrino contribution for masses lighter than the nuclear scale and leading to vanishing neutrinoless double beta decay amplitudes even if neutrinos are Majorana particles. We also discuss how seesaw models could reconcile large rates of neutrinoless double beta decay with more stringent cosmological bounds on neutrino masses.Comment: 34 pages, 5 eps figures and 1 axodraw figure. Final version published in JHEP. NME results available in Appendi

Cosmology with Interaction between Phantom Dark Energy and Dark Matter and the Coincidence Problem

We study a cosmological model in which phantom dark energy is coupled to dark matter by phenomenologically introducing a coupled term to the equations of motion of dark energy and dark matter. This term is parameterized by a dimensionless coupling function $\delta$, Hubble parameter and the energy density of dark matter, and it describes an energy flow between the dark energy and dark matter. We discuss two cases: one is the case where the equation-of-state $\omega_e$ of the dark energy is a constant; the other is that the dimensionless coupling function $\delta$ is a constant. We investigate the effect of the interaction on the evolution of the universe, the total lifetime of the universe, and the ratio of the period when the universe is in the coincidence state to its total lifetime. It turns out that the interaction will produce significant deviation from the case without the interaction.Comment: Latex, 17 pages including 14 figures, minor change

Holographic Dark Energy Model and Scalar-Tensor Theories

We study the holographic dark energy model in a generalized scalar tensor theory. In a universe filled with cold dark matter and dark energy, the effect of potential of the scalar field is investigated in the equation of state parameter. We show that for a various types of potentials, the equation of state parameter is negative and transition from deceleration to acceleration expansion of the universe is possible.Comment: 11 pages, no figure. To appear in General Relativity and Gravitatio

Light Sterile Neutrinos: A White Paper

This white paper addresses the hypothesis of light sterile neutrinos based on recent anomalies observed in neutrino experiments and the latest astrophysical data

Cosmic Evolution in a Modified Brans-Dicke Theory

We consider Brans-Dicke theory with a self-interacting potential in Einstein conformal frame. We introduce a class of solutions in which an accelerating expansion is possible in a spatially flat universe for positive and large values of the Brans-Dicke parameter consistent with local gravity experiments. In this Einstein frame formulation, the theory appears as an interacting quintessence model in which the interaction term is given by the conformal transformation. In such an interacting model, we shall show that the solutions lead simultaneously to a constant ratio of energy densities of matter and the scalar field.Comment: 11 pages, 3 figures, To appear in Astrophysics and Space Scienc

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms