Trends in incidence of hospitalization for hypoglycemia and diabetic ketoacidosis in individuals with type 1 or type 2 diabetes with and without severe mental illness, in Denmark from 1996-2020:A nationwide study

OBJECTIVETo examine trends in incidence of acute diabetes complications in individuals with type 1 or type 2 diabetes with and without severe mental illness (SMI) in Denmark by age and calendar year.RESEARCH DESIGN AND METHODSWe conducted a cohort study using nationwide registers from 1996-2020 to identify individuals with diabetes, ascertain SMI status (schizophrenia, bipolar disorder, or major depression) and identify the outcomes, hospitalization for hypoglycemia and diabetic ketoacidosis (DKA). We used Poisson regression to estimate incidence rates (IRs) and incidence rate ratios (IRRs) of recurrent hypoglycemia and DKA events by SMI, age, calendar year, accounting for sex, diabetes duration, education, and country of origin.RESULTSAmongst 433,609 individuals with diabetes, 9% had SMI. Risk of (first and subsequent) hypoglycemia events was higher in individuals with SMI versus without SMI (IRR for first hypoglycemia event: type 1 diabetes: 1.77 [95% CI, 1.56-2.00], type 2 diabetes: 1.64 [95% CI, 1.56-1.74]). Individuals with schizophrenia were particularly at risk of recurrent hypoglycemia events. Risk of first DKA event was higher in individuals with SMI (IRR of first DKA event: type 1 diabetes: 1.78 [95% CI. 1.50-2.11], type 2 diabetes: 1.85 [95% CI. 1.64-2.09]). Except for DKA in the type 2 diabetes group, incidence rate differences between individuals with and without SMI were highest in younger individuals (&lt;50 years) but stable across calendar year. CONCLUSIONSSMI is an important risk factor for acute diabetes complication and effective prevention is needed in this population, especially among the younger population and those with schizophrenia.<br/

Objectively measured physical activity, sedentary behaviour and all-cause mortality in older men: does volume of activity matter more than pattern of accumulation?

OBJECTIVES: To understand how device-measured sedentary behaviour and physical activity are related to all-cause mortality in older men, an age group with high levels of inactivity and sedentary behaviour. METHODS: Prospective population-based cohort study of men recruited from 24 UK General Practices in 1978-1980. In 2010-2012, 3137 surviving men were invited to a follow-up, 1655 (aged 71-92 years) agreed. Nurses measured height and weight, men completed health and demographic questionnaires and wore an ActiGraph GT3x accelerometer. All-cause mortality was collected through National Health Service central registers up to 1 June 2016. RESULTS: After median 5.0 years' follow-up, 194 deaths occurred in 1181 men without pre-existing cardiovascular disease. For each additional 30 min in sedentary behaviour, or light physical activity (LIPA), or 10 min in moderate to vigorous physical activity (MVPA), HRs for mortality were 1.17 (95% CI 1.10 to 1.25), 0.83 (95% CI 0.77 to 0.90) and 0.90 (95% CI 0.84 to 0.96), respectively. Adjustments for confounders did not meaningfully change estimates. Only LIPA remained significant on mutual adjustment for all intensities. The HR for accumulating 150 min MVPA/week in sporadic minutes (achieved by 66% of men) was 0.59 (95% CI 0.43 to 0.81) and 0.58 (95% CI 0.33 to 1.00) for accumulating 150 min MVPA/week in bouts lasting ≥10 min (achieved by 16% of men). Sedentary breaks were not associated with mortality. CONCLUSIONS: In older men, all activities (of light intensity upwards) were beneficial and accumulation of activity in bouts ≥10 min did not appear important beyond total volume of activity. Findings can inform physical activity guidelines for older adults

Late Glacial and Holocene Palaeolake History of the Última Esperanza Region of Southern Patagonia

We undertook multi-proxy analyses on two sediment cores from Lago Pato, a small lake basin at 51°S topographically separated from Lago del Toro in Torres del Paine (TdP), to provide insights into glacier dynamics and lake-level change in the TdP and Última Esperanza region over the last ∼30,000 cal a BP (30 ka). Lago Pato is situated in a region overridden by the Southern Patagonian Ice Field during the Last Glacial and in a transitional climatic zone of Southern Patagonia sensitive to seasonal- to millennial-scale changes in the Southern Hemisphere Westerly Winds (SWW). Results show that a deep ice-dammed and enlarged palaeolake encompassed Lago del Toro and Lago Pato c. 30–20 ka after the ice had retreated from local-Last Glacial Maximum (l-LGM) limits at c. 48–34 ka and during the build-up to the global-Last Glacial Maximum (g-LGM), c. 26–19 ka. Gaps in both sediment records between c. 20–13.4 ka and c. 20–10 ka suggest hiatuses in sediment accumulation during the g-LGM and Antarctic Cold Reversal (ACR) readvances and/or removal by lake lowering or flushing during the Late Glacial–early Holocene. The palaeolake level dropped from >100 m a.s.l. to ∼40–50 m a.s.l. towards the end of the ACR c. 13.4–13.0 ka, creating a shallower glaciolacustrine environment dammed by an ice tongue in the Estancia Puerto Consuelo–Última Esperanza fjord. Further lowering of the enlarged palaeolake level occurred when the ice thinned to <40 m a.s.l., eventually isolating Lago Pato from Lago del Toro and glaciogenic sediment input at c. 11.7 ka. After isolation, the ecology and water levels in Lago Pato became sensitive to regional climate shifts. The shallow, stable, and highly anoxic environment that developed after c. 11.7 ka is associated with weaker (or poleward shifted) SWW at 51°S and was replaced at c. 10 ka by an increasingly productive shallow-littoral lake with a variable lake-level and periodic shifts in anoxic-oxic bottom water conditions and ratios of benthic-planktonic diatoms. A more open Nothofagus forest, established at c. 8.6–7.5 ka, and more arid conditions c. 7.5–5.7 cal ka BP are linked to another phase of weaker (or poleward shifted) SWW at 51°S. More persistently wet conditions from c. 5.7 ka, with extensive closed Nothofagus forests and planktonic diatoms dominant, are associated with stronger (or equatorward shifted) SWW over 51°S. The abrupt return of benthic-to-tychoplanktonic diatoms after c. 3 ka reflects enhanced SWW at 51°S. Increasingly stable lacustrine and littoral wetland conditions established in the last ∼500 years reflect weaker SWW and lasted until recent decades

The SAMI Galaxy Survey: A Range in S0 Properties Indicating Multiple Formation Pathways

It has been proposed that S0 galaxies are either fading spirals or the result of galaxy mergers. The relative contribution of each pathway, and the environments in which they occur remains unknown. Here we investigate stellar and gas kinematics of 219 S0s in the SAMI Survey to look for signs of multiple formation pathways occurring across the full range of environments. We identify a large range of rotational support in their stellar kinematics, which correspond to ranges in their physical structure. We find that pressure-supported S0s with $v/{\sigma}$ below 0.5 tend to be more compact and feature misaligned stellar and gas components, suggesting an external origin for their gas. We postulate that these S0s are consistent with being formed through a merger process. Meanwhile, comparisons of ellipticity, stellar mass and S\'ersic index distributions with spiral galaxies shows that the rotationally supported S0s with $v/{\sigma}$ above 0.5 are more consistent with a faded spiral origin. In addition, a simulated merger pathway involving a compact elliptical and gas-rich satellite results in an S0 that lies within the pressure-supported group. We conclude that two S0 formation pathways are active, with mergers dominating in isolated galaxies and small groups, and the faded spiral pathway being most prominent in large groups ($10^{13} < M_{halo} < 10^{14}$).Comment: 14 pages, 12 figures, accepted for publication in MNRA

Measuring retention within the adolescent brain cognitive development (ABCD)SM study

The Adolescent Brain Cognitive Development (ABCD

The VLA/ALMA Nascent Disk and Multiplicity (VANDAM) Survey of Orion Protostars IV. Unveiling the Embedded Intermediate-Mass Protostar and Disk within OMC2-FIR3/HOPS-370

We present ALMA (0.87~mm and 1.3~mm) and VLA (9~mm) observations toward the candidate intermediate-mass protostar OMC2-FIR3 (HOPS-370; L$_{bol}$~314~L$_{\odot}$) at $\sim$0.1" (40~au) resolution for the continuum emission and ~0.25" (100 au) resolution of nine molecular lines. The dust continuum observed with ALMA at 0.87~mm and 1.3~mm resolve a near edge-on disk toward HOPS-370 with an apparent radius of ~100 au. The VLA observations detect both the disk in dust continuum and free-free emission extended along the jet direction. The ALMA observations of molecular lines (H$_2$CO, SO, CH$_3$OH, $^{13}$CO, C$^{18}$O, NS, and H$^{13}$CN) reveal rotation of the apparent disk surrounding HOPS-370 orthogonal to the jet/outflow direction. We fit radiative transfer models to both the dust continuum structure of the disk and molecular line kinematics of the inner envelope and disk for the H$_2$CO, CH$_3$OH, NS, and SO lines. The central protostar mass is determined to be $\sim$2.5 M_sun with a disk radius of $\sim$94~au, when fit using combinations of the H$_2$CO, CH$_3$OH, NS, and SO lines, consistent with an intermediate-mass protostar. Modeling of the dust continuum and spectral energy distribution (SED) yields a disk mass of 0.035~M$_{\odot}$ (inferred dust+gas) and a dust disk radius of 62~au, thus the dust disk may have a smaller radius than the gas disk, similar to Class II disks. In order to explain the observed luminosity with the measured protostar mass, HOPS-370 must be accreting at a rate between 1.7 and 3.2$\times$10$^{-5}$~M$_{\odot}$~yr$^{-1}$.Comment: Accepted to ApJ; 51 pages, 12 Figures, 7 Table