Adapting Urban Water Systems to Manage Scarcity in the 21st Century: The Case of Los Angeles.

Acute water shortages for large metropolitan regions are likely to become more frequent as climate changes impact historic precipitation levels and urban population grows. California and Los Angeles County have just experienced a severe four year drought followed by a year of high precipitation, and likely drought conditions again in Southern California. We show how the embedded preferences for distant sources, and their local manifestations, have created and/or exacerbated fluctuations in local water availability and suboptimal management. As a socio technical system, water management in the Los Angeles metropolitan region has created a kind of scarcity lock-in in years of low rainfall. We come to this through a decade of coupled research examining landscapes and water use, the development of the complex institutional water management infrastructure, hydrology and a systems network model. Such integrated research is a model for other regions to unpack and understand the actual water resources of a metropolitan region, how it is managed and potential ability to become more water self reliant if the institutions collaborate and manage the resource both parsimoniously, but also in an integrated and conjunctive manner. The Los Angeles County metropolitan region, we find, could transition to a nearly water self sufficient system

Best Practices for Educational Interpreters in South Carolina

The purpose of this reference is to provide districts, charter schools, and state operated programs with best practices for working with educational interpreters including, but not limited to, roles and responsibilities, code of professional conduct, and suggested credentialing. It is not required by regulation but is simply the most up-to-date recommendation from the field

Banner News

https://openspace.dmacc.edu/banner_news/1333/thumbnail.jp

The Grizzly, February 4, 1991

Ursinus Celebrates Black History Month • Welcome Back President Richter • Noted Psychologist to Speak at Ursinus Forum • Kirstin Border Crowned • Sophomore Scholarship Competition Announced • Operation Ursinus Cares • Peace Activist Speaks • Veteran Leads Discussion • King Swamp • The Dark Half • Organ Recital • Fact vs. Fiction • Wrestlers Take It To the Mat • Football Players Honored at Banquet • Swimmers Drown E-town • Martin Scores 1,00th Career Point • Hoopsters Fall to Hopkins • Donald R. Groff Named New Softball Coach • Peace Movement Needs Agenda • Why we are at War: The Opinion of One Informed Layperson • Garbage: A Terrible Thing to Waste • Chemistry of the Gulf Warhttps://digitalcommons.ursinus.edu/grizzlynews/1269/thumbnail.jp

The Grizzly, October 9, 1990

Student Activities Reorganized • Homecoming 1990: Student and Alumnae Festivities • LaRouche Supporter to Speak • Pledging Rules In Effect • EcBa Club Holds First Meeting • The Path to Opportunities • Ursinus Goes South of the Border • Olin Brick Explained • Esther Remembered • Homecoming Festivities • Comedy Brightens Wismer • Pennsylvania Impressionist • Acting Sports • Presenting ProTheatre • Russian Trumpeter • Soccer Team Gets It Together • Grubb\u27s Fearless Predictions • Football Impresses • Field Hockey Rebounds • Harley\u27s Haven • Letters: RAs Question Editorial; Congrats, Now be Quiet! • Classics: Guaranteed to Improve Your Life • Losing Traditions • Grading Our Food Service • Middleton: Man of Many Projectshttps://digitalcommons.ursinus.edu/grizzlynews/1260/thumbnail.jp

The Grizzly, January 28, 1991

Policies and Statistics, A Security Concern: New Quad Regulations; Crime Report Released • Sonia Sanchez: Poet for Peace • Gulf Dialogue Continues • Independence Dogs • Financial Aid Month • You Asked for it: You Got It!! • New Quad Policy • Presidency Symposium • When is Dr. Martin Luther King, Jr.\u27s Birthday? • Who\u27s Who Announced • Mission Conference Held • Back to the Basics • The Innocent • Swimmers on Win Streak • Women Hope for Good Things to Come • A Roller Coaster Season for the Hoopsters • Women Rounding-out Season • The Dream Lives On • Letter: Bundle Up! • Researchers Psyched Out • The Technology of War • A Wasted Solution?https://digitalcommons.ursinus.edu/grizzlynews/1268/thumbnail.jp

The Grizzly, October 2, 1990

Books Stolen From Students and Professors: Suspect Arrested, 81 Books Confiscated • New Era of Recycling to Change Actions and Minds • Utilities Tunnel Nears Completion • Hardman\u27s Biography of Finney Turns Paperback • Gender Stereotypes by Dr. Englund • Speech Exemption Exam • Stolen Book List • Foreign Spotlight • Ghost Search Continues • AC/DC High Voltage Rock N\u27 Roll • Cop Rock Off-Key • Prince Premier • WVOU Schedule • Medieval Melodies Fill Forum • Homecoming Candidates • Vital Signs of the Trauma Center • Summer Science at Ursinus • Facelift for LSB • Bear Pack Wins Mets • Come Sailing! • Bears Lose 12-7 • Flag Football Kicks Off • Wagner Takes First in Mets Meet • US Must Aid Soviet Economic Woes • Temple Strike: Avoiding The Real Issue • Letters: Doughty Appreciates Grizzly; Wall Destruction Coincidental? • Soccer Working Hard • Hockey Splitshttps://digitalcommons.ursinus.edu/grizzlynews/1259/thumbnail.jp

Plunge Show Card

Haggerty Gallery Inaugural Opening. Show Card for Plunge.https://digitalcommons.udallas.edu/plunge/1000/thumbnail.jp

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead