Effective fire extinguishing systems for lithium-ion battery

Lithium-ion batteries are a popular choice of power source for a variety of energy and power demanding applications for both stationary applications and electromobility. Among electrochemical storage systems, Lithium-ion batteries were found to be promising candidate, due to their high power and high energy density. In order to assemble high power batteries for plug-in hybrid electric vehicles and pure electric vehicles, several hundreds of large-format Lithium-ion cells will be required, and even more cells for power/energy demanding stationary applications. However, safety remains a significant concern, as battery failure leads to ejection of hazardous materials and rapid heat release. The failure of a single cell can generate a large amount of heat which can then initiate, in the worst case, the thermal runaway of neighbouring cells, leading to failure throughout the battery pack. The heat accumulation can also run into the venting of a cell, with the emission of flammable organic solvent inside the battery pack. Battery failure can be initiated via a number of different abuse scenarios, such as overheating, overcharging, puncture/crushing, water immersion, or external short circuit. Development of effective mitigation strategies necessitates a study on battery failure events and a better understanding of important characteristics relating to safety, such as heat release, hazardous materials ejection, and thermal propagation. On the other hand, when a fire event is initiated, proper intervention strategies have to be defined in order to avoid it becoming catastrophic. In this paper are reported the results of thermal abuse tests on single Lithium-ion cells and a battery pack. The tests were performed with the technical equipment and resources of National Fire Corps. Screening tests for battery fire extinguishing agents were also performed. The effectiveness of an agent was evaluated through experiments on the cooling effect of fire extinguishing agents. Among the various agents, water and foam were found to be the most effective

The coupling of high-pressure oceanic and continental units in Alpine Corsica: Evidence for syn-exhumation tectonic erosion at the roof of the plate interface

The subduction of continental crust is now a matter of fact but which are the mechanisms and the factors control- ling the exhumation of continental units and their coupling with oceanic units are still a matter of debate. We herein present the tectono-metamorphic study of selected continental units belonging to the Alpine Corsica (Corte area, Central Corsica, France). The tectonic pile in the study area features thin slices of oceanic units (i.e. Schistes Lustrés Complex) tectonically stacked between the continental units (i.e. the Lower Units), which record a pressure–temperature-deformation (P-T-d) evolution related to their burial, down to P-T-peak conditions in the blueschist facies and subsequent exhumation during the Late Cretaceous – Early Oligocene time span. The metamorphic conditions were calculated crossing the results of three different thermobarometers based on the HP-LT metapelites. The continental units only recorded the P-peak conditions of 1.2 GPa-250 °C, up to the T-peak conditions of 0.8 GPa-400 °C, and the retrograde path up to LP-LT conditions. The metamorphic record of the oceanic units includes part of the prograde path occurring before the peak conditions reached at 1.0 GPa-250 °C followed by the last metamorphic event related to LP-LT conditions. The results indicate that each unit experienced a multistage independent pressure–temperature-deformation (P-T-d) evolution and sug- gest that the oceanic and continental units were coupled during the rising of the last ones at about 10 km of depth, where the oceanic units were stored at the base of the wedge. Subsequently they were deformed together by the last ductile deformation event during exhumation. We propose a mechanism of tectonic erosion at the base of the wedge, by which slices of Schistes Lustrés Complex were removed at the roof of the plate interface during the exhumation of the Lower Units

Microbial translocation in chronic liver diseases.

The intestinal microflora is not only involved in the digestion of nutrients, but also in local immunity, forming a barrier against pathogenic microorganisms. The derangement of the gut microflora may lead to microbial translocation, defined as the passage of viable microorganisms or bacterial products (i.e., LPS, lipopeptides) from the intestinal lumen to the mesenteric lymph nodes and other extraintestinal sites. The most recent evidence suggests that microbial translocation (MT) may occur not only in cirrhosis, but also in the early stage of several liver diseases, including alcoholic hepatopathy and nonalcoholic fatty liver disease. Different mechanisms, such as small intestinal bacterial overgrowth, increased permeability of intestinal mucosa, and impaired immunity, may favor MT. Furthermore, MT has been implicated in the pathogenesis of the complications of cirrhosis, which are a significant cause of morbidity and mortality in cirrhotic subjects. Therapeutic strategies aiming at modulating the gut microflora and reducing MT have focused on antibiotic-based options, such as selective intestinal decontamination, and nonantibiotic-based options, such as prokinetics and probiotics. In particular, probiotics may represent an attractive strategy, even though the promising results of experimental models and limited clinical studies need to be confirmed in larger randomized trials

Serafino Zappacosta: An Enlightened Mentor and Educator.

With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science. The authors discuss how the combination of Serafino Zappacosta's extraordinary commitment to teaching and passion for science created a fostering educational environment that led to the creation of the "Ruggero Ceppellini Advanced School of Immunology." The review also illustrates how the research on the MHC and the inspirational scientific context in the Zappacosta's laboratory influenced the authors' early scientific interests, and subsequent professional work as immunologists

Breaking Symmetry Rules Enhance the Options for Stereoselective Propene Polymerization Catalysis

An example of breaking "Ewen's symmetry rule" for olefin catalysis polymerization is proposed by DFT calculations. Catalyst precursors with Cs symmetry are suggested to promote the isotactic propene polymerization by a modification of the active site geometry obtained via coordination with AlH-alkyl species in solution. The origin of stereocontrol in olefin polymerization is due to a dual mechanism dictated by the chiral catalyst. These findings may expand the toolbox for promoting stereoselective olefin polymerization by transition metal catalysts

Prevalence and associated factors of obesity in inflammatory bowel disease: A case-control study

BACKGROUND In recent years, an increasing prevalence of obesity in inflammatory bowel disease (IBD) has been observed. Obesity, moreover, has been directly correlated with a more severe clinical course and loss of response to treatment. AIM To assess the prevalence and associated factors of obesity in IBD. METHODS We collected data about IBD disease pattern and activity, drugs and laboratory investigations in our center. Anthropometric measures were retrieved and obesity defined as a body mass index (BMI) > 30. Then, we compared characteristics of obese vs non obese patients, and Chi-squared test and Student’s t test were used for discrete and continuous variables, respectively, at univariate analysis. For multivariate analysis, we used binomial logistic regression and estimated odd ratios (OR) and 95% confidence intervals (CI) to ascertain factors associated with obesity. RESULTS We enrolled 807 patients with IBD, either ulcerative colitis (UC) or Crohn’s disease (CD). Four hundred seventy-four patients were male (58.7%); the average age was 46.2 ± 13.2 years; 438 (54.2%) patients had CD and 369 (45.8%) UC. We enrolled 378 controls, who were comparable to IBD group for age, sex, BMI, obesity, diabetes and abdominal circumference, while more smokers and more subjects with hypertension were observed among controls. The prevalence of obesity was 6.9% in IBD and 7.9% in controls (not statistically different; P = 0.38). In the comparison of obese IBD patients and obese controls, we did not find any difference regarding diabetes and hypertension prevalence, nor in sex or smoking habits. Obese IBD patients were younger than obese controls (51.2 ± 14.9 years vs 60.7 ± 12.1 years, P = 0.03). At univariate analysis, obese IBD were older than normal weight ones (51.2 ± 14.9 vs 44.5 ± 15.8, P = 0.002). IBD onset age was earlier in obese population (44.8 ± 13.6 vs 35.6 ± 15.6, P = 0.004). We did not detect any difference in disease extension. Obese subjects had consumed more frequently long course of systemic steroids (66.6% vs 12.5%, P = 0.02) as well as antibiotics such as metronidazole or ciprofloxacin (71.4% vs 54.7%, P = 0.05). No difference about other drugs (biologics, mesalazine or thiopurines) was observed. Disease activity was similar between obese and non obese subjects both for UC and CD. Obese IBD patients suffered more frequently from arterial hypertension, type 2 diabetes, non-alcoholic fatty liver disease. Regarding laboratory investigations, obese IBD patients had higher levels of triglyceridemia, fasting blood glucose, gamma-glutamyl-transpeptidase. On multivariate analysis, however, the only factor that appeared to be independently linked to obesity in IBD was the high abdominal circumference (OR = 16.3, 95%CI: 1.03-250, P = 0.04). CONCLUSION Obese IBD patients seem to have features similar to general obese population, and there is no disease-specific factor (disease activity, extension or therapy) that may foster obesity in IBD

Analysis of Corneal Deformation in Paediatric Patients Affected by Maturity Onset Diabetes of the Young Type 2

Abstract Background: To evaluate corneal deformation in Maturity Onset Diabetes of the Young type 2 (MODY2), paediatric subjects were analysed using a Scheimpflug-based device. The purpose of this analysis was to find new biomarkers for MODY2 disease and to gain a better understanding of the pathogenesis of the disease. Methods: A total of 15 patients with genetic and metabolic diagnoses of MODY2 (mean age 12.8 ± 5.66 years) and 15 age-matched healthy subjects were included. The biochemical and anthropometric data of MODY2 patients were collected from clinical records, and a complete ophthalmic check with a Pentacam HR EM-3000 Specular Microscope and Corvis ST devices was performed in both groups. Results: Highest concavity (HC) deflection length, Applanation 1 (A1) deflection amplitude, and A1 deflection area showed significantly lower values in MODY2 patients compared to healthy subjects. A significant positive correlation was observed between Body Mass Index (BMI) and HC deflection area and between waist circumference (WC) and the following parameters: maximum deformation amplitude, HC deformation amplitude, and HC deflection area. The glycosylated hemoglobin level (HbA1c) showed a significant positive correlation with Applanation 2 time and HC time. Conclusions: The obtained results show, for the first time, differences regarding corneal distortion features in the MODY2 population compared with healthy eyes

Sturge-Weber syndrome: a report of 14 cases

Sturge-Weber-Krabe syndrome (SWS), also known as encephalotrigeminalangiomatosis and named the forthfacomatosis, recall the names of the authors who first describedit in its basic clinical, radiological andanatomopathological aspects. We report here 14 cases of Sturge-Weber disease. In 6 of these, despite what had been previously described in literature, an extension of the angioma has been noted in other parts of the body. The study of these subjects stresses not only the need for a pharmacological/neuropsychomotor intervention, but alsothe need of a psychotherapeutic approach, for the emotional and affective implications thatcould derive from this syndrome. The reported cases are similar to those presented in literature for their main features. In particular, two elements are interesting: i) the exceptional diffusion of the red nevousto the whole hemicorpo; and ii) the evaluation of the way the patients live the disease, which has not beenpreviously considered in literature. We can conclude that SWS is a multisystem disorder that requires the neurologist to be aware of the possible endocrine, psychiatric, ophthalmological, and other medical issues that can arise and impact on the neurological status of the patients. and neuropsychomotor therapies, but also a psychotherapeutic support to patients. It should be noted that the literature does not take psychotherapeutic support into consideration