Diagnosis and treatment of idiopathic premature ventricular contractions: A stepwise approach based on the site of origin

Premature ventricular contractions in the absence of structural heart disease are among the most common arrhythmias in clinical practice, with well-defined sites of origin in the right and left ventricle. In this review, starting from the electrocardiographic localization of premature ventricular contractions, we investigated the mechanisms, prevalence in the general population, diagnostic work-up, prognosis and treatment of premature ventricular contractions, according to current scientific evidence

Anatomy of the AGN in NGC 5548: I. A global model for the broadband spectral energy distribution

An extensive multi-satellite campaign on NGC 5548 has revealed this archetypal Seyfert-1 galaxy to be in an exceptional state of persistent heavy absorption. Our observations taken in 2013-2014 with XMM-Newton, Swift, NuSTAR, INTEGRAL, Chandra, HST and two ground-based observatories have together enabled us to establish that this unexpected phenomenon is caused by an outflowing stream of weakly ionised gas (called the obscurer), extending from the vicinity of the accretion disk to the broad-line region. In this work we present the details of our campaign and the data obtained by all the observatories. We determine the spectral energy distribution of NGC 5548 from near-infrared to hard X-rays by establishing the contribution of various emission and absorption processes taking place along our line of sight towards the central engine. We thus uncover the intrinsic emission and produce a broadband continuum model for both obscured (average summer 2013 data) and unobscured ($<$ 2011) epochs of NGC 5548. Our results suggest that the intrinsic NIR/optical/UV continuum is a single Comptonised component with its higher energy tail creating the 'soft X-ray excess'. This component is compatible with emission from a warm, optically-thick corona as part of the inner accretion disk. We then investigate the effects of the continuum on the ionisation balance and thermal stability of photoionised gas for unobscured and obscured epochs.Comment: Accepted for publication in A&A, 19 pages, 13 figure

A fast and long-lived outflow from the supermassive black hole in NGC 5548

Supermassive black holes in the nuclei of active galaxies expel large amounts of matter through powerful winds of ionized gas. The archetypal active galaxy NGC 5548 has been studied for decades, and high-resolution X-ray and UV observations have previously shown a persistent ionized outflow. An observing campaign in 2013 with six space observatories shows the nucleus to be obscured by a long-lasting, clumpy stream of ionized gas never seen before. It blocks 90% of the soft X-ray emission and causes simultaneous deep, broad UV absorption troughs. The outflow velocities of this gas are up to five times faster than those in the persistent outflow, and at a distance of only a few light days from the nucleus, it may likely originate from the accretion disk.Comment: 25 pages, 8 figures. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science, electronically available at Science Express (June 19, 2014). For a brief video explaining the key results of this paper, please visit http://www.issibern.ch/teams/ngc5548/?page_id=2

Trend of incidence, subsite distribution and staging of colorectal neoplasms in the 15-year experience of a specialised cancer registry

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Study of the excess Fe XXV line emission in the central degrees of the Galactic centre using XMM-Newton data

The diffuse Fe XXV (6.7 keV) line emission observed in the Galactic ridge is widely accepted to be produced by a superposition of a large number of unresolved X-ray point sources. In the very central degrees of our Galaxy, however, the existence of an extremely hot (~7 keV) diffuse plasma is still under debate. In this work we measure the Fe XXV line emission using all available XMM-Newton observations of the Galactic centre (GC) and inner disc (-10 &lt; l &lt; 10, -2 &lt; b &lt; 2). We use recent stellar mass distribution models to estimate the amount of X-ray emission originating from unresolved point sources, and find that within a region of l = ±1 and b = ±0.25 the 6.7keV emission is 1.3-1.5 times in excess of what is expected from unresolved point sources. The excess emission is enhanced towards regions where known supernova remnants are located, suggesting that at least a part of this emission is due to genuine diffuse very hot plasma. If the entire excess is due to very hot plasma, an energy injection rate of at least ~6 × 1040 erg s-1 is required, which cannot be provided by the measured supernova explosion rate or past Sgr A∗ activity alone. However, we find that almost the entire excess we observe can be explained by assuming GC stellar populations with iron abundances ~1.9 times higher than those in the bar/bulge, a value that can be reproduced by fitting diffuse X-ray spectra from the corresponding regions. Even in this case, a leftover X-ray excess is concentrated within l = ±0.3 and b = ±0.15, corresponding to a thermal energy of ~2 × 1052 erg, which can be reproduced by the estimated supernova explosion rate in the GC. Finally we discuss a possible connection to the observed GC Fermi-LAT excess

Anatomy of the AGN in NGC 5548. III. The high-energy view with NuSTAR and INTEGRAL

We describe the analysis of the seven broad-band X-ray continuum observations of the archetypal Seyfert 1 galaxy NGC 5548 that were obtained with XMM-Newton or Chandra, simultaneously with high-energy (>10 keV) observations with NuSTAR and INTEGRAL. These data were obtained as part of a multiwavelength campaign undertaken from the summer of 2013 till early 2014. We find evidence of a high-energy cut-off in at least one observation, which we attribute to thermal Comptonization, and a constant reflected component that is likely due to neutral material at least a few light months away from the continuum source. We confirm the presence of strong, partial covering X-ray absorption as the explanation for the sharp decrease in flux through the soft X-ray band. The obscurers appear to be variable in column density and covering fraction on time scales as short as weeks. A fit of the average spectrum over the range 0.3–400 keV with a realistic Comptonization model indicates the presence of a hot corona with a temperature of 40^(+40)_(-10) keV and an optical depth of 2.7^(+0.7)_(-1.2) if a spherical geometry is assumed

The ICRF antenna of DTT: Design status and perspectives

The basis of design for the Ion Cyclotron Range of Frequency (ICRF) antennas of the Divertor Tokamak Test facility (DTT) is defined and the most suitable design solutions abiding by such requirements are shown. DTT will be equipped with one, two or three ICRF modules – the final choice to be taken during the first years of operations – and each module will have two antennas. Each antenna has to reliably couple a radiofrequency (RF) power ≥1.5 MW in the range 60÷90 MHz to the single-null, 6 T, 5.5 MA, DTT scenario and allow for remote (dis)assembling and maintenance operations of its plasma-facing components. Most documented antenna concepts are considered and a large set of alternatives, based on toroidal arrays of two, three or four straps with different shapes and constraints, is quantitatively assessed in terms of RF performances. Two most promising candidates are identified: the one, selected to access a detailed design phase, relies on traditional radiating elements, the other is an innovative concept requiring some R&D

Transient obscuration event captured in NGC 3227. I. Continuum model for the broadband spectral energy distribution

© ESO 2021. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1051/0004-6361/202141324From Swift monitoring of a sample of active galactic nuclei (AGN) we found a transient X-ray obscuration event in Seyfert-1 galaxy NGC 3227, and thus triggered our joint XMM-Newton, NuSTAR, and Hubble Space Telescope (HST) observations to study this event. Here in the first paper of our series we present the broadband continuum modelling of the spectral energy distribution (SED) for NGC 3227, extending from near infrared (NIR) to hard X-rays. We use our new spectra taken with XMM-Newton, NuSTAR, and HST/COS in 2019, together with archival unobscured XMM-Newton, NuSTAR, and HST/STIS data, in order to disentangle various spectral components of NGC 3227 and recover the underlying continuum. We find the observed NIR-optical-UV continuum is explained well by an accretion disk blackbody component (Tmax = 10 eV), which is internally reddened by E(B-V) = 0.45 with a Small Magellanic Cloud (SMC) extinction law. We derive the inner radius (12 Rg) and the accretion rate (0.1 solar mass per year) of the disk by modelling the thermal disk emission. The internal reddening in NGC 3227 is most likely associated with outflows from the dusty AGN torus. In addition, an unreddened continuum component is also evident, which likely arises from scattered radiation, associated with the extended narrow-line region (NLR) of NGC 3227. The extreme ultraviolet (EUV) continuum, and the 'soft X-ray excess', can be explained with a 'warm Comptonisation' component. The hard X-rays are consistent with a power-law and a neutral reflection component. The intrinsic bolometric luminosity of the AGN in NGC 3227 is about 2.2e+43 erg/s in 2019, corresponding to 3% Eddington luminosity. Our continuum modelling of the new triggered data of NGC 3227 requires the presence of a new obscuring gas with column density NH = 5e+22 cm^-2, partially covering the X-ray source (Cf = 0.6).Peer reviewe

Anatomy of the AGN in NGC 5548: II. The spatial, temporal, and physical nature of the outflow from HST/COS Observations

Context. AGN outflows are thought to influence the evolution of their host galaxies and of super massive black holes. Our deep multiwavelength campaign on NGC 5548 has revealed a new, unusually strong X-ray obscuration, accompanied by broad UV absorption troughs observed for the first time in this object. The X-ray obscuration caused a dramatic decrease in the incident ionizing flux on the outflow that produces the long-studied narrow UV absorption lines in this AGN. The resulting data allowed us to construct a comprehensive physical, spatial, and temporal picture for this enduring AGN wind. / Aims. We aim to determine the distance of the narrow UV outflow components from the central source, their total column-density, and the mechanism responsible for their observed absorption variability. Methods. We study the UV spectra acquired during the campaign, as well as from four previous epochs (1998−2011). Our main analysis tools are ionic column-density extraction techniques, photoionization models based on the code CLOUDY, and collisional excitation simulations. / Results. A simple model based on a fixed total column-density absorber, reacting to changes in ionizing illumination, matches the very different ionization states seen in five spectroscopic epochs spanning 16 years. The main component of the enduring outflow is situated at 3.5 ± 1.1 pc from the central source, and its distance and number density are similar to those of the narrow-emitting-line region in this object. Three other components are situated between 5−70 pc and two are farther than 100 pc. The wealth of observational constraints and the anti-correlation between the observed X-ray and UV flux in the 2002 and 2013 epochs make our physical model a leading contender for interpreting trough variability data of quasar outflows. / Conclusions. This campaign, in combination with prior UV and X-ray data, yields the first simple model that can explain the physical characteristics and the substantial variability observed in an AGN outflow