A NEW STRATEGIC WAVE MEASUREMENT STATION OFF NAPLES PORT MAIN BREAKWATER

The accuracy of directional wave spectra sensors is crucial for obtaining accurate forecasts of ocean and coastal wave conditions for scientific and engineering applications. In this paper, a newly designed, low-cost GPS-based wave buoy, called the Directional Wave Spectra Drifter (DWSD), is presented. A field test campaign was conducted at the Gulf of Naples, Italy with the goal of comparing the directional wave properties obtained with the DWSD and with a nearly co-located bottom-mounted Acoustic Doppler Current Profiler (ADCP) from Teledyne RD-Instruments. The comparison shows a very good agreement between the two methodologies. The reliability of this innovative instrument and its low costs allow a large variety of applications, including the implementation of a global, satellite-linked, real-time open-ocean network of drifting directional wave spectra sensors and monitoring the sea-state in harbors to aid ship transit and for planning coastal and offshore constructions. The DWSD is currently in use to better constrain the wave energy climatology with the goal of optimizing the design of a full-scale prototype Wave Energy Converter (WEC) in the port of Naples, Italy

Physical and Numerical Modeling of an Innovative Vertical Breakwater for Sustainable Power Generation in Ports: SE@PORTS Project

This work has been supported by the OCEANERA-NET project, SE@PORTS (Sustainable Energy at Sea Ports); reference OCEANERA/0003/2016, under the frame of Sociedad para el Desarrollo Regional de Cantabria S.A. (SODERCAN)

DNA damage and repair biomarkers in cervical cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

Cervical cancer cells commonly harbour a defective G1/S checkpoint owing to the interaction of viral oncoproteins with p53 and retinoblastoma protein. The activation of the G2/M checkpoint may thus become essential for protecting cancer cells from genotoxic insults, such as chemotherapy. In 52 cervical cancer patients treated with neoadjuvant chemotherapy, we investigated whether the levels of phosphorylated Wee1 (pWee1), a key G2/M checkpoint kinase, and y-H2AX, a marker of DNA double-strand breaks, discriminated between patients with a pathological complete response (pCR) and those with residual disease. We also tested the association between pWee1 and phosphorylated Chk1 (pChk1), a kinase acting upstream Wee1 in the G2/M checkpoint pathway. pWee1, y-H2AX and pChk1 were retrospectively assessed in diagnostic biopsies by immunohistochemistry. The degrees of pWee1 and pChk1 expression were defined using three different classification methods, i.e., staining intensity, Allred score, and a multiplicative score. y-H2AX was analyzed both as continuous and categorical variable. Irrespective of the classification used, elevated levels of pWee1 and y-H2AX were significantly associated with a lower rate of pCR. In univariate and multivariate analyses, pWee1 and y-H2AX were both associated with reduced pCR. Internal validation conducted through a re-sampling without replacement procedure confirmed the robustness of the multivariate model. Finally, we found a significant association between pWee1 and pChk1. The message conveyed by the present analysis is that biomarkers of DNA damage and repair may predict the efficacy of neoadjuvant chemotherapy in cervical cancer. Further studies are warranted to prospectively validate these encouraging findings

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

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