Hearts of Darkness: the inside out probing of black holes

Classical black holes shield us from the singularities that inevitably appear in general relativity. Singularity regularization being one of the main landmarks for a successful theory of quantum gravity, quantum black holes are not obliged to hide their inner core from the outside world. Notwithstanding the aforesaid, it is often implicitly assumed that quantum gravity effects must remain confined to black hole interiors. In this essay, we argue in the opposite direction, discussing theoretical evidence for the existence of strong correlations between the physics inside and outside nonsingular black holes. We conclude that astronomical tests of the surroundings of black holes can provide invaluable information about their so-far unexplored interiors

Transformation-tolerant object recognition in rats revealed by visual priming

Successful use of rodents as models for studying object vision crucially depends on the ability of their visual system to construct representations of visual objects that tolerate (i.e., remain relatively unchanged with respect to) the tremendous changes in object appearance produced, for instance, by size and viewpoint variation. Whether this is the case is still controversial, despite some recent demonstration of transformation-tolerant object recognition in rats. In fact, it remains unknown to what extent such a tolerant recognition has a spontaneous, perceptual basis, or, alternatively, mainly reflects learning of arbitrary associative relations among trained object appearances. In this study, we addressed this question by training rats to categorize a continuum of morph objects resulting from blending two object prototypes. The resulting psychometric curve (reporting the proportion of responses to one prototype along the morph line) served as a reference when, in a second phase of the experiment, either prototype was briefly presented as a prime, immediately before a test morph object. The resulting shift of the psychometric curve showed that recognition became biased toward the identity of the prime. Critically, this bias was observed also when the primes were transformed along a variety of dimensions (i.e., size, position, viewpoint, and their combination) that the animals had never experienced before. These results indicate that rats spontaneously perceive different views/appearances of an object as similar (i.e., as instances of the same object) and argue for the existence of neuronal substrates underlying formation of transformation-tolerant object representations in rats

Healthcare Associated Infections. educational intervention by "Adult Learning" in an Italian teaching hospital

An educational intervention for HAI prevention based on a combination of training, motivation and subsequent application in the current clinical practice in an Italian teaching hospital

INTEGRATION OF ACTIVE SENSORS FOR GEOMETRIC ANALYSIS OF THE CHAPEL OF THE HOLY SHROUD

Abstract. The digital acquisition of Cultural Heritage is a complex process, highly depending on the nature of the object as well as the purpose of its detection. Even if there are different survey techniques and sensors that allow the generation of realistic 3D models, defined by a good metric quality and a detail consistent with the geometric characteristics of the object, an interesting goal could be to develop a unified treatment of the methodologies. The Chapel of the Holy Shroud, with its intricate articulation, becomes the benchmark to test an integrated protocol between a terrestrial laser scanner (TLS) and a wearable mobile laser system (WMLS) based on a SLAM approach. In order to quantify the accuracy and precision of the latter solution, several forms of comparison are proposed. For the case study the ZEB-REVO, produced and marketed by GeoSLAM, is tested. Computations of cloud-to-cloud (C2C) absolute distances, comparisons of slices and extractions of planar features are performed, using stationary laser scanner (Faro FocusS S350) as a reference. Finally, the obtained results are reported, allowing us to assert that the quality of the WMLS measurements is compatible with the data provided by the manufacturer, thus making the instrumentation suitable for certain specific applications.</p

Seismic vulnerability of above-ground storage tanks with unanchored support conditions for Na-tech risks based on Gaussian process regression

AbstractThis paper aims to investigate the seismic vulnerability of an existing unanchored steel storage tank ideally installed in a refinery in Sicily (Italy), along the lines of performance-based earthquake engineering. Tank performance is estimated by means of component-level fragility curves for specific limit states. The assessment is based on a framework that relies on a three-dimensional finite element (3D FE) model and a low-fidelity demand model based on Gaussian process regression, which allows for cheaper simulations. Moreover, to approximate the system response corresponding to the random variation of both peak ground acceleration and liquid filling level, a second-order design of experiments method is adopted. Hence, a parametric investigation is conducted on a specific existing unanchored steel storage tank. The relevant 3D FE model is validated with an experimental campaign carried out on a shaking table test. Special attention is paid to the base uplift due to significant inelastic deformations that occur at the baseplate close to the welded baseplate-to-wall connection, offering extensive information on both capacity and demand. As a result, the tank performance is estimated by means of component-level fragility curves for the aforementioned limit state which are derived through Monte Carlo simulations. The flexibility of the proposed framework allows fragility curves to be derived considering both deterministic and random filling levels. The comparison of the seismic vulnerability of the tank obtained with probabilistic and deterministic mechanical models demonstrates the conservatism of the latter. The same trend is also exhibited in terms of risk assessment

On the Inner Horizon Instability of Non-Singular Black Holes

Regular black holes represent a conservative model in which the classical singularity is replaced by a non-singular core without necessarily modifying the spacetime outside the trapping horizon. Given the possible lack of phenomenological signatures, it is crucial to study the consistency of the model. In this short work, we review the physical mechanism leading to the instability of the central core, arguing that that non-perturbative backreation is non-negligible and must be taken into account to provide a meaningful description of physical black holes

Seismic Vulnerability Analysis of a Coupled Tank-Piping System by Means of Hybrid Simulation and Acoustic Emission

AbstractIn order to shed light on the seismic response of complex industrial plants, advanced finite element models should take into account both multicomponents and relevant coupling effects. These models are usually computationally expensive and rely on significant computational resources. Moreover, the relationships between seismic action, system response and relevant damage levels are often characterized by a high level of nonlinearity, which requires a solid background of experimental data. Vulnerability and reliability analyses both depend on the adoption of a significant number of seismic waveforms that are generally not available when seismic risk evaluation is strictly site-specific. In addition, detection of most vulnerable components, i.e., pipe bends and welding points, is an important step to prevent leakage events. In order to handle these issues, a methodology based on a stochastic seismic ground motion model, hybrid simulation and acoustic emission is presented in this paper. The seismic model is able to generate synthetic ground motions coherent with site-specific analysis. In greater detail, the system is composed of a steel slender tank, i.e., the numerical substructure, and a piping network connected through a bolted flange joint, i.e., the physical substructure. Moreover, to monitor the seismic performance of the pipeline and harness the use of sensor technology, acoustic emission sensors are placed through the pipeline. Thus, real-time acoustic emission signals of the system under study are acquired using acoustic emission sensors. Moreover, in addition to seismic events, also a severe monotonic loading is exerted on the physical substructure. As a result, deformation levels of each critical component were investigated; and the processing of acoustic emission signals provided a more in-depth view of the damage of the analysed components

Hyperthermic Perfusion 16 Years After its First Clinical Applications

It is known that above-normal temperatures (42°-42.5°C) provoke selective damage to neoplastic cells. We used heated circulating blood as a method for heat transfer on patients with limb tumors. From October 1964 to December 1979, we treated a total of 198 patients with hyperthermic perfusion for melanoma of the limbs (91), osteosarcoma (57), and soft tissue sarcoma (50). For melanoma patients, the five-year survival rate, excluding Stage IV, was 60%. For patients with soft tissue sarcoma, the five-year survival rates were 53% and 56% for hyperthermic perfusion and hyperthermic antiblastic perfusion. respectively. For 29 patients with osteosarcoma, hyperthermic perfusion was combined with systematic amputation ofthe limb for a 60% survival rate over a five-year period. Newer studies with osteosarcoma patients involve a multistep treatment that saves the tumor-bearing limb without reducing survival rates. Our 16-year clinical trial demonstrates that hyperthermia is effective in curing some tumors of the limbs, especially osteosarcoma and melanoma. We believe that perfusion remains the most reliable heat transfer method for loco-regional treatment and perhaps even for whole-body treatment for limb tumors

Early melanoma invasivity correlates with gut fungal and bacterial profiles

7openInternationalItalian coauthor/editorBackground The microbiome is emerging as a crucial player of the immune checkpoint in cancer. Melanoma is a highly immunogenic tumour, and the composition of the gut microbiome has been correlated to prognosis and evolution of advanced melanoma and proposed as a biomarker for immune checkpoint therapy. Objectives We investigated the gut fungal and bacterial compositions in early-stage melanoma and correlated microbial profiles with histopathological features. Methods Sequencing of bacterial 16S rRNA and the fungal internal transcribed spacer region was performed on faecal samples of patients with stage I and II melanoma, and healthy controls. A meta-analysis with gut microbiota data from patients with metastatic melanoma was also carried out. Results We found a combination of gut fungal and bacterial profiles significantly discriminating patients with melanoma from controls. In patients with melanoma, we observed an abundance of Prevotella copri and yeasts belonging to the order Saccharomycetales. We found that the bacterial and fungal community correlated to melanoma invasiveness, whereas the specific fungal profile correlated to melanoma regression. Bacteroides was identified as general marker of immunogenicity, being shared by regressive and invasive melanoma. In addition, the bacterial communities in patients with stage I and II melanoma were different in structure and richer than those from patients with metastatic melanoma. Conclusions The composition of the gut microbiota in early-stage melanoma changes along the gradient from in situ to invasive (and metastatic) melanoma. Changes in the microbiota and mycobiota are correlated to the histological features of early-stage melanoma, and to the clinical course and response to immune therapies of advanced-stage melanoma, through direct or indirect immunomodulation.openVitali, F.; Colucci, R.; Di Paola, M.; Pindo, M.; De Filippo, C.; Moretti, S.; Cavalieri, D.Vitali, F.; Colucci, R.; Di Paola, M.; Pindo, M.; De Filippo, C.; Moretti, S.; Cavalieri, D