Detection chain and electronic readout of the QUBIC instrument

The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10⁻¹⁶ W/√Hz

Detection chain and electronic readout of the QUBIC instrument

The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10⁻¹⁶ W/√Hz

De novo protein design enables the precise induction of RSV-neutralizing antibodies

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remains a cornerstone for next-generation vaccines. Here, we present a protein design algorithm called TopoBuilder, with which we engineered epitope-focused immunogens displaying complex structural motifs. In both mice and nonhuman primates, cocktails of three de novo-designed immunogens induced robust neutralizing responses against the respiratory syncytial virus. Furthermore, the immunogens refocused preexisting antibody responses toward defined neutralization epitopes. Overall, our design approach opens the possibility of targeting specific epitopes for the development of vaccines and therapeutic antibodies and, more generally, will be applicable to the design of de novo proteins displaying complex functional motifs. Copyrigh

LISA AIVT Optical Ground Support Equipement technology developments

International audienceThe LISA space interferometer aims at GW detection with »3x10-20/√Hz strain sensitivity, resulting in a displacement sensitivity of 11pm/√Hz over a path length of 2.5x109 m in the frequency range from 3x10-5 to 1 Hz.The LISA France Collaboration is in charge of the ground optical tests of the MOSA (Moving Optical Sub-Assembly), including the Optical Bench, Telescope and Gravitational Reference Sensor. Special check-out equipment is required, such as the Far-Field Optical Ground Support Equipment aiming at measuring the Tilt-To-Length coupling coefficient between angular residual beam jitter and longitudinal path length. The FF-OGSE simulates the incoming jittering beam and measures the associated longitudinal path length change.We present two prototypes – the Zerodur InterFerOmeter and the TTL-OB - that will demonstrate the optical performance, the functional tests, the limits on sensitivity and the precision of the path length measurements achievable on-ground. These two benches are the first part of the design and specification for the FF-OGSE.The Stray Light OGSE aims at stray light characterization in the integrated MOSA. It measures and identifies, separately, the different sources of stray light through the measurement of the corresponding fringe patterns while scanning the laser’s optical frequency

LISA AIVT Optical Ground Support Equipement technology developments

International audienceThe LISA space interferometer aims at GW detection with »3x10-20/√Hz strain sensitivity, resulting in a displacement sensitivity of 11pm/√Hz over a path length of 2.5x109 m in the frequency range from 3x10-5 to 1 Hz.The LISA France Collaboration is in charge of the ground optical tests of the MOSA (Moving Optical Sub-Assembly), including the Optical Bench, Telescope and Gravitational Reference Sensor. Special check-out equipment is required, such as the Far-Field Optical Ground Support Equipment aiming at measuring the Tilt-To-Length coupling coefficient between angular residual beam jitter and longitudinal path length. The FF-OGSE simulates the incoming jittering beam and measures the associated longitudinal path length change.We present two prototypes – the Zerodur InterFerOmeter and the TTL-OB - that will demonstrate the optical performance, the functional tests, the limits on sensitivity and the precision of the path length measurements achievable on-ground. These two benches are the first part of the design and specification for the FF-OGSE.The Stray Light OGSE aims at stray light characterization in the integrated MOSA. It measures and identifies, separately, the different sources of stray light through the measurement of the corresponding fringe patterns while scanning the laser’s optical frequency

LISA AIVT Optical Ground Support Equipement technology developments

International audienceThe LISA space interferometer aims at GW detection with »3x10-20/√Hz strain sensitivity, resulting in a displacement sensitivity of 11pm/√Hz over a path length of 2.5x109 m in the frequency range from 3x10-5 to 1 Hz.The LISA France Collaboration is in charge of the ground optical tests of the MOSA (Moving Optical Sub-Assembly), including the Optical Bench, Telescope and Gravitational Reference Sensor. Special check-out equipment is required, such as the Far-Field Optical Ground Support Equipment aiming at measuring the Tilt-To-Length coupling coefficient between angular residual beam jitter and longitudinal path length. The FF-OGSE simulates the incoming jittering beam and measures the associated longitudinal path length change.We present two prototypes – the Zerodur InterFerOmeter and the TTL-OB - that will demonstrate the optical performance, the functional tests, the limits on sensitivity and the precision of the path length measurements achievable on-ground. These two benches are the first part of the design and specification for the FF-OGSE.The Stray Light OGSE aims at stray light characterization in the integrated MOSA. It measures and identifies, separately, the different sources of stray light through the measurement of the corresponding fringe patterns while scanning the laser’s optical frequency

LISA AIVT Optical Ground Support Equipement technology developments

International audienceThe LISA space interferometer aims at GW detection with »3x10-20/√Hz strain sensitivity, resulting in a displacement sensitivity of 11pm/√Hz over a path length of 2.5x109 m in the frequency range from 3x10-5 to 1 Hz.The LISA France Collaboration is in charge of the ground optical tests of the MOSA (Moving Optical Sub-Assembly), including the Optical Bench, Telescope and Gravitational Reference Sensor. Special check-out equipment is required, such as the Far-Field Optical Ground Support Equipment aiming at measuring the Tilt-To-Length coupling coefficient between angular residual beam jitter and longitudinal path length. The FF-OGSE simulates the incoming jittering beam and measures the associated longitudinal path length change.We present two prototypes – the Zerodur InterFerOmeter and the TTL-OB - that will demonstrate the optical performance, the functional tests, the limits on sensitivity and the precision of the path length measurements achievable on-ground. These two benches are the first part of the design and specification for the FF-OGSE.The Stray Light OGSE aims at stray light characterization in the integrated MOSA. It measures and identifies, separately, the different sources of stray light through the measurement of the corresponding fringe patterns while scanning the laser’s optical frequency

LISA AIVT Optical Ground Support Equipement technology developments

International audienceThe LISA space interferometer aims at GW detection with »3x10-20/√Hz strain sensitivity, resulting in a displacement sensitivity of 11pm/√Hz over a path length of 2.5x109 m in the frequency range from 3x10-5 to 1 Hz.The LISA France Collaboration is in charge of the ground optical tests of the MOSA (Moving Optical Sub-Assembly), including the Optical Bench, Telescope and Gravitational Reference Sensor. Special check-out equipment is required, such as the Far-Field Optical Ground Support Equipment aiming at measuring the Tilt-To-Length coupling coefficient between angular residual beam jitter and longitudinal path length. The FF-OGSE simulates the incoming jittering beam and measures the associated longitudinal path length change.We present two prototypes – the Zerodur InterFerOmeter and the TTL-OB - that will demonstrate the optical performance, the functional tests, the limits on sensitivity and the precision of the path length measurements achievable on-ground. These two benches are the first part of the design and specification for the FF-OGSE.The Stray Light OGSE aims at stray light characterization in the integrated MOSA. It measures and identifies, separately, the different sources of stray light through the measurement of the corresponding fringe patterns while scanning the laser’s optical frequency