Automated Slope Stability Analysis of Zoned Dams

The study pertains to the pseudo-static stability analysis of zoned dams with geologic discontinuities in the foundation. Sequential unconstrained minimization technique in conjunction with Janbu\u27s generalized procedure of slices has been used for finding the critical slip surface and the corresponding minimum factor of safety. The method has been found to be quite efficient in solving such problems

Study of fragmentation using clusterization algorithm with realistic binding energies

We here study fragmentation using \emph{simulated annealing clusterization algorithm} (SACA) with binding energy at a microscopic level. In an earlier version, a constant binding energy (4 MeV/nucleon) was used. We improve this binding energy criterion by calculating the binding energy of different clusters using modified Bethe-Weizs\"{a}cker mass (BWM) formula. We also compare our calculations with experimental data of ALADiN group. Nearly no effect is visible of this modification

On the Torsion of Elastic Half Space with Penny Shaped Crack

The investigation deals with the effect of an embedded flaw-a penny-shaped crack in an elastic half-space subject to torsional deformation. The problem is reduced to a system of Fredholm integral equations. Graphical display of the results are included

Evaluation of catalyst for the oxidative ammonolysis of m-xylene.

Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.A.Sc.)--University of Windsor (Canada), 1972

From fusion to total disassembly: global stopping in heavy-ion collisions

Using the quantum molecular dynamics model, we aim to investigate the emis- sion of light complex particles, and degree of stopping reached in heavy-ion colli- sions. We took incident energies between 50 and 1000 MeV/nucleon. In addition, central and peripheral collisions and different masses are also considered. We ob- serve that the light complex particles act in almost similar manner as anisotropic ratio. In other words, multiplicity of light complex particles is an indicator of global stopping in heavy-ion collisions. We see that maximum light complex particles and stopping is obtained for heavier masses in central collisions

Limits on stable iron in Type \,Ia supernovae from NIR spectroscopy

We obtained optical and near-infrared spectra of Type$\,$Ia supernovae (SNe$\,$Ia) at epochs ranging from 224 to 496 days after the explosion. The spectra show emission lines from forbidden transitions of singly ionised iron and cobalt atoms. We used non-local thermodynamic equilibrium (NLTE) modelling of the first and second ionisation stages of iron, nickel, and cobalt to fit the spectra using a sampling algorithm allowing us to probe a broad parameter space. We derive velocity shifts, line widths, and abundance ratios for iron and cobalt. The measured line widths and velocity shifts of the singly ionised ions suggest a shared emitting region. Our data are fully compatible with radioactive $^{56}$Ni decay as the origin for cobalt and iron. We compare the measured abundance ratios of iron and cobalt to theoretical predictions of various SN$\,$Ia explosion models. These models include, in addition to $^{56}$Ni, different amounts of $^{57}$Ni and stable $^{54,56}$Fe. We can exclude models that produced only $^{54,56}$Fe or only $^{57}$Ni in addition to $^{56}$Ni. If we consider a model that has $^{56}$Ni, $^{57}$Ni, and $^{54,56}$Fe then our data imply that these ratios are $^{54,56}$Fe / $^{56}$Ni $=0.272\pm0.086$ and $^{57}$Ni / $^{56}$Ni $=0.032\pm0.011$.Comment: 10 pages, 7 figures, Accepted for publication in A&

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

<p>Abstract</p> <p>Background</p> <p>Beta amyloid (Aβ) peptides are the major constituents of the senile plaques present in Alzheimer's diseased brain. Pathogenesis has been associated with the aggregated form of the peptide as these fibrils are the conformation readily found in the plaques. However, recent studies have shown that the nonaggregated, soluble assemblies of Aβ have the potential to stimulate neuronal dysfunction and may play a prominent role in the pathogenesis of Alzheimer's disease.</p> <p>Methods</p> <p>Soluble, synthetic Aβ1–42 oligomers were prepared producing mainly dimer-trimer conformations as assessed by SDS-PAGE. Similar analysis demonstrated fibril preparations to produce large insoluble aggregates unable to migrate out of the stacking portion of the gels. These peptide preparations were used to stimulate primary murine microglia and cortical neuron cultures. Microglia were analyzed for changes in signaling response and secretory phenotype via Western analysis and ELISA. Viability was examined by quantifying lactate dehydrogenase release from the cultures.</p> <p>Results</p> <p>Aβ oligomers and fibrils were used to stimulate microglia for comparison. Both the oligomers and fibrils stimulated proinflammatory activation of primary microglia but the specific conformation of the peptide determined the activation profile. Oligomers stimulated increased levels of active, phosphorylated Lyn and Syk kinase as well as p38 MAP kinase compared to fibrils. Moreover, oligomers stimulated a differential secretory profile for interleukin 6, monocyte chemoattractant protein-1 and keratinocyte chemoattractant when compared to fibrils. Finally, soluble oligomers stimulated death of cultured cortical neurons that was exacerbated by the presence of microglia.</p> <p>Conclusion</p> <p>These data suggest that fibrils and oligomers stimulate unique signaling responses in microglia leading to discrete secretory changes and effects on neuron survival. This suggests that inflammation changes during disease may be the consequence of unique peptide-stimulated events and each conformation may represent an individual anti-inflammatory therapeutic target.</p

Nebular spectroscopy of SN 2014J: Detection of stable nickel in near infrared spectra

We present near infrared (NIR) spectroscopy of the nearby supernova 2014J obtained $\sim$450 d after explosion. We detect the [Ni II] 1.939 $\mu$m line in the spectra indicating the presence of stable $^{58}$Ni in the ejecta. The stable nickel is not centrally concentrated but rather distributed as the iron. The spectra are dominated by forbidden [Fe II] and [Co II] lines. We use lines, in the NIR spectra, arising from the same upper energy levels to place constraints on the extinction from host galaxy dust. We find that that our data are in agreement with the high $A_V$ and low $R_V$ found in earlier studies from data near maximum light. Using a $^{56}$Ni mass prior from near maximum light $\gamma$-ray observations, we find $\sim$0.05 M$_\odot$ of stable nickel to be present in the ejecta. We find that the iron group features are redshifted from the host galaxy rest frame by $\sim$600 km s$^{-1}$.Comment: 6 pages, 4 figures, submitted to A&