Mc Cune Albright syndrome: gynecological perspective

The key features of McCune-Albright syndrome include sexual precocious puberty, polyostotic fibrous dysplasia and café au lait spots. It is associated with hyperfunction of multiple endocrine glands. Other endocrine dysfunctions often associated are growth hormone excess, hyperthyroidism, Cushing’s syndrome, hyperprolactinemia and phosphate wasting. We had a case of McCune-Albright syndrome with precocious puberty and irregular cycles and was managed. It is a rare cause of precocious puberty and should be kept in mind while dealing with such cases

LOW POWER AND LOW AREA MULTIPLICATION CIRCUITS THROUGH PARTIAL PRODUCT PERFORATION

Focus on hardware-level approximation by introducing the partial product perforation technique for designing approximate multiplication circuits. The partial product perforation method for creating approximate multipliers. It omit the generation of some partial products, thus reducing the number of partial products that have to be accumulated; we decrease the area, power. The major contributions of this work, the software-based perforation technique on the design of hardware circuits, obtaining the optimized design solutions regarding the power–area–error tradeoffs. Analyze in a mathematically rigorous manner the arithmetic accuracy of partial product perforation and prove that it delivers a bounded and predictable output error. Error analysis is not bound to specific multiplier architecture and can be applied with error guarantees to every multiplication circuit regardless of its architecture that compared with the respective exact design, the partial product perforation. Index Terms: Approximate Arithmetic Circuits, Approximate Computing, Approximate Multiplier, Error Analysis & Low Power

Estudo palinológico dos sedimentos Devonianos, Bacia do Paraná: perfil Ponta Grossa - Campo Largo

The present communication deals with the palynological observations on the Devoniam sediments from Parana Basin, Paraná State, Brazil. This is the first of a series of research work under study and records observations on the paleoecology and biostratigraphy of this region. Though the assemblage is not very rich it has some characteristic spores along with acritarchs which suggests a lower Denovian age (Emsian) to the sediments studied. General comments based on palynological assemblage are also attempted.Este trabalho apresenta algumas observações sobre os palinomorfos dos sedimentos devonianos da Bacia do Paraná, no Estado do Paraná. Trata-se do primeiro de uma série de estudos que estão em andamento, visando melhor compreensão da bioestratigrafia e paleoecologia do Devoniano naquele Estado. A assembléia palinológica por nós estudada e identificada, embora escassa, conte'm esporos e acritarcas que comparados com os de palinozonas devonianas de outras regiões, sugerem uma idade, preliminar, devoniana inferior (Emsiano)

Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding (UCON) : a randomised controlled phase III trial

Acknowledgments This project was funded by the Efficacy and Mechanism Evaluation programme, a Medical Research Council and National Institute for Health Research partnership (grant 12/206/52). Medical Research Council (MRC) Centre grants to the Centre for Reproductive Health (CRH) (G1002033 and MR/N022556/1) are also gratefully acknowledged. The views expressed in this publication are those of the authors and not necessarily those of the Medical Research Council, National Institute for Health Research, or Department of Health and Social Care. We thank our Collaborative Group (listed in the Supplementary Material) for their contribution to recruitment, randomisation and collection of data, and to our Trial Steering and Data Monitoring Committees (members listed in Supplementary Material).Peer reviewedPublisher PD

Pharmacoinformatic investigation of medicinal plants from East Africa

Medicinal plants have widely been used in the traditional treatment of ailments and have been proven effective. Their contribution still holds an important place in modern drug discovery due to their chemical, and biological diversities. However, the poor documentation of traditional medicine, in developing African countries for instance, can lead to the loss of knowledge related to such practices. In this study, we present the Eastern Africa Natural Products Database (EANPDB) containing the structural and bioactivity information of 1870 unique molecules isolated from about 300 source species from the Eastern African region. This represents the largest collection of natural products (NPs) from this geographical region, covering literature data of the period from 1962 to 2019. The computed physicochemical properties and toxicity profiles of each compound have been included. A comparative analysis of some physico-chemical properties like molecular weight, H-bond donor/acceptor, logP(o/w), etc. as well scaffold diversity analysis has been carried out with other published NP databases. EANPDB was combined with the previously published Northern African Natural Products Database (NANPDB), to form a merger African Natural Products Database (ANPDB), containing similar to 6500 unique molecules isolated from about 1000 source species (freely available at http://african-compounds.org). As a case study, latrunculins A and B isolated from the spongeNegombata magnifica(Podospongiidae) with previously reported antitumour activities, were identified via substructure searching as molecules to be explored as putative binders of histone deacetylases (HDACs)

Aberrant Dyskerin Expression Is Related to Proliferation and Poor Survival in Endometrial Cancer

Dyskerin is a core-component of the telomerase holo-enzyme, which elongates telomeres. Telomerase is involved in endometrial epithelial cell proliferation. Most endometrial cancers (ECs) have high telomerase activity; however, dyskerin expression in human healthy endometrium or in endometrial pathologies has not been investigated yet. We aimed to examine the expression, prognostic relevance, and functional role of dyskerin in human EC. Endometrial samples from a cohort of 175 women were examined with immunohistochemistry, immunoblotting, and qPCR. The EC cells were transfected with Myc-DDK-DKC1 plasmid and the effect of dyskerin overexpression on EC cell proliferation was assessed by flow cytometry. Human endometrium expresses dyskerin (DKC1) and dyskerin protein levels are significantly reduced in ECs when compared with healthy postmenopausal endometrium. Low dyskerin immunoscores were potentially associated with worse outcomes, suggesting a possible prognostic relevance. Cancer Genome Atlas (TCGA) ECs dataset (n = 589) was also interrogated. The TCGA dataset further confirmed changes in DKC1 expression in EC with prognostic significance. Transient dyskerin overexpression had a negative effect on EC cell proliferation. Our data demonstrates a role for dyskerin in normal endometrium for the first time and confirms aberrant expression with possible prognostic relevance in EC. Interventions aimed at modulating dyskerin levels may provide novel therapeutic options in EC

The Green, Green Grass of Home: an archaeo-ecological approach to pastoralist settlement in central Kenya

© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This paper considers the ecological residues of pastoralist occupation at the site of Maili Sita in Laikipia, central Kenya, drawing links with the archaeological record so as to contribute a fresh approach to the ephemeral settlement sites of mobile herding communities, a methodological aspect of African archaeology that remains problematic. Variations in the geochemical and micromorphological composition of soils along transects across the site are compared with vegetation distributions and satellite imagery to propose an occupation pattern not dissimilar to contemporary Cushitic-speaking groups further north. We argue that Maili Sita exemplifies the broad migratory and cultural exchange networks in place during the mid- to late second millennium AD, with pastoralist occupants who were both physically and culturally mobile.British Academy (2002-5 Funding) European Union - Marie Curie Initiatives (EXT grant 2007-11

Search for low-mass dark matter via bremsstrahlung radiation and the Migdal effect in SuperCDMS

We present a new analysis of previously published SuperCDMS data using a profile likelihood framework to search for sub-GeV dark matter (DM) particles through two inelastic scattering channels: bremsstrahlung radiation and the Migdal effect. By considering these possible inelastic scattering channels, experimental sensitivity can be extended to DM masses that are undetectable through the DM-nucleon elastic scattering channel, given the energy threshold of current experiments. We exclude DM masses down to 220  MeV/c2 at 2.7×10−30  cm2 via the bremsstrahlung channel. The Migdal channel search provides overall considerably more stringent limits and excludes DM masses down to 30  MeV/c2 at 5.0×10−30  cm2