71 research outputs found
Current Status of Simulations
As the title suggests, the purpose of this chapter is to review the current
status of numerical simulations of black hole accretion disks. This chapter
focuses exclusively on global simulations of the accretion process within a few
tens of gravitational radii of the black hole. Most of the simulations
discussed are performed using general relativistic magnetohydrodynamic (MHD)
schemes, although some mention is made of Newtonian radiation MHD simulations
and smoothed particle hydrodynamics. The goal is to convey some of the exciting
work that has been going on in the past few years and provide some speculation
on future directions.Comment: 15 pages, 14 figures, to appear in the proceedings of the ISSI-Bern
workshop on "The Physics of Accretion onto Black Holes" (8-12 October 2012
Black Hole Spin via Continuum Fitting and the Role of Spin in Powering Transient Jets
The spins of ten stellar black holes have been measured using the
continuum-fitting method. These black holes are located in two distinct classes
of X-ray binary systems, one that is persistently X-ray bright and another that
is transient. Both the persistent and transient black holes remain for long
periods in a state where their spectra are dominated by a thermal accretion
disk component. The spin of a black hole of known mass and distance can be
measured by fitting this thermal continuum spectrum to the thin-disk model of
Novikov and Thorne; the key fit parameter is the radius of the inner edge of
the black hole's accretion disk. Strong observational and theoretical evidence
links the inner-disk radius to the radius of the innermost stable circular
orbit, which is trivially related to the dimensionless spin parameter a_* of
the black hole (|a_*| < 1). The ten spins that have so far been measured by
this continuum-fitting method range widely from a_* \approx 0 to a_* > 0.95.
The robustness of the method is demonstrated by the dozens or hundreds of
independent and consistent measurements of spin that have been obtained for
several black holes, and through careful consideration of many sources of
systematic error. Among the results discussed is a dichotomy between the
transient and persistent black holes; the latter have higher spins and larger
masses. Also discussed is recently discovered evidence in the transient sources
for a correlation between the power of ballistic jets and black hole spin.Comment: 30 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher). Changes to Sections 5.2,
6.1 and 7.4. Section 7.4 responds to Russell et al. 2013 (MNRAS, 431, 405)
who find no evidence for a correlation between the power of ballistic jets
and black hole spi
General Overview of Black Hole Accretion Theory
I provide a broad overview of the basic theoretical paradigms of black hole
accretion flows. Models that make contact with observations continue to be
mostly based on the four decade old alpha stress prescription of Shakura &
Sunyaev (1973), and I discuss the properties of both radiatively efficient and
inefficient models, including their local properties, their expected stability
to secular perturbations, and how they might be tied together in global flow
geometries. The alpha stress is a prescription for turbulence, for which the
only existing plausible candidate is that which develops from the
magnetorotational instability (MRI). I therefore also review what is currently
known about the local properties of such turbulence, and the physical issues
that have been elucidated and that remain uncertain that are relevant for the
various alpha-based black hole accretion flow models.Comment: To be published in Space Science Reviews and as hard cover in the
Space Sciences Series of ISSI: The Physics of Accretion on to Black Holes
(Springer Publisher
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
BACKGROUND: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated participants. To discover rare PD susceptibility variants, we performed WES in 1148 unrelated cases and 503 control participants. Candidate genes were subsequently validated for functions relevant to PD based on parallel RNA-interference (RNAi) screens in human cell culture and Drosophila and C. elegans models. RESULTS: Assuming autosomal recessive inheritance, we identify 27 genes that have homozygous or compound heterozygous loss-of-function variants in PD cases. Definitive replication and confirmation of these findings were hindered by potential heterogeneity and by the rarity of the implicated alleles. We therefore looked for potential genetic interactions with established PD mechanisms. Following RNAi-mediated knockdown, 15 of the genes modulated mitochondrial dynamics in human neuronal cultures and four candidates enhanced α-synuclein-induced neurodegeneration in Drosophila. Based on complementary analyses in independent human datasets, five functionally validated genes-GPATCH2L, UHRF1BP1L, PTPRH, ARSB, and VPS13C-also showed evidence consistent with genetic replication. CONCLUSIONS: By integrating human genetic and functional evidence, we identify several PD susceptibility gene candidates for further investigation. Our approach highlights a powerful experimental strategy with broad applicability for future studies of disorders with complex genetic etiologies
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