2,885 research outputs found
The role of (de-)essentialisation within siting conflicts: an interdisciplinary approach
Large-scale renewable energy and associated technologies (RET), such as high voltage power lines (HVPL), often meet opposition from the local communities living nearby. Research has suggested that one of the main aspects that might contribute to this is the fact that RET are represented as industrial and urban, and thus, as having a different essence from rural landscapes, where they are usually deployed and which are represented as natural and unspoilt. However, this 'hypothesis' of landscape essentialisation shaping people's responses to RET has not been explicitly examined. By drawing upon research from Social Psychology and Human Geography on essentialisation, we will examine if and how landscape (de-)essentialisation plays a role in people's responses to RET. Namely, by examining it as a rhetorical construction that can be strategically used to negotiate and legitimize given relations with place and associated responses to RET.Focus groups were conducted in the UK and Norway with members of local communities to be affected by the construction of HVPLs that will connect to new low carbon energy technologies. Analyses show that participants present British and Norwegian rural landscapes in general and HVPL as having two different essences, which justifies opposition to those infrastructures. However, analyses also show that essentialisation of the countryside is strategically used. Namely, participants also present the countryside in the place where they live as having more of the essence of the British or Norwegian countryside than other areas of the UK and Norway. In turn, this allows them to legitimize claims that whereas HVPL are 'out of place' in the countryside in general, they are more so in the place where they live.The implications of these results for the definition of acceptable locations for RET and for research on people-place relations and responses to place change, are discussed.info:eu-repo/semantics/acceptedVersio
Monoclonal antibodies reacting with the MUC2 mucin core protein.
This study sought to produce monoclonal antibodies (MAbs) which reacted with the MUC2 core protein. Two MAbs [3A2 (IgG1) and 4F1 (IgM)] were produced by immunising female BALB/c mice with gel-formed mucin from the LS174T colon cancer cell line followed by a KLH conjugate of a 29 amino acid synthetic peptide whose sequence was derived from the variable number of tandem repeats (VNTR) region of a MUC2 cDNA clone. The MAbs reacted with synthetic MUC2 VNTR peptides but not synthetic MUC1 or MUC3 VNTR peptides, and showed specific reactivity in Western blotting with a high molecular weight protein produced by the LS174T colon carcinoma cell line. The use of shorter peptides indicated that the minimum peptide epitopes for these MAbs were different. Mab 3A2 reacted with amino acids 5-19 of the MUC2 VNTR by inhibition ELISA but not by direct ELISA, while 4F1 reacted with this peptide in both assays. Furthermore, 4F1 reacted in direct ELISA when a larger (29 amino acid) MUC2-derived peptide was coated onto the assay plate by incubating in carbonate buffer or by drying the peptide onto the assay plate, while 3A2 only reacted when this peptide was coated in carbonate buffer. The different specificity of the MAbs was also illustrated by the reactivity of 4F1 but not 3A2 with partially deglycosylated cystic fibrosis mucin. Immunohistochemical analysis with these MAbs revealed a strong reactivity with lung, gastric and colon tumours relative to normal tissue, with some breast and ovarian tumours also reacting. Both MAbs stained some normal goblet cells in the perinuclear region but not the mucin droplet or secreted mucin, indicating a reaction with immature (poorly glycosylated) mucin in the endoplasmic reticulum and/or golgi, but not with mature (fully glycosylated) mucin. In contrast, tumours showed strong diffuse cytoplasmic staining. 4F1 also showed weak apical cytoplasmic staining in some goblet cells and stained some tumours which showed no reactivity with 3A2. These antibodies should prove useful in the study of MUC2 structure and function, and in the diagnosis of some tumours
Confidential Boosting with Random Linear Classifiers for Outsourced User-generated Data
User-generated data is crucial to predictive modeling in many applications.
With a web/mobile/wearable interface, a data owner can continuously record data
generated by distributed users and build various predictive models from the
data to improve their operations, services, and revenue. Due to the large size
and evolving nature of users data, data owners may rely on public cloud service
providers (Cloud) for storage and computation scalability. Exposing sensitive
user-generated data and advanced analytic models to Cloud raises privacy
concerns. We present a confidential learning framework, SecureBoost, for data
owners that want to learn predictive models from aggregated user-generated data
but offload the storage and computational burden to Cloud without having to
worry about protecting the sensitive data. SecureBoost allows users to submit
encrypted or randomly masked data to designated Cloud directly. Our framework
utilizes random linear classifiers (RLCs) as the base classifiers in the
boosting framework to dramatically simplify the design of the proposed
confidential boosting protocols, yet still preserve the model quality. A
Cryptographic Service Provider (CSP) is used to assist the Cloud's processing,
reducing the complexity of the protocol constructions. We present two
constructions of SecureBoost: HE+GC and SecSh+GC, using combinations of
homomorphic encryption, garbled circuits, and random masking to achieve both
security and efficiency. For a boosted model, Cloud learns only the RLCs and
the CSP learns only the weights of the RLCs. Finally, the data owner collects
the two parts to get the complete model. We conduct extensive experiments to
understand the quality of the RLC-based boosting and the cost distribution of
the constructions. Our results show that SecureBoost can efficiently learn
high-quality boosting models from protected user-generated data
Constructing practices of engagement with users and communities: Comparing emergent state-led smart local energy systems
This is the final version. Available on open access from Elsevier via the DOI in this recordData availability:
The data that has been used is confidential.Energy transitions require engagement with users, local communities and wider publics in order to be fair, acceptable and, ultimately, successful. Here we focus on the development of decentralised energy systems instigated by central government. Smart Local Energy Systems (SLES), involving low carbon generation, demand sources and smart technologies in a geographically-bounded location, are important but unexplored contexts for public engagement. Drawing on 23 interviews with partner organisations in 12 UK SLES projects, we investigate the targets, methods and rationales of engagement. Partners engage a range of user and community groups around multiple energy system components using a variety of methods, directly and via intermediary organisations. Project size is not a major influence on breadth and intensity of engagement. Project partners rationalise practices with reference to characterisations of users and engagement, and practices are conditioned by a range of factors (e.g. technological boundaries, place, partners involved, and the wider organisational context within which SLES projects take place). We highlight a need for future SLES policy to emphasise engagement as a key facet, institute systematic social learning between SLES projects, and consider how to engage publics beyond the boundaries of individual projects.Engineering and Physical Sciences Research Council (EPSRC)Science Foundation Ireland (SFI
Physics Based Model for Online Fault Detection in Autonomous Cryogenic Loading System
We report the progress in the development of the chilldown model for rapid cryogenic loading system developed at KSC. The nontrivial characteristic feature of the analyzed chilldown regime is its active control by dump valves. The two-phase flow model of the chilldown is approximated as one-dimensional homogeneous fluid flow with no slip condition for the interphase velocity. The model is built using commercial SINDAFLUINT software. The results of numerical predictions are in good agreement with the experimental time traces. The obtained results pave the way to the application of the SINDAFLUINT model as a verification tool for the design and algorithm development required for autonomous loading operation
Early contact with palliative care services: A randomised trial in patients with newly detected incurable metastatic cancer
Relativistic three-body bound states and the reduction from four to three dimensions
Beginning with an effective field theory based upon meson exchange, the
Bethe-Salpeter equation for the three-particle propagator (six-point function)
is obtained. Using the one-boson-exchange form of the kernel, this equation is
then analyzed using time-ordered perturbation theory, and a three-dimensional
equation for the propagator is developed. The propagator consists of a
pre-factor in which the relative energies are fixed by the initial state of the
particles, an intermediate part in which only global propagation of the
particles occurs, and a post-factor in which relative energies are fixed by the
final state of the particles. The pre- and post-factors are necessary in order
to account for the transition from states where particles are off their mass
shell to states described by the global propagator with all of the particle
energies on shell. The pole structure of the intermediate part of the
propagator is used to determine the equation for the three-body bound state: a
Schr{\"o}dinger-like relativistic equation with a single, global Green's
function. The role of the pre- and post-factors in the relativistic dynamics is
to incorporate the poles of the breakup channels in the initial and final
states. The derivation of this equation by integrating over the relative times
rather than via a constraint on relative momenta allows the inclusion of
retardation and dynamical boost corrections without introducing unphysical
singularities.Comment: REVTeX, 21 pages, 4 figures, epsf.st
Thermal expansion, heat capacity and magnetostriction of RAl (R = Tm, Yb, Lu) single crystals
We present thermal expansion and longitudinal magnetostriction data for cubic
RAl3 (R = Tm, Yb, Lu) single crystals. The thermal expansion coefficient for
YbAl3 is consistent with an intermediate valence of the Yb ion, whereas the
data for TmAl3 show crystal electric field contributions and have strong
magnetic field dependencies. de Haas-van Alphen-like oscillations were observed
in the magnetostriction data of YbAl3 and LuAl3, several new extreme orbits
were measured and their effective masses were estimated. Zero and 140 kOe
specific heat data taken on both LuAl3 and TmAl3 for T < 200 K allow for the
determination of a CEF splitting scheme for TmAl3
Electron-deuteron scattering in a current-conserving description of relativistic bound states: formalism and impulse approximation calculations
The electromagnetic interactions of a relativistic two-body bound state are
formulated in three dimensions using an equal-time (ET) formalism. This
involves a systematic reduction of four-dimensional dynamics to a
three-dimensional form by integrating out the time components of relative
momenta. A conserved electromagnetic current is developed for the ET formalism.
It is shown that consistent truncations of the electromagnetic current and the
interaction kernel may be made, order-by-order in the coupling constants,
such that appropriate Ward-Takahashi identities are satisfied. A meson-exchange
model of the interaction is used to calculate deuteron vertex functions.
Calculations of electromagnetic form factors for elastic scattering of
electrons by deuterium are performed using an impulse-approximation current.
Negative-energy components of the deuteron's vertex function and retardation
effects in the meson-exchange interaction are found to have only minor effects
on the deuteron form factors.Comment: 42 pages, RevTe
- …